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Protein

P2X purinoceptor

Gene

P2rx4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1338859. P2rx4.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33423HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016028.
HOVERGENiHBG053086.
OrthoDBiEOG78PV92.

Family and domain databases

Gene3Di2.60.490.10. 2 hits.
InterProiIPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
PfamiPF00864. P2X_receptor. 2 hits.
[Graphical view]
PRINTSiPR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCCSVLRA FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF
110 120 130 140 150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV
160 170 180 190 200
PFNASVKTCE VAAWCPVEND AGVPTRNILP NITTSYLKSC IYNARTDPFC
210 220 230 240 250
PIFRLGQIVA DAGHSFQEMA VEGGIMGIQI KWDCNLDRAA SHCLPRYSFR
260 270 280 290 300
RLDTRDLEHN VSPGYNFRFA KYYRDLAGNE QRTLTKAYGI RFDIIVFGKA
310 320 330 340 350
GKFDIIPTMI NVGSGLALLG VATVLCDVIV LYCMKKRYYY RDKKYKYVED
360
YEQGLSGETD Q
Length:361
Mass (Da):40,308
Last modified:May 1, 1999 - v1
Checksum:i26BB4DE78AF91D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115728 Genomic DNA. No translation available.
AF089752 mRNA. Translation: AAC95602.1.
BC005597 mRNA. Translation: AAH05597.1.
RefSeqiNP_001297649.1. NM_001310720.1.
UniGeneiMm.290884.
Mm.463383.

Genome annotation databases

EnsembliENSMUST00000081554; ENSMUSP00000080269; ENSMUSG00000029470.
GeneIDi18438.
UCSCiuc008zlv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115728 Genomic DNA. No translation available.
AF089752 mRNA. Translation: AAC95602.1.
BC005597 mRNA. Translation: AAH05597.1.
RefSeqiNP_001297649.1. NM_001310720.1.
UniGeneiMm.290884.
Mm.463383.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081554; ENSMUSP00000080269; ENSMUSG00000029470.
GeneIDi18438.
UCSCiuc008zlv.1. mouse.

Organism-specific databases

CTDi5025.
MGIiMGI:1338859. P2rx4.

Phylogenomic databases

GeneTreeiENSGT00390000016028.
HOVERGENiHBG053086.
OrthoDBiEOG78PV92.

Enzyme and pathway databases

ReactomeiR-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.490.10. 2 hits.
InterProiIPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
PfamiPF00864. P2X_receptor. 2 hits.
[Graphical view]
PRINTSiPR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors."
    Townsend-Nicholson A., King B.F., Wildman S.S., Burnstock G.
    Brain Res. Mol. Brain Res. 64:246-254(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57Black/6Imported.
    Tissue: BrainImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.
  3. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9Z256_MOUSE
AccessioniPrimary (citable) accession number: Q9Z256
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.