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Protein

Growth/differentiation factor 11

Gene

Gdf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 11
Short name:
GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name:
BMP-11
Gene namesi
Name:Gdf11
Synonyms:Bmp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2673. Gdf11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei‹1 – 242›242By similarityPRO_0000033990Add
BLAST
Chaini243 – ›345›103Growth/differentiation factor 11PRO_0000033991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi257 ↔ 316By similarity
Disulfide bondi315 – 315InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z217.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010035.

Structurei

3D structure databases

ProteinModelPortaliQ9Z217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 1596Poly-Gly

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiQ9Z217.
PhylomeDBiQ9Z217.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PEPDGCPVCV WRQHSRRVRL GSIKSQILSK LRLKEAPNIS REVVKQLLPK
60 70 80 90 100
APPLQQILDL HDFQGDALQP EDFLEEDEYH ATTETVISMA QETDPAVQTD
110 120 130 140 150
GSPLCCHFHF SPKVMFTKVL KAQLWVYLRP VPRPATVYLQ ILRLKPLTGE
160 170 180 190 200
GTAGGGGGGR RHIRIRSLKI ELHSRSGHWQ SIDFKQVLHS WFRQPQSNWG
210 220 230 240 250
IEINAFDPSG TDLAVTSLGP GAEGCHPFME LRVLENTKRS RRNLGLDCDE
260 270 280 290 300
HSSESRCCRY PLTVDFEASG WDWIIAPKRY KANYCSGQCE YMFMQKYPHT
310 320 330 340
HLVQQANPRG SAGPCCTPTK MSPINMLYFN DKQQIIYGKI PGMVV
Length:345
Mass (Da):39,094
Last modified:May 1, 1999 - v1
Checksum:i81D5B93FED6B0443
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei345 – 3451

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092733 mRNA. Translation: AAD05266.1.
UniGeneiRn.51292.

Genome annotation databases

UCSCiRGD:2673. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092733 mRNA. Translation: AAD05266.1.
UniGeneiRn.51292.

3D structure databases

ProteinModelPortaliQ9Z217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010035.

Proteomic databases

PaxDbiQ9Z217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2673. rat.

Organism-specific databases

RGDi2673. Gdf11.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiQ9Z217.
PhylomeDBiQ9Z217.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis."
    Nakashima M., Toyono T., Akamine A., Joyner A.
    Mech. Dev. 80:185-189(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Dental pulp.

Entry informationi

Entry nameiGDF11_RAT
AccessioniPrimary (citable) accession number: Q9Z217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.