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Q9Z1S7

- OMD_RAT

UniProt

Q9Z1S7 - OMD_RAT

Protein

Osteomodulin

Gene

Omd

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. regulation of bone mineralization Source: RGD

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteomodulin
    Alternative name(s):
    Keratan sulfate proteoglycan osteomodulin
    Short name:
    KSPG osteomodulin
    Osteoadherin
    Short name:
    OSAD
    Gene namesi
    Name:Omd
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621818. Omd.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 423403OsteomodulinPRO_0000032756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221SulfotyrosineBy similarity
    Modified residuei25 – 251SulfotyrosineBy similarity
    Modified residuei31 – 311SulfotyrosineBy similarity
    Modified residuei39 – 391SulfotyrosineBy similarity
    Modified residuei51 – 511SulfotyrosineBy similarity
    Modified residuei77 – 771SulfotyrosineBy similarity
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi321 ↔ 353By similarity
    Modified residuei413 – 4131SulfotyrosineBy similarity
    Modified residuei414 – 4141SulfotyrosineBy similarity

    Post-translational modificationi

    Binds keratan sulfate chains.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

    Proteomic databases

    PaxDbiQ9Z1S7.
    PRIDEiQ9Z1S7.

    Expressioni

    Tissue specificityi

    Osteoblast and odontoblast. Expressed in femoral bone and calvaria tissues. Detected in femoral head, rib, tendon and bone marrow.1 Publication

    Developmental stagei

    In developing molars, it was first detected in alveolar bone in 19-day-old embryos. In more mature teeth (newborn and 2-day-old rats), the expression starts in the polarized odontoblasts and increases in the secretory and mature odontoblasts.1 Publication

    Gene expression databases

    GenevestigatoriQ9Z1S7.

    Interactioni

    Subunit structurei

    Binds the alpha(V)beta(3)-integrin.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020648.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 9139LRRNTAdd
    BLAST
    Repeati92 – 11322LRR 1Add
    BLAST
    Repeati116 – 12914LRR 2Add
    BLAST
    Repeati142 – 16423LRR 3Add
    BLAST
    Repeati165 – 18420LRR 4Add
    BLAST
    Repeati187 – 20721LRR 5Add
    BLAST
    Repeati213 – 23321LRR 6Add
    BLAST
    Repeati234 – 25522LRR 7Add
    BLAST
    Repeati258 – 27922LRR 8Add
    BLAST
    Repeati281 – 29414LRR 9Add
    BLAST
    Repeati301 – 32222LRR 10Add
    BLAST
    Repeati331 – 35323LRR 11Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi385 – 40723Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 11 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000234447.
    HOVERGENiHBG108061.
    InParanoidiQ9Z1S7.
    KOiK08124.
    PhylomeDBiQ9Z1S7.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z1S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCLRPIYVL FFCFVVRVYG QYEAYQWDED YEQEPSEDYE PEFQFHQNIE    50
    YGAPFYQNIL GCAKECFCPT NFPTSMYCDN RKLKTIPDIP MHIQQLNLQF 100
    NDIEAVTADS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL SNLQQLHLDH 150
    NNLEEFPFPL PKSLERLLLG YNEISTLPTH AMDGLVNVTM LDLCYNHLSD 200
    STLKGKILSK LEKLMQLNLC NNRLESMPPG LPLSLMYLSL ENNSISSIPE 250
    DYFQKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR 300
    NLEHLYLQNN EIQSINVTMM CPSLDPLHHH HLTYLRVDQN KLKEPISSYI 350
    FFCFPRIHSI YYGEQRSTNG ETIQLKTQVF RRYQDEEEEE EDDSQDHTLE 400
    GQEETEEHFN SHYYEMQAWQ NTI 423
    Length:423
    Mass (Da):49,783
    Last modified:May 1, 1999 - v1
    Checksum:i587D679FD9482E9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104362 mRNA. Translation: AAD04570.1.
    RefSeqiNP_114005.1. NM_031817.1.
    UniGeneiRn.30124.

    Genome annotation databases

    GeneIDi83717.
    KEGGirno:83717.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104362 mRNA. Translation: AAD04570.1 .
    RefSeqi NP_114005.1. NM_031817.1.
    UniGenei Rn.30124.

    3D structure databases

    ProteinModelPortali Q9Z1S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020648.

    Proteomic databases

    PaxDbi Q9Z1S7.
    PRIDEi Q9Z1S7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 83717.
    KEGGi rno:83717.

    Organism-specific databases

    CTDi 4958.
    RGDi 621818. Omd.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000234447.
    HOVERGENi HBG108061.
    InParanoidi Q9Z1S7.
    KOi K08124.
    PhylomeDBi Q9Z1S7.

    Miscellaneous databases

    NextBioi 616285.
    PROi Q9Z1S7.

    Gene expression databases

    Genevestigatori Q9Z1S7.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue distribution of a novel cell binding protein, osteoadherin, in the rat."
      Shen Z., Gantcheva S., Sommarin Y., Heinegaard D.
      Matrix Biol. 18:533-542(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Calvaria.

    Entry informationi

    Entry nameiOMD_RAT
    AccessioniPrimary (citable) accession number: Q9Z1S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3