Extended synaptotagmin-1 - Rattus norvegicus (Rat)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Extended synaptotagmin-1
Short name=E-Syt1

Alternative name(s):
Membrane-bound C2 domain-containing protein
vp115

Gene names

Name:	Esyt1
Synonyms:	Fam62a, Mbc2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1088 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role as calcium-regulated intrinsic membrane protein By similarity.
Subcellular location	Membrane; Multi-pass membrane protein. Note: Localizes to intracellular membranes. Found in the plasma membrane and in high density microsome fractions By similarity.
Tissue specificity	Ubiquitously expressed with a higher expression in spleen and white adipose tissue. Ref.1
Sequence similarities	Belongs to the extended synaptotagmin family. Contains 5 C2 domains.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1088

1088

Extended synaptotagmin-1

PRO_0000234347

Regions

Transmembrane

55 – 75

21

Helical; Potential

Transmembrane

237 – 257

21

Helical; Potential

Domain

308 – 409

102

C2 1

Domain

457 – 550

94

C2 2

Domain

623 – 724

102

C2 3

Domain

774 – 866

93

C2 4

Domain

956 – 1061

106

C2 5

Compositional bias

912 – 917

6

Poly-Ser

Amino acid modifications

Modified residue

806

1

N6-acetyllysine By similarity

Modified residue

809

1

Phosphoserine By similarity

Modified residue

947

1

Phosphoserine By similarity

Experimental info

Sequence conflict

373

1

H → R in AAI01858. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Z1X1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: E7E12D9737FFB89D
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FASTA

1,088

121,159

        10         20         30         40         50         60 
MERSPEEGAG PEPSGQSPAT DSTRERDGGS GVPPAGPGAA SEALAVLTSF GRRLLVLVPV 

        70         80         90        100        110        120 
YLAGAAGLSV GFVLFGLALY LGWRRVRDGK ERSLRAARQL LDDEERITAE TLYMSHRELP 

       130        140        150        160        170        180 
AWVSFPDVEK AEWLNKIVVQ VWPFLGQYME KLLAETVAPA VRGANPHLQT FTFTRVELGE 

       190        200        210        220        230        240 
KPVRIIGVKV HPSQRKDQIL LDLNVSYVGD LQIDVEVKKY FCKAGVKGMQ LHGVLRVILE 

       250        260        270        280        290        300 
PLIGDLPIVG AVSMFFIKRP TLDINWTGMT NLLDIPGLSS LSDTMIMDSI AAFLVLPNRL 

       310        320        330        340        350        360 
LVPLVPDLQD VAQLRSPLPR GIIRIHLLAA RGLSSKDKYV KGLIEGKSDP YALVRVGTQT 

       370        380        390        400        410        420 
FCSRVIDEEL NPHWGETYEV IVHEVPGQEI EVEVFDKDPD KDDFLGRMKL DVGKVLQAGV 

       430        440        450        460        470        480 
LDNWYPLQGG QGQVHLRLEW LSLLPDAEKL DQVLQWNRGI TSRPEPPSAA ILVVYLDRAQ 

       490        500        510        520        530        540 
DLPLKKGNKE PNPMVQLSVQ DVTQESKATY STNCPVWEEA FRFFLQDPRS QELDVQVKDD 

       550        560        570        580        590        600 
SRALTLGALT LPLARLLTAS ELTLDQWFQL SSSGPNSRLY MKLVMRILYL DSSEMRLPTE 

       610        620        630        640        650        660 
PGAQDWDSES PETGSSVDAP PRPYHTTPNS HFGTENVLRI HVLEAQDLIA KDRFLGGLVK 

       670        680        690        700        710        720 
GKSDPYVKLK VAGRSLRTHV VREDLNPRWN EVFEVIVTSI PGQELDIEVF DKDLDKDDFL 

       730        740        750        760        770        780 
GRYKVGLTTV LNSGFLDEWL TLEDVPSGRL HLRLERLSPR PTAAELEEVL QVNSLIQTQK 

       790        800        810        820        830        840 
SSELAAALLS VYLERSEDLP LRKGTKPPSP YAILTVGETS HKTKTVSQTS APIWEESASF 

       850        860        870        880        890        900 
LIRKPHAESL ELQVRGEGTG TLGSISLPLS ELLQEEQLCL DRWFALSGQG QVLMRVQLGI 

       910        920        930        940        950        960 
LVSQHSGVEA HSHSSSSLNE EPEVLGDPTH TASPVLEVRH RLTHGDSPSE ALIGPLGQVK 

       970        980        990       1000       1010       1020 
LTVWYHSDEQ KLISIIHSCR ALRQNGRDLP DPYVSVLLLP DKNRGTKRKT SQKKRTLNPE 

      1030       1040       1050       1060       1070       1080 
FNERFEWDLP LDGTLRRKLD VSVKSNSSFM SRERELLGKV QLDLAEIDLS QGAAQWYDLI 


DDRDKGGS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains." Morris N.J., Ross S.A., Neveu J.M., Lane W.S., Lienhard G.E. Biochim. Biophys. Acta 1431:525-530(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF099138 mRNA. Translation: AAD10051.1. BC101857 mRNA. Translation: AAI01858.1.
IPI	IPI00209291.
RefSeq	NP_058945.2. NM_017249.2.
UniGene	Rn.11636.
3D structure databases
ProteinModelPortal	Q9Z1X1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z1X1. 1 interaction.
PTM databases
PhosphoSite	Q9Z1X1.
Proteomic databases
PaxDb	Q9Z1X1.
PRIDE	Q9Z1X1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000006119; ENSRNOP00000006119; ENSRNOG00000003909.
GeneID	29579.
KEGG	rno:29579.
UCSC	RGD:3053. rat.
Organism-specific databases
CTD	23344.
RGD	3053. Esyt1.
Phylogenomic databases
eggNOG	COG5038.
GeneTree	ENSGT00550000074417.
HOGENOM	HOG000043080.
HOVERGEN	HBG055795.
InParanoid	Q9Z1X1.
OrthoDB	EOG44F68F.
Gene expression databases
Genevestigator	Q9Z1X1.
GermOnline	ENSRNOG00000003909. Rattus norvegicus.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR020477. C2_dom. IPR018029. C2_membr_targeting. [Graphical view]
Pfam	PF00168. C2. 5 hits. [Graphical view]
PRINTS	PR00360. C2DOMAIN.
SMART	SM00239. C2. 5 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 5 hits.
PROSITE	PS50004. C2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	609682.

Entry information

Entry name

ESYT1_RAT

Accession

Primary (citable) accession number: Q9Z1X1
Secondary accession number(s): Q3T1L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents