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Protein

Cell division control protein 45 homolog

Gene

Cdc45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for initiation of chromosomal DNA replication.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_314754. E2F mediated regulation of DNA replication.
REACT_319408. Unwinding of DNA.
REACT_339329. G1/S-Specific Transcription.
REACT_351504. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 45 homolog
Alternative name(s):
PORC-PI-1
Gene namesi
Name:Cdc45
Synonyms:Cdc45l, Cdc45l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1338073. Cdc45.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Cell division control protein 45 homologPRO_0000192816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301PhosphotyrosineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z1X9.
PRIDEiQ9Z1X9.

PTM databases

PhosphoSiteiQ9Z1X9.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9Z1X9.
ExpressionAtlasiQ9Z1X9. baseline and differential.
GenevestigatoriQ9Z1X9.

Interactioni

Protein-protein interaction databases

BioGridi198628. 1 interaction.
IntActiQ9Z1X9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC45 family.Curated

Phylogenomic databases

eggNOGiNOG321683.
GeneTreeiENSGT00390000009662.
HOGENOMiHOG000253949.
HOVERGENiHBG050819.
InParanoidiQ9Z1X9.
KOiK06628.
OMAiTTMILTH.
OrthoDBiEOG7PZRXS.
PhylomeDBiQ9Z1X9.
TreeFamiTF101062.

Family and domain databases

InterProiIPR003874. CDC45.
[Graphical view]
PANTHERiPTHR10507. PTHR10507. 1 hit.
PfamiPF02724. CDC45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVTDFRKEF YETVHNQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV
60 70 80 90 100
PVSGWQELET AYLEHKEQFS YFILINCGAN VDLLDILQPD EDSIFFVCDT
110 120 130 140 150
HRPVNVVNVY NDTQIKLLIK QEDDLEVPAY DDIFRDEAED EDLSDSDGDG
160 170 180 190 200
SEPSEKRTRL EEEIVERNRK RRQRREWEAR RKDILFDYEQ YEYYGTSSAM
210 220 230 240 250
VMFDLAWMMS KDLNDMLWWA IVGLTDQWVH DKITQMKYVT DVGILQRHVS
260 270 280 290 300
RHNHRNEAEE NMLSVDCTRI SFEYDLCLVL YQHWSLHESL YNTSYTAARF
310 320 330 340 350
KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ SMDVSLKGNL REMIEESANK
360 370 380 390 400
FGMKDMRVQT FSIQFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA
410 420 430 440 450
LDSLSRSNLD KLYLGLELAK KHLQATQQTI ASCLCTNLVT SQGPFLYCSL
460 470 480 490 500
MEGTPDVTLF SKPASLSLLS RHLLKSFVYS TKNRRCKLLP LVMAAPLSVE
510 520 530 540 550
QGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRTLHN YFDLSVIELK
560
AEDRSKFLDA LVSLLS
Length:566
Mass (Da):65,384
Last modified:December 1, 2000 - v2
Checksum:i9BA69F0EA9CFAD9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421D → Y in AAC95057 (Ref. 1) Curated
Sequence conflicti168 – 17710NRKRRQRREW → ETGRGGRPGSG in CAA11531 (PubMed:9724329).Curated
Sequence conflicti175 – 1751R → K in AAD08999 (PubMed:10051334).Curated
Sequence conflicti175 – 1751R → K in AAD09000 (PubMed:10051334).Curated
Sequence conflicti175 – 1751R → K in AAD09001 (PubMed:10051334).Curated
Sequence conflicti197 – 1971S → T in CAA11531 (PubMed:9724329).Curated
Sequence conflicti249 – 2491V → L in CAA11531 (PubMed:9724329).Curated
Sequence conflicti337 – 3426KGNLRE → EGESAR in CAA11531 (PubMed:9724329).Curated
Sequence conflicti373 – 3731A → T in CAA11531 (PubMed:9724329).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098068 mRNA. Translation: AAC95057.1.
AJ223729 mRNA. Translation: CAA11531.1.
AF081536 mRNA. Translation: AAD08999.1.
AF081537 mRNA. Translation: AAD09000.1.
AF081538 mRNA. Translation: AAD09001.1.
AF081539 mRNA. Translation: AAD09002.1.
BC028635 mRNA. Translation: AAH28635.1.
CCDSiCCDS28027.1.
RefSeqiNP_001155095.1. NM_001161623.1.
NP_033992.2. NM_009862.2.
XP_006521807.1. XM_006521744.1.
XP_006536880.1. XM_006536817.1.
UniGeneiMm.1248.

Genome annotation databases

EnsembliENSMUST00000000028; ENSMUSP00000000028; ENSMUSG00000000028.
GeneIDi12544.
KEGGimmu:12544.
UCSCiuc007yom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098068 mRNA. Translation: AAC95057.1.
AJ223729 mRNA. Translation: CAA11531.1.
AF081536 mRNA. Translation: AAD08999.1.
AF081537 mRNA. Translation: AAD09000.1.
AF081538 mRNA. Translation: AAD09001.1.
AF081539 mRNA. Translation: AAD09002.1.
BC028635 mRNA. Translation: AAH28635.1.
CCDSiCCDS28027.1.
RefSeqiNP_001155095.1. NM_001161623.1.
NP_033992.2. NM_009862.2.
XP_006521807.1. XM_006521744.1.
XP_006536880.1. XM_006536817.1.
UniGeneiMm.1248.

3D structure databases

ProteinModelPortaliQ9Z1X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198628. 1 interaction.
IntActiQ9Z1X9. 1 interaction.

PTM databases

PhosphoSiteiQ9Z1X9.

Proteomic databases

MaxQBiQ9Z1X9.
PRIDEiQ9Z1X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000028; ENSMUSP00000000028; ENSMUSG00000000028.
GeneIDi12544.
KEGGimmu:12544.
UCSCiuc007yom.2. mouse.

Organism-specific databases

CTDi8318.
MGIiMGI:1338073. Cdc45.

Phylogenomic databases

eggNOGiNOG321683.
GeneTreeiENSGT00390000009662.
HOGENOMiHOG000253949.
HOVERGENiHBG050819.
InParanoidiQ9Z1X9.
KOiK06628.
OMAiTTMILTH.
OrthoDBiEOG7PZRXS.
PhylomeDBiQ9Z1X9.
TreeFamiTF101062.

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_314754. E2F mediated regulation of DNA replication.
REACT_319408. Unwinding of DNA.
REACT_339329. G1/S-Specific Transcription.
REACT_351504. Activation of the pre-replicative complex.

Miscellaneous databases

NextBioi281586.
PROiQ9Z1X9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z1X9.
ExpressionAtlasiQ9Z1X9. baseline and differential.
GenevestigatoriQ9Z1X9.

Family and domain databases

InterProiIPR003874. CDC45.
[Graphical view]
PANTHERiPTHR10507. PTHR10507. 1 hit.
PfamiPF02724. CDC45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Breyer P., Staib C., Lepke M., Springer J., Grummt F.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene."
    McKie J.M., Wadey R.B., Sutherland H.F., Taylor C.L., Scambler P.J.
    Genome Res. 8:834-841(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development."
    Shaikh T.H., Gottlieb S., Sellinger B., Chen F., Roe B.A., Oakey R.J., Emanuel B.S., Budarf M.L.
    Mamm. Genome 10:322-326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ectoplacental cone and Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiCDC45_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1X9
Secondary accession number(s): O70547, Q9QUK1, Q9R212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: April 1, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.