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Q9Z222

- B3GN2_MOUSE

UniProt

Q9Z222 - B3GN2_MOUSE

Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Gene

B3gnt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains.1 Publication

    Cofactori

    Manganese.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. galactosyltransferase activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: MGI
    2. protein glycosylation Source: MGI
    3. sensory perception of smell Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    ReactomeiREACT_198517. O-linked glycosylation of mucins.
    REACT_198578. Keratan sulfate biosynthesis.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (EC:2.4.1.-)
    Short name:
    BGnT-2
    Short name:
    Beta-1,3-Gn-T2
    Short name:
    Beta-1,3-N-acetylglucosaminyltransferase 2
    Short name:
    Beta3Gn-T2
    Alternative name(s):
    Beta-1,3-N-acetylglucosaminyltransferase 1
    Short name:
    BGnT-1
    Short name:
    Beta-1,3-Gn-T1
    Short name:
    Beta3Gn-T1
    Beta-1,3-galactosyltransferase 7
    Short name:
    Beta-1,3-GalTase 7
    Short name:
    Beta3Gal-T7
    Short name:
    Beta3GalT7
    Short name:
    b3Gal-T7
    Beta-3-Gx-T7
    UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7
    UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7
    Gene namesi
    Name:B3gnt2
    Synonyms:B3gnt1, Beta3gnt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1889505. B3gnt2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2PRO_0000219171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)1 Publication
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Z222.

    PTM databases

    PhosphoSiteiQ9Z222.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, lung, kidney and testis and, to a lesser extent, in liver and skeletal muscle. No expression in spleen.1 Publication

    Gene expression databases

    BgeeiQ9Z222.
    GenevestigatoriQ9Z222.

    Interactioni

    Subunit structurei

    Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000060247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z222.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 325297LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Sequence Analysis

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262849.
    GeneTreeiENSGT00740000115391.
    HOGENOMiHOG000232195.
    HOVERGENiHBG050653.
    InParanoidiQ9Z222.
    KOiK00741.
    OMAiRNNICSY.
    OrthoDBiEOG7BGHKT.
    PhylomeDBiQ9Z222.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVGRRRVKL LGILMMANVF IYLIVEVSKN SSQDKNGKGG VIIPKEKFWK    50
    PPSTPRAYWN REQEKLNRWY NPILNRVANQ TGELATSPNT SHLSYCEPDS 100
    TVMTAVTDFN NLPDRFKDFL LYLRCRNYSL LIDQPKKCAK KPFLLLAIKS 150
    LIPHFARRQA IRESWGRETN VGNQTVVRVF LLGKTPPEDN HPDLSDMLKF 200
    ESDKHQDILM WNYRDTFFNL SLKEVLFLRW VSTSCPDAEF VFKGDDDVFV 250
    NTHHILNYLN SLSKSKAKDL FIGDVIHNAG PHRDKKLKYY IPEVFYTGVY 300
    PPYAGGGGFL YSGPLALRLY SATSRVHLYP IDDVYTGMCL QKLGLVPEKH 350
    KGFRTFDIEE KNKKNICSYI DLMLVHSRKP QEMIDIWSQL QSPNLKC 397
    Length:397
    Mass (Da):45,883
    Last modified:October 25, 2004 - v3
    Checksum:iD8BBEA1866C1D106
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti283 – 2831R → S in AAD09763. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092050 mRNA. Translation: AAD09763.2.
    AY043479 mRNA. Translation: AAK95359.1.
    BC009075 mRNA. Translation: AAH09075.1.
    CCDSiCCDS24471.1.
    RefSeqiNP_001162585.1. NM_001169114.1.
    NP_058584.3. NM_016888.5.
    UniGeneiMm.395495.

    Genome annotation databases

    EnsembliENSMUST00000055549; ENSMUSP00000053528; ENSMUSG00000051650.
    ENSMUST00000062844; ENSMUSP00000060247; ENSMUSG00000051650.
    GeneIDi53625.
    KEGGimmu:53625.
    UCSCiuc007ieh.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    MGC32391: hypothetical protein MGC32391/hypothetical protein MGC32391

    Functional Glycomics Gateway - GTase

    beta 3 GlcNAc-T I

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092050 mRNA. Translation: AAD09763.2 .
    AY043479 mRNA. Translation: AAK95359.1 .
    BC009075 mRNA. Translation: AAH09075.1 .
    CCDSi CCDS24471.1.
    RefSeqi NP_001162585.1. NM_001169114.1.
    NP_058584.3. NM_016888.5.
    UniGenei Mm.395495.

    3D structure databases

    ProteinModelPortali Q9Z222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000060247.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q9Z222.

    Proteomic databases

    PRIDEi Q9Z222.

    Protocols and materials databases

    DNASUi 53625.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055549 ; ENSMUSP00000053528 ; ENSMUSG00000051650 .
    ENSMUST00000062844 ; ENSMUSP00000060247 ; ENSMUSG00000051650 .
    GeneIDi 53625.
    KEGGi mmu:53625.
    UCSCi uc007ieh.2. mouse.

    Organism-specific databases

    CTDi 10678.
    MGIi MGI:1889505. B3gnt2.

    Phylogenomic databases

    eggNOGi NOG262849.
    GeneTreei ENSGT00740000115391.
    HOGENOMi HOG000232195.
    HOVERGENi HBG050653.
    InParanoidi Q9Z222.
    KOi K00741.
    OMAi RNNICSY.
    OrthoDBi EOG7BGHKT.
    PhylomeDBi Q9Z222.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_198517. O-linked glycosylation of mucins.
    REACT_198578. Keratan sulfate biosynthesis.

    Miscellaneous databases

    ChiTaRSi B3GNT2. mouse.
    NextBioi 310369.
    PROi Q9Z222.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z222.
    Genevestigatori Q9Z222.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases."
      Zhou D., Dinter A., Gutierrez Gallego R., Kamerling J.P., Vliegenthart J.F.G., Berger E.G., Hennet T.
      Proc. Natl. Acad. Sci. U.S.A. 96:406-411(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY.
      Strain: ICR1 Publication.
      Tissue: Neonatal brain1 Publication.
    2. Zhou D., Berger E.G., Hennet T.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Molecular cloning and expression analysis of a mouse UDP-GlcNAc:Gal(beta1-4)Glc(NAc)-R beta1,3-N-acetylglucosaminyltransferase homologous to Drosophila melanogaster Brainiac and the beta1,3-galactosyltransferase family."
      Egan S., Cohen B., Sarkar M., Ying Y., Cohen S., Singh N., Wang W., Flock G., Goh T., Schachter H.
      Glycoconj. J. 17:867-875(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C.B17Imported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRIImported.
      Tissue: Mammary glandImported.
    5. "Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells."
      Seko A., Yamashita K.
      J. Biol. Chem. 283:33094-33100(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH B3GNT8.
    6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-173.

    Entry informationi

    Entry nameiB3GN2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z222
    Secondary accession number(s): Q91V18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3