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Q9Z247

- FKBP9_MOUSE

UniProt

Q9Z247 - FKBP9_MOUSE

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

Fkbp9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi501 – 512121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi546 – 557122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. FK506 binding Source: RefGenome
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein folding Source: UniProtKB
  3. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_244970. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
63 kDa FK506-binding protein
Short name:
63 kDa FKBP
Short name:
FKBP-63
FK506-binding protein 9
Short name:
FKBP-9
FKBP65RS
Rotamase
Gene namesi
Name:Fkbp9
Synonyms:Fkbp60, Fkbp63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1350921. Fkbp9.

Subcellular locationi

Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 570546Peptidyl-prolyl cis-trans isomerase FKBP9PRO_0000025516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)1 Publication
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z247.
PaxDbiQ9Z247.
PRIDEiQ9Z247.

Expressioni

Tissue specificityi

Predominantly expressed in heart, skeletal muscle, lung, liver and kidney. Lower levels found in brain, spleen and testis.2 Publications

Developmental stagei

Expressed in all developmental stages.1 Publication

Gene expression databases

BgeeiQ9Z247.
CleanExiMM_FKBP9.
GenevestigatoriQ9Z247.

Interactioni

Protein-protein interaction databases

BioGridi205110. 1 interaction.
IntActiQ9Z247. 3 interactions.
MINTiMINT-4095122.
STRINGi10090.ENSMUSP00000031795.

Structurei

3D structure databases

ProteinModelPortaliQ9Z247.
SMRiQ9Z247. Positions 50-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 14289PPIase FKBP-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 25489PPIase FKBP-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 36588PPIase FKBP-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 47789PPIase FKBP-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini488 – 52336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 56836EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi567 – 5704Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ9Z247.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG7T1R9S.
PhylomeDBiQ9Z247.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z247-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGARGWRR RSLLLLLLWV TGQAAPVLGL AVSSELQIQQ SFVPDECPRT
60 70 80 90 100
VHSGDFVRYH YVGTFLDGQK FDSSYDRDST FNVFVGKGQL IAGMDQALVG
110 120 130 140 150
MCVNERRLVT IPPNLAYGSE GVSGVIPPNS VLHFDVLLVD IWNSEDQVHI
160 170 180 190 200
QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG TLFDSSHNRM KTYDTYVGIG
210 220 230 240 250
WLIPGMDKGL LGMCVGEKRI ITVPPFLAYG EEGDGKDIPG QASLVFDVAL
260 270 280 290 300
LDLHNPKDTI SIENKVVPEN CERRSQSGDF LRYHYNGTLL DGTLFDSSYS
310 320 330 340 350
RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEKGRGSIP
360 370 380 390 400
GSAVLVFDIH VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL
410 420 430 440 450
LDGTLLDSTW NLGKTYNIVL GSGQVVLGMD MGLREMCVGE KRTVIIPPHL
460 470 480 490 500
GYGEAGVDGE VPGSAVLVFD IELLELVSGL PEGYMFIWNG EVSPNLFEEI
510 520 530 540 550
DRDGNGEVLL EEFSEYIHAQ VATGKGKLAP GFNAEMIVKN MFTNQDRNGD
560 570
GKVTAEEFKL KDQEAKHDEL
Length:570
Mass (Da):62,995
Last modified:May 1, 1999 - v1
Checksum:iDFE8B8F2F6A0F1DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401Q → R in AAH26133. (PubMed:15489334)Curated
Sequence conflicti149 – 1491H → Q in AAH26133. (PubMed:15489334)Curated
Sequence conflicti234 – 2363DGK → NGE in AAF79215. (PubMed:11710534)Curated
Sequence conflicti321 – 3211G → S in BAB25071. (PubMed:16141072)Curated
Sequence conflicti351 – 3511G → A in AAF79215. (PubMed:11710534)Curated
Sequence conflicti353 – 3531A → T in BAB25071. (PubMed:16141072)Curated
Sequence conflicti361 – 3611V → F in AAF79215. (PubMed:11710534)Curated
Sequence conflicti364 – 3641F → V in AAF79215. (PubMed:11710534)Curated
Sequence conflicti378 – 3781K → N in AAF79215. (PubMed:11710534)Curated
Sequence conflicti386 – 3861S → I in AAF79215. (PubMed:11710534)Curated
Sequence conflicti475 – 4751E → D in AAF79215. (PubMed:11710534)Curated
Sequence conflicti548 – 5481N → S in AAH43129. (PubMed:15489334)Curated
Sequence conflicti550 – 5501D → N in AAF79215. (PubMed:11710534)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090334 mRNA. Translation: AAC72964.1.
AF279263 mRNA. Translation: AAF79215.1.
BC026133 mRNA. Translation: AAH26133.1.
BC043129 mRNA. Translation: AAH43129.1.
AK007499 mRNA. Translation: BAB25071.1.
CCDSiCCDS39494.1.
RefSeqiNP_036186.2. NM_012056.2.
UniGeneiMm.20943.

Genome annotation databases

EnsembliENSMUST00000031795; ENSMUSP00000031795; ENSMUSG00000029781.
GeneIDi27055.
KEGGimmu:27055.
UCSCiuc009cbp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090334 mRNA. Translation: AAC72964.1 .
AF279263 mRNA. Translation: AAF79215.1 .
BC026133 mRNA. Translation: AAH26133.1 .
BC043129 mRNA. Translation: AAH43129.1 .
AK007499 mRNA. Translation: BAB25071.1 .
CCDSi CCDS39494.1.
RefSeqi NP_036186.2. NM_012056.2.
UniGenei Mm.20943.

3D structure databases

ProteinModelPortali Q9Z247.
SMRi Q9Z247. Positions 50-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205110. 1 interaction.
IntActi Q9Z247. 3 interactions.
MINTi MINT-4095122.
STRINGi 10090.ENSMUSP00000031795.

Proteomic databases

MaxQBi Q9Z247.
PaxDbi Q9Z247.
PRIDEi Q9Z247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031795 ; ENSMUSP00000031795 ; ENSMUSG00000029781 .
GeneIDi 27055.
KEGGi mmu:27055.
UCSCi uc009cbp.2. mouse.

Organism-specific databases

CTDi 11328.
MGIi MGI:1350921. Fkbp9.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00530000062784.
HOGENOMi HOG000230960.
HOVERGENi HBG051620.
InParanoidi Q9Z247.
KOi K09575.
OMAi EMIVKNM.
OrthoDBi EOG7T1R9S.
PhylomeDBi Q9Z247.
TreeFami TF105296.

Enzyme and pathway databases

Reactomei REACT_244970. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

ChiTaRSi Fkbp9. mouse.
NextBioi 304999.
PROi Q9Z247.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z247.
CleanExi MM_FKBP9.
Genevestigatori Q9Z247.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 4 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Biochemical analysis of mouse FKBP60, a novel member of the FKBP family."
    Shadidy M., Caubit X., Olsen R., Seternes O.M., Moens U., Krauss S.
    Biochim. Biophys. Acta 1446:295-307(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, CALCIUM-BINDING.
  2. "Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family."
    Jo D., Lyu M.S., Cho E.-G., Park D., Kozak C.A., Kim M.G.
    Mol. Cells 12:272-275(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and Czech II.
    Tissue: Fetal brain and Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-570.
    Strain: C57BL/6J.
    Tissue: Pancreas.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174.

Entry informationi

Entry nameiFKBP9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z247
Secondary accession number(s): Q80ZZ6
, Q8R386, Q9CVM0, Q9JHX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3