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Q9Z1W4

- GDF11_MOUSE

UniProt

Q9Z1W4 - GDF11_MOUSE

Protein

Growth/differentiation factor 11

Gene

Gdf11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. camera-type eye morphogenesis Source: MGI
    3. cell maturation Source: MGI
    4. growth Source: InterPro
    5. metanephros development Source: MGI
    6. negative regulation of cell differentiation Source: MGI
    7. negative regulation of cell proliferation Source: MGI
    8. organ morphogenesis Source: MGI
    9. palate development Source: MGI
    10. pancreas development Source: MGI
    11. skeletal system development Source: MGI
    12. spinal cord anterior/posterior patterning Source: MGI
    13. ureteric bud development Source: MGI

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 11
    Short name:
    GDF-11
    Alternative name(s):
    Bone morphogenetic protein 11
    Short name:
    BMP-11
    Gene namesi
    Name:Gdf11
    Synonyms:Bmp11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1338027. Gdf11.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 296276By similarityPRO_0000033988Add
    BLAST
    Chaini297 – 405109Growth/differentiation factor 11PRO_0000033989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi311 ↔ 370By similarity
    Disulfide bondi339 ↔ 402By similarity
    Disulfide bondi343 ↔ 404By similarity
    Disulfide bondi369 – 369InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Z1W4.
    PRIDEiQ9Z1W4.

    PTM databases

    PhosphoSiteiQ9Z1W4.

    Miscellaneous databases

    PMAP-CutDBQ9Z1W4.

    Expressioni

    Tissue specificityi

    Highly expressed in the developing limb bud, initially detected in the distal mesenchyme, and later localizing to regions around the developing bones. Is also expressed in adult dental pulp and brain.

    Developmental stagei

    First strongly expressed in restricted domains at 8.5 dpc where it is highest in the tail bud. At 10.5 dpc, expressed in the branchial arches, limb bud, tail bud and posterior dorsal neural tube. Later, expressed in terminally-differentiated odontoblasts, the nasal epithelium, retina and specific regions of the brain.

    Gene expression databases

    BgeeiQ9Z1W4.
    CleanExiMM_GDF11.
    GenevestigatoriQ9Z1W4.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi199886. 3 interactions.
    DIPiDIP-29907N.
    IntActiQ9Z1W4. 1 interaction.
    MINTiMINT-2842224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1W4.
    SMRiQ9Z1W4. Positions 73-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 3911Poly-AlaAdd
    BLAST
    Compositional biasi208 – 2136Poly-Gly

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG310007.
    GeneTreeiENSGT00620000087687.
    HOGENOMiHOG000006566.
    HOVERGENiHBG000217.
    InParanoidiQ9Z1W4.
    KOiK05497.
    OMAiHGKIPGM.
    OrthoDBiEOG74R1Q4.
    PhylomeDBiQ9Z1W4.
    TreeFamiTF318514.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z1W4-1 [UniParc]FASTAAdd to Basket

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    MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAG VGGERSSRPA    50
    PSAPPEPDGC PVCVWRQHSR ELRLESIKSQ ILSKLRLKEA PNISREVVKQ 100
    LLPKAPPLQQ ILDLHDFQGD ALQPEDFLEE DEYHATTETV ISMAQETDPA 150
    VQTDGSPLCC HFHFSPKVMF TKVLKAQLWV YLRPVPRPAT VYLQILRLKP 200
    LTGEGTAGGG GGGRRHIRIR SLKIELHSRS GHWQSIDFKQ VLHSWFRQPQ 250
    SNWGIEINAF DPSGTDLAVT SLGPGAEGLH PFMELRVLEN TKRSRRNLGL 300
    DCDEHSSESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GQCEYMFMQK 350
    YPHTHLVQQA NPRGSAGPCC TPTKMSPINM LYFNDKQQII YGKIPGMVVD 400
    RCGCS 405
    Length:405
    Mass (Da):44,947
    Last modified:May 1, 1999 - v1
    Checksum:iA74E382710A14781
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751E → G in AAD05267. (PubMed:10072786)Curated
    Sequence conflicti171 – 1711T → N in AAF21633. (PubMed:10391213)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100906, AF100904, AF100905 Genomic DNA. Translation: AAC72853.1.
    AF028337, AF028335, AF028336 Genomic DNA. Translation: AAF21633.1.
    AF092734 mRNA. Translation: AAD05267.1.
    CCDSiCCDS24296.1.
    RefSeqiNP_034402.1. NM_010272.1.
    UniGeneiMm.299218.

    Genome annotation databases

    EnsembliENSMUST00000026408; ENSMUSP00000026408; ENSMUSG00000025352.
    GeneIDi14561.
    KEGGimmu:14561.
    UCSCiuc007hot.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100906 , AF100904 , AF100905 Genomic DNA. Translation: AAC72853.1 .
    AF028337 , AF028335 , AF028336 Genomic DNA. Translation: AAF21633.1 .
    AF092734 mRNA. Translation: AAD05267.1 .
    CCDSi CCDS24296.1.
    RefSeqi NP_034402.1. NM_010272.1.
    UniGenei Mm.299218.

    3D structure databases

    ProteinModelPortali Q9Z1W4.
    SMRi Q9Z1W4. Positions 73-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199886. 3 interactions.
    DIPi DIP-29907N.
    IntActi Q9Z1W4. 1 interaction.
    MINTi MINT-2842224.

    PTM databases

    PhosphoSitei Q9Z1W4.

    Proteomic databases

    PaxDbi Q9Z1W4.
    PRIDEi Q9Z1W4.

    Protocols and materials databases

    DNASUi 14561.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026408 ; ENSMUSP00000026408 ; ENSMUSG00000025352 .
    GeneIDi 14561.
    KEGGi mmu:14561.
    UCSCi uc007hot.1. mouse.

    Organism-specific databases

    CTDi 10220.
    MGIi MGI:1338027. Gdf11.

    Phylogenomic databases

    eggNOGi NOG310007.
    GeneTreei ENSGT00620000087687.
    HOGENOMi HOG000006566.
    HOVERGENi HBG000217.
    InParanoidi Q9Z1W4.
    KOi K05497.
    OMAi HGKIPGM.
    OrthoDBi EOG74R1Q4.
    PhylomeDBi Q9Z1W4.
    TreeFami TF318514.

    Miscellaneous databases

    NextBioi 286262.
    PMAP-CutDB Q9Z1W4.
    PROi Q9Z1W4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z1W4.
    CleanExi MM_GDF11.
    Genevestigatori Q9Z1W4.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."
      Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.
      Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."
      McPherron A.C., Lawler A.M., Lee S.-J.
      Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis."
      Nakashima M., Toyono T., Akamine A., Joyner A.
      Mech. Dev. 80:185-189(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-405.

    Entry informationi

    Entry nameiGDF11_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1W4
    Secondary accession number(s): Q9QX55, Q9R221
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3