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Protein

Zinc finger protein AEBP2

Gene

Aebp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription corepressor activity Source: MGI

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
Gene namesi
Name:Aebp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1338038. Aebp2.

Subcellular locationi

GO - Cellular componenti

  • ESC/E(Z) complex Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi315 – 316HS → R: Abrogates transcriptional repression but does not affect DNA-binding. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003415912 – 504Zinc finger protein AEBP2Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei131PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z248.
PeptideAtlasiQ9Z248.
PRIDEiQ9Z248.

PTM databases

iPTMnetiQ9Z248.
PhosphoSitePlusiQ9Z248.

Expressioni

Tissue specificityi

Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000030232.
ExpressionAtlasiQ9Z248. baseline and differential.
GenevisibleiQ9Z248. MM.

Interactioni

Subunit structurei

Self-associates (By similarity). Interacts with EED, EZH2, RBBP4 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. May also interact with RBBP7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198014. 5 interactors.
IntActiQ9Z248. 5 interactors.
STRINGi10090.ENSMUSP00000084896.

Structurei

3D structure databases

ProteinModelPortaliQ9Z248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni202 – 287Interaction with RBBP4By similarityAdd BLAST86
Regioni346 – 504Interaction with SUZ12By similarityAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 112Glu-richAdd BLAST79
Compositional biasi59 – 198Gly-richAdd BLAST140
Compositional biasi100 – 234Ser-richAdd BLAST135

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri293 – 315C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 345C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
HOVERGENiHBG061621.
InParanoidiQ9Z248.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
PhylomeDBiQ9Z248.
TreeFamiTF328864.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALADMAD LEELSRLSPL SPGSPGPAAR GRAEPPEEEE EEDDEEAEAE
60 70 80 90 100
AVAALLLNGG AGGGAGGGEA ETMSEPSPES ASQAGGDEDE DEEDDEDEGS
110 120 130 140 150
SSGGAEEESS AESLVGSSSG GCSGDETRSL SPGAASSSSG DGDGKEGLEE
160 170 180 190 200
PKGPRGGPGG PGSSGGGSSS SSVVSSGGDE GYGTGGGGSS ATSGGRRGSL
210 220 230 240 250
EMSSDGEPLS RMDSEDSISS TLMDIDSTIS SGRSTPAMMN GQGSTTASSK
260 270 280 290 300
HIAYNCCWDQ CQACFNSSPD LADHIRSIHV DGQRGGVFVC LWKGCKVYNT
310 320 330 340 350
PSTSQSWLQR HMLTHSGDKP FKCVVGGCNA SFASQGGLAR HVPTHFSQQN
360 370 380 390 400
SSKVSSQPKA KEESPSKAGM NKRRKLKNKR RRSLPRPHDF FDAQTLDAIR
410 420 430 440 450
HRAICFNLSA HIESLGKGHS VVFHSTVIAK RKEESGKIKL LLHWMPEDIL
460 470 480 490 500
PDVWVNESER HQLKTKVVHL SKLPKDTALL LDPNIYRTMP QKRLKRFDIL

NFPR
Length:504
Mass (Da):52,963
Last modified:June 10, 2008 - v2
Checksum:iB08BF191E9C4A289
GO
Isoform 2 (identifier: Q9Z248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-504: Missing.

Show »
Length:496
Mass (Da):51,960
Checksum:iE5A37F94432336E3
GO
Isoform 3 (identifier: Q9Z248-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: FDILNFPR → TLIRKMFNLYLSKQ

Show »
Length:288
Mass (Da):32,501
Checksum:iE484297639CBAE11
GO
Isoform 4 (identifier: Q9Z248-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: Missing.

Show »
Length:274
Mass (Da):30,764
Checksum:i588029CAA56B6C64
GO
Isoform 5 (identifier: Q9Z248-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-197: Missing.
     497-504: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):44,767
Checksum:i55A81750356EB17B
GO

Sequence cautioni

The sequence AAD02854 differs from that shown. Reason: Frameshift at position 192.Curated
The sequence BAC32508 differs from that shown. Reason: Frameshift at position 472.Curated
The sequence BAC32562 differs from that shown. Reason: Frameshift at position 472.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95D → E in AAH31376 (PubMed:15489334).Curated1
Sequence conflicti189S → T in AAD02854 (PubMed:10329662).Curated1
Sequence conflicti273D → Y in BAC26241 (PubMed:16141072).Curated1
Sequence conflicti355S → F in BAC26241 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0343601 – 222Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_034361116 – 197Missing in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_034362497 – 504Missing in isoform 2, isoform 4 and isoform 5. 2 Publications8
Alternative sequenceiVSP_034363497 – 504FDILNFPR → TLIRKMFNLYLSKQ in isoform 3. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA. Translation: BAC26241.1.
AK045838 mRNA. Translation: BAC32508.1. Sequence problems.
AK045987 mRNA. Translation: BAC32562.1. Sequence problems.
AK155272 mRNA. Translation: BAE33156.1.
BC031376 mRNA. Translation: AAH31376.1.
BC057681 mRNA. Translation: AAH57681.1.
AF090326 mRNA. Translation: AAD02854.1. Frameshift.
CCDSiCCDS20673.1. [Q9Z248-2]
CCDS20674.1. [Q9Z248-4]
CCDS39689.1. [Q9Z248-1]
CCDS80631.1. [Q9Z248-3]
RefSeqiNP_001005605.1. NM_001005605.2. [Q9Z248-2]
NP_001296365.1. NM_001309436.1. [Q9Z248-3]
NP_001296366.1. NM_001309437.1. [Q9Z248-3]
NP_033767.2. NM_009637.4. [Q9Z248-1]
NP_848918.1. NM_178803.2. [Q9Z248-4]
XP_006506969.1. XM_006506906.1. [Q9Z248-2]
XP_006506972.1. XM_006506909.3. [Q9Z248-3]
UniGeneiMm.479349.
Mm.86453.

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232. [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232. [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232. [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232. [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232. [Q9Z248-3]
GeneIDi11569.
KEGGimmu:11569.
UCSCiuc009eoi.1. mouse. [Q9Z248-1]
uc009eol.1. mouse. [Q9Z248-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA. Translation: BAC26241.1.
AK045838 mRNA. Translation: BAC32508.1. Sequence problems.
AK045987 mRNA. Translation: BAC32562.1. Sequence problems.
AK155272 mRNA. Translation: BAE33156.1.
BC031376 mRNA. Translation: AAH31376.1.
BC057681 mRNA. Translation: AAH57681.1.
AF090326 mRNA. Translation: AAD02854.1. Frameshift.
CCDSiCCDS20673.1. [Q9Z248-2]
CCDS20674.1. [Q9Z248-4]
CCDS39689.1. [Q9Z248-1]
CCDS80631.1. [Q9Z248-3]
RefSeqiNP_001005605.1. NM_001005605.2. [Q9Z248-2]
NP_001296365.1. NM_001309436.1. [Q9Z248-3]
NP_001296366.1. NM_001309437.1. [Q9Z248-3]
NP_033767.2. NM_009637.4. [Q9Z248-1]
NP_848918.1. NM_178803.2. [Q9Z248-4]
XP_006506969.1. XM_006506906.1. [Q9Z248-2]
XP_006506972.1. XM_006506909.3. [Q9Z248-3]
UniGeneiMm.479349.
Mm.86453.

3D structure databases

ProteinModelPortaliQ9Z248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198014. 5 interactors.
IntActiQ9Z248. 5 interactors.
STRINGi10090.ENSMUSP00000084896.

PTM databases

iPTMnetiQ9Z248.
PhosphoSitePlusiQ9Z248.

Proteomic databases

PaxDbiQ9Z248.
PeptideAtlasiQ9Z248.
PRIDEiQ9Z248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232. [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232. [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232. [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232. [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232. [Q9Z248-3]
GeneIDi11569.
KEGGimmu:11569.
UCSCiuc009eoi.1. mouse. [Q9Z248-1]
uc009eol.1. mouse. [Q9Z248-3]

Organism-specific databases

CTDi121536.
MGIiMGI:1338038. Aebp2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
HOVERGENiHBG061621.
InParanoidiQ9Z248.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
PhylomeDBiQ9Z248.
TreeFamiTF328864.

Enzyme and pathway databases

ReactomeiR-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSiAebp2. mouse.
PROiQ9Z248.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030232.
ExpressionAtlasiQ9Z248. baseline and differential.
GenevisibleiQ9Z248. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAEBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z248
Secondary accession number(s): Q6PF91
, Q78HB0, Q8BGV1, Q8CE51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.