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Protein

Stress-associated endoplasmic reticulum protein 1

Gene

Serp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).By similarity

GO - Biological processi

  • endoplasmic reticulum unfolded protein response Source: MGI
  • glucose metabolic process Source: MGI
  • multicellular organism aging Source: MGI
  • muscle organ morphogenesis Source: MGI
  • positive regulation of growth hormone secretion Source: MGI
  • positive regulation of insulin secretion Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of translation Source: MGI
  • post-embryonic development Source: MGI
  • protein glycosylation Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 1
Alternative name(s):
Ribosome-attached membrane protein 4
Gene namesi
Name:Serp1
Synonyms:D3Ucla1, Ramp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:92638. Serp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini60 – 667ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Stress-associated endoplasmic reticulum protein 1PRO_0000274795Add
BLAST

Proteomic databases

PaxDbiQ9Z1W5.

PTM databases

PhosphoSiteiQ9Z1W5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027808.
GenevisibleiQ9Z1W5. MM.

Interactioni

Subunit structurei

Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029385.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ9Z1W5.
OMAiKNVNNRG.
OrthoDBiEOG091G17CZ.
PhylomeDBiQ9Z1W5.
TreeFamiTF313229.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV
60
CGSAIFQIIQ SIRMGM
Length:66
Mass (Da):7,374
Last modified:May 1, 1999 - v1
Checksum:iDC15C0143AAE0D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002653 mRNA. Translation: BAB22260.1.
AB041655 mRNA. Translation: BAB93547.1.
AK032680 mRNA. Translation: BAC27985.1.
AK050508 mRNA. Translation: BAC34297.1.
AK075776 mRNA. Translation: BAC35950.1.
AK144732 mRNA. Translation: BAE26037.1.
AK148485 mRNA. Translation: BAE28580.1.
AK149786 mRNA. Translation: BAE29083.1.
AK150005 mRNA. Translation: BAE29232.1.
AK150025 mRNA. Translation: BAE29250.1.
AK150368 mRNA. Translation: BAE29501.1.
AK150428 mRNA. Translation: BAE29551.1.
AK150659 mRNA. Translation: BAE29745.1.
AK150714 mRNA. Translation: BAE29792.1.
AK150770 mRNA. Translation: BAE29836.1.
AK150809 mRNA. Translation: BAE29872.1.
AK151323 mRNA. Translation: BAE30304.1.
AK151384 mRNA. Translation: BAE30356.1.
AK151456 mRNA. Translation: BAE30415.1.
AK151669 mRNA. Translation: BAE30595.1.
AK152373 mRNA. Translation: BAE31163.1.
AK152383 mRNA. Translation: BAE31171.1.
AK152583 mRNA. Translation: BAE31333.1.
AK152636 mRNA. Translation: BAE31378.1.
AK152806 mRNA. Translation: BAE31511.1.
AK152882 mRNA. Translation: BAE31567.1.
AK152996 mRNA. Translation: BAE31639.1.
AK153056 mRNA. Translation: BAE31682.1.
AK153118 mRNA. Translation: BAE31733.1.
AK153138 mRNA. Translation: BAE31750.1.
AK153286 mRNA. Translation: BAE31869.1.
AK153415 mRNA. Translation: BAE31975.1.
AK159271 mRNA. Translation: BAE34950.1.
AK161595 mRNA. Translation: BAE36482.1.
AK166004 mRNA. Translation: BAE38513.1. Different termination.
AK166052 mRNA. Translation: BAE38545.1.
AK167482 mRNA. Translation: BAE39563.1.
AK167952 mRNA. Translation: BAE39953.1.
AK168046 mRNA. Translation: BAE40028.1.
AK168569 mRNA. Translation: BAE40439.1.
AK168734 mRNA. Translation: BAE40575.1.
AK168754 mRNA. Translation: BAE40592.1.
AK168947 mRNA. Translation: BAE40753.1.
AK169049 mRNA. Translation: BAE40837.1.
AK169175 mRNA. Translation: BAE40954.1.
AK170734 mRNA. Translation: BAE41989.1.
BC002114 mRNA. Translation: AAH02114.1.
CCDSiCCDS38436.1.
RefSeqiNP_109610.1. NM_030685.3.
UniGeneiMm.29702.

Genome annotation databases

EnsembliENSMUST00000029385; ENSMUSP00000029385; ENSMUSG00000027808.
GeneIDi28146.
KEGGimmu:28146.
UCSCiuc008phs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002653 mRNA. Translation: BAB22260.1.
AB041655 mRNA. Translation: BAB93547.1.
AK032680 mRNA. Translation: BAC27985.1.
AK050508 mRNA. Translation: BAC34297.1.
AK075776 mRNA. Translation: BAC35950.1.
AK144732 mRNA. Translation: BAE26037.1.
AK148485 mRNA. Translation: BAE28580.1.
AK149786 mRNA. Translation: BAE29083.1.
AK150005 mRNA. Translation: BAE29232.1.
AK150025 mRNA. Translation: BAE29250.1.
AK150368 mRNA. Translation: BAE29501.1.
AK150428 mRNA. Translation: BAE29551.1.
AK150659 mRNA. Translation: BAE29745.1.
AK150714 mRNA. Translation: BAE29792.1.
AK150770 mRNA. Translation: BAE29836.1.
AK150809 mRNA. Translation: BAE29872.1.
AK151323 mRNA. Translation: BAE30304.1.
AK151384 mRNA. Translation: BAE30356.1.
AK151456 mRNA. Translation: BAE30415.1.
AK151669 mRNA. Translation: BAE30595.1.
AK152373 mRNA. Translation: BAE31163.1.
AK152383 mRNA. Translation: BAE31171.1.
AK152583 mRNA. Translation: BAE31333.1.
AK152636 mRNA. Translation: BAE31378.1.
AK152806 mRNA. Translation: BAE31511.1.
AK152882 mRNA. Translation: BAE31567.1.
AK152996 mRNA. Translation: BAE31639.1.
AK153056 mRNA. Translation: BAE31682.1.
AK153118 mRNA. Translation: BAE31733.1.
AK153138 mRNA. Translation: BAE31750.1.
AK153286 mRNA. Translation: BAE31869.1.
AK153415 mRNA. Translation: BAE31975.1.
AK159271 mRNA. Translation: BAE34950.1.
AK161595 mRNA. Translation: BAE36482.1.
AK166004 mRNA. Translation: BAE38513.1. Different termination.
AK166052 mRNA. Translation: BAE38545.1.
AK167482 mRNA. Translation: BAE39563.1.
AK167952 mRNA. Translation: BAE39953.1.
AK168046 mRNA. Translation: BAE40028.1.
AK168569 mRNA. Translation: BAE40439.1.
AK168734 mRNA. Translation: BAE40575.1.
AK168754 mRNA. Translation: BAE40592.1.
AK168947 mRNA. Translation: BAE40753.1.
AK169049 mRNA. Translation: BAE40837.1.
AK169175 mRNA. Translation: BAE40954.1.
AK170734 mRNA. Translation: BAE41989.1.
BC002114 mRNA. Translation: AAH02114.1.
CCDSiCCDS38436.1.
RefSeqiNP_109610.1. NM_030685.3.
UniGeneiMm.29702.

3D structure databases

ProteinModelPortaliQ9Z1W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029385.

PTM databases

PhosphoSiteiQ9Z1W5.

Proteomic databases

PaxDbiQ9Z1W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029385; ENSMUSP00000029385; ENSMUSG00000027808.
GeneIDi28146.
KEGGimmu:28146.
UCSCiuc008phs.2. mouse.

Organism-specific databases

CTDi27230.
MGIiMGI:92638. Serp1.

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ9Z1W5.
OMAiKNVNNRG.
OrthoDBiEOG091G17CZ.
PhylomeDBiQ9Z1W5.
TreeFamiTF313229.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSerp1. mouse.
PROiQ9Z1W5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027808.
GenevisibleiQ9Z1W5. MM.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERP1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1W5
Secondary accession number(s): Q3TMC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.