SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z204

- HNRPC_MOUSE

UniProt

Q9Z204 - HNRPC_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Heterogeneous nuclear ribonucleoproteins C1/C2
Gene
Hnrnpc, Hnrpc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules By similarity.

GO - Molecular functioni

  1. mRNA binding Source: MGI
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
Gene namesi
Name:Hnrnpc
Synonyms:Hnrpc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107795. Hnrnpc.

Subcellular locationi

Nucleus By similarity
Note: Component of ribonucleosomes By similarity.

GO - Cellular componenti

  1. nucleus Source: MGI
  2. pronucleus Source: MGI
  3. spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 313312Heterogeneous nuclear ribonucleoproteins C1/C2
PRO_0000081845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei113 – 1131Phosphoserine By similarity
Modified residuei115 – 1151Phosphoserine By similarity
Modified residuei162 – 1621Phosphoserine By similarity
Modified residuei166 – 1661Phosphoserine By similarity
Modified residuei176 – 1761N6-acetyllysine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei241 – 2411Phosphoserine1 Publication
Modified residuei249 – 2491Phosphoserine By similarity
Cross-linki258 – 258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei261 – 2611Phosphoserine By similarity
Modified residuei268 – 2681Phosphoserine2 Publications
Modified residuei306 – 3061Phosphoserine By similarity
Modified residuei313 – 3131Phosphoserine By similarity

Post-translational modificationi

Phosphorylated on Ser-268 and Ser-306 in resting cells By similarity.
Sumoylated. Sumoylation reduces affinity for mRNA By similarity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Z204.
PaxDbiQ9Z204.
PRIDEiQ9Z204.

PTM databases

PhosphoSiteiQ9Z204.

Expressioni

Gene expression databases

BgeeiQ9Z204.
CleanExiMM_HNRNPC.
GenevestigatoriQ9Z204.

Interactioni

Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1 By similarity.

Protein-protein interaction databases

BioGridi200356. 3 interactions.
DIPiDIP-59747N.
IntActiQ9Z204. 1 interaction.
MINTiMINT-1864181.

Structurei

3D structure databases

ProteinModelPortaliQ9Z204.
SMRiQ9Z204. Positions 2-92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772RRM
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi155 – 1617Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 303123Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG311712.
GeneTreeiENSGT00390000006718.
HOVERGENiHBG002302.
KOiK12884.
OMAiFSSPVEM.
OrthoDBiEOG7KWSK9.
PhylomeDBiQ9Z204.
TreeFamiTF330974.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C_Raly.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform C2 (identifier: Q9Z204-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK    50
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS 100
AAEMYGSVPE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA 150
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSSKSGKLK GDDLQAIKKE 200
LTQIKQKVDS LLESLEKIEK EQSKQADLSF SSPVEMKNEK SEEEQSSASV 250
KKDETNVKME SEAGADDSAE EGDLLDDDDN EDRGDDQLEL KDDEKEPEEG 300
EDDRDSANGE DDS 313
Length:313
Mass (Da):34,385
Last modified:May 1, 1999 - v1
Checksum:i4AB834051E3E301B
GO
Isoform C1 (identifier: Q9Z204-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:300
Mass (Da):33,056
Checksum:i5D602FF5656B750B
GO
Isoform 3 (identifier: Q9Z204-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-233: Missing.

Show »
Length:293
Mass (Da):32,323
Checksum:i7AC110DB06014FEC
GO
Isoform 4 (identifier: Q9Z204-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     227-234: Missing.

Show »
Length:292
Mass (Da):32,223
Checksum:i84A26D34AABD5806
GO
Isoform 5 (identifier: Q9Z204-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-233: Missing.

Show »
Length:306
Mass (Da):33,651
Checksum:i7AD8B459F9A7FF9B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei108 – 12013Missing in isoform C1, isoform 3 and isoform 4.
VSP_005832Add
BLAST
Alternative sequencei227 – 2348Missing in isoform 4.
VSP_019227
Alternative sequencei227 – 2337Missing in isoform 3 and isoform 5.
VSP_005833

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461C → R in AAH04706. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095257 mRNA. Translation: AAD03717.1.
AF095258 Genomic DNA. Translation: AAD19892.1.
AK011336 mRNA. Translation: BAB27553.1.
AK012633 mRNA. Translation: BAB28370.1.
AK019958 mRNA. Translation: BAB31934.1.
AK088245 mRNA. Translation: BAC40233.1.
AK088678 mRNA. Translation: BAC40499.1.
AK089061 mRNA. Translation: BAC40728.1.
AK166590 mRNA. Translation: BAE38877.1.
AK168802 mRNA. Translation: BAE40632.1.
BC004706 mRNA. Translation: AAH04706.1.
BC095922 mRNA. Translation: AAH95922.1.
CCDSiCCDS36917.1. [Q9Z204-1]
RefSeqiNP_001164452.1. NM_001170981.1. [Q9Z204-2]
NP_001164453.1. NM_001170982.1. [Q9Z204-2]
NP_001164454.1. NM_001170983.1. [Q9Z204-3]
NP_001164455.1. NM_001170984.1. [Q9Z204-4]
NP_058580.1. NM_016884.3. [Q9Z204-1]
XP_006518634.1. XM_006518571.1. [Q9Z204-1]
XP_006518635.1. XM_006518572.1. [Q9Z204-1]
XP_006518636.1. XM_006518573.1. [Q9Z204-1]
XP_006518637.1. XM_006518574.1. [Q9Z204-5]
XP_006518639.1. XM_006518576.1. [Q9Z204-2]
XP_006518640.1. XM_006518577.1. [Q9Z204-3]
XP_006518641.1. XM_006518578.1. [Q9Z204-3]
XP_006518642.1. XM_006518579.1. [Q9Z204-3]
XP_006518643.1. XM_006518580.1. [Q9Z204-4]
XP_006518644.1. XM_006518581.1. [Q9Z204-4]
UniGeneiMm.427321.
Mm.473169.

Genome annotation databases

EnsembliENSMUST00000111610; ENSMUSP00000107237; ENSMUSG00000060373. [Q9Z204-1]
ENSMUST00000164655; ENSMUSP00000133052; ENSMUSG00000060373. [Q9Z204-1]
GeneIDi15381.
KEGGimmu:15381.
UCSCiuc007tob.2. mouse. [Q9Z204-1]
uc007toc.2. mouse. [Q9Z204-4]
uc007tod.2. mouse. [Q9Z204-2]
uc007toe.2. mouse. [Q9Z204-3]
uc007tof.2. mouse. [Q9Z204-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095257 mRNA. Translation: AAD03717.1 .
AF095258 Genomic DNA. Translation: AAD19892.1 .
AK011336 mRNA. Translation: BAB27553.1 .
AK012633 mRNA. Translation: BAB28370.1 .
AK019958 mRNA. Translation: BAB31934.1 .
AK088245 mRNA. Translation: BAC40233.1 .
AK088678 mRNA. Translation: BAC40499.1 .
AK089061 mRNA. Translation: BAC40728.1 .
AK166590 mRNA. Translation: BAE38877.1 .
AK168802 mRNA. Translation: BAE40632.1 .
BC004706 mRNA. Translation: AAH04706.1 .
BC095922 mRNA. Translation: AAH95922.1 .
CCDSi CCDS36917.1. [Q9Z204-1 ]
RefSeqi NP_001164452.1. NM_001170981.1. [Q9Z204-2 ]
NP_001164453.1. NM_001170982.1. [Q9Z204-2 ]
NP_001164454.1. NM_001170983.1. [Q9Z204-3 ]
NP_001164455.1. NM_001170984.1. [Q9Z204-4 ]
NP_058580.1. NM_016884.3. [Q9Z204-1 ]
XP_006518634.1. XM_006518571.1. [Q9Z204-1 ]
XP_006518635.1. XM_006518572.1. [Q9Z204-1 ]
XP_006518636.1. XM_006518573.1. [Q9Z204-1 ]
XP_006518637.1. XM_006518574.1. [Q9Z204-5 ]
XP_006518639.1. XM_006518576.1. [Q9Z204-2 ]
XP_006518640.1. XM_006518577.1. [Q9Z204-3 ]
XP_006518641.1. XM_006518578.1. [Q9Z204-3 ]
XP_006518642.1. XM_006518579.1. [Q9Z204-3 ]
XP_006518643.1. XM_006518580.1. [Q9Z204-4 ]
XP_006518644.1. XM_006518581.1. [Q9Z204-4 ]
UniGenei Mm.427321.
Mm.473169.

3D structure databases

ProteinModelPortali Q9Z204.
SMRi Q9Z204. Positions 2-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200356. 3 interactions.
DIPi DIP-59747N.
IntActi Q9Z204. 1 interaction.
MINTi MINT-1864181.

PTM databases

PhosphoSitei Q9Z204.

Proteomic databases

MaxQBi Q9Z204.
PaxDbi Q9Z204.
PRIDEi Q9Z204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111610 ; ENSMUSP00000107237 ; ENSMUSG00000060373 . [Q9Z204-1 ]
ENSMUST00000164655 ; ENSMUSP00000133052 ; ENSMUSG00000060373 . [Q9Z204-1 ]
GeneIDi 15381.
KEGGi mmu:15381.
UCSCi uc007tob.2. mouse. [Q9Z204-1 ]
uc007toc.2. mouse. [Q9Z204-4 ]
uc007tod.2. mouse. [Q9Z204-2 ]
uc007toe.2. mouse. [Q9Z204-3 ]
uc007tof.2. mouse. [Q9Z204-5 ]

Organism-specific databases

CTDi 3183.
MGIi MGI:107795. Hnrnpc.

Phylogenomic databases

eggNOGi NOG311712.
GeneTreei ENSGT00390000006718.
HOVERGENi HBG002302.
KOi K12884.
OMAi FSSPVEM.
OrthoDBi EOG7KWSK9.
PhylomeDBi Q9Z204.
TreeFami TF330974.

Miscellaneous databases

ChiTaRSi HNRNPC. mouse.
NextBioi 288046.
PROi Q9Z204.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z204.
CleanExi MM_HNRNPC.
Genevestigatori Q9Z204.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR017347. hnRNP_C_Raly.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "hnRNP C is required for postimplantation mouse development but is dispensable for cell viability."
    Williamson D.J., Banik-Maiti S., DeGregori J., Ruley H.E.
    Mol. Cell. Biol. 20:4094-4105(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM C2).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C1; C2; 3 AND 5).
    Strain: C57BL/6J and NOD.
    Tissue: Colon, Embryo and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C1 AND 4).
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Lubec G., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 51-61.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241 AND SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHNRPC_MOUSE
AccessioniPrimary (citable) accession number: Q9Z204
Secondary accession number(s): Q3TLB5
, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi