Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin-E2

Gene

Ccne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the late G1 and early S phase.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome organization involved in meiotic cell cycle Source: MGI
  • DNA replication initiation Source: MGI
  • G1/S transition of mitotic cell cycle Source: InterPro
  • regulation of cell cycle Source: MGI
  • regulation of cellular protein localization Source: MGI
  • synapsis Source: MGI
  • telomere maintenance Source: MGI

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-1538133 G0 and Early G1
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E2
Gene namesi
Name:Ccne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1329034 Ccne2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804621 – 404G1/S-specific cyclin-E2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei392PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z238
MaxQBiQ9Z238
PaxDbiQ9Z238
PRIDEiQ9Z238

PTM databases

iPTMnetiQ9Z238
PhosphoSitePlusiQ9Z238

Expressioni

Tissue specificityi

Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.

Gene expression databases

BgeeiENSMUSG00000028212
CleanExiMM_CCNE2
ExpressionAtlasiQ9Z238 baseline and differential
GenevisibleiQ9Z238 MM

Interactioni

Subunit structurei

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103960

Structurei

3D structure databases

ProteinModelPortaliQ9Z238
SMRiQ9Z238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi297 – 300Poly-Ala4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiQ9Z238
KOiK06626
OMAiISPCIII
OrthoDBiEOG091G0DAW
PhylomeDBiQ9Z238

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF70 PTHR10177:SF70, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH
60 70 80 90 100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS
110 120 130 140 150
PLPDLSWACS QEVWQNMLQK ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL
160 170 180 190 200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV NKNMLQLIGI TSLFIASKLE
210 220 230 240 250
EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP VTVISWLNLF
260 270 280 290 300
LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA
310 320 330 340 350
LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP
360 370 380 390 400
MEDRHNIQTH TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP

PGKH
Length:404
Mass (Da):46,669
Last modified:May 1, 1999 - v1
Checksum:i0612C4ACBEE47DAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6Missing in AAD08817 (PubMed:9858585).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091432 mRNA Translation: AAC80527.1
AF106691 mRNA Translation: AAD08817.1
CCDSiCCDS17965.1
RefSeqiNP_001032211.1, NM_001037134.2
NP_001269872.1, NM_001282943.1
NP_033960.1, NM_009830.3
XP_006537636.1, XM_006537573.3
XP_006537637.1, XM_006537574.3
XP_006537638.1, XM_006537575.3
XP_011248215.1, XM_011249913.2
UniGeneiMm.35867

Genome annotation databases

EnsembliENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212
ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212
GeneIDi12448
KEGGimmu:12448
UCSCiuc008rzd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCCNE2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z238
Secondary accession number(s): Q9QWU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health