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Protein

P2X purinoceptor

Gene

P2rx4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotation, ReceptorUniRule annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1338859 P2rx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 334HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000029470

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016028
HOVERGENiHBG053086

Family and domain databases

Gene3Di2.60.490.10, 2 hits
InterProiView protein in InterPro
IPR003047 P2X4_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 2 hits
PfamiView protein in Pfam
PF00864 P2X_receptor, 2 hits
PIRSFiPIRSF005713 P2X_purinoceptor, 2 hits
PRINTSiPR01311 P2X4RECEPTOR
PR01307 P2XRECEPTOR
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCCSVLRA FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF
110 120 130 140 150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV
160 170 180 190 200
PFNASVKTCE VAAWCPVEND AGVPTRNILP NITTSYLKSC IYNARTDPFC
210 220 230 240 250
PIFRLGQIVA DAGHSFQEMA VEGGIMGIQI KWDCNLDRAA SHCLPRYSFR
260 270 280 290 300
RLDTRDLEHN VSPGYNFRFA KYYRDLAGNE QRTLTKAYGI RFDIIVFGKA
310 320 330 340 350
GKFDIIPTMI NVGSGLALLG VATVLCDVIV LYCMKKRYYY RDKKYKYVED
360
YEQGLSGETD Q
Length:361
Mass (Da):40,308
Last modified:May 1, 1999 - v1
Checksum:i26BB4DE78AF91D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115728 Genomic DNA No translation available.
AF089752 mRNA Translation: AAC95602.1
BC005597 mRNA Translation: AAH05597.1
RefSeqiNP_001297649.1, NM_001310720.1
UniGeneiMm.290884
Mm.463383

Genome annotation databases

EnsembliENSMUST00000081554; ENSMUSP00000080269; ENSMUSG00000029470
GeneIDi18438
UCSCiuc008zlv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9Z256_MOUSE
AccessioniPrimary (citable) accession number: Q9Z256
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health