Reviewed, UniProtKB/Swiss-Prot Q9Z254 (GIPC1_RAT)

Names and origin

Protein names

Recommended name:
    PDZ domain-containing protein GIPC1
Alternative name(s):
    RGS19-interacting protein 1
    GAIP C-terminus-interacting protein
    RGS-GAIP-interacting protein
    GLUT1 C-terminal-binding protein
      Short name=GLUT1CBP

Gene names

Name:	Gipc1
Synonyms:	Gipc, Rgs19ip1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in G protein-linked signaling By similarity.
Subunit structure	Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C By similarity. Interacts with RGS19 (C-terminus), GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the GIPC family. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Gene Ontology (GO)
Cellular component	brush border Inferred from direct assay. Source: RGD cytosolic part Inferred from direct assay. Source: RGD endocytic vesicle Inferred from direct assay. Source: RGD membrane fraction Inferred from direct assay. Source: RGD
Molecular function	PDZ domain binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ADRB1	P08588	1	EBI-991162,EBI-991009	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	PDZ domain-containing protein GIPC1		PRO_0000087494
Experimental info
	Sequence conflict	253	1	V → I in AAC67549. Ref.1
	Sequence conflict	270	1	D → E in AAC67549. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z254-1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 2DE14E6839A218D6	FASTA	333	36,133
	10 20 30 40 50 60 MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSGA GESQMGLPPP PASLRPRLVF 70 80 90 100 110 120 HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC TLNTHKVDMD KLLGGQIGLE 130 140 150 160 170 180 DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA 190 200 210 220 230 240 INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSSGGHP GSGPQLGTGR 250 260 270 280 290 300 GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 310 320 330 AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP." De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G. Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed: 9770488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RGS19. Tissue: Pituitary.
[2]	"Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton." Bunn R.C., Jensen M.A., Reed B.C. Mol. Biol. Cell 10:819-832(1999) [PubMed: 10198040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ACTN1; GLUT1; KIF1B AND MYO6. Strain: Fischer 344. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype." Liu M., Horowitz A. Mol. Biol. Cell 17:1880-1887(2006) [PubMed: 16467373] [Abstract] Cited for: INTERACTION WITH PLEKHG5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF089817 mRNA. Translation: AAC67549.1. AF032120 mRNA. Translation: AAC69268.1. BC070505 mRNA. Translation: AAH70505.1.
IPI	IPI00209253.
RefSeq	NP_445793.1.
UniGene	Rn.30044
3D structure databases
HSSP	HSSP built from PDB template 1QAV based on UniProtKB P29476.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z254. 1 interaction.
Genome annotation databases
Ensembl	ENSRNOG00000003864. Rattus norvegicus. [Contig view]
GeneID	83823.
KEGG	rno:83823.
Organism-specific databases
RGD	68338. Gipc1.
Phylogenomic databases
HOVERGEN	Q9Z254.
OMA	Q9Z254. DHIQLIS.
Gene expression databases
ArrayExpress	Q9Z254.
GermOnline	ENSRNOG00000003864. Rattus norvegicus.
Family and domain databases
InterPro	IPR001478. PDZ/DHR/GLGF. IPR017379. UCP038083_PDZ. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. [Graphical view]
PIRSF	PIRSF038083. UCP038083_GIPC. 1 hit.
SMART	SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	616438.

Entry information

Entry name

GIPC1_RAT

Accession

Primary (citable) accession number: Q9Z254
Secondary accession number(s): Q6GR70, Q9QUQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	May 1, 2007
Last modified:	June 16, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)