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Q9Z1Y9 (IOD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type II iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene names
Name:Dio2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subunit structure

Interacts with USP20 and USP33. Interacts with MARCH6 By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in mammary gland and in brain. Ref.2

Post-translational modification

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Biophysicochemical properties

Kinetic parameters:

KM=1.1 nM for T4 Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Type II iodothyronine deiodinase
PRO_0000154318

Regions

Transmembrane10 – 3425Helical; Potential

Sites

Active site1301

Amino acid modifications

Non-standard residue1301Selenocysteine
Non-standard residue2631Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q9Z1Y9 [UniParc].

Last modified February 26, 2008. Version 4.
Checksum: B2FD28E171DC5486

FASTA26629,929
        10         20         30         40         50         60 
MGLLSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVALL LSRSKSTRGE WRRMLTSEGL 

        70         80         90        100        110        120 
RCVWNSFLLD AYKQVKLGED APNSSVVHVS NPESGNNYAS EKTADGAECH LLDFASAERP 

       130        140        150        160        170        180 
LVVNFGSATU PPFTRQLPAF RQLVEEFSSV ADFLLVYIDE AHPSDGWAVP GDSSLSFEVK 

       190        200        210        220        230        240 
KHRNQEDRCA AAHQLLERFS LPPQCQVVAD RMDNNANVAY GVAFERVCIV QRRKIAYLGG 

       250        260 
KGPFSYNLQE VRSWLEKNFS KRUILD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase."
Davey J.C., Schneider M.J., Becker K.B., Galton V.A.
Endocrinology 140:1022-1025(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland."
Song S., Sorimachi K., Adachi K., Oka T.
Mol. Cell. Endocrinol. 160:173-181(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Strain: C3H/HeN.
Tissue: Brain.
[3]"Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing."
Campos-Barros A., Amma L.L., Faris J.S., Shailam R., Kelley M.W., Forrest D.
Proc. Natl. Acad. Sci. U.S.A. 97:1287-1292(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cochlea.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF096875 mRNA. Translation: AAD11422.1.
AF177196 mRNA. Translation: AAD53113.1.
AF093137 mRNA. Translation: AAF00069.2.
BC125383 mRNA. Translation: AAI25384.1.
BC125385 mRNA. Translation: AAI25386.1.
CCDSCCDS36514.1.
RefSeqNP_034180.1. NM_010050.2.
UniGeneMm.21389.
Mm.408815.

3D structure databases

ProteinModelPortalQ9Z1Y9.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9Z1Y9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082432; ENSMUSP00000081013; ENSMUSG00000007682.
GeneID13371.
KEGGmmu:13371.
UCSCuc007okf.1. mouse.

Organism-specific databases

CTD1734.
MGIMGI:1338833. Dio2.

Phylogenomic databases

eggNOGNOG146259.
GeneTreeENSGT00730000110840.
HOGENOMHOG000007088.
HOVERGENHBG000099.
InParanoidQ9Z1Y9.
KOK17904.
OMAAFERVCI.
OrthoDBEOG7XPZ7H.
PhylomeDBQ9Z1Y9.
TreeFamTF329721.

Enzyme and pathway databases

BRENDA1.97.1.10. 3474.

Gene expression databases

ArrayExpressQ9Z1Y9.
BgeeQ9Z1Y9.
CleanExMM_DIO2.
GenevestigatorQ9Z1Y9.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDIO2. mouse.
NextBio283720.
PROQ9Z1Y9.
SOURCESearch...

Entry information

Entry nameIOD2_MOUSE
AccessionPrimary (citable) accession number: Q9Z1Y9
Secondary accession number(s): Q05A70, Q9JHH1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 112 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot