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Q9Z1X9

- CDC45_MOUSE

UniProt

Q9Z1X9 - CDC45_MOUSE

Protein

Cell division control protein 45 homolog

Gene

Cdc45

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Required for initiation of chromosomal DNA replication.

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. DNA replication initiation Source: InterPro

    Keywords - Biological processi

    Cell cycle, DNA replication

    Enzyme and pathway databases

    ReactomeiREACT_198608. G1/S-Specific Transcription.
    REACT_206830. E2F mediated regulation of DNA replication.
    REACT_217374. Unwinding of DNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 45 homolog
    Alternative name(s):
    PORC-PI-1
    Gene namesi
    Name:Cdc45
    Synonyms:Cdc45l, Cdc45l2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1338073. Cdc45.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Cell division control protein 45 homologPRO_0000192816Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301PhosphotyrosineBy similarity
    Modified residuei144 – 1441PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9Z1X9.

    PTM databases

    PhosphoSiteiQ9Z1X9.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ9Z1X9.
    BgeeiQ9Z1X9.
    GenevestigatoriQ9Z1X9.

    Interactioni

    Protein-protein interaction databases

    BioGridi198628. 1 interaction.
    IntActiQ9Z1X9. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDC45 family.Curated

    Phylogenomic databases

    eggNOGiNOG321683.
    GeneTreeiENSGT00390000009662.
    HOGENOMiHOG000253949.
    HOVERGENiHBG050819.
    InParanoidiQ9Z1X9.
    KOiK06628.
    OMAiINVVNVY.
    OrthoDBiEOG7PZRXS.
    PhylomeDBiQ9Z1X9.
    TreeFamiTF101062.

    Family and domain databases

    InterProiIPR003874. CDC45.
    [Graphical view]
    PANTHERiPTHR10507. PTHR10507. 1 hit.
    PfamiPF02724. CDC45. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z1X9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVTDFRKEF YETVHNQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV    50
    PVSGWQELET AYLEHKEQFS YFILINCGAN VDLLDILQPD EDSIFFVCDT 100
    HRPVNVVNVY NDTQIKLLIK QEDDLEVPAY DDIFRDEAED EDLSDSDGDG 150
    SEPSEKRTRL EEEIVERNRK RRQRREWEAR RKDILFDYEQ YEYYGTSSAM 200
    VMFDLAWMMS KDLNDMLWWA IVGLTDQWVH DKITQMKYVT DVGILQRHVS 250
    RHNHRNEAEE NMLSVDCTRI SFEYDLCLVL YQHWSLHESL YNTSYTAARF 300
    KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ SMDVSLKGNL REMIEESANK 350
    FGMKDMRVQT FSIQFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA 400
    LDSLSRSNLD KLYLGLELAK KHLQATQQTI ASCLCTNLVT SQGPFLYCSL 450
    MEGTPDVTLF SKPASLSLLS RHLLKSFVYS TKNRRCKLLP LVMAAPLSVE 500
    QGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRTLHN YFDLSVIELK 550
    AEDRSKFLDA LVSLLS 566
    Length:566
    Mass (Da):65,384
    Last modified:December 1, 2000 - v2
    Checksum:i9BA69F0EA9CFAD9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421D → Y in AAC95057. 1 PublicationCurated
    Sequence conflicti168 – 17710NRKRRQRREW → ETGRGGRPGSG in CAA11531. (PubMed:9724329)Curated
    Sequence conflicti175 – 1751R → K in AAD08999. (PubMed:10051334)Curated
    Sequence conflicti175 – 1751R → K in AAD09000. (PubMed:10051334)Curated
    Sequence conflicti175 – 1751R → K in AAD09001. (PubMed:10051334)Curated
    Sequence conflicti197 – 1971S → T in CAA11531. (PubMed:9724329)Curated
    Sequence conflicti249 – 2491V → L in CAA11531. (PubMed:9724329)Curated
    Sequence conflicti337 – 3426KGNLRE → EGESAR in CAA11531. (PubMed:9724329)Curated
    Sequence conflicti373 – 3731A → T in CAA11531. (PubMed:9724329)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098068 mRNA. Translation: AAC95057.1.
    AJ223729 mRNA. Translation: CAA11531.1.
    AF081536 mRNA. Translation: AAD08999.1.
    AF081537 mRNA. Translation: AAD09000.1.
    AF081538 mRNA. Translation: AAD09001.1.
    AF081539 mRNA. Translation: AAD09002.1.
    BC028635 mRNA. Translation: AAH28635.1.
    CCDSiCCDS28027.1.
    RefSeqiNP_001155095.1. NM_001161623.1.
    NP_033992.2. NM_009862.2.
    XP_006521807.1. XM_006521744.1.
    XP_006536880.1. XM_006536817.1.
    UniGeneiMm.1248.

    Genome annotation databases

    EnsembliENSMUST00000000028; ENSMUSP00000000028; ENSMUSG00000000028.
    GeneIDi12544.
    KEGGimmu:12544.
    UCSCiuc007yom.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098068 mRNA. Translation: AAC95057.1 .
    AJ223729 mRNA. Translation: CAA11531.1 .
    AF081536 mRNA. Translation: AAD08999.1 .
    AF081537 mRNA. Translation: AAD09000.1 .
    AF081538 mRNA. Translation: AAD09001.1 .
    AF081539 mRNA. Translation: AAD09002.1 .
    BC028635 mRNA. Translation: AAH28635.1 .
    CCDSi CCDS28027.1.
    RefSeqi NP_001155095.1. NM_001161623.1.
    NP_033992.2. NM_009862.2.
    XP_006521807.1. XM_006521744.1.
    XP_006536880.1. XM_006536817.1.
    UniGenei Mm.1248.

    3D structure databases

    ProteinModelPortali Q9Z1X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198628. 1 interaction.
    IntActi Q9Z1X9. 1 interaction.

    PTM databases

    PhosphoSitei Q9Z1X9.

    Proteomic databases

    PRIDEi Q9Z1X9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000028 ; ENSMUSP00000000028 ; ENSMUSG00000000028 .
    GeneIDi 12544.
    KEGGi mmu:12544.
    UCSCi uc007yom.2. mouse.

    Organism-specific databases

    CTDi 8318.
    MGIi MGI:1338073. Cdc45.

    Phylogenomic databases

    eggNOGi NOG321683.
    GeneTreei ENSGT00390000009662.
    HOGENOMi HOG000253949.
    HOVERGENi HBG050819.
    InParanoidi Q9Z1X9.
    KOi K06628.
    OMAi INVVNVY.
    OrthoDBi EOG7PZRXS.
    PhylomeDBi Q9Z1X9.
    TreeFami TF101062.

    Enzyme and pathway databases

    Reactomei REACT_198608. G1/S-Specific Transcription.
    REACT_206830. E2F mediated regulation of DNA replication.
    REACT_217374. Unwinding of DNA.

    Miscellaneous databases

    NextBioi 281586.
    PROi Q9Z1X9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z1X9.
    Bgeei Q9Z1X9.
    Genevestigatori Q9Z1X9.

    Family and domain databases

    InterProi IPR003874. CDC45.
    [Graphical view ]
    PANTHERi PTHR10507. PTHR10507. 1 hit.
    Pfami PF02724. CDC45. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Breyer P., Staib C., Lepke M., Springer J., Grummt F.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene."
      McKie J.M., Wadey R.B., Sutherland H.F., Taylor C.L., Scambler P.J.
      Genome Res. 8:834-841(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development."
      Shaikh T.H., Gottlieb S., Sellinger B., Chen F., Roe B.A., Oakey R.J., Emanuel B.S., Budarf M.L.
      Mamm. Genome 10:322-326(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ectoplacental cone and Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCDC45_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1X9
    Secondary accession number(s): O70547, Q9QUK1, Q9R212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3