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Q9Z238 (CCNE2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin-E2
Gene names
Name:Ccne2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the late G1 and early S phase.

Subunit structure

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.

Post-translational modification

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway By similarity.

Sequence similarities

Belongs to the cyclin family. Cyclin E subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404G1/S-specific cyclin-E2
PRO_0000080462

Regions

Compositional bias297 – 3004Poly-Ala

Amino acid modifications

Modified residue211Phosphoserine By similarity
Modified residue3831Phosphoserine By similarity
Modified residue3921Phosphothreonine By similarity

Experimental info

Sequence conflict61Missing in AAD08817. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z238 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0612C4ACBEE47DAA

FASTA40446,669
        10         20         30         40         50         60 
MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH QYEIRNCWPP 

        70         80         90        100        110        120 
VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWACS QEVWQNMLQK 

       130        140        150        160        170        180 
ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV 

       190        200        210        220        230        240 
NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP 

       250        260        270        280        290        300 
VTVISWLNLF LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA 

       310        320        330        340        350        360 
LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP MEDRHNIQTH 

       370        380        390        400 
TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP PGKH 

« Hide

References

[1]"Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle."
Lauper N., Beck A.R.P., Cariou S., Richman L., Hofmann K., Reith W., Slingerland J.M., Amati B.
Oncogene 17:2637-2643(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers."
Gudas J.M., Payton M., Thukral S., Chen E., Bass M., Robinson M.O., Coats S.
Mol. Cell. Biol. 19:612-622(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF091432 mRNA. Translation: AAC80527.1.
AF106691 mRNA. Translation: AAD08817.1.
CCDSCCDS17965.1.
RefSeqNP_001032211.1. NM_001037134.2.
NP_001269872.1. NM_001282943.1.
NP_033960.1. NM_009830.3.
XP_006537636.1. XM_006537573.1.
XP_006537637.1. XM_006537574.1.
XP_006537638.1. XM_006537575.1.
UniGeneMm.35867.

3D structure databases

ProteinModelPortalQ9Z238.
SMRQ9Z238. Positions 100-369.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Z238.

Proteomic databases

PRIDEQ9Z238.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212.
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212.
GeneID12448.
KEGGmmu:12448.
UCSCuc008rzd.1. mouse.

Organism-specific databases

CTD9134.
MGIMGI:1329034. Ccne2.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00750000117276.
HOGENOMHOG000231743.
HOVERGENHBG050834.
InParanoidQ9Z238.
KOK06626.
OMAYSQEKFI.
PhylomeDBQ9Z238.

Gene expression databases

ArrayExpressQ9Z238.
BgeeQ9Z238.
CleanExMM_CCNE2.
GenevestigatorQ9Z238.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF70. PTHR10177:SF70. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281276.
PROQ9Z238.
SOURCESearch...

Entry information

Entry nameCCNE2_MOUSE
AccessionPrimary (citable) accession number: Q9Z238
Secondary accession number(s): Q9QWU5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot