Q9Z1T6 (FYV1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphatidylinositol 3-phosphate 5-kinase
Short name=Phosphatidylinositol 3-phosphate 5-kinase
EC=2.7.1.150

Alternative name(s):
FYVE finger-containing phosphoinositide kinase
PIKfyve
Phosphatidylinositol 3-phosphate 5-kinase type III
Short name=PIPkin-III
Short name=Type III PIP kinase
p235

Gene names

Name:	Pikfyve
Synonyms:	Kiaa0981, Pip5k3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2097 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Ref.8
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. Ref.5
Subunit structure	Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Ref.8
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane By similarity. Note: Associated with vesicle structures. Displays a peripheral vesicular punctate pattern. Mainly associated with membranes of the late endocytic pathway By similarity. Ref.8
Tissue specificity	Ubiquitous. Ref.7
Sequence similarities	Contains 1 DEP domain. Contains 1 FYVE-type zinc finger. Contains 1 PIPK domain.
Sequence caution	The sequence AAD10191.1 differs from that shown. Reason: Frameshift at several positions. The sequence BAB30626.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAD32355.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Endosome Membrane
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein metabolic process Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from direct assay Ref.1. Source: UniProtKB myelin assembly Inferred from genetic interaction PubMed 22028665. Source: MGI
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome cytoplasmic vesicle Inferred from direct assay PubMed 11112776. Source: MGI cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from direct assay PubMed 11112776. Source: MGI early endosome membrane Traceable author statement. Source: Reactome late endosome membrane Traceable author statement. Source: Reactome perinuclear region of cytoplasm Inferred from direct assay PubMed 19056739. Source: MGI vesicle membrane Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	1-phosphatidylinositol-3-phosphate 5-kinase activity Traceable author statement. Source: Reactome 1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from direct assay Ref.1. Source: UniProtKB 1-phosphatidylinositol-5-kinase activity Traceable author statement. Source: Reactome ATP binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z1T6-2)

Also known as: p235S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z1T6-1)

Also known as: p235L;

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: L → LENTLPHPQEST
     490-545: Missing.

Isoform 3 (identifier: Q9Z1T6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     490-497: NSASPSKR → SKFGFLML
     498-2097: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 2097	2096	1-phosphatidylinositol 3-phosphate 5-kinase		PRO_0000185453
Regions
	Domain	365 – 440	76	DEP
	Domain	1757 – 2083	327	PIPK
	Zinc finger	158 – 218	61	FYVE-type
	Region	1841 – 2097	257	Catalytic By similarity
	Compositional bias	1222 – 1225	4	Poly-Ser
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	299	1	Phosphoserine By similarity
	Modified residue	307	1	Phosphoserine Ref.6
	Modified residue	318	1	Phosphoserine; by PKB/AKT1 or PKB/AKT2 By similarity
	Modified residue	329	1	Phosphoserine By similarity
	Modified residue	1543	1	Phosphoserine By similarity
	Modified residue	1548	1	Phosphoserine By similarity
	Modified residue	1753	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	107	1	L → LENTLPHPQEST in isoform 2.		VSP_034953
	Alternative sequence	490 – 545	56	Missing in isoform 2.		VSP_034954
	Alternative sequence	490 – 497	8	NSASPSKR → SKFGFLML in isoform 3.		VSP_034955
	Alternative sequence	498 – 2097	1600	Missing in isoform 3.		VSP_034956
Experimental info
	Sequence conflict	546	1	E → K in AAD10191. Ref.1
	Sequence conflict	944	1	K → Q in BAD32355. Ref.2
	Sequence conflict	994 – 995	2	QP → HR in AAD10191. Ref.1
	Sequence conflict	1107	1	R → T in BAB30626. Ref.3
	Sequence conflict	1141	1	L → V in AAD10191. Ref.1
	Sequence conflict	1264	1	S → Y in AAD10191. Ref.1
	Sequence conflict	1996	1	V → E in AAD10191. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (p235S) [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 8C529E86FBEED8E6	FASTA	2,097	236,877
	10 20 30 40 50 60 MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG 70 80 90 100 110 120 EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLDSR RKAEPACGGH 130 140 150 160 170 180 DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC 190 200 210 220 230 240 RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDST 250 260 270 280 290 300 CSVSILDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNSALSTRLV SVQEDAGKSP 310 320 330 340 350 360 ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRNYIRTE TTEDERKILL DSAQLKDLWK 370 380 390 400 410 420 KICHHTSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD 430 440 450 460 470 480 CVSHHDQLFR DEYALYRPLQ STEFSETPSP DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI 490 500 510 520 530 540 AEEGDDNLAN SASPSKRTSV SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH 550 560 570 580 590 600 PADQKEYLVS DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENE 610 620 630 640 650 660 EKQAMERLLS ANHNHMMALL QQLLQNESLS SSWRDIIVSL VCQVVQTVRP DVKHQDDDMD 670 680 690 700 710 720 IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMNSCIK NPKILLLKCS IEYLYREETK 730 740 750 760 770 780 FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV LVEKTVSRIA QDMLLEHGIT LVINVKSQVL 790 800 810 820 830 840 ERISRMTQGD LVVSMDQLLT KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK 850 860 870 880 890 900 LRGGSDYELA RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQSPSFH LLTEGRGEEG 910 920 930 940 950 960 ASQEQVSGSS LPQDPECPRE ALSSEDSTLL ESRTVLEKGE LDNKSIPQAV ASLKHQDYTT 970 980 990 1000 1010 1020 PTCPAGIPCA LFALVPESLL PLHMDQQDAV GNEQPETSQQ TDEQQDPKSQ MKAFRDPLQD 1030 1040 1050 1060 1070 1080 DTGMYVTEEV TSSEDQRKTY ALTFKQELKD VILCISPVIT FREPFLLTEK GMRCSTRDYF 1090 1100 1110 1120 1130 1140 PEQIYWSPLL NKEVKEMESR RKKQLLRDLS GLQGMNGSVQ AKSIQVLPSH ELVSTRIAEH 1150 1160 1170 1180 1190 1200 LGDSQTLGRM LADYRARGGR IQSKHLDPFV HSKDASCTSG GKSGNKTESD EERGLIPSDV 1210 1220 1230 1240 1250 1260 IWPTKVDCLN PANHQRLCVL FSSSSAQSSN APSACVSPWI VTMEFYGKND LTLGIFLERY 1270 1280 1290 1300 1310 1320 CFRSSYQCPS MFCDTPMVHH IRRFVHGQGC VQIILKELDS PVPGYQHTIL TYSWCRICKQ 1330 1340 1350 1360 1370 1380 VTPVVALSNE SWSMSFAKYL ELRFYGHQYT RRANAEPCGH SIHHDYHQYF SYNQMVASFS 1390 1400 1410 1420 1430 1440 YSPIRLLEVC VPLPKIFIKR QAPLKVSLLQ DLKDFFQKVS QVYLAVDERL ASLKTDTFSK 1450 1460 1470 1480 1490 1500 TREEKMEDIF AQKEMEEGEF KNWTEKMQAR LMSSSVDTPQ QLQSIFESLI AKKQSLCEVL 1510 1520 1530 1540 1550 1560 QAWNSRLQDL FQQEKGRKRP SVPPSPGRLR QGEESKINAM DTSPRNISPG LHNGEKEDRF 1570 1580 1590 1600 1610 1620 LTTLSSQSST SSTHLQLPTP PEALAEQVVG GPTDLDSASG SEDVFDGHLL GSTDSQVKEK 1630 1640 1650 1660 1670 1680 STMKAIFANL LPGNSYNPIP FPFDPDKHYL MYEHERVPIA VCEKEPSSII AFALSCKEYR 1690 1700 1710 1720 1730 1740 NALEELSKAT LRNSAEEGLP ANSALDNRPK SSSPIRLPEI SGGQTNRTVE AEPQPTKKAS 1750 1760 1770 1780 1790 1800 GMLSFFRGTA GKSPDLSSQK RETLRGADSA YYQVGQAGKE GLESQGLEPQ DEVDGGDTQK 1810 1820 1830 1840 1850 1860 KQLTNPHVEL QFSDANAKFY CRLYYAGEFH KMREVILGSS EEEFIRSLSH SSPWQARGGK 1870 1880 1890 1900 1910 1920 SGAAFYATED DRFILKQMPR LEVQSFLDFA PHYFNYITNA VQQKRPTALA KILGVYRIGY 1930 1940 1950 1960 1970 1980 KNSQNNTEKK LDLLVMENLF YGRKMAQVFD LKGSLRNRNV KTDTGKESCD VVLLDENLLK 1990 2000 2010 2020 2030 2040 MVRDNPLYIR SHSKSVLRTS IHSDAHFLSS HLIIDYSLLV GRDDTSNELV VGIIDYIRTF 2050 2060 2070 2080 2090 TWDKKLEMVV KSTGILGGQG KMPTVVSPEL YRTRFCEAMD KYFLMVPDHW TGLDLNC
	Isoform 2 (p235L) [UniParc]. Checksum: C7FA5897A3319DA0	FASTA	2,052	232,081
	10 20 30 40 50 60 MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG 70 80 90 100 110 120 EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLENT LPHPQESTDS 130 140 150 160 170 180 RRKAEPACGG HDPRTAVQLR SLSTVLKRLK EIMEGKSQDS DLKQYWMPDS QCKECYDCSE 190 200 210 220 230 240 KFTTFRRRHH CRLCGQIFCS RCCNQEIPGK FMGYTGDLRA CTYCRKIALS YAHSTDSNSI 250 260 270 280 290 300 GEDLNALSDS TCSVSILDPS EPRTPVGSRK ASRNIFLEDD LAWQSLIHPD SSNSALSTRL 310 320 330 340 350 360 VSVQEDAGKS PARNRSASIT NLSLDRSGSP MVPSYETSVS PQANRNYIRT ETTEDERKIL 370 380 390 400 410 420 LDSAQLKDLW KKICHHTSGM EFQDHRYWLR THPNCIVGKE LVNWLIRNGH IATRAQAIAI 430 440 450 460 470 480 GQAMVDGRWL DCVSHHDQLF RDEYALYRPL QSTEFSETPS PDSDSVNSVE GHSEPSWFKD 490 500 510 520 530 540 IKFDDSDTEQ IAEEGDDNLA EYLVSDTGGQ QLSISDAFIK ESLFNRRVEE KSKELPFTPL 550 560 570 580 590 600 GWHHNNLELL REENEEKQAM ERLLSANHNH MMALLQQLLQ NESLSSSWRD IIVSLVCQVV 610 620 630 640 650 660 QTVRPDVKHQ DDDMDIRQFV HIKKIPGGKK FDSVVVNGFV CTKNIAHKKM NSCIKNPKIL 670 680 690 700 710 720 LLKCSIEYLY REETKFTCID PIVLQEREFL KNYVQRIVDV RPTLVLVEKT VSRIAQDMLL 730 740 750 760 770 780 EHGITLVINV KSQVLERISR MTQGDLVVSM DQLLTKPHLG TCHKFYMQIF QLPNEQTKTL 790 800 810 820 830 840 MFFEGCPQHL GCTIKLRGGS DYELARVKEI LIFMICVAYH SQLEISFLMD EFAMPPTLMQ 850 860 870 880 890 900 SPSFHLLTEG RGEEGASQEQ VSGSSLPQDP ECPREALSSE DSTLLESRTV LEKGELDNKS 910 920 930 940 950 960 IPQAVASLKH QDYTTPTCPA GIPCALFALV PESLLPLHMD QQDAVGNEQP ETSQQTDEQQ 970 980 990 1000 1010 1020 DPKSQMKAFR DPLQDDTGMY VTEEVTSSED QRKTYALTFK QELKDVILCI SPVITFREPF 1030 1040 1050 1060 1070 1080 LLTEKGMRCS TRDYFPEQIY WSPLLNKEVK EMESRRKKQL LRDLSGLQGM NGSVQAKSIQ 1090 1100 1110 1120 1130 1140 VLPSHELVST RIAEHLGDSQ TLGRMLADYR ARGGRIQSKH LDPFVHSKDA SCTSGGKSGN 1150 1160 1170 1180 1190 1200 KTESDEERGL IPSDVIWPTK VDCLNPANHQ RLCVLFSSSS AQSSNAPSAC VSPWIVTMEF 1210 1220 1230 1240 1250 1260 YGKNDLTLGI FLERYCFRSS YQCPSMFCDT PMVHHIRRFV HGQGCVQIIL KELDSPVPGY 1270 1280 1290 1300 1310 1320 QHTILTYSWC RICKQVTPVV ALSNESWSMS FAKYLELRFY GHQYTRRANA EPCGHSIHHD 1330 1340 1350 1360 1370 1380 YHQYFSYNQM VASFSYSPIR LLEVCVPLPK IFIKRQAPLK VSLLQDLKDF FQKVSQVYLA 1390 1400 1410 1420 1430 1440 VDERLASLKT DTFSKTREEK MEDIFAQKEM EEGEFKNWTE KMQARLMSSS VDTPQQLQSI 1450 1460 1470 1480 1490 1500 FESLIAKKQS LCEVLQAWNS RLQDLFQQEK GRKRPSVPPS PGRLRQGEES KINAMDTSPR 1510 1520 1530 1540 1550 1560 NISPGLHNGE KEDRFLTTLS SQSSTSSTHL QLPTPPEALA EQVVGGPTDL DSASGSEDVF 1570 1580 1590 1600 1610 1620 DGHLLGSTDS QVKEKSTMKA IFANLLPGNS YNPIPFPFDP DKHYLMYEHE RVPIAVCEKE 1630 1640 1650 1660 1670 1680 PSSIIAFALS CKEYRNALEE LSKATLRNSA EEGLPANSAL DNRPKSSSPI RLPEISGGQT 1690 1700 1710 1720 1730 1740 NRTVEAEPQP TKKASGMLSF FRGTAGKSPD LSSQKRETLR GADSAYYQVG QAGKEGLESQ 1750 1760 1770 1780 1790 1800 GLEPQDEVDG GDTQKKQLTN PHVELQFSDA NAKFYCRLYY AGEFHKMREV ILGSSEEEFI 1810 1820 1830 1840 1850 1860 RSLSHSSPWQ ARGGKSGAAF YATEDDRFIL KQMPRLEVQS FLDFAPHYFN YITNAVQQKR 1870 1880 1890 1900 1910 1920 PTALAKILGV YRIGYKNSQN NTEKKLDLLV MENLFYGRKM AQVFDLKGSL RNRNVKTDTG 1930 1940 1950 1960 1970 1980 KESCDVVLLD ENLLKMVRDN PLYIRSHSKS VLRTSIHSDA HFLSSHLIID YSLLVGRDDT 1990 2000 2010 2020 2030 2040 SNELVVGIID YIRTFTWDKK LEMVVKSTGI LGGQGKMPTV VSPELYRTRF CEAMDKYFLM 2050 VPDHWTGLDL NC
	Isoform 3 [UniParc]. Checksum: 5BB1E9BE48047A7A	FASTA	497	55,999
	10 20 30 40 50 60 MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG 70 80 90 100 110 120 EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLDSR RKAEPACGGH 130 140 150 160 170 180 DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC 190 200 210 220 230 240 RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDST 250 260 270 280 290 300 CSVSILDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNSALSTRLV SVQEDAGKSP 310 320 330 340 350 360 ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRNYIRTE TTEDERKILL DSAQLKDLWK 370 380 390 400 410 420 KICHHTSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD 430 440 450 460 470 480 CVSHHDQLFR DEYALYRPLQ STEFSETPSP DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI 490 AEEGDDNLAS KFGFLML

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells." Shisheva A., Sbrissa D., Ikonomov O. Mol. Cell. Biol. 19:623-634(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION. Tissue: Adipose tissue.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreatic islet.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6J. Tissue: Cerebellum, Ovary, Spleen and Uterus.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases." McEwen R.K., Dove S.K., Cooke F.T., Painter G.F., Holmes A.B., Shisheva A., Ohya Y., Parker P.J., Michell R.H. J. Biol. Chem. 274:33905-33912(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CATALYTIC ACTIVITY.
[6]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, MASS SPECTROMETRY. Tissue: Liver.
[7]	"Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice." Zhang Y., Zolov S.N., Chow C.Y., Slutsky S.G., Richardson S.C., Piper R.C., Yang B., Nau J.J., Westrick R.J., Morrison S.J., Meisler M.H., Weisman L.S. Proc. Natl. Acad. Sci. U.S.A. 104:17518-17523(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse." Jin N., Chow C.Y., Liu L., Zolov S.N., Bronson R., Davisson M., Petersen J.L., Zhang Y., Park S., Duex J.E., Goldowitz D., Meisler M.H., Weisman L.S. EMBO J. 27:3221-3234(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF102777 mRNA. Translation: AAD10191.1. Frameshift. AK173077 mRNA. Translation: BAD32355.1. Different initiation. AK017186 mRNA. Translation: BAB30626.3. Different initiation. AK139116 mRNA. Translation: BAE23894.1. AK165350 mRNA. Translation: BAE38145.1. AC164079 Genomic DNA. No translation available.
IPI	IPI00130449. IPI00230618. IPI01007893.
PIR	T18290.
RefSeq	NP_035216.2. NM_011086.2.
UniGene	Mm.38370.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z1T6. 1 interaction.
STRING	10090.ENSMUSP00000109676.
PTM databases
PhosphoSite	Q9Z1T6.
2D gel databases
SWISS-2DPAGE	Q9Z1T6.
Proteomic databases
PaxDb	Q9Z1T6.
PRIDE	Q9Z1T6.
Protocols and materials databases
DNASU	18711.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000097707; ENSMUSP00000095314; ENSMUSG00000025949.
GeneID	18711.
KEGG	mmu:18711.
UCSC	uc007bho.1. mouse. uc007bhs.1. mouse. uc007bht.1. mouse.
Organism-specific databases
CTD	200576.
MGI	MGI:1335106. Pikfyve.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0459.
GeneTree	ENSGT00670000097904.
HOGENOM	HOG000059273.
HOVERGEN	HBG005775.
KO	K00921.
OMA	KAEPTFG.
OrthoDB	EOG45755P.
Enzyme and pathway databases
Reactome	REACT_112621. Metabolism.
Gene expression databases
ArrayExpress	Q9Z1T6.
Bgee	Q9Z1T6.
Genevestigator	Q9Z1T6.
GermOnline	ENSMUSG00000025949. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.30.40.10. 1 hit.
InterPro	IPR002423. Cpn60/TCP-1. IPR000591. DEP_dom. IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. IPR011991. WHTH_DNA-bd_dom. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. PF00610. DEP. 1 hit. PF01363. FYVE. 1 hit. PF01504. PIP5K. 1 hit. [Graphical view]
SMART	SM00049. DEP. 1 hit. SM00064. FYVE. 1 hit. SM00330. PIPKc. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS51455. PIPK. 1 hit. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294793.
SOURCE	Search...

Entry information

Entry name

FYV1_MOUSE

Accession

Primary (citable) accession number: Q9Z1T6
Secondary accession number(s): E9QL40 , Q3TNE4, Q3UTT6, Q69ZU1, Q9CU94

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program