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Q9Z222

- B3GN2_MOUSE

UniProt

Q9Z222 - B3GN2_MOUSE

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Protein
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Gene
B3gnt2, B3gnt1, Beta3gnt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains.1 Publication

Cofactori

Manganese.1 Publication

Pathwayi

GO - Molecular functioni

  1. galactosyltransferase activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: MGI
  2. protein glycosylation Source: MGI
  3. sensory perception of smell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

ReactomeiREACT_198517. O-linked glycosylation of mucins.
REACT_198578. Keratan sulfate biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (EC:2.4.1.-)
Short name:
BGnT-2
Short name:
Beta-1,3-Gn-T2
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 2
Short name:
Beta3Gn-T2
Alternative name(s):
Beta-1,3-N-acetylglucosaminyltransferase 1
Short name:
BGnT-1
Short name:
Beta-1,3-Gn-T1
Short name:
Beta3Gn-T1
Beta-1,3-galactosyltransferase 7
Short name:
Beta-1,3-GalTase 7
Short name:
Beta3Gal-T7
Short name:
Beta3GalT7
Short name:
b3Gal-T7
Beta-3-Gx-T7
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7
Gene namesi
Name:B3gnt2
Synonyms:B3gnt1, Beta3gnt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1889505. B3gnt2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini29 – 325297Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
PRO_0000219171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...)1 Publication
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z222.

PTM databases

PhosphoSiteiQ9Z222.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, kidney and testis and, to a lesser extent, in liver and skeletal muscle. No expression in spleen.1 Publication

Gene expression databases

BgeeiQ9Z222.
GenevestigatoriQ9Z222.

Interactioni

Subunit structurei

Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060247.

Structurei

3D structure databases

ProteinModelPortaliQ9Z222.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262849.
GeneTreeiENSGT00740000115391.
HOGENOMiHOG000232195.
HOVERGENiHBG050653.
InParanoidiQ9Z222.
KOiK00741.
OMAiRNNICSY.
OrthoDBiEOG7BGHKT.
PhylomeDBiQ9Z222.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z222-1 [UniParc]FASTAAdd to Basket

« Hide

MSVGRRRVKL LGILMMANVF IYLIVEVSKN SSQDKNGKGG VIIPKEKFWK    50
PPSTPRAYWN REQEKLNRWY NPILNRVANQ TGELATSPNT SHLSYCEPDS 100
TVMTAVTDFN NLPDRFKDFL LYLRCRNYSL LIDQPKKCAK KPFLLLAIKS 150
LIPHFARRQA IRESWGRETN VGNQTVVRVF LLGKTPPEDN HPDLSDMLKF 200
ESDKHQDILM WNYRDTFFNL SLKEVLFLRW VSTSCPDAEF VFKGDDDVFV 250
NTHHILNYLN SLSKSKAKDL FIGDVIHNAG PHRDKKLKYY IPEVFYTGVY 300
PPYAGGGGFL YSGPLALRLY SATSRVHLYP IDDVYTGMCL QKLGLVPEKH 350
KGFRTFDIEE KNKKNICSYI DLMLVHSRKP QEMIDIWSQL QSPNLKC 397
Length:397
Mass (Da):45,883
Last modified:October 25, 2004 - v3
Checksum:iD8BBEA1866C1D106
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831R → S in AAD09763. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092050 mRNA. Translation: AAD09763.2.
AY043479 mRNA. Translation: AAK95359.1.
BC009075 mRNA. Translation: AAH09075.1.
CCDSiCCDS24471.1.
RefSeqiNP_001162585.1. NM_001169114.1.
NP_058584.3. NM_016888.5.
UniGeneiMm.395495.

Genome annotation databases

EnsembliENSMUST00000055549; ENSMUSP00000053528; ENSMUSG00000051650.
ENSMUST00000062844; ENSMUSP00000060247; ENSMUSG00000051650.
GeneIDi53625.
KEGGimmu:53625.
UCSCiuc007ieh.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

MGC32391: hypothetical protein MGC32391/hypothetical protein MGC32391

Functional Glycomics Gateway - GTase

beta 3 GlcNAc-T I

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092050 mRNA. Translation: AAD09763.2 .
AY043479 mRNA. Translation: AAK95359.1 .
BC009075 mRNA. Translation: AAH09075.1 .
CCDSi CCDS24471.1.
RefSeqi NP_001162585.1. NM_001169114.1.
NP_058584.3. NM_016888.5.
UniGenei Mm.395495.

3D structure databases

ProteinModelPortali Q9Z222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000060247.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei Q9Z222.

Proteomic databases

PRIDEi Q9Z222.

Protocols and materials databases

DNASUi 53625.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055549 ; ENSMUSP00000053528 ; ENSMUSG00000051650 .
ENSMUST00000062844 ; ENSMUSP00000060247 ; ENSMUSG00000051650 .
GeneIDi 53625.
KEGGi mmu:53625.
UCSCi uc007ieh.2. mouse.

Organism-specific databases

CTDi 10678.
MGIi MGI:1889505. B3gnt2.

Phylogenomic databases

eggNOGi NOG262849.
GeneTreei ENSGT00740000115391.
HOGENOMi HOG000232195.
HOVERGENi HBG050653.
InParanoidi Q9Z222.
KOi K00741.
OMAi RNNICSY.
OrthoDBi EOG7BGHKT.
PhylomeDBi Q9Z222.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_198517. O-linked glycosylation of mucins.
REACT_198578. Keratan sulfate biosynthesis.

Miscellaneous databases

ChiTaRSi B3GNT2. mouse.
NextBioi 310369.
PROi Q9Z222.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z222.
Genevestigatori Q9Z222.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases."
    Zhou D., Dinter A., Gutierrez Gallego R., Kamerling J.P., Vliegenthart J.F.G., Berger E.G., Hennet T.
    Proc. Natl. Acad. Sci. U.S.A. 96:406-411(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Neonatal brain.
  2. Zhou D., Berger E.G., Hennet T.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family."
    Egan S., Cohen B., Sarkar M., Ying Y., Cohen S., Singh N., Wang W., Flock G., Goh T., Schachter H.
    Glycoconj. J. 17:867-875(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C.B17.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary gland.
  5. "Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells."
    Seko A., Yamashita K.
    J. Biol. Chem. 283:33094-33100(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH B3GNT8.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-173.

Entry informationi

Entry nameiB3GN2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z222
Secondary accession number(s): Q91V18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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