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Protein

Olfactory receptor 49

Gene

Olfr49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • isoprenoid binding Source: MGI
  • olfactory receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 49Imported
Alternative name(s):
Olfactory receptor 118-1
Olfactory receptor I-C61 Publication
Gene namesi
Name:Olfr49Imported
Synonyms:Mor118-1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1333764. Olfr49.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 49PRO_0000422153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z1V0.

Expressioni

Gene expression databases

GenevisibleiQ9Z1V0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054361.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1V0.
SMRiQ9Z1V0. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG3B. Eukaryota.
ENOG410YCPU. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Z1V0.
KOiK04257.
OMAiYTILHIP.
OrthoDBiEOG741Z2S.
PhylomeDBiQ9Z1V0.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSTTVTEF ILLGLSDACE LQVLIFLGFL LTYFLILLGN FLIIFITLVD
60 70 80 90 100
RRLYTPMYYF LRNFAMLEIW FTSVIFPKML TNIITGHKTI SLLGCFLQAF
110 120 130 140 150
LYFFLGTTEF FLLAVMSFDR YVAICNPLRY ATIMSKRVCV QLVFCSWMSG
160 170 180 190 200
LLLIIVPSSI VFQQPFCGPN IINHFFCDNF PLMELICADT SLVEFLGFVI
210 220 230 240 250
ANFSLLGTLA VTATCYGHIL YTILHIPSAK ERKKAFSTCS SHIIVVSLFY
260 270 280 290 300
GSCIFMYVRS GKNGQGEDHN KVVALLNTVV TPTLNPFIYT LRNKQVKQVF
310
REHVSKFQKF SQT
Length:313
Mass (Da):35,689
Last modified:May 1, 1999 - v1
Checksum:i4457CEDF63458615
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491V → A in AAL61277 (PubMed:11802173).Curated
Sequence conflicti49 – 491V → A in AAP71780 (PubMed:14611657).Curated
Sequence conflicti49 – 491V → A in EDL36361 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102523 Genomic DNA. Translation: AAD13315.1.
AY073614 Genomic DNA. Translation: AAL61277.1.
AY318614 Genomic DNA. Translation: AAP71780.1.
CT573018 Genomic DNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36361.1.
BC145891 mRNA. Translation: AAI45892.1.
BC145893 mRNA. Translation: AAI45894.1.
CCDSiCCDS27085.1.
RefSeqiNP_035121.1. NM_010991.2.
UniGeneiMm.436623.

Genome annotation databases

EnsembliENSMUST00000059996; ENSMUSP00000054361; ENSMUSG00000048153.
GeneIDi18348.
KEGGimmu:18348.
UCSCiuc007tvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102523 Genomic DNA. Translation: AAD13315.1.
AY073614 Genomic DNA. Translation: AAL61277.1.
AY318614 Genomic DNA. Translation: AAP71780.1.
CT573018 Genomic DNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36361.1.
BC145891 mRNA. Translation: AAI45892.1.
BC145893 mRNA. Translation: AAI45894.1.
CCDSiCCDS27085.1.
RefSeqiNP_035121.1. NM_010991.2.
UniGeneiMm.436623.

3D structure databases

ProteinModelPortaliQ9Z1V0.
SMRiQ9Z1V0. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054361.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9Z1V0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059996; ENSMUSP00000054361; ENSMUSG00000048153.
GeneIDi18348.
KEGGimmu:18348.
UCSCiuc007tvs.2. mouse.

Organism-specific databases

CTDi18348.
MGIiMGI:1333764. Olfr49.

Phylogenomic databases

eggNOGiENOG410IG3B. Eukaryota.
ENOG410YCPU. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Z1V0.
KOiK04257.
OMAiYTILHIP.
OrthoDBiEOG741Z2S.
PhylomeDBiQ9Z1V0.
TreeFamiTF336833.

Miscellaneous databases

PROiQ9Z1V0.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ9Z1V0. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of ligands for olfactory receptors by functional expression of a receptor library."
    Krautwurst D., Yau K.W., Reed R.R.
    Cell 95:917-926(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: 129/SvJImported.
  2. "The olfactory receptor gene superfamily of the mouse."
    Zhang X., Firestein S.
    Nat. Neurosci. 5:124-133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels."
    Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A., Walker M., Williams E.M., Trask B.J.
    Genome Biol. 4:R71.1-R71.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOLF49_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1V0
Secondary accession number(s): Q8VFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.