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Q9Z239

- PLM_MOUSE

UniProt

Q9Z239 - PLM_MOUSE

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Protein

Phospholemman

Gene

Fxyd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed (By similarity).By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. ion channel binding Source: BHF-UCL
  3. sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. muscle contraction Source: Ensembl
  3. positive regulation of sodium ion export from cell Source: BHF-UCL
  4. regulation of cardiac muscle cell membrane potential Source: BHF-UCL
  5. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholemman
Alternative name(s):
FXYD domain-containing ion transport regulator 1
Gene namesi
Name:Fxyd1
Synonyms:Plm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1889273. Fxyd1.

Subcellular locationi

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
  2. sarcolemma Source: BHF-UCL
  3. sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 9272PhospholemmanPRO_0000010360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi60 – 601S-palmitoyl cysteineBy similarity
Lipidationi62 – 621S-palmitoyl cysteineBy similarity
Modified residuei79 – 791Phosphothreonine1 Publication
Modified residuei83 – 831Phosphoserine; alternate1 Publication
Modified residuei83 – 831Phosphoserine; by PKA and PKC; alternateBy similarity
Modified residuei88 – 881Phosphoserine; by PKABy similarity

Post-translational modificationi

Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK (By similarity).By similarity
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9Z239.
PRIDEiQ9Z239.

PTM databases

PhosphoSiteiQ9Z239.

Expressioni

Gene expression databases

BgeeiQ9Z239.
CleanExiMM_FXYD1.
GenevestigatoriQ9Z239.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048460.

Structurei

3D structure databases

ProteinModelPortaliQ9Z239.
SMRiQ9Z239. Positions 21-92.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 3515ExtracellularSequence AnalysisAdd
BLAST
Topological domaini57 – 9236CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42110.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ9Z239.
KOiK13360.
OMAiQEPDPFT.
OrthoDBiEOG7WHHDM.
PhylomeDBiQ9Z239.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z239-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPGHILAL CVCLLSMASA EAPQEPDPFT YDYHTLRIGG LTIAGILFIL
60 70 80 90
GILIILSKRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSSR RR
Length:92
Mass (Da):10,323
Last modified:May 1, 1999 - v1
Checksum:i0BDB1DC83417F3AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091390 Genomic DNA. Translation: AAD11781.1.
AF089734 mRNA. Translation: AAD41683.1.
AK002585 mRNA. Translation: BAB22208.1.
BC024671 mRNA. Translation: AAH24671.1.
CCDSiCCDS21123.1.
RefSeqiNP_062376.2. NM_019503.4.
NP_443717.1. NM_052991.4.
NP_443718.1. NM_052992.3.
NP_919302.1. NM_194321.2.
XP_006540283.1. XM_006540220.1.
UniGeneiMm.1491.

Genome annotation databases

EnsembliENSMUST00000039909; ENSMUSP00000048460; ENSMUSG00000036570.
ENSMUST00000071697; ENSMUSP00000071617; ENSMUSG00000036570.
ENSMUST00000108110; ENSMUSP00000103745; ENSMUSG00000036570.
GeneIDi56188.
KEGGimmu:56188.
UCSCiuc009ghu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091390 Genomic DNA. Translation: AAD11781.1 .
AF089734 mRNA. Translation: AAD41683.1 .
AK002585 mRNA. Translation: BAB22208.1 .
BC024671 mRNA. Translation: AAH24671.1 .
CCDSi CCDS21123.1.
RefSeqi NP_062376.2. NM_019503.4.
NP_443717.1. NM_052991.4.
NP_443718.1. NM_052992.3.
NP_919302.1. NM_194321.2.
XP_006540283.1. XM_006540220.1.
UniGenei Mm.1491.

3D structure databases

ProteinModelPortali Q9Z239.
SMRi Q9Z239. Positions 21-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048460.

PTM databases

PhosphoSitei Q9Z239.

Proteomic databases

PaxDbi Q9Z239.
PRIDEi Q9Z239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039909 ; ENSMUSP00000048460 ; ENSMUSG00000036570 .
ENSMUST00000071697 ; ENSMUSP00000071617 ; ENSMUSG00000036570 .
ENSMUST00000108110 ; ENSMUSP00000103745 ; ENSMUSG00000036570 .
GeneIDi 56188.
KEGGi mmu:56188.
UCSCi uc009ghu.2. mouse.

Organism-specific databases

CTDi 5348.
MGIi MGI:1889273. Fxyd1.

Phylogenomic databases

eggNOGi NOG42110.
GeneTreei ENSGT00530000063932.
HOGENOMi HOG000234467.
HOVERGENi HBG008212.
InParanoidi Q9Z239.
KOi K13360.
OMAi QEPDPFT.
OrthoDBi EOG7WHHDM.
PhylomeDBi Q9Z239.
TreeFami TF333443.

Miscellaneous databases

ChiTaRSi FXYD1. mouse.
NextBioi 311978.
PROi Q9Z239.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z239.
CleanExi MM_FXYD1.
Genevestigatori Q9Z239.

Family and domain databases

InterProi IPR000272. Ion-transport_regulator_FXYD.
[Graphical view ]
Pfami PF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view ]
ProDomi PD005989. PD005989. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS01310. FXYD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPLM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3