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Q9Z1Y9

- IOD2_MOUSE

UniProt

Q9Z1Y9 - IOD2_MOUSE

Protein

Type II iodothyronine deiodinase

Gene

Dio2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 4 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development By similarity.By similarity

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Kineticsi

    1. KM=1.1 nM for T41 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW
    2. thyroid hormone catabolic process Source: MGI
    3. thyroid-stimulating hormone secretion Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Enzyme and pathway databases

    BRENDAi1.97.1.10. 3474.
    ReactomeiREACT_210325. Regulation of thyroid hormone activity.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type II iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DII
    DIOII
    Type 2 DI
    Type-II 5'-deiodinase
    Gene namesi
    Name:Dio2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1338833. Dio2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Type II iodothyronine deiodinasePRO_0000154318Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ9Z1Y9.

    Expressioni

    Tissue specificityi

    Expressed in mammary gland and in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z1Y9.
    BgeeiQ9Z1Y9.
    CleanExiMM_DIO2.
    GenevestigatoriQ9Z1Y9.

    Interactioni

    Subunit structurei

    Interacts with USP20 and USP33. Interacts with MARCH6 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1Y9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3425HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146259.
    GeneTreeiENSGT00730000110840.
    HOGENOMiHOG000007088.
    HOVERGENiHBG000099.
    InParanoidiQ9Z1Y9.
    KOiK17904.
    OMAiAFERVCI.
    OrthoDBiEOG7XPZ7H.
    PhylomeDBiQ9Z1Y9.
    TreeFamiTF329721.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z1Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVALL LSRSKSTRGE    50
    WRRMLTSEGL RCVWNSFLLD AYKQVKLGED APNSSVVHVS NPESGNNYAS 100
    EKTADGAECH LLDFASAERP LVVNFGSATU PPFTRQLPAF RQLVEEFSSV 150
    ADFLLVYIDE AHPSDGWAVP GDSSLSFEVK KHRNQEDRCA AAHQLLERFS 200
    LPPQCQVVAD RMDNNANVAY GVAFERVCIV QRRKIAYLGG KGPFSYNLQE 250
    VRSWLEKNFS KRUILD 266
    Length:266
    Mass (Da):29,929
    Last modified:February 26, 2008 - v4
    Checksum:iB2FD28E171DC5486
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei130 – 1301Selenocysteine
    Non-standard residuei263 – 2631Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096875 mRNA. Translation: AAD11422.1.
    AF177196 mRNA. Translation: AAD53113.1.
    AF093137 mRNA. Translation: AAF00069.2.
    BC125383 mRNA. Translation: AAI25384.1.
    BC125385 mRNA. Translation: AAI25386.1.
    CCDSiCCDS36514.1.
    RefSeqiNP_034180.1. NM_010050.2.
    UniGeneiMm.21389.
    Mm.408815.

    Genome annotation databases

    EnsembliENSMUST00000082432; ENSMUSP00000081013; ENSMUSG00000007682.
    GeneIDi13371.
    KEGGimmu:13371.
    UCSCiuc007okf.1. mouse.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096875 mRNA. Translation: AAD11422.1 .
    AF177196 mRNA. Translation: AAD53113.1 .
    AF093137 mRNA. Translation: AAF00069.2 .
    BC125383 mRNA. Translation: AAI25384.1 .
    BC125385 mRNA. Translation: AAI25386.1 .
    CCDSi CCDS36514.1.
    RefSeqi NP_034180.1. NM_010050.2.
    UniGenei Mm.21389.
    Mm.408815.

    3D structure databases

    ProteinModelPortali Q9Z1Y9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9Z1Y9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082432 ; ENSMUSP00000081013 ; ENSMUSG00000007682 .
    GeneIDi 13371.
    KEGGi mmu:13371.
    UCSCi uc007okf.1. mouse.

    Organism-specific databases

    CTDi 1734.
    MGIi MGI:1338833. Dio2.

    Phylogenomic databases

    eggNOGi NOG146259.
    GeneTreei ENSGT00730000110840.
    HOGENOMi HOG000007088.
    HOVERGENi HBG000099.
    InParanoidi Q9Z1Y9.
    KOi K17904.
    OMAi AFERVCI.
    OrthoDBi EOG7XPZ7H.
    PhylomeDBi Q9Z1Y9.
    TreeFami TF329721.

    Enzyme and pathway databases

    BRENDAi 1.97.1.10. 3474.
    Reactomei REACT_210325. Regulation of thyroid hormone activity.

    Miscellaneous databases

    ChiTaRSi DIO2. mouse.
    NextBioi 283720.
    PROi Q9Z1Y9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z1Y9.
    Bgeei Q9Z1Y9.
    CleanExi MM_DIO2.
    Genevestigatori Q9Z1Y9.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase."
      Davey J.C., Schneider M.J., Becker K.B., Galton V.A.
      Endocrinology 140:1022-1025(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland."
      Song S., Sorimachi K., Adachi K., Oka T.
      Mol. Cell. Endocrinol. 160:173-181(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Strain: C3H/HeN.
      Tissue: Brain.
    3. "Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing."
      Campos-Barros A., Amma L.L., Faris J.S., Shailam R., Kelley M.W., Forrest D.
      Proc. Natl. Acad. Sci. U.S.A. 97:1287-1292(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cochlea.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiIOD2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1Y9
    Secondary accession number(s): Q05A70, Q9JHH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 114 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3