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Protein

Serine-threonine kinase receptor-associated protein

Gene

Strap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-2173788. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-threonine kinase receptor-associated protein
Alternative name(s):
UNR-interacting protein
Gene namesi
Name:Strap
Synonyms:Unrip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1329037. Strap.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localized predominantly in the cytoplasm but also found in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512311 – 350Serine-threonine kinase receptor-associated proteinAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Modified residuei342PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z1Z2.
MaxQBiQ9Z1Z2.
PaxDbiQ9Z1Z2.
PRIDEiQ9Z1Z2.

2D gel databases

REPRODUCTION-2DPAGEIPI00130670.
Q9Z1Z2.

PTM databases

iPTMnetiQ9Z1Z2.
PhosphoSitePlusiQ9Z1Z2.
SwissPalmiQ9Z1Z2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030224.
ExpressionAtlasiQ9Z1Z2. baseline and differential.
GenevisibleiQ9Z1Z2. MM.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1 (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi203557. 4 interactors.
IntActiQ9Z1Z2. 2 interactors.
MINTiMINT-1870065.
STRINGi10090.ENSMUSP00000068267.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1Z2.
SMRiQ9Z1Z2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 56WD 1Add BLAST45
Repeati57 – 96WD 2Add BLAST40
Repeati98 – 137WD 3Add BLAST40
Repeati141 – 179WD 4Add BLAST39
Repeati180 – 212WD 5Add BLAST33
Repeati221 – 262WD 6Add BLAST42
Repeati263 – 302WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat STRAP family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ9Z1Z2.
KOiK13137.
OMAiHGPIWSI.
OrthoDBiEOG091G0BY5.
PhylomeDBiQ9Z1Z2.
TreeFamiTF323287.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD
60 70 80 90 100
WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK
110 120 130 140 150
HIVKTVDFTQ DSNYLLTGGQ DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL
160 170 180 190 200
WCSDDKQILS ADDKTVRLWD HATMTEVKSL NFNMSVSSME YIPEGEILVI
210 220 230 240 250
TYGRSIAFHS AVSLEPIKSF EAPATINSAS LHPEKEFLVA GGEDFKLYKY
260 270 280 290 300
DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY
310 320 330 340 350
GLWKCVLPEE DSGELAKPKI GFPETAEEEL EEIASENSDS IYSSTPEVKA
Length:350
Mass (Da):38,442
Last modified:January 15, 2008 - v2
Checksum:i99A71583618B1514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288T → P in BAC36834 (PubMed:16141072).Curated1
Sequence conflicti330L → LA in AAC98300 (PubMed:9856985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096285 mRNA. Translation: AAC98300.1.
AK075804 mRNA. Translation: BAC35972.1.
AK077504 mRNA. Translation: BAC36834.1.
AK145971 mRNA. Translation: BAE26796.1.
AK152283 mRNA. Translation: BAE31097.1.
CCDSiCCDS51945.1.
RefSeqiNP_035629.2. NM_011499.3.
UniGeneiMm.22584.

Genome annotation databases

EnsembliENSMUST00000064910; ENSMUSP00000068267; ENSMUSG00000030224.
GeneIDi20901.
KEGGimmu:20901.
UCSCiuc012euz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096285 mRNA. Translation: AAC98300.1.
AK075804 mRNA. Translation: BAC35972.1.
AK077504 mRNA. Translation: BAC36834.1.
AK145971 mRNA. Translation: BAE26796.1.
AK152283 mRNA. Translation: BAE31097.1.
CCDSiCCDS51945.1.
RefSeqiNP_035629.2. NM_011499.3.
UniGeneiMm.22584.

3D structure databases

ProteinModelPortaliQ9Z1Z2.
SMRiQ9Z1Z2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203557. 4 interactors.
IntActiQ9Z1Z2. 2 interactors.
MINTiMINT-1870065.
STRINGi10090.ENSMUSP00000068267.

PTM databases

iPTMnetiQ9Z1Z2.
PhosphoSitePlusiQ9Z1Z2.
SwissPalmiQ9Z1Z2.

2D gel databases

REPRODUCTION-2DPAGEIPI00130670.
Q9Z1Z2.

Proteomic databases

EPDiQ9Z1Z2.
MaxQBiQ9Z1Z2.
PaxDbiQ9Z1Z2.
PRIDEiQ9Z1Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064910; ENSMUSP00000068267; ENSMUSG00000030224.
GeneIDi20901.
KEGGimmu:20901.
UCSCiuc012euz.1. mouse.

Organism-specific databases

CTDi11171.
MGIiMGI:1329037. Strap.

Phylogenomic databases

eggNOGiKOG0278. Eukaryota.
ENOG410XPJ4. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000174258.
HOVERGENiHBG055228.
InParanoidiQ9Z1Z2.
KOiK13137.
OMAiHGPIWSI.
OrthoDBiEOG091G0BY5.
PhylomeDBiQ9Z1Z2.
TreeFamiTF323287.

Enzyme and pathway databases

ReactomeiR-MMU-2173788. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

ChiTaRSiStrap. mouse.
PROiQ9Z1Z2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030224.
ExpressionAtlasiQ9Z1Z2. baseline and differential.
GenevisibleiQ9Z1Z2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1Z2
Secondary accession number(s): Q8BP89, Q8C6F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.