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Protein

Phospholemman

Gene

Fxyd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed (By similarity).By similarity

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • ion channel binding Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • positive regulation of sodium ion export from cell Source: BHF-UCL
  • regulation of cardiac muscle cell membrane potential Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholemman
Alternative name(s):
FXYD domain-containing ion transport regulator 1
Gene namesi
Name:Fxyd1
Synonyms:Plm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1889273. Fxyd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 35ExtracellularSequence analysisAdd BLAST15
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 92CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • integral component of plasma membrane Source: GO_Central
  • sarcolemma Source: BHF-UCL
  • sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001036021 – 92PhospholemmanAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi60S-palmitoyl cysteineBy similarity1
Lipidationi62S-palmitoyl cysteineBy similarity1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei88Phosphoserine; by PKABy similarity1

Post-translational modificationi

Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK (By similarity).By similarity
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9Z239.
PeptideAtlasiQ9Z239.
PRIDEiQ9Z239.

PTM databases

iPTMnetiQ9Z239.
PhosphoSitePlusiQ9Z239.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036570.
CleanExiMM_FXYD1.
ExpressionAtlasiQ9Z239. baseline and differential.
GenevisibleiQ9Z239. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048460.

Structurei

3D structure databases

ProteinModelPortaliQ9Z239.
SMRiQ9Z239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J08K. Eukaryota.
ENOG410YYN6. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ9Z239.
KOiK13360.
OMAiQEPDPFT.
OrthoDBiEOG091G17BP.
PhylomeDBiQ9Z239.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGHILAL CVCLLSMASA EAPQEPDPFT YDYHTLRIGG LTIAGILFIL
60 70 80 90
GILIILSKRC RCKFNQQQRT GEPDEEEGTF RSSIRRLSSR RR
Length:92
Mass (Da):10,323
Last modified:May 1, 1999 - v1
Checksum:i0BDB1DC83417F3AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091390 Genomic DNA. Translation: AAD11781.1.
AF089734 mRNA. Translation: AAD41683.1.
AK002585 mRNA. Translation: BAB22208.1.
BC024671 mRNA. Translation: AAH24671.1.
CCDSiCCDS21123.1.
RefSeqiNP_062376.2. NM_019503.4.
NP_443717.1. NM_052991.4.
NP_443718.1. NM_052992.3.
NP_919302.1. NM_194321.2.
UniGeneiMm.1491.

Genome annotation databases

EnsembliENSMUST00000039909; ENSMUSP00000048460; ENSMUSG00000036570.
ENSMUST00000071697; ENSMUSP00000071617; ENSMUSG00000036570.
ENSMUST00000108110; ENSMUSP00000103745; ENSMUSG00000036570.
ENSMUST00000205439; ENSMUSP00000146064; ENSMUSG00000036570.
ENSMUST00000205778; ENSMUSP00000145818; ENSMUSG00000036570.
ENSMUST00000206012; ENSMUSP00000146295; ENSMUSG00000036570.
ENSMUST00000206305; ENSMUSP00000145589; ENSMUSG00000036570.
ENSMUST00000206328; ENSMUSP00000145712; ENSMUSG00000036570.
ENSMUST00000206474; ENSMUSP00000145920; ENSMUSG00000036570.
ENSMUST00000206860; ENSMUSP00000146288; ENSMUSG00000036570.
GeneIDi56188.
KEGGimmu:56188.
UCSCiuc009ghu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091390 Genomic DNA. Translation: AAD11781.1.
AF089734 mRNA. Translation: AAD41683.1.
AK002585 mRNA. Translation: BAB22208.1.
BC024671 mRNA. Translation: AAH24671.1.
CCDSiCCDS21123.1.
RefSeqiNP_062376.2. NM_019503.4.
NP_443717.1. NM_052991.4.
NP_443718.1. NM_052992.3.
NP_919302.1. NM_194321.2.
UniGeneiMm.1491.

3D structure databases

ProteinModelPortaliQ9Z239.
SMRiQ9Z239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048460.

PTM databases

iPTMnetiQ9Z239.
PhosphoSitePlusiQ9Z239.

Proteomic databases

PaxDbiQ9Z239.
PeptideAtlasiQ9Z239.
PRIDEiQ9Z239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039909; ENSMUSP00000048460; ENSMUSG00000036570.
ENSMUST00000071697; ENSMUSP00000071617; ENSMUSG00000036570.
ENSMUST00000108110; ENSMUSP00000103745; ENSMUSG00000036570.
ENSMUST00000205439; ENSMUSP00000146064; ENSMUSG00000036570.
ENSMUST00000205778; ENSMUSP00000145818; ENSMUSG00000036570.
ENSMUST00000206012; ENSMUSP00000146295; ENSMUSG00000036570.
ENSMUST00000206305; ENSMUSP00000145589; ENSMUSG00000036570.
ENSMUST00000206328; ENSMUSP00000145712; ENSMUSG00000036570.
ENSMUST00000206474; ENSMUSP00000145920; ENSMUSG00000036570.
ENSMUST00000206860; ENSMUSP00000146288; ENSMUSG00000036570.
GeneIDi56188.
KEGGimmu:56188.
UCSCiuc009ghu.2. mouse.

Organism-specific databases

CTDi5348.
MGIiMGI:1889273. Fxyd1.

Phylogenomic databases

eggNOGiENOG410J08K. Eukaryota.
ENOG410YYN6. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ9Z239.
KOiK13360.
OMAiQEPDPFT.
OrthoDBiEOG091G17BP.
PhylomeDBiQ9Z239.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiFxyd1. mouse.
PROiQ9Z239.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036570.
CleanExiMM_FXYD1.
ExpressionAtlasiQ9Z239. baseline and differential.
GenevisibleiQ9Z239. MM.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.