Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heterogeneous nuclear ribonucleoproteins C1/C2

Gene

Hnrnpc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
Gene namesi
Name:Hnrnpc
Synonyms:Hnrpc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107795 Hnrnpc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000818452 – 313Heterogeneous nuclear ribonucleoproteins C1/C2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei113PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei162PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei176N6-acetyllysine; alternateCombined sources1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei229PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei241PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei249PhosphoserineBy similarity1
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei261PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on Ser-268 and Ser-306 in resting cells.By similarity
Sumoylated. Sumoylation reduces affinity for mRNA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z204
PaxDbiQ9Z204
PeptideAtlasiQ9Z204
PRIDEiQ9Z204
TopDownProteomicsiQ9Z204-1 [Q9Z204-1]
Q9Z204-4 [Q9Z204-4]

PTM databases

iPTMnetiQ9Z204
PhosphoSitePlusiQ9Z204
SwissPalmiQ9Z204

Expressioni

Gene expression databases

BgeeiENSMUSG00000060373
CleanExiMM_HNRNPC
GenevisibleiQ9Z204 MM

Interactioni

Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200356, 4 interactors
DIPiDIP-59747N
IntActiQ9Z204, 4 interactors
MINTiQ9Z204
STRINGi10090.ENSMUSP00000107237

Structurei

3D structure databases

ProteinModelPortaliQ9Z204
SMRiQ9Z204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 226Sequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 161Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 303Asp/Glu-rich (acidic)Add BLAST123

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000006718
HOVERGENiHBG002302
InParanoidiQ9Z204
KOiK12884
OMAiHRSKTSK
OrthoDBiEOG091G0O1Q
PhylomeDBiQ9Z204
TreeFamiTF330974

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C2 (identifier: Q9Z204-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK
60 70 80 90 100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS
110 120 130 140 150
AAEMYGSVPE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA
160 170 180 190 200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSSKSGKLK GDDLQAIKKE
210 220 230 240 250
LTQIKQKVDS LLESLEKIEK EQSKQADLSF SSPVEMKNEK SEEEQSSASV
260 270 280 290 300
KKDETNVKME SEAGADDSAE EGDLLDDDDN EDRGDDQLEL KDDEKEPEEG
310
EDDRDSANGE DDS
Length:313
Mass (Da):34,385
Last modified:May 1, 1999 - v1
Checksum:i4AB834051E3E301B
GO
Isoform C1 (identifier: Q9Z204-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:300
Mass (Da):33,056
Checksum:i5D602FF5656B750B
GO
Isoform 3 (identifier: Q9Z204-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-233: Missing.

Show »
Length:293
Mass (Da):32,323
Checksum:i7AC110DB06014FEC
GO
Isoform 4 (identifier: Q9Z204-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-234: Missing.

Show »
Length:292
Mass (Da):32,223
Checksum:i84A26D34AABD5806
GO
Isoform 5 (identifier: Q9Z204-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-233: Missing.

Show »
Length:306
Mass (Da):33,651
Checksum:i7AD8B459F9A7FF9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46C → R in AAH04706 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005832108 – 120Missing in isoform C1, isoform 3 and isoform 4. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_019227227 – 234Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_005833227 – 233Missing in isoform 3 and isoform 5. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095257 mRNA Translation: AAD03717.1
AF095258 Genomic DNA Translation: AAD19892.1
AK011336 mRNA Translation: BAB27553.1
AK012633 mRNA Translation: BAB28370.1
AK019958 mRNA Translation: BAB31934.1
AK088245 mRNA Translation: BAC40233.1
AK088678 mRNA Translation: BAC40499.1
AK089061 mRNA Translation: BAC40728.1
AK166590 mRNA Translation: BAE38877.1
AK168802 mRNA Translation: BAE40632.1
BC004706 mRNA Translation: AAH04706.1
BC095922 mRNA Translation: AAH95922.1
CCDSiCCDS36917.1 [Q9Z204-1]
RefSeqiNP_001164452.1, NM_001170981.1 [Q9Z204-2]
NP_001164453.1, NM_001170982.1 [Q9Z204-2]
NP_001164454.1, NM_001170983.1 [Q9Z204-3]
NP_001164455.1, NM_001170984.1 [Q9Z204-4]
NP_058580.1, NM_016884.3 [Q9Z204-1]
XP_006518634.1, XM_006518571.3 [Q9Z204-1]
XP_006518635.1, XM_006518572.3 [Q9Z204-1]
XP_006518637.1, XM_006518574.2 [Q9Z204-5]
XP_006518641.1, XM_006518578.2 [Q9Z204-3]
XP_006518644.1, XM_006518581.2 [Q9Z204-4]
XP_017171338.1, XM_017315849.1 [Q9Z204-1]
XP_017171339.1, XM_017315850.1 [Q9Z204-5]
XP_017171340.1, XM_017315851.1 [Q9Z204-5]
XP_017171344.1, XM_017315855.1 [Q9Z204-2]
XP_017171345.1, XM_017315856.1 [Q9Z204-2]
XP_017171346.1, XM_017315857.1 [Q9Z204-3]
XP_017171347.1, XM_017315858.1 [Q9Z204-3]
XP_017171348.1, XM_017315859.1 [Q9Z204-4]
UniGeneiMm.427321
Mm.473169

Genome annotation databases

EnsembliENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373 [Q9Z204-1]
ENSMUST00000227242; ENSMUSP00000154757; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000227458; ENSMUSP00000154238; ENSMUSG00000060373 [Q9Z204-4]
ENSMUST00000227536; ENSMUSP00000154737; ENSMUSG00000060373 [Q9Z204-2]
ENSMUST00000228198; ENSMUSP00000154212; ENSMUSG00000060373 [Q9Z204-5]
ENSMUST00000228232; ENSMUSP00000154619; ENSMUSG00000060373 [Q9Z204-3]
ENSMUST00000228748; ENSMUSP00000154166; ENSMUSG00000060373 [Q9Z204-3]
GeneIDi15381
KEGGimmu:15381
UCSCiuc007tob.2 mouse [Q9Z204-1]
uc007toc.2 mouse [Q9Z204-4]
uc007tod.2 mouse [Q9Z204-2]
uc007toe.2 mouse [Q9Z204-3]
uc007tof.2 mouse [Q9Z204-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHNRPC_MOUSE
AccessioniPrimary (citable) accession number: Q9Z204
Secondary accession number(s): Q3TLB5
, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health