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Q9Z1W4 (GDF11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 11

Short name=GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name=BMP-11
Gene names
Name:Gdf11
Synonyms:Bmp11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Tissue specificity

Highly expressed in the developing limb bud, initially detected in the distal mesenchyme, and later localizing to regions around the developing bones. Is also expressed in adult dental pulp and brain.

Developmental stage

First strongly expressed in restricted domains at 8.5 dpc where it is highest in the tail bud. At 10.5 dpc, expressed in the branchial arches, limb bud, tail bud and posterior dorsal neural tube. Later, expressed in terminally-differentiated odontoblasts, the nasal epithelium, retina and specific regions of the brain.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype Ref.2PubMed 23918385. Source: MGI

camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 15976303. Source: MGI

cell maturation

Inferred from mutant phenotype PubMed 15548585. Source: MGI

growth

Inferred from electronic annotation. Source: InterPro

metanephros development

Inferred from direct assay PubMed 12729564. Source: MGI

negative regulation of cell differentiation

Inferred from direct assay PubMed 15976303. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 15548585. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 15548585. Source: MGI

palate development

Inferred from genetic interaction PubMed 24019467. Source: MGI

pancreas development

Inferred from mutant phenotype PubMed 15548585. Source: MGI

skeletal system development

Inferred from genetic interaction PubMed 24019467. Source: MGI

spinal cord anterior/posterior patterning

Inferred from mutant phenotype PubMed 16790475. Source: MGI

ureteric bud development

Inferred from mutant phenotype PubMed 12729564. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 12729564. Source: MGI

protein complex

Inferred from sequence orthology PubMed 24019467. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 16845371. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 296276 By similarity
PRO_0000033988
Chain297 – 405109Growth/differentiation factor 11
PRO_0000033989

Regions

Compositional bias29 – 3911Poly-Ala
Compositional bias208 – 2136Poly-Gly

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Disulfide bond311 ↔ 370 By similarity
Disulfide bond339 ↔ 402 By similarity
Disulfide bond343 ↔ 404 By similarity
Disulfide bond369Interchain By similarity

Experimental info

Sequence conflict751E → G in AAD05267. Ref.3
Sequence conflict1711T → N in AAF21633. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z1W4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A74E382710A14781

FASTA40544,947
        10         20         30         40         50         60 
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAG VGGERSSRPA PSAPPEPDGC 

        70         80         90        100        110        120 
PVCVWRQHSR ELRLESIKSQ ILSKLRLKEA PNISREVVKQ LLPKAPPLQQ ILDLHDFQGD 

       130        140        150        160        170        180 
ALQPEDFLEE DEYHATTETV ISMAQETDPA VQTDGSPLCC HFHFSPKVMF TKVLKAQLWV 

       190        200        210        220        230        240 
YLRPVPRPAT VYLQILRLKP LTGEGTAGGG GGGRRHIRIR SLKIELHSRS GHWQSIDFKQ 

       250        260        270        280        290        300 
VLHSWFRQPQ SNWGIEINAF DPSGTDLAVT SLGPGAEGLH PFMELRVLEN TKRSRRNLGL 

       310        320        330        340        350        360 
DCDEHSSESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GQCEYMFMQK YPHTHLVQQA 

       370        380        390        400 
NPRGSAGPCC TPTKMSPINM LYFNDKQQII YGKIPGMVVD RCGCS 

« Hide

References

[1]"A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."
Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.
Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."
McPherron A.C., Lawler A.M., Lee S.-J.
Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis."
Nakashima M., Toyono T., Akamine A., Joyner A.
Mech. Dev. 80:185-189(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-405.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF100906, AF100904, AF100905 Genomic DNA. Translation: AAC72853.1.
AF028337, AF028335, AF028336 Genomic DNA. Translation: AAF21633.1.
AF092734 mRNA. Translation: AAD05267.1.
CCDSCCDS24296.1.
RefSeqNP_034402.1. NM_010272.1.
UniGeneMm.299218.

3D structure databases

ProteinModelPortalQ9Z1W4.
SMRQ9Z1W4. Positions 73-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199886. 3 interactions.
DIPDIP-29907N.
IntActQ9Z1W4. 1 interaction.
MINTMINT-2842224.

PTM databases

PhosphoSiteQ9Z1W4.

Proteomic databases

PaxDbQ9Z1W4.
PRIDEQ9Z1W4.

Protocols and materials databases

DNASU14561.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026408; ENSMUSP00000026408; ENSMUSG00000025352.
GeneID14561.
KEGGmmu:14561.
UCSCuc007hot.1. mouse.

Organism-specific databases

CTD10220.
MGIMGI:1338027. Gdf11.

Phylogenomic databases

eggNOGNOG310007.
GeneTreeENSGT00620000087687.
HOGENOMHOG000006566.
HOVERGENHBG000217.
InParanoidQ9Z1W4.
KOK05497.
OMAHGKIPGM.
OrthoDBEOG74R1Q4.
PhylomeDBQ9Z1W4.
TreeFamTF318514.

Gene expression databases

BgeeQ9Z1W4.
CleanExMM_GDF11.
GenevestigatorQ9Z1W4.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286262.
PMAP-CutDBQ9Z1W4.
PROQ9Z1W4.
SOURCESearch...

Entry information

Entry nameGDF11_MOUSE
AccessionPrimary (citable) accession number: Q9Z1W4
Secondary accession number(s): Q9QX55, Q9R221
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot