Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin-E2

Gene

Ccne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the late G1 and early S phase.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. DNA replication initiation Source: MGI
  3. G1/S transition of mitotic cell cycle Source: InterPro
  4. regulation of cell cycle Source: MGI
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_199110. G0 and Early G1.
REACT_219010. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_257943. p53-Dependent G1 DNA Damage Response.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E2
Gene namesi
Name:Ccne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1329034. Ccne2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404G1/S-specific cyclin-E2PRO_0000080462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei383 – 3831PhosphoserineBy similarity
Modified residuei392 – 3921PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9Z238.

PTM databases

PhosphoSiteiQ9Z238.

Expressioni

Tissue specificityi

Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.

Gene expression databases

BgeeiQ9Z238.
CleanExiMM_CCNE2.
ExpressionAtlasiQ9Z238. baseline and differential.
GenevestigatoriQ9Z238.

Interactioni

Subunit structurei

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Z238.
SMRiQ9Z238. Positions 100-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 3004Poly-Ala

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000231743.
HOVERGENiHBG050834.
InParanoidiQ9Z238.
KOiK06626.
OMAiYSQEKFI.
PhylomeDBiQ9Z238.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF70. PTHR10177:SF70. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z238-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH
60 70 80 90 100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS
110 120 130 140 150
PLPDLSWACS QEVWQNMLQK ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL
160 170 180 190 200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV NKNMLQLIGI TSLFIASKLE
210 220 230 240 250
EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP VTVISWLNLF
260 270 280 290 300
LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA
310 320 330 340 350
LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP
360 370 380 390 400
MEDRHNIQTH TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP

PGKH
Length:404
Mass (Da):46,669
Last modified:May 1, 1999 - v1
Checksum:i0612C4ACBEE47DAA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61Missing in AAD08817. (PubMed:9858585)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091432 mRNA. Translation: AAC80527.1.
AF106691 mRNA. Translation: AAD08817.1.
CCDSiCCDS17965.1.
RefSeqiNP_001032211.1. NM_001037134.2.
NP_001269872.1. NM_001282943.1.
NP_033960.1. NM_009830.3.
XP_006537636.1. XM_006537573.1.
XP_006537637.1. XM_006537574.1.
XP_006537638.1. XM_006537575.1.
UniGeneiMm.35867.

Genome annotation databases

EnsembliENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212.
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212.
GeneIDi12448.
KEGGimmu:12448.
UCSCiuc008rzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091432 mRNA. Translation: AAC80527.1.
AF106691 mRNA. Translation: AAD08817.1.
CCDSiCCDS17965.1.
RefSeqiNP_001032211.1. NM_001037134.2.
NP_001269872.1. NM_001282943.1.
NP_033960.1. NM_009830.3.
XP_006537636.1. XM_006537573.1.
XP_006537637.1. XM_006537574.1.
XP_006537638.1. XM_006537575.1.
UniGeneiMm.35867.

3D structure databases

ProteinModelPortaliQ9Z238.
SMRiQ9Z238. Positions 100-369.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9Z238.

Proteomic databases

PRIDEiQ9Z238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212.
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212.
GeneIDi12448.
KEGGimmu:12448.
UCSCiuc008rzd.1. mouse.

Organism-specific databases

CTDi9134.
MGIiMGI:1329034. Ccne2.

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000231743.
HOVERGENiHBG050834.
InParanoidiQ9Z238.
KOiK06626.
OMAiYSQEKFI.
PhylomeDBiQ9Z238.

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_199110. G0 and Early G1.
REACT_219010. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_257943. p53-Dependent G1 DNA Damage Response.

Miscellaneous databases

NextBioi281276.
PROiQ9Z238.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z238.
CleanExiMM_CCNE2.
ExpressionAtlasiQ9Z238. baseline and differential.
GenevestigatoriQ9Z238.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF70. PTHR10177:SF70. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle."
    Lauper N., Beck A.R.P., Cariou S., Richman L., Hofmann K., Reith W., Slingerland J.M., Amati B.
    Oncogene 17:2637-2643(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers."
    Gudas J.M., Payton M., Thukral S., Chen E., Bass M., Robinson M.O., Coats S.
    Mol. Cell. Biol. 19:612-622(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCNE2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z238
Secondary accession number(s): Q9QWU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.