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Protein

Growth/differentiation factor 11

Gene

Gdf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 11
Short name:
GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name:
BMP-11
Gene namesi
Name:Gdf11
Synonyms:Bmp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 7, Unplaced

Organism-specific databases

RGDi2673. Gdf11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000003399025 – 296By similarityAdd BLAST272
ChainiPRO_0000033991297 – 405Growth/differentiation factor 11Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi302 ↔ 312By similarity
Disulfide bondi311 ↔ 370By similarity
Disulfide bondi339 ↔ 402By similarity
Disulfide bondi343 ↔ 404By similarity
Disulfide bondi369InterchainBy similarity

Post-translational modificationi

Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119 – 120CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z217.
PRIDEiQ9Z217.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007610.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts directly with ACVR2B. Interacts directly with ACVR2A. Interacts with ACVR1B, TGFBR1 and ACVR1C in an ACVR2B-dependent manner (By similarity). Interacts with FST isoform 2/FS288 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010035.

Structurei

3D structure databases

ProteinModelPortaliQ9Z217.
SMRiQ9Z217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 213Poly-Gly6

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiQ9Z217.
KOiK05497.
OMAiGSHECSA.
OrthoDBiEOG091G078V.
PhylomeDBiQ9Z217.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAG VGGERSSRPA
60 70 80 90 100
PSAAPEPDGC PVCVWRQHSR ELRLESIKSQ ILSKLRLKEA PNISREVVKQ
110 120 130 140 150
LLPKAPPLQQ ILDLHDFQGD ALQPEDFLEE DEYHATTETV ISMAQETDPA
160 170 180 190 200
VQTDGSPLCC HFHFSPKVMF TKVLKAQLWV YLRPVPRPAT VYLQILRLKP
210 220 230 240 250
LTGEGTAGGG GGGRRHIRIR SLKIELHSRS GHWQSIDFKQ VLHSWFRQPQ
260 270 280 290 300
SNWGIEINAF DPSGTDLAVT SLGPGAEGLH PFMELRVLEN TKRSRRNLGL
310 320 330 340 350
DCDEHSSESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GQCEYMFMQK
360 370 380 390 400
YPHTHLVQQA NPRGSAGPCC TPTKMSPINM LYFNDKQQII YGKIPGMVVD

RCGCS
Length:405
Mass (Da):44,921
Last modified:September 27, 2017 - v2
Checksum:i47B467845D9C7350
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71 – 75ELRLE → RVRGL in AAD05266 (PubMed:10072786).Curated5
Sequence conflicti279L → C in AAD05266 (PubMed:10072786).Curated1
Sequence conflicti323F → S in AAD05266 (PubMed:10072786).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141508 Genomic DNA. No translation available.
CH474104 Genomic DNA. Translation: EDL84790.1.
AF092733 mRNA. Translation: AAD05266.1.
RefSeqiNP_058899.1. NM_017203.1.
UniGeneiRn.51292.

Genome annotation databases

EnsembliENSRNOT00000010035; ENSRNOP00000010035; ENSRNOG00000007610.
GeneIDi29454.
KEGGirno:29454.
UCSCiRGD:2673. rat.

Similar proteinsi

Entry informationi

Entry nameiGDF11_RAT
AccessioniPrimary (citable) accession number: Q9Z217
Secondary accession number(s): G3V6Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: September 27, 2017
Last modified: September 27, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families