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Q9Z238

- CCNE2_MOUSE

UniProt

Q9Z238 - CCNE2_MOUSE

Protein

G1/S-specific cyclin-E2

Gene

Ccne2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the late G1 and early S phase.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. DNA replication initiation Source: MGI
    3. G1/S transition of mitotic cell cycle Source: InterPro
    4. regulation of cell cycle Source: MGI
    5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
    REACT_199110. G0 and Early G1.
    REACT_219010. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin-E2
    Gene namesi
    Name:Ccne2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1329034. Ccne2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404G1/S-specific cyclin-E2PRO_0000080462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211PhosphoserineBy similarity
    Modified residuei383 – 3831PhosphoserineBy similarity
    Modified residuei392 – 3921PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9Z238.

    PTM databases

    PhosphoSiteiQ9Z238.

    Expressioni

    Tissue specificityi

    Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.

    Gene expression databases

    ArrayExpressiQ9Z238.
    BgeeiQ9Z238.
    CleanExiMM_CCNE2.
    GenevestigatoriQ9Z238.

    Interactioni

    Subunit structurei

    Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z238.
    SMRiQ9Z238. Positions 100-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi297 – 3004Poly-Ala

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin E subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00750000117276.
    HOGENOMiHOG000231743.
    HOVERGENiHBG050834.
    InParanoidiQ9Z238.
    KOiK06626.
    OMAiYSQEKFI.
    PhylomeDBiQ9Z238.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR028858. Cyclin_E.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF70. PTHR10177:SF70. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z238-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH    50
    QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS 100
    PLPDLSWACS QEVWQNMLQK ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL 150
    EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV NKNMLQLIGI TSLFIASKLE 200
    EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP VTVISWLNLF 250
    LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA 300
    LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP 350
    MEDRHNIQTH TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP 400
    PGKH 404
    Length:404
    Mass (Da):46,669
    Last modified:May 1, 1999 - v1
    Checksum:i0612C4ACBEE47DAA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61Missing in AAD08817. (PubMed:9858585)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091432 mRNA. Translation: AAC80527.1.
    AF106691 mRNA. Translation: AAD08817.1.
    CCDSiCCDS17965.1.
    RefSeqiNP_001032211.1. NM_001037134.2.
    NP_001269872.1. NM_001282943.1.
    NP_033960.1. NM_009830.3.
    XP_006537636.1. XM_006537573.1.
    XP_006537637.1. XM_006537574.1.
    XP_006537638.1. XM_006537575.1.
    UniGeneiMm.35867.

    Genome annotation databases

    EnsembliENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212.
    ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212.
    GeneIDi12448.
    KEGGimmu:12448.
    UCSCiuc008rzd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091432 mRNA. Translation: AAC80527.1 .
    AF106691 mRNA. Translation: AAD08817.1 .
    CCDSi CCDS17965.1.
    RefSeqi NP_001032211.1. NM_001037134.2.
    NP_001269872.1. NM_001282943.1.
    NP_033960.1. NM_009830.3.
    XP_006537636.1. XM_006537573.1.
    XP_006537637.1. XM_006537574.1.
    XP_006537638.1. XM_006537575.1.
    UniGenei Mm.35867.

    3D structure databases

    ProteinModelPortali Q9Z238.
    SMRi Q9Z238. Positions 100-369.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z238.

    Proteomic databases

    PRIDEi Q9Z238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108324 ; ENSMUSP00000103960 ; ENSMUSG00000028212 .
    ENSMUST00000170901 ; ENSMUSP00000130693 ; ENSMUSG00000028212 .
    GeneIDi 12448.
    KEGGi mmu:12448.
    UCSCi uc008rzd.1. mouse.

    Organism-specific databases

    CTDi 9134.
    MGIi MGI:1329034. Ccne2.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00750000117276.
    HOGENOMi HOG000231743.
    HOVERGENi HBG050834.
    InParanoidi Q9Z238.
    KOi K06626.
    OMAi YSQEKFI.
    PhylomeDBi Q9Z238.

    Enzyme and pathway databases

    Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
    REACT_199110. G0 and Early G1.
    REACT_219010. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

    Miscellaneous databases

    NextBioi 281276.
    PROi Q9Z238.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z238.
    Bgeei Q9Z238.
    CleanExi MM_CCNE2.
    Genevestigatori Q9Z238.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR028858. Cyclin_E.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF70. PTHR10177:SF70. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle."
      Lauper N., Beck A.R.P., Cariou S., Richman L., Hofmann K., Reith W., Slingerland J.M., Amati B.
      Oncogene 17:2637-2643(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers."
      Gudas J.M., Payton M., Thukral S., Chen E., Bass M., Robinson M.O., Coats S.
      Mol. Cell. Biol. 19:612-622(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCNE2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z238
    Secondary accession number(s): Q9QWU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3