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Q9Z1T6

- FYV1_MOUSE

UniProt

Q9Z1T6 - FYV1_MOUSE

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Protein
1-phosphatidylinositol 3-phosphate 5-kinase
Gene
Pikfyve, Kiaa0981, Pip5k3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 21861FYVE-type
Add
BLAST

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-phosphate 5-kinase activity Source: Reactome
  2. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB
  3. 1-phosphatidylinositol-5-kinase activity Source: Reactome
  4. ATP binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. zinc ion binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cellular protein metabolic process Source: InterPro
  2. intracellular signal transduction Source: UniProtKB
  3. myelin assembly Source: MGI
  4. phosphatidylinositol phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198970. Synthesis of PIPs at the Golgi membrane.
REACT_198972. Synthesis of PIPs at the late endosome membrane.
REACT_198975. Synthesis of PIPs at the early endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 3-phosphate 5-kinase (EC:2.7.1.150)
Short name:
Phosphatidylinositol 3-phosphate 5-kinase
Alternative name(s):
FYVE finger-containing phosphoinositide kinase
PIKfyve
Phosphatidylinositol 3-phosphate 5-kinase type III
Short name:
PIPkin-III
Short name:
Type III PIP kinase
p235
Gene namesi
Name:Pikfyve
Synonyms:Kiaa0981, Pip5k3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1335106. Pikfyve.

Subcellular locationi

Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane By similarity
Note: Associated with vesicle structures. Displays a peripheral vesicular punctate pattern. Mainly associated with membranes of the late endocytic pathway By similarity.1 Publication

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. cell-cell junction Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  5. cytosol Source: MGI
  6. early endosome membrane Source: Reactome
  7. late endosome membrane Source: Reactome
  8. perinuclear region of cytoplasm Source: MGI
  9. vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 209720961-phosphatidylinositol 3-phosphate 5-kinase
PRO_0000185453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei299 – 2991Phosphoserine By similarity
Modified residuei318 – 3181Phosphoserine; by PKB/AKT1 or PKB/AKT2 By similarity
Modified residuei329 – 3291Phosphoserine By similarity
Modified residuei1543 – 15431Phosphoserine By similarity
Modified residuei1548 – 15481Phosphoserine By similarity
Modified residuei1753 – 17531Phosphoserine By similarity

Post-translational modificationi

Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z1T6.
PRIDEiQ9Z1T6.

2D gel databases

SWISS-2DPAGEiQ9Z1T6.

PTM databases

PhosphoSiteiQ9Z1T6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9Z1T6.
GenevestigatoriQ9Z1T6.

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.1 Publication

Protein-protein interaction databases

BioGridi202165. 2 interactions.
IntActiQ9Z1T6. 1 interaction.
STRINGi10090.ENSMUSP00000109676.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini365 – 44076DEP
Add
BLAST
Domaini1757 – 2083327PIPK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1841 – 2097257Catalytic By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1222 – 12254Poly-Ser

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 PIPK domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00750000117278.
HOGENOMiHOG000059273.
HOVERGENiHBG005775.
KOiK00921.
OMAiWTEKMQA.
OrthoDBiEOG757CWH.
TreeFamiTF321717.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
SUPFAMiSSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z1T6-2) [UniParc]FASTAAdd to Basket

Also known as: p235S

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV     50
NLFRFNKERG EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL 100
HRRSSVLDSR RKAEPACGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD 150
LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF 200
MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDST CSVSILDPSE 250
PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNSALSTRLV SVQEDAGKSP 300
ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRNYIRTE TTEDERKILL 350
DSAQLKDLWK KICHHTSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI 400
ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ STEFSETPSP 450
DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI AEEGDDNLAN SASPSKRTSV 500
SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH PADQKEYLVS 550
DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENE 600
EKQAMERLLS ANHNHMMALL QQLLQNESLS SSWRDIIVSL VCQVVQTVRP 650
DVKHQDDDMD IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMNSCIK 700
NPKILLLKCS IEYLYREETK FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV 750
LVEKTVSRIA QDMLLEHGIT LVINVKSQVL ERISRMTQGD LVVSMDQLLT 800
KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK LRGGSDYELA 850
RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQSPSFH LLTEGRGEEG 900
ASQEQVSGSS LPQDPECPRE ALSSEDSTLL ESRTVLEKGE LDNKSIPQAV 950
ASLKHQDYTT PTCPAGIPCA LFALVPESLL PLHMDQQDAV GNEQPETSQQ 1000
TDEQQDPKSQ MKAFRDPLQD DTGMYVTEEV TSSEDQRKTY ALTFKQELKD 1050
VILCISPVIT FREPFLLTEK GMRCSTRDYF PEQIYWSPLL NKEVKEMESR 1100
RKKQLLRDLS GLQGMNGSVQ AKSIQVLPSH ELVSTRIAEH LGDSQTLGRM 1150
LADYRARGGR IQSKHLDPFV HSKDASCTSG GKSGNKTESD EERGLIPSDV 1200
IWPTKVDCLN PANHQRLCVL FSSSSAQSSN APSACVSPWI VTMEFYGKND 1250
LTLGIFLERY CFRSSYQCPS MFCDTPMVHH IRRFVHGQGC VQIILKELDS 1300
PVPGYQHTIL TYSWCRICKQ VTPVVALSNE SWSMSFAKYL ELRFYGHQYT 1350
RRANAEPCGH SIHHDYHQYF SYNQMVASFS YSPIRLLEVC VPLPKIFIKR 1400
QAPLKVSLLQ DLKDFFQKVS QVYLAVDERL ASLKTDTFSK TREEKMEDIF 1450
AQKEMEEGEF KNWTEKMQAR LMSSSVDTPQ QLQSIFESLI AKKQSLCEVL 1500
QAWNSRLQDL FQQEKGRKRP SVPPSPGRLR QGEESKINAM DTSPRNISPG 1550
LHNGEKEDRF LTTLSSQSST SSTHLQLPTP PEALAEQVVG GPTDLDSASG 1600
SEDVFDGHLL GSTDSQVKEK STMKAIFANL LPGNSYNPIP FPFDPDKHYL 1650
MYEHERVPIA VCEKEPSSII AFALSCKEYR NALEELSKAT LRNSAEEGLP 1700
ANSALDNRPK SSSPIRLPEI SGGQTNRTVE AEPQPTKKAS GMLSFFRGTA 1750
GKSPDLSSQK RETLRGADSA YYQVGQAGKE GLESQGLEPQ DEVDGGDTQK 1800
KQLTNPHVEL QFSDANAKFY CRLYYAGEFH KMREVILGSS EEEFIRSLSH 1850
SSPWQARGGK SGAAFYATED DRFILKQMPR LEVQSFLDFA PHYFNYITNA 1900
VQQKRPTALA KILGVYRIGY KNSQNNTEKK LDLLVMENLF YGRKMAQVFD 1950
LKGSLRNRNV KTDTGKESCD VVLLDENLLK MVRDNPLYIR SHSKSVLRTS 2000
IHSDAHFLSS HLIIDYSLLV GRDDTSNELV VGIIDYIRTF TWDKKLEMVV 2050
KSTGILGGQG KMPTVVSPEL YRTRFCEAMD KYFLMVPDHW TGLDLNC 2097
Length:2,097
Mass (Da):236,877
Last modified:July 27, 2011 - v3
Checksum:i8C529E86FBEED8E6
GO
Isoform 2 (identifier: Q9Z1T6-1) [UniParc]FASTAAdd to Basket

Also known as: p235L

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: L → LENTLPHPQEST
     490-545: Missing.

Show »
Length:2,052
Mass (Da):232,081
Checksum:iC7FA5897A3319DA0
GO
Isoform 3 (identifier: Q9Z1T6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-497: NSASPSKR → SKFGFLML
     498-2097: Missing.

Show »
Length:497
Mass (Da):55,999
Checksum:i5BB1E9BE48047A7A
GO

Sequence cautioni

The sequence AAD10191.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAB30626.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAD32355.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1071L → LENTLPHPQEST in isoform 2.
VSP_034953
Alternative sequencei490 – 54556Missing in isoform 2.
VSP_034954Add
BLAST
Alternative sequencei490 – 4978NSASPSKR → SKFGFLML in isoform 3.
VSP_034955
Alternative sequencei498 – 20971600Missing in isoform 3.
VSP_034956Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti546 – 5461E → K in AAD10191. 1 Publication
Sequence conflicti944 – 9441K → Q in BAD32355. 1 Publication
Sequence conflicti994 – 9952QP → HR in AAD10191. 1 Publication
Sequence conflicti1107 – 11071R → T in BAB30626. 1 Publication
Sequence conflicti1141 – 11411L → V in AAD10191. 1 Publication
Sequence conflicti1264 – 12641S → Y in AAD10191. 1 Publication
Sequence conflicti1996 – 19961V → E in AAD10191. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102777 mRNA. Translation: AAD10191.1. Frameshift.
AK173077 mRNA. Translation: BAD32355.1. Different initiation.
AK017186 mRNA. Translation: BAB30626.3. Different initiation.
AK139116 mRNA. Translation: BAE23894.1.
AK165350 mRNA. Translation: BAE38145.1.
AC164079 Genomic DNA. No translation available.
CCDSiCCDS35601.1. [Q9Z1T6-1]
PIRiT18290.
RefSeqiNP_035216.2. NM_011086.2.
XP_006495843.1. XM_006495780.1. [Q9Z1T6-2]
XP_006495844.1. XM_006495781.1. [Q9Z1T6-2]
UniGeneiMm.38370.

Genome annotation databases

EnsembliENSMUST00000097707; ENSMUSP00000095314; ENSMUSG00000025949. [Q9Z1T6-2]
GeneIDi18711.
KEGGimmu:18711.
UCSCiuc007bho.1. mouse. [Q9Z1T6-3]
uc007bht.1. mouse. [Q9Z1T6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102777 mRNA. Translation: AAD10191.1 . Frameshift.
AK173077 mRNA. Translation: BAD32355.1 . Different initiation.
AK017186 mRNA. Translation: BAB30626.3 . Different initiation.
AK139116 mRNA. Translation: BAE23894.1 .
AK165350 mRNA. Translation: BAE38145.1 .
AC164079 Genomic DNA. No translation available.
CCDSi CCDS35601.1. [Q9Z1T6-1 ]
PIRi T18290.
RefSeqi NP_035216.2. NM_011086.2.
XP_006495843.1. XM_006495780.1. [Q9Z1T6-2 ]
XP_006495844.1. XM_006495781.1. [Q9Z1T6-2 ]
UniGenei Mm.38370.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 202165. 2 interactions.
IntActi Q9Z1T6. 1 interaction.
STRINGi 10090.ENSMUSP00000109676.

Chemistry

ChEMBLi CHEMBL2176842.

PTM databases

PhosphoSitei Q9Z1T6.

2D gel databases

SWISS-2DPAGEi Q9Z1T6.

Proteomic databases

PaxDbi Q9Z1T6.
PRIDEi Q9Z1T6.

Protocols and materials databases

DNASUi 18711.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097707 ; ENSMUSP00000095314 ; ENSMUSG00000025949 . [Q9Z1T6-2 ]
GeneIDi 18711.
KEGGi mmu:18711.
UCSCi uc007bho.1. mouse. [Q9Z1T6-3 ]
uc007bht.1. mouse. [Q9Z1T6-2 ]

Organism-specific databases

CTDi 200576.
MGIi MGI:1335106. Pikfyve.
Rougei Search...

Phylogenomic databases

eggNOGi COG0459.
GeneTreei ENSGT00750000117278.
HOGENOMi HOG000059273.
HOVERGENi HBG005775.
KOi K00921.
OMAi WTEKMQA.
OrthoDBi EOG757CWH.
TreeFami TF321717.

Enzyme and pathway databases

Reactomei REACT_198970. Synthesis of PIPs at the Golgi membrane.
REACT_198972. Synthesis of PIPs at the late endosome membrane.
REACT_198975. Synthesis of PIPs at the early endosome membrane.

Miscellaneous databases

NextBioi 294793.
PROi Q9Z1T6.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z1T6.
Genevestigatori Q9Z1T6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.260.10. 2 hits.
3.30.40.10. 1 hit.
3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
3.50.7.10. 1 hit.
InterProi IPR002423. Cpn60/TCP-1.
IPR000591. DEP_dom.
IPR027409. GroEL-like_apical_dom.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
IPR027410. TCP-1-like_intermed.
IPR011991. WHTH_DNA-bd_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 1 hit.
[Graphical view ]
SMARTi SM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52029. SSF52029. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells."
    Shisheva A., Sbrissa D., Ikonomov O.
    Mol. Cell. Biol. 19:623-634(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION.
    Tissue: Adipose tissue.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Ovary, Spleen and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases."
    McEwen R.K., Dove S.K., Cooke F.T., Painter G.F., Holmes A.B., Shisheva A., Ohya Y., Parker P.J., Michell R.H.
    J. Biol. Chem. 274:33905-33912(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice."
    Zhang Y., Zolov S.N., Chow C.Y., Slutsky S.G., Richardson S.C., Piper R.C., Yang B., Nau J.J., Westrick R.J., Morrison S.J., Meisler M.H., Weisman L.S.
    Proc. Natl. Acad. Sci. U.S.A. 104:17518-17523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse."
    Jin N., Chow C.Y., Liu L., Zolov S.N., Bronson R., Davisson M., Petersen J.L., Zhang Y., Park S., Duex J.E., Goldowitz D., Meisler M.H., Weisman L.S.
    EMBO J. 27:3221-3234(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
  9. "Regulation of PIKfyve phosphorylation by insulin and osmotic stress."
    Hill E.V., Hudson C.A., Vertommen D., Rider M.H., Tavare J.M.
    Biochem. Biophys. Res. Commun. 397:650-655(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-318.

Entry informationi

Entry nameiFYV1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1T6
Secondary accession number(s): E9QL40
, Q3TNE4, Q3UTT6, Q69ZU1, Q9CU94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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