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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

Fkbp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi501 – 5121PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi546 – 5572PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • FK506 binding Source: GO_Central
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
63 kDa FK506-binding protein
Short name:
63 kDa FKBP
Short name:
FKBP-63
FK506-binding protein 9
Short name:
FKBP-9
FKBP65RS
Rotamase
Gene namesi
Name:Fkbp9
Synonyms:Fkbp60, Fkbp63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1350921. Fkbp9.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002551625 – 570Peptidyl-prolyl cis-trans isomerase FKBP9Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)1 Publication1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z247.
PaxDbiQ9Z247.
PeptideAtlasiQ9Z247.
PRIDEiQ9Z247.

PTM databases

iPTMnetiQ9Z247.
PhosphoSitePlusiQ9Z247.

Expressioni

Tissue specificityi

Predominantly expressed in heart, skeletal muscle, lung, liver and kidney. Lower levels found in brain, spleen and testis.2 Publications

Developmental stagei

Expressed in all developmental stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000029781.
CleanExiMM_FKBP9.
GenevisibleiQ9Z247. MM.

Interactioni

Protein-protein interaction databases

BioGridi205110. 1 interactor.
IntActiQ9Z247. 3 interactors.
MINTiMINT-4095122.
STRINGi10090.ENSMUSP00000031795.

Structurei

3D structure databases

ProteinModelPortaliQ9Z247.
SMRiQ9Z247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 142PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini166 – 254PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini278 – 365PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini389 – 477PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini488 – 523EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini533 – 568EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi567 – 570Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ9Z247.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9Z247.
TreeFamiTF105296.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGARGWRR RSLLLLLLWV TGQAAPVLGL AVSSELQIQQ SFVPDECPRT
60 70 80 90 100
VHSGDFVRYH YVGTFLDGQK FDSSYDRDST FNVFVGKGQL IAGMDQALVG
110 120 130 140 150
MCVNERRLVT IPPNLAYGSE GVSGVIPPNS VLHFDVLLVD IWNSEDQVHI
160 170 180 190 200
QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG TLFDSSHNRM KTYDTYVGIG
210 220 230 240 250
WLIPGMDKGL LGMCVGEKRI ITVPPFLAYG EEGDGKDIPG QASLVFDVAL
260 270 280 290 300
LDLHNPKDTI SIENKVVPEN CERRSQSGDF LRYHYNGTLL DGTLFDSSYS
310 320 330 340 350
RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEKGRGSIP
360 370 380 390 400
GSAVLVFDIH VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL
410 420 430 440 450
LDGTLLDSTW NLGKTYNIVL GSGQVVLGMD MGLREMCVGE KRTVIIPPHL
460 470 480 490 500
GYGEAGVDGE VPGSAVLVFD IELLELVSGL PEGYMFIWNG EVSPNLFEEI
510 520 530 540 550
DRDGNGEVLL EEFSEYIHAQ VATGKGKLAP GFNAEMIVKN MFTNQDRNGD
560 570
GKVTAEEFKL KDQEAKHDEL
Length:570
Mass (Da):62,995
Last modified:May 1, 1999 - v1
Checksum:iDFE8B8F2F6A0F1DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40Q → R in AAH26133 (PubMed:15489334).Curated1
Sequence conflicti149H → Q in AAH26133 (PubMed:15489334).Curated1
Sequence conflicti234 – 236DGK → NGE in AAF79215 (PubMed:11710534).Curated3
Sequence conflicti321G → S in BAB25071 (PubMed:16141072).Curated1
Sequence conflicti351G → A in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti353A → T in BAB25071 (PubMed:16141072).Curated1
Sequence conflicti361V → F in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti364F → V in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti378K → N in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti386S → I in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti475E → D in AAF79215 (PubMed:11710534).Curated1
Sequence conflicti548N → S in AAH43129 (PubMed:15489334).Curated1
Sequence conflicti550D → N in AAF79215 (PubMed:11710534).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090334 mRNA. Translation: AAC72964.1.
AF279263 mRNA. Translation: AAF79215.1.
BC026133 mRNA. Translation: AAH26133.1.
BC043129 mRNA. Translation: AAH43129.1.
AK007499 mRNA. Translation: BAB25071.1.
CCDSiCCDS39494.1.
RefSeqiNP_036186.2. NM_012056.2.
UniGeneiMm.20943.

Genome annotation databases

EnsembliENSMUST00000031795; ENSMUSP00000031795; ENSMUSG00000029781.
GeneIDi27055.
KEGGimmu:27055.
UCSCiuc009cbp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090334 mRNA. Translation: AAC72964.1.
AF279263 mRNA. Translation: AAF79215.1.
BC026133 mRNA. Translation: AAH26133.1.
BC043129 mRNA. Translation: AAH43129.1.
AK007499 mRNA. Translation: BAB25071.1.
CCDSiCCDS39494.1.
RefSeqiNP_036186.2. NM_012056.2.
UniGeneiMm.20943.

3D structure databases

ProteinModelPortaliQ9Z247.
SMRiQ9Z247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205110. 1 interactor.
IntActiQ9Z247. 3 interactors.
MINTiMINT-4095122.
STRINGi10090.ENSMUSP00000031795.

PTM databases

iPTMnetiQ9Z247.
PhosphoSitePlusiQ9Z247.

Proteomic databases

MaxQBiQ9Z247.
PaxDbiQ9Z247.
PeptideAtlasiQ9Z247.
PRIDEiQ9Z247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031795; ENSMUSP00000031795; ENSMUSG00000029781.
GeneIDi27055.
KEGGimmu:27055.
UCSCiuc009cbp.2. mouse.

Organism-specific databases

CTDi11328.
MGIiMGI:1350921. Fkbp9.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ9Z247.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9Z247.
TreeFamiTF105296.

Miscellaneous databases

ChiTaRSiFkbp9. mouse.
PROiQ9Z247.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029781.
CleanExiMM_FKBP9.
GenevisibleiQ9Z247. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z247
Secondary accession number(s): Q80ZZ6
, Q8R386, Q9CVM0, Q9JHX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.