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Q9Z1Y9

- IOD2_MOUSE

UniProt

Q9Z1Y9 - IOD2_MOUSE

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Protein
Type II iodothyronine deiodinase
Gene
Dio2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development By similarity.

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Kineticsi

  1. KM=1.1 nM for T41 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
  2. thyroid hormone catabolic process Source: MGI
  3. thyroid-stimulating hormone secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

BRENDAi1.97.1.10. 3474.
ReactomeiREACT_210325. Regulation of thyroid hormone activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:Dio2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1338833. Dio2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3425Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Type II iodothyronine deiodinase
PRO_0000154318Add
BLAST

Post-translational modificationi

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9Z1Y9.

Expressioni

Tissue specificityi

Expressed in mammary gland and in brain.1 Publication

Gene expression databases

ArrayExpressiQ9Z1Y9.
BgeeiQ9Z1Y9.
CleanExiMM_DIO2.
GenevestigatoriQ9Z1Y9.

Interactioni

Subunit structurei

Interacts with USP20 and USP33. Interacts with MARCH6 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1Y9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146259.
GeneTreeiENSGT00730000110840.
HOGENOMiHOG000007088.
HOVERGENiHBG000099.
InParanoidiQ9Z1Y9.
KOiK17904.
OMAiAFERVCI.
OrthoDBiEOG7XPZ7H.
PhylomeDBiQ9Z1Y9.
TreeFamiTF329721.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MGLLSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVALL LSRSKSTRGE    50
WRRMLTSEGL RCVWNSFLLD AYKQVKLGED APNSSVVHVS NPESGNNYAS 100
EKTADGAECH LLDFASAERP LVVNFGSATU PPFTRQLPAF RQLVEEFSSV 150
ADFLLVYIDE AHPSDGWAVP GDSSLSFEVK KHRNQEDRCA AAHQLLERFS 200
LPPQCQVVAD RMDNNANVAY GVAFERVCIV QRRKIAYLGG KGPFSYNLQE 250
VRSWLEKNFS KRUILD 266
Length:266
Mass (Da):29,929
Last modified:February 26, 2008 - v4
Checksum:iB2FD28E171DC5486
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei130 – 1301Selenocysteine
Non-standard residuei263 – 2631Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096875 mRNA. Translation: AAD11422.1.
AF177196 mRNA. Translation: AAD53113.1.
AF093137 mRNA. Translation: AAF00069.2.
BC125383 mRNA. Translation: AAI25384.1.
BC125385 mRNA. Translation: AAI25386.1.
CCDSiCCDS36514.1.
RefSeqiNP_034180.1. NM_010050.2.
UniGeneiMm.21389.
Mm.408815.

Genome annotation databases

EnsembliENSMUST00000082432; ENSMUSP00000081013; ENSMUSG00000007682.
GeneIDi13371.
KEGGimmu:13371.
UCSCiuc007okf.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096875 mRNA. Translation: AAD11422.1 .
AF177196 mRNA. Translation: AAD53113.1 .
AF093137 mRNA. Translation: AAF00069.2 .
BC125383 mRNA. Translation: AAI25384.1 .
BC125385 mRNA. Translation: AAI25386.1 .
CCDSi CCDS36514.1.
RefSeqi NP_034180.1. NM_010050.2.
UniGenei Mm.21389.
Mm.408815.

3D structure databases

ProteinModelPortali Q9Z1Y9.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9Z1Y9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082432 ; ENSMUSP00000081013 ; ENSMUSG00000007682 .
GeneIDi 13371.
KEGGi mmu:13371.
UCSCi uc007okf.1. mouse.

Organism-specific databases

CTDi 1734.
MGIi MGI:1338833. Dio2.

Phylogenomic databases

eggNOGi NOG146259.
GeneTreei ENSGT00730000110840.
HOGENOMi HOG000007088.
HOVERGENi HBG000099.
InParanoidi Q9Z1Y9.
KOi K17904.
OMAi AFERVCI.
OrthoDBi EOG7XPZ7H.
PhylomeDBi Q9Z1Y9.
TreeFami TF329721.

Enzyme and pathway databases

BRENDAi 1.97.1.10. 3474.
Reactomei REACT_210325. Regulation of thyroid hormone activity.

Miscellaneous databases

ChiTaRSi DIO2. mouse.
NextBioi 283720.
PROi Q9Z1Y9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z1Y9.
Bgeei Q9Z1Y9.
CleanExi MM_DIO2.
Genevestigatori Q9Z1Y9.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase."
    Davey J.C., Schneider M.J., Becker K.B., Galton V.A.
    Endocrinology 140:1022-1025(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland."
    Song S., Sorimachi K., Adachi K., Oka T.
    Mol. Cell. Endocrinol. 160:173-181(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Strain: C3H/HeN.
    Tissue: Brain.
  3. "Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing."
    Campos-Barros A., Amma L.L., Faris J.S., Shailam R., Kelley M.W., Forrest D.
    Proc. Natl. Acad. Sci. U.S.A. 97:1287-1292(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cochlea.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIOD2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1Y9
Secondary accession number(s): Q05A70, Q9JHH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 113 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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