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Protein

Thyroid receptor-interacting protein 6

Gene

Trip6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid receptor-interacting protein 6
Short name:
TR-interacting protein 6
Short name:
TRIP-6
Alternative name(s):
Zyxin-related protein 1
Short name:
ZRP-1
Gene namesi
Name:Trip6
Synonyms:Zrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1343458. Trip6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746891 – 480Thyroid receptor-interacting protein 6Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei25Omega-N-methylarginine; alternateBy similarity1
Modified residuei55Phosphotyrosine; by SRCBy similarity1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111Omega-N-methylarginineBy similarity1
Modified residuei183Omega-N-methylarginineBy similarity1
Modified residuei190Omega-N-methylarginineCombined sources1
Modified residuei193PhosphoserineBy similarity1
Modified residuei209Omega-N-methylarginineCombined sources1
Modified residuei242Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13 (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z1Y4.
PaxDbiQ9Z1Y4.
PRIDEiQ9Z1Y4.

PTM databases

iPTMnetiQ9Z1Y4.
PhosphoSitePlusiQ9Z1Y4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023348.
CleanExiMM_TRIP6.
ExpressionAtlasiQ9Z1Y4. baseline and differential.
GenevisibleiQ9Z1Y4. MM.

Interactioni

Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. Interacts with PTPN13. Interacts with SVIL isoform 2. Interacts with LPAR2 but not other LPA receptors. Interacts with PRKAA2. Interacts with SCRIB (By similarity). In case of infection, interacts with S.typhimurium protein sseI.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdlim4P702712EBI-643879,EBI-7288319

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204317. 1 interactor.
IntActiQ9Z1Y4. 7 interactors.
MINTiMINT-1611825.
STRINGi10090.ENSMUSP00000024119.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1Y4.
SMRiQ9Z1Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 339LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST59
Domaini341 – 401LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini404 – 471LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni473 – 480Interaction with MAGI1 and PTPN13By similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 256Pro-richAdd BLAST253

Domaini

The LIM zinc-binding domains mediate interaction with LPAR2.By similarity

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ9Z1Y4.
KOiK12792.
OMAiAGYRSHR.
OrthoDBiEOG091G085F.
PhylomeDBiQ9Z1Y4.
TreeFamiTF320310.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPTWLPPK QPEPSRLPQG RSLPRGALGP PTAHGATLQP HPRVNFCPLP
60 70 80 90 100
PEHCYQPPGV PEDRGPTWVG SHGTPQRLQG LPPDRGIIRP GSLDAEIDSL
110 120 130 140 150
TSMLADLDGG RSHAPRRPDR QAFEAPPPHA YRGGSLKPSG GAVPTPMLPA
160 170 180 190 200
SHYGGPTPAS YATASTPAGP AFPVQVKVAQ PVRGCGLPRR GASQASGPLP
210 220 230 240 250
GPHFPLTGRG EVWGAGYRSH REPGPGVPEG PSGVHIPAGG GRGGGHEPQG
260 270 280 290 300
PLGQPPEEEL ERLTKKLVHD MSHPPSGEYF GRCGGCGEDV VGDGAGVVAL
310 320 330 340 350
DRVFHIGCFV CSTCRAQLRG QHFYAVERRA YCESCYVATL EKCSTCSEPI
360 370 380 390 400
LDRILRAMGK AYHPGCFTCV VCHRGLDGIP FTVDATSQIH CIEDFHRKFA
410 420 430 440 450
PRCSVCGGAI MPEPGQEETV RIVALDRSFH IGCYKCEECG LLLSSEGECQ
460 470 480
GCYPLDGHIL CKACSAWRIQ ELSATVTTDC
Length:480
Mass (Da):50,934
Last modified:May 1, 1999 - v1
Checksum:iFA6C5A79D4834CF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141G → D in BAE35042 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116823 mRNA. Translation: AAD45984.1.
AF097511 mRNA. Translation: AAC72380.1.
AF312033 Genomic DNA. Translation: AAK28821.1.
AK010435 mRNA. Translation: BAB26937.1.
AK159387 mRNA. Translation: BAE35042.1.
CCDSiCCDS19765.1.
RefSeqiNP_035769.1. NM_011639.3.
UniGeneiMm.27063.

Genome annotation databases

EnsembliENSMUST00000024119; ENSMUSP00000024119; ENSMUSG00000023348.
GeneIDi22051.
KEGGimmu:22051.
UCSCiuc009acd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116823 mRNA. Translation: AAD45984.1.
AF097511 mRNA. Translation: AAC72380.1.
AF312033 Genomic DNA. Translation: AAK28821.1.
AK010435 mRNA. Translation: BAB26937.1.
AK159387 mRNA. Translation: BAE35042.1.
CCDSiCCDS19765.1.
RefSeqiNP_035769.1. NM_011639.3.
UniGeneiMm.27063.

3D structure databases

ProteinModelPortaliQ9Z1Y4.
SMRiQ9Z1Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204317. 1 interactor.
IntActiQ9Z1Y4. 7 interactors.
MINTiMINT-1611825.
STRINGi10090.ENSMUSP00000024119.

PTM databases

iPTMnetiQ9Z1Y4.
PhosphoSitePlusiQ9Z1Y4.

Proteomic databases

MaxQBiQ9Z1Y4.
PaxDbiQ9Z1Y4.
PRIDEiQ9Z1Y4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024119; ENSMUSP00000024119; ENSMUSG00000023348.
GeneIDi22051.
KEGGimmu:22051.
UCSCiuc009acd.1. mouse.

Organism-specific databases

CTDi7205.
MGIiMGI:1343458. Trip6.

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
HOVERGENiHBG093602.
InParanoidiQ9Z1Y4.
KOiK12792.
OMAiAGYRSHR.
OrthoDBiEOG091G085F.
PhylomeDBiQ9Z1Y4.
TreeFamiTF320310.

Miscellaneous databases

ChiTaRSiTrip6. mouse.
PROiQ9Z1Y4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023348.
CleanExiMM_TRIP6.
ExpressionAtlasiQ9Z1Y4. baseline and differential.
GenevisibleiQ9Z1Y4. MM.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIP6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1Y4
Secondary accession number(s): Q3TX74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.