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Reviewed, UniProtKB/Swiss-Prot Q9Z1T6 (FYV1_MOUSE)

Last modified July 7, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    FYVE finger-containing phosphoinositide kinase
    EC=2.7.1.68
Alternative name(s):
    PIKfyve
    1-phosphatidylinositol-4-phosphate 5-kinase
      Short name=PtdIns(4)P-5-kinase
      Short name=PIP5K
    p235
Gene names
Name: Pikfyve
Synonyms: Kiaa0981, Pip5k3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length2097 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P2 pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P2 from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

Subcellular location

Cytoplasmic vesicle membrane; Peripheral membrane protein. Note: Associated with vesicle structures. Displays a peripheral vesicular punctate pattern.

Sequence similarities

Contains 1 DEP domain.

Contains 1 FYVE-type zinc finger.

Contains 1 PIPK domain.

Sequence caution

The sequence AAD10191.1 differs from that shown. Reason: Frameshift at several positions.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z1T6-2)

Also known as: p235S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z1T6-1)

Also known as: p235L;

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: L → LENTLPHPQEST
     490-545: Missing.
Isoform 3 (identifier: Q9Z1T6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     490-497: NSASPSKR → SKFGFLML
     498-2097: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20972097FYVE finger-containing phosphoinositide kinase
PRO_0000185453

Regions

Domain365 – 44076DEP
Domain1757 – 2083327PIPK
Zinc finger158 – 21861FYVE-type
Region1841 – 2097257Catalytic By similarity
Compositional bias1222 – 12254Poly-Ser

Amino acid modifications

Modified residue461Phosphotyrosine By similarity
Modified residue761Phosphoserine By similarity
Modified residue2991Phosphoserine By similarity
Modified residue3071Phosphoserine Ref.4
Modified residue3181Phosphoserine By similarity
Modified residue3291Phosphoserine By similarity
Modified residue3521Phosphoserine By similarity
Modified residue11541Phosphotyrosine By similarity
Modified residue15431Phosphoserine By similarity
Modified residue15481Phosphoserine By similarity
Modified residue17531Phosphoserine By similarity
Modified residue17711Phosphotyrosine By similarity

Natural variations

Alternative sequence1071L → LENTLPHPQEST in isoform 2.
VSP_034953
Alternative sequence490 – 54556Missing in isoform 2.
VSP_034954
Alternative sequence490 – 4978NSASPSKR → SKFGFLML in isoform 3.
VSP_034955
Alternative sequence498 – 20971600Missing in isoform 3.
VSP_034956

Experimental info

Sequence conflict5461E → K in AAD10191. Ref.1
Sequence conflict9441Q → K in AAD10191. Ref.1
Sequence conflict994 – 9952QP → HR in AAD10191. Ref.1
Sequence conflict11071R → T in BAB30626. Ref.3
Sequence conflict11411L → V in AAD10191. Ref.1
Sequence conflict12641S → Y in AAD10191. Ref.1
Sequence conflict19961V → E in AAD10191. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (p235S) [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 191A26607FD4A372

FASTA2,097236,877
        10         20         30         40         50         60 
MATDDKSSPT LDSANDLPRS PASPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERG 

        70         80         90        100        110        120 
EGGQGEQQSP SSSWASPQIP SRTQSVRSPV PYKKQLNEEL HRRSSVLDSR RKAEPACGGH 

       130        140        150        160        170        180 
DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC 

       190        200        210        220        230        240 
RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDST 

       250        260        270        280        290        300 
CSVSILDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNSALSTRLV SVQEDAGKSP 

       310        320        330        340        350        360 
ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRNYIRTE TTEDERKILL DSAQLKDLWK 

       370        380        390        400        410        420 
KICHHTSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD 

       430        440        450        460        470        480 
CVSHHDQLFR DEYALYRPLQ STEFSETPSP DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI 

       490        500        510        520        530        540 
AEEGDDNLAN SASPSKRTSV SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH 

       550        560        570        580        590        600 
PADQKEYLVS DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENE 

       610        620        630        640        650        660 
EKQAMERLLS ANHNHMMALL QQLLQNESLS SSWRDIIVSL VCQVVQTVRP DVKHQDDDMD 

       670        680        690        700        710        720 
IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMNSCIK NPKILLLKCS IEYLYREETK 

       730        740        750        760        770        780 
FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV LVEKTVSRIA QDMLLEHGIT LVINVKSQVL 

       790        800        810        820        830        840 
ERISRMTQGD LVVSMDQLLT KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK 

       850        860        870        880        890        900 
LRGGSDYELA RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQSPSFH LLTEGRGEEG 

       910        920        930        940        950        960 
ASQEQVSGSS LPQDPECPRE ALSSEDSTLL ESRTVLEKGE LDNQSIPQAV ASLKHQDYTT 

       970        980        990       1000       1010       1020 
PTCPAGIPCA LFALVPESLL PLHMDQQDAV GNEQPETSQQ TDEQQDPKSQ MKAFRDPLQD 

      1030       1040       1050       1060       1070       1080 
DTGMYVTEEV TSSEDQRKTY ALTFKQELKD VILCISPVIT FREPFLLTEK GMRCSTRDYF 

      1090       1100       1110       1120       1130       1140 
PEQIYWSPLL NKEVKEMESR RKKQLLRDLS GLQGMNGSVQ AKSIQVLPSH ELVSTRIAEH 

      1150       1160       1170       1180       1190       1200 
LGDSQTLGRM LADYRARGGR IQSKHLDPFV HSKDASCTSG GKSGNKTESD EERGLIPSDV 

      1210       1220       1230       1240       1250       1260 
IWPTKVDCLN PANHQRLCVL FSSSSAQSSN APSACVSPWI VTMEFYGKND LTLGIFLERY 

      1270       1280       1290       1300       1310       1320 
CFRSSYQCPS MFCDTPMVHH IRRFVHGQGC VQIILKELDS PVPGYQHTIL TYSWCRICKQ 

      1330       1340       1350       1360       1370       1380 
VTPVVALSNE SWSMSFAKYL ELRFYGHQYT RRANAEPCGH SIHHDYHQYF SYNQMVASFS 

      1390       1400       1410       1420       1430       1440 
YSPIRLLEVC VPLPKIFIKR QAPLKVSLLQ DLKDFFQKVS QVYLAVDERL ASLKTDTFSK 

      1450       1460       1470       1480       1490       1500 
TREEKMEDIF AQKEMEEGEF KNWTEKMQAR LMSSSVDTPQ QLQSIFESLI AKKQSLCEVL 

      1510       1520       1530       1540       1550       1560 
QAWNSRLQDL FQQEKGRKRP SVPPSPGRLR QGEESKINAM DTSPRNISPG LHNGEKEDRF 

      1570       1580       1590       1600       1610       1620 
LTTLSSQSST SSTHLQLPTP PEALAEQVVG GPTDLDSASG SEDVFDGHLL GSTDSQVKEK 

      1630       1640       1650       1660       1670       1680 
STMKAIFANL LPGNSYNPIP FPFDPDKHYL MYEHERVPIA VCEKEPSSII AFALSCKEYR 

      1690       1700       1710       1720       1730       1740 
NALEELSKAT LRNSAEEGLP ANSALDNRPK SSSPIRLPEI SGGQTNRTVE AEPQPTKKAS 

      1750       1760       1770       1780       1790       1800 
GMLSFFRGTA GKSPDLSSQK RETLRGADSA YYQVGQAGKE GLESQGLEPQ DEVDGGDTQK 

      1810       1820       1830       1840       1850       1860 
KQLTNPHVEL QFSDANAKFY CRLYYAGEFH KMREVILGSS EEEFIRSLSH SSPWQARGGK 

      1870       1880       1890       1900       1910       1920 
SGAAFYATED DRFILKQMPR LEVQSFLDFA PHYFNYITNA VQQKRPTALA KILGVYRIGY 

      1930       1940       1950       1960       1970       1980 
KNSQNNTEKK LDLLVMENLF YGRKMAQVFD LKGSLRNRNV KTDTGKESCD VVLLDENLLK 

      1990       2000       2010       2020       2030       2040 
MVRDNPLYIR SHSKSVLRTS IHSDAHFLSS HLIIDYSLLV GRDDTSNELV VGIIDYIRTF 

      2050       2060       2070       2080       2090 
TWDKKLEMVV KSTGILGGQG KMPTVVSPEL YRTRFCEAMD KYFLMVPDHW TGLDLNC 

« Hide

Isoform 2 (p235L).

Checksum: 52B2E071270BE634
Show »

FASTA2,052232,081
Isoform 3.

Checksum: 5BB1E9BE48047A7A
Show »

FASTA49755,999

References

« Hide 'large scale' references
[1]"Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells."
Shisheva A., Sbrissa D., Ikonomov O.
Mol. Cell. Biol. 19:623-634(1999) [PubMed: 9858586] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION.
Tissue: Adipose tissue.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed: 15368895] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pancreatic islet.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6J.
Tissue: Cerebellum, Ovary, Spleen and Uterus.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF102777 mRNA. Translation: AAD10191.1. Frameshift.
AK173077 mRNA. Translation: BAD32355.1. Different initiation.
AK017186 mRNA. Translation: BAB30626.3. Different initiation.
AK139116 mRNA. Translation: BAE23894.1.
AK165350 mRNA. Translation: BAE38145.1.
IPIIPI00130449.
IPI00230618.
IPI00874822.
PIRT18290.
RefSeqNP_035216.2.
UniGeneMm.38370

3D structure databases

HSSPHSSP built from PDB template 1GML based on UniProtKB P80318.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Z1T6.

2-D gel databases

SWISS-2DPAGEQ9Z1T6.

Genome annotation databases

GeneID18711.
KEGGmmu:18711.

Organism-specific databases

MGIMGI:1335106. Pikfyve.
RougeSearch...

Phylogenomic databases

HOGENOMQ9Z1T6.
HOVERGENQ9Z1T6.

Enzyme and pathway databases

BRENDA2.7.1.68. 244.

Gene expression databases

ArrayExpressQ9Z1T6.
GermOnlineENSMUSG00000025949. Mus musculus.

Family and domain databases

InterProIPR002423. Cpn60/TCP-1.
IPR002498. PInositol-4-P-5-kinase_core.
IPR016034. PInositol-4P-5-kinase_core_sub.
IPR000591. Pleckstrin/G-protein_interact.
IPR011991. Wing_hlx_DNA_bd.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHERPTHR11353. Cpn60/TCP-1. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
PF00610. DEP. 1 hit.
PF01363. FYVE. 1 hit.
PF01504. PIP5K. 1 hit.
[Graphical view]
SMARTSM00049. DEP. 1 hit.
SM00064. FYVE. 1 hit.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEPS50186. DEP. 1 hit.
PS51455. PIPK. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio294793.
SOURCESearch...

Entry information

Entry nameFYV1_MOUSE
AccessionPrimary (citable) accession number: Q9Z1T6
Secondary accession number(s): Q3TNE4 expand/collapse secondary AC list , Q3UTT6, Q69ZU1, Q9CU94
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: July 7, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents