Q9Z238 (CCNE2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G1/S-specific cyclin-E2

Gene names

Name:

Ccne2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for the control of the cell cycle at the late G1 and early S phase.
Subunit structure	Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon.
Post-translational modification	Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway By similarity.
Sequence similarities	Belongs to the cyclin family. Cyclin E subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Nucleus
Molecular function	Cyclin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication initiation Inferred from mutant phenotype PubMed 12941272. Source: MGI cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell cycle Inferred from direct assay Ref.1. Source: MGI regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	G1/S-specific cyclin-E2		PRO_0000080462
Regions
	Compositional bias	297 – 300	4	Poly-Ala
Amino acid modifications
	Modified residue	21	1	Phosphoserine By similarity
	Modified residue	383	1	Phosphoserine By similarity
	Modified residue	392	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	6	1	Missing in AAD08817. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Z238 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0612C4ACBEE47DAA	FASTA	404	46,669
	10 20 30 40 50 60 MSRRSSRLQA KQHAQPNQPD SPQETQIIQA KKRKTAQDVK KRKEEITKKH QYEIRNCWPP 70 80 90 100 110 120 VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWACS QEVWQNMLQK 130 140 150 160 170 180 ENRYVHDKHF QVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDV 190 200 210 220 230 240 NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE VDILKMELNI LKALKWELCP 250 260 270 280 290 300 VTVISWLNLF LQVDAVKDVP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILAAAA 310 320 330 340 350 360 LCHFTSIEVV KKASGLEWDD ISECVDWMVP FVSVVKSVSP VKLKTFKKIP MEDRHNIQTH 370 380 390 400 TNYLALLNEV NYVNIYRKGG QLSPVCNGGI MTPPKSTEKP PGKH

References

[1]	"Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle." Lauper N., Beck A.R.P., Cariou S., Richman L., Hofmann K., Reith W., Slingerland J.M., Amati B. Oncogene 17:2637-2643(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers." Gudas J.M., Payton M., Thukral S., Chen E., Bass M., Robinson M.O., Coats S. Mol. Cell. Biol. 19:612-622(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091432 mRNA. Translation: AAC80527.1. AF106691 mRNA. Translation: AAD08817.1.
IPI	IPI00130452.
RefSeq	NP_001032211.1. NM_001037134.1. NP_033960.1. NM_009830.3.
UniGene	Mm.35867.
3D structure databases
ProteinModelPortal	Q9Z238.
SMR	Q9Z238. Positions 100-369.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z238.
Proteomic databases
PRIDE	Q9Z238.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000108324; ENSMUSP00000103960; ENSMUSG00000028212. ENSMUST00000170901; ENSMUSP00000130693; ENSMUSG00000028212.
GeneID	12448.
KEGG	mmu:12448.
Organism-specific databases
CTD	9134.
MGI	MGI:1329034. Ccne2.
Phylogenomic databases
eggNOG	COG5024.
GeneTree	ENSGT00680000099652.
HOGENOM	HOG000231743.
HOVERGEN	HBG050834.
InParanoid	Q9Z238.
KO	K06626.
OMA	FIQIAQL.
Gene expression databases
ArrayExpress	Q9Z238.
Bgee	Q9Z238.
CleanEx	MM_CCNE2.
Genevestigator	Q9Z238.
GermOnline	ENSMUSG00000028212. Mus musculus.
Family and domain databases
Gene3D	1.10.472.10. 2 hits.
InterPro	IPR013763. Cyclin-like. IPR014400. Cyclin_A/B/D/E. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 1 hit.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281276.
SOURCE	Search...

Entry information

Entry name

CCNE2_MOUSE

Accession

Primary (citable) accession number: Q9Z238
Secondary accession number(s): Q9QWU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program