Q9Z239 (PLM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholemman

Alternative name(s):
FXYD domain-containing ion transport regulator 1

Gene names

Name:	Fxyd1
Synonyms:	Plm

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK By similarity. Ref.4
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 92	72	Phospholemman		PRO_0000010360
Regions
	Topological domain	21 – 35	15	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 92	36	Cytoplasmic Potential
Amino acid modifications
	Modified residue	79	1	Phosphothreonine Ref.4
	Modified residue	83	1	Phosphoserine; by PKA and PKC By similarity
	Modified residue	88	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z239 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0BDB1DC83417F3AD	FASTA	92	10,323
	10 20 30 40 50 60 MASPGHILAL CVCLLSMASA EAPQEPDPFT YDYHTLRIGG LTIAGILFIL GILIILSKRC 70 80 90 RCKFNQQQRT GEPDEEEGTF RSSIRRLSSR RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene structure and expression of phospholemman in mouse." Bogaev R.C., Jia L.G., Kobayashi Y.M., Palmer C.J., Mounsey J.P., Moorman J.R., Jones L.R., Tucker A.L. Gene 271:69-79(2001) [PubMed: 11410367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79 AND SER-83, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091390 Genomic DNA. Translation: AAD11781.1. AF089734 mRNA. Translation: AAD41683.1. AK002585 mRNA. Translation: BAB22208.1. BC024671 mRNA. Translation: AAH24671.1.
IPI	IPI00130455.
RefSeq	NP_062376.2. NM_019503.4. NP_443717.1. NM_052991.4. NP_443718.1. NM_052992.3. NP_919302.1. NM_194321.2.
UniGene	Mm.1491.
3D structure databases
ProteinModelPortal	Q9Z239.
SMR	Q9Z239. Positions 21-92.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Z239.
PTM databases
PhosphoSite	Q9Z239.
Proteomic databases
PRIDE	Q9Z239.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039909; ENSMUSP00000048460; ENSMUSG00000036570. ENSMUST00000071697; ENSMUSP00000071617; ENSMUSG00000036570. ENSMUST00000108110; ENSMUSP00000103745; ENSMUSG00000036570.
GeneID	56188.
KEGG	mmu:56188.
UCSC	uc009ghu.2. mouse.
Organism-specific databases
CTD	5348.
MGI	MGI:1889273. Fxyd1.
Phylogenomic databases
eggNOG	maNOG21518.
GeneTree	ENSGT00530000063932.
HOGENOM	HBG444253.
HOVERGEN	HBG008212.
InParanoid	Q9Z239.
OMA	RKCRCKF.
OrthoDB	EOG4PG62F.
PhylomeDB	Q9Z239.
Gene expression databases
ArrayExpress	Q9Z239.
Bgee	Q9Z239.
CleanEx	MM_FXYD1.
Genevestigator	Q9Z239.
GermOnline	ENSMUSG00000036570. Mus musculus.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13360.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311978.
SOURCE	Search...

Entry information

Entry name

PLM_MOUSE

Accession

Primary (citable) accession number: Q9Z239

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1999
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program