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Protein

PDZ domain-containing protein GIPC1

Gene

Gipc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in G protein-linked signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
GLUT1 C-terminal-binding protein
Short name:
GLUT1CBP
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Gene namesi
Name:Gipc1
Synonyms:Gipc, Rgs19ip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi68338. Gipc1.

Subcellular locationi

GO - Cellular componenti

  • brush border Source: RGD
  • cell cortex Source: Ensembl
  • cytosol Source: RGD
  • dendritic shaft Source: Ensembl
  • dendritic spine Source: Ensembl
  • endocytic vesicle Source: RGD
  • extracellular exosome Source: Ensembl
  • membrane Source: RGD
  • synaptic vesicle Source: Ensembl
  • vesicle membrane Source: Ensembl

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874941 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei242PhosphothreonineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z254.
PRIDEiQ9Z254.

PTM databases

iPTMnetiQ9Z254.
PhosphoSitePlusiQ9Z254.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSRNOG00000003864.
GenevisibleiQ9Z254. RN.

Interactioni

Subunit structurei

Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 (C-terminus), GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Plekhg5Q6RFZ73EBI-991162,EBI-9079908

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249850. 4 interactors.
IntActiQ9Z254. 4 interactors.
MINTiMINT-89437.
STRINGi10116.ENSRNOP00000005374.

Structurei

3D structure databases

ProteinModelPortaliQ9Z254.
SMRiQ9Z254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938. Eukaryota.
ENOG410XQ87. LUCA.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiQ9Z254.
KOiK20056.
OMAiMIESING.
OrthoDBiEOG091G0D3X.
PhylomeDBiQ9Z254.
TreeFamiTF313878.

Family and domain databases

InterProiView protein in InterPro
IPR017379. GIPC1/2/3.
IPR001478. PDZ.
PANTHERiPTHR12259. PTHR12259. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSGA GESQMGLPPP
60 70 80 90 100
PASLRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSSGGHP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,133
Last modified:May 1, 2007 - v2
Checksum:i2DE14E6839A218D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253V → I in AAC67549 (PubMed:9770488).Curated1
Sequence conflicti270D → E in AAC67549 (PubMed:9770488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089817 mRNA. Translation: AAC67549.1.
AF032120 mRNA. Translation: AAC69268.1.
BC070505 mRNA. Translation: AAH70505.1.
RefSeqiNP_445793.1. NM_053341.1.
XP_017456861.1. XM_017601372.1.
UniGeneiRn.30044.

Genome annotation databases

EnsembliENSRNOT00000005374; ENSRNOP00000005374; ENSRNOG00000003864.
GeneIDi83823.
KEGGirno:83823.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGIPC1_RAT
AccessioniPrimary (citable) accession number: Q9Z254
Secondary accession number(s): Q6GR70, Q9QUQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2007
Last modified: June 7, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families