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Protein

Zinc finger protein AEBP2

Gene

Aebp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27926C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34525C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription corepressor activity Source: MGI

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein AEBP2
Alternative name(s):
Adipocyte enhancer-binding protein 2
Short name:
AE-binding protein 2
Gene namesi
Name:Aebp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1338038. Aebp2.

Subcellular locationi

GO - Cellular componenti

  • ESC/E(Z) complex Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi315 – 3162HS → R: Abrogates transcriptional repression but does not affect DNA-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 504503Zinc finger protein AEBP2PRO_0000341591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei131 – 1311PhosphoserineBy similarity
Modified residuei199 – 1991PhosphoserineCombined sources
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei383 – 3831PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z248.
PaxDbiQ9Z248.
PeptideAtlasiQ9Z248.
PRIDEiQ9Z248.

PTM databases

iPTMnetiQ9Z248.
PhosphoSiteiQ9Z248.

Expressioni

Tissue specificityi

Expressed in brain, brown adipose tissue, white adipose tissue, heart, kidney, lung, skeletal muscle, small intestine and spleen. Expressed at low levels in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000030232.
ExpressionAtlasiQ9Z248. baseline and differential.
GenevisibleiQ9Z248. MM.

Interactioni

Subunit structurei

Self-associates (By similarity). Interacts with EED, EZH2, RBBP4 and SUZ12 (By similarity). Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. May also interact with RBBP7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198014. 5 interactions.
IntActiQ9Z248. 5 interactions.
STRINGi10090.ENSMUSP00000084896.

Structurei

3D structure databases

ProteinModelPortaliQ9Z248.
SMRiQ9Z248. Positions 255-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 28786Interaction with RBBP4By similarityAdd
BLAST
Regioni346 – 504159Interaction with SUZ12By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 11279Glu-richAdd
BLAST
Compositional biasi59 – 198140Gly-richAdd
BLAST
Compositional biasi100 – 234135Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri254 – 27926C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34525C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
HOVERGENiHBG061621.
InParanoidiQ9Z248.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
PhylomeDBiQ9Z248.
TreeFamiTF328864.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALADMAD LEELSRLSPL SPGSPGPAAR GRAEPPEEEE EEDDEEAEAE
60 70 80 90 100
AVAALLLNGG AGGGAGGGEA ETMSEPSPES ASQAGGDEDE DEEDDEDEGS
110 120 130 140 150
SSGGAEEESS AESLVGSSSG GCSGDETRSL SPGAASSSSG DGDGKEGLEE
160 170 180 190 200
PKGPRGGPGG PGSSGGGSSS SSVVSSGGDE GYGTGGGGSS ATSGGRRGSL
210 220 230 240 250
EMSSDGEPLS RMDSEDSISS TLMDIDSTIS SGRSTPAMMN GQGSTTASSK
260 270 280 290 300
HIAYNCCWDQ CQACFNSSPD LADHIRSIHV DGQRGGVFVC LWKGCKVYNT
310 320 330 340 350
PSTSQSWLQR HMLTHSGDKP FKCVVGGCNA SFASQGGLAR HVPTHFSQQN
360 370 380 390 400
SSKVSSQPKA KEESPSKAGM NKRRKLKNKR RRSLPRPHDF FDAQTLDAIR
410 420 430 440 450
HRAICFNLSA HIESLGKGHS VVFHSTVIAK RKEESGKIKL LLHWMPEDIL
460 470 480 490 500
PDVWVNESER HQLKTKVVHL SKLPKDTALL LDPNIYRTMP QKRLKRFDIL

NFPR
Length:504
Mass (Da):52,963
Last modified:June 10, 2008 - v2
Checksum:iB08BF191E9C4A289
GO
Isoform 2 (identifier: Q9Z248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-504: Missing.

Show »
Length:496
Mass (Da):51,960
Checksum:iE5A37F94432336E3
GO
Isoform 3 (identifier: Q9Z248-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: FDILNFPR → TLIRKMFNLYLSKQ

Show »
Length:288
Mass (Da):32,501
Checksum:iE484297639CBAE11
GO
Isoform 4 (identifier: Q9Z248-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     497-504: Missing.

Show »
Length:274
Mass (Da):30,764
Checksum:i588029CAA56B6C64
GO
Isoform 5 (identifier: Q9Z248-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-197: Missing.
     497-504: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):44,767
Checksum:i55A81750356EB17B
GO

Sequence cautioni

The sequence AAD02854 differs from that shown. Reason: Frameshift at position 192. Curated
The sequence BAC32508 differs from that shown. Reason: Frameshift at position 472. Curated
The sequence BAC32562 differs from that shown. Reason: Frameshift at position 472. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951D → E in AAH31376 (PubMed:15489334).Curated
Sequence conflicti189 – 1891S → T in AAD02854 (PubMed:10329662).Curated
Sequence conflicti273 – 2731D → Y in BAC26241 (PubMed:16141072).Curated
Sequence conflicti355 – 3551S → F in BAC26241 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 222222Missing in isoform 3 and isoform 4. 2 PublicationsVSP_034360Add
BLAST
Alternative sequencei116 – 19782Missing in isoform 5. 1 PublicationVSP_034361Add
BLAST
Alternative sequencei497 – 5048Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_034362
Alternative sequencei497 – 5048FDILNFPR → TLIRKMFNLYLSKQ in isoform 3. 2 PublicationsVSP_034363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA. Translation: BAC26241.1.
AK045838 mRNA. Translation: BAC32508.1. Sequence problems.
AK045987 mRNA. Translation: BAC32562.1. Sequence problems.
AK155272 mRNA. Translation: BAE33156.1.
BC031376 mRNA. Translation: AAH31376.1.
BC057681 mRNA. Translation: AAH57681.1.
AF090326 mRNA. Translation: AAD02854.1. Frameshift.
CCDSiCCDS20673.1. [Q9Z248-2]
CCDS20674.1. [Q9Z248-4]
CCDS39689.1. [Q9Z248-1]
CCDS80631.1. [Q9Z248-3]
RefSeqiNP_001005605.1. NM_001005605.2. [Q9Z248-2]
NP_001296365.1. NM_001309436.1. [Q9Z248-3]
NP_001296366.1. NM_001309437.1. [Q9Z248-3]
NP_033767.2. NM_009637.4. [Q9Z248-1]
NP_848918.1. NM_178803.2. [Q9Z248-4]
XP_006506969.1. XM_006506906.1. [Q9Z248-2]
XP_006506972.1. XM_006506909.2. [Q9Z248-3]
UniGeneiMm.479349.
Mm.86453.

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232. [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232. [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232. [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232. [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232. [Q9Z248-3]
GeneIDi11569.
KEGGimmu:11569.
UCSCiuc009eoi.1. mouse. [Q9Z248-1]
uc009eol.1. mouse. [Q9Z248-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029011 mRNA. Translation: BAC26241.1.
AK045838 mRNA. Translation: BAC32508.1. Sequence problems.
AK045987 mRNA. Translation: BAC32562.1. Sequence problems.
AK155272 mRNA. Translation: BAE33156.1.
BC031376 mRNA. Translation: AAH31376.1.
BC057681 mRNA. Translation: AAH57681.1.
AF090326 mRNA. Translation: AAD02854.1. Frameshift.
CCDSiCCDS20673.1. [Q9Z248-2]
CCDS20674.1. [Q9Z248-4]
CCDS39689.1. [Q9Z248-1]
CCDS80631.1. [Q9Z248-3]
RefSeqiNP_001005605.1. NM_001005605.2. [Q9Z248-2]
NP_001296365.1. NM_001309436.1. [Q9Z248-3]
NP_001296366.1. NM_001309437.1. [Q9Z248-3]
NP_033767.2. NM_009637.4. [Q9Z248-1]
NP_848918.1. NM_178803.2. [Q9Z248-4]
XP_006506969.1. XM_006506906.1. [Q9Z248-2]
XP_006506972.1. XM_006506909.2. [Q9Z248-3]
UniGeneiMm.479349.
Mm.86453.

3D structure databases

ProteinModelPortaliQ9Z248.
SMRiQ9Z248. Positions 255-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198014. 5 interactions.
IntActiQ9Z248. 5 interactions.
STRINGi10090.ENSMUSP00000084896.

PTM databases

iPTMnetiQ9Z248.
PhosphoSiteiQ9Z248.

Proteomic databases

MaxQBiQ9Z248.
PaxDbiQ9Z248.
PeptideAtlasiQ9Z248.
PRIDEiQ9Z248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032359; ENSMUSP00000032359; ENSMUSG00000030232. [Q9Z248-4]
ENSMUST00000087614; ENSMUSP00000084896; ENSMUSG00000030232. [Q9Z248-2]
ENSMUST00000095350; ENSMUSP00000092993; ENSMUSG00000030232. [Q9Z248-1]
ENSMUST00000160836; ENSMUSP00000124148; ENSMUSG00000030232. [Q9Z248-3]
ENSMUST00000161335; ENSMUSP00000125479; ENSMUSG00000030232. [Q9Z248-3]
GeneIDi11569.
KEGGimmu:11569.
UCSCiuc009eoi.1. mouse. [Q9Z248-1]
uc009eol.1. mouse. [Q9Z248-3]

Organism-specific databases

CTDi121536.
MGIiMGI:1338038. Aebp2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048519.
HOGENOMiHOG000033826.
HOVERGENiHBG061621.
InParanoidiQ9Z248.
KOiK17452.
OMAiFAENICL.
OrthoDBiEOG091G0594.
PhylomeDBiQ9Z248.
TreeFamiTF328864.

Enzyme and pathway databases

ReactomeiR-MMU-212300. PRC2 methylates histones and DNA.
R-MMU-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSiAebp2. mouse.
PROiQ9Z248.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030232.
ExpressionAtlasiQ9Z248. baseline and differential.
GenevisibleiQ9Z248. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAEBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z248
Secondary accession number(s): Q6PF91
, Q78HB0, Q8BGV1, Q8CE51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.