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Protein

Olfactory receptor 49

Gene

Olfr49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • isoprenoid binding Source: MGI
  • olfactory receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 49Imported
Alternative name(s):
Olfactory receptor 118-1
Olfactory receptor I-C61 Publication
Gene namesi
Name:Olfr49Imported
Synonyms:Mor118-1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1333764. Olfr49.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004221531 – 313Olfactory receptor 49Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z1V0.
PRIDEiQ9Z1V0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048153.
GenevisibleiQ9Z1V0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054361.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG3B. Eukaryota.
ENOG410YCPU. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Z1V0.
KOiK04257.
OMAiACSSHII.
OrthoDBiEOG091G0EDL.
PhylomeDBiQ9Z1V0.
TreeFamiTF336833.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSTTVTEF ILLGLSDACE LQVLIFLGFL LTYFLILLGN FLIIFITLVD
60 70 80 90 100
RRLYTPMYYF LRNFAMLEIW FTSVIFPKML TNIITGHKTI SLLGCFLQAF
110 120 130 140 150
LYFFLGTTEF FLLAVMSFDR YVAICNPLRY ATIMSKRVCV QLVFCSWMSG
160 170 180 190 200
LLLIIVPSSI VFQQPFCGPN IINHFFCDNF PLMELICADT SLVEFLGFVI
210 220 230 240 250
ANFSLLGTLA VTATCYGHIL YTILHIPSAK ERKKAFSTCS SHIIVVSLFY
260 270 280 290 300
GSCIFMYVRS GKNGQGEDHN KVVALLNTVV TPTLNPFIYT LRNKQVKQVF
310
REHVSKFQKF SQT
Length:313
Mass (Da):35,689
Last modified:May 1, 1999 - v1
Checksum:i4457CEDF63458615
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49V → A in AAL61277 (PubMed:11802173).Curated1
Sequence conflicti49V → A in AAP71780 (PubMed:14611657).Curated1
Sequence conflicti49V → A in EDL36361 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102523 Genomic DNA. Translation: AAD13315.1.
AY073614 Genomic DNA. Translation: AAL61277.1.
AY318614 Genomic DNA. Translation: AAP71780.1.
CT573018 Genomic DNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36361.1.
BC145891 mRNA. Translation: AAI45892.1.
BC145893 mRNA. Translation: AAI45894.1.
CCDSiCCDS27085.1.
RefSeqiNP_035121.1. NM_010991.2.
UniGeneiMm.436623.

Genome annotation databases

EnsembliENSMUST00000059996; ENSMUSP00000054361; ENSMUSG00000048153.
ENSMUST00000216214; ENSMUSP00000149840; ENSMUSG00000048153.
GeneIDi18348.
KEGGimmu:18348.
UCSCiuc007tvs.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiOLF49_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1V0
Secondary accession number(s): Q8VFB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families