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Q9Z1S7 (OMD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name=KSPG osteomodulin
Osteoadherin
Short name=OSAD
Gene names
Name:Omd
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.

Subunit structure

Binds the alpha(V)beta(3)-integrin.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Osteoblast and odontoblast. Expressed in femoral bone and calvaria tissues. Detected in femoral head, rib, tendon and bone marrow. Ref.1

Developmental stage

In developing molars, it was first detected in alveolar bone in 19-day-old embryos. In more mature teeth (newborn and 2-day-old rats), the expression starts in the polarized odontoblasts and increases in the secretory and mature odontoblasts. Ref.1

Post-translational modification

Binds keratan sulfate chains.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 11 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 423403Osteomodulin
PRO_0000032756

Regions

Domain53 – 9139LRRNT
Repeat92 – 11322LRR 1
Repeat116 – 12914LRR 2
Repeat142 – 16423LRR 3
Repeat165 – 18420LRR 4
Repeat187 – 20721LRR 5
Repeat213 – 23321LRR 6
Repeat234 – 25522LRR 7
Repeat258 – 27922LRR 8
Repeat281 – 29414LRR 9
Repeat301 – 32222LRR 10
Repeat331 – 35323LRR 11
Compositional bias385 – 40723Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue221Sulfotyrosine By similarity
Modified residue251Sulfotyrosine By similarity
Modified residue311Sulfotyrosine By similarity
Modified residue391Sulfotyrosine By similarity
Modified residue511Sulfotyrosine By similarity
Modified residue771Sulfotyrosine By similarity
Modified residue4131Sulfotyrosine By similarity
Modified residue4141Sulfotyrosine By similarity
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Disulfide bond321 ↔ 353 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z1S7 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 587D679FD9482E9F

FASTA42349,783
        10         20         30         40         50         60 
MGCLRPIYVL FFCFVVRVYG QYEAYQWDED YEQEPSEDYE PEFQFHQNIE YGAPFYQNIL 

        70         80         90        100        110        120 
GCAKECFCPT NFPTSMYCDN RKLKTIPDIP MHIQQLNLQF NDIEAVTADS FINATHLKEI 

       130        140        150        160        170        180 
NLSHNKIKSQ KIDYGVFAKL SNLQQLHLDH NNLEEFPFPL PKSLERLLLG YNEISTLPTH 

       190        200        210        220        230        240 
AMDGLVNVTM LDLCYNHLSD STLKGKILSK LEKLMQLNLC NNRLESMPPG LPLSLMYLSL 

       250        260        270        280        290        300 
ENNSISSIPE DYFQKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR 

       310        320        330        340        350        360 
NLEHLYLQNN EIQSINVTMM CPSLDPLHHH HLTYLRVDQN KLKEPISSYI FFCFPRIHSI 

       370        380        390        400        410        420 
YYGEQRSTNG ETIQLKTQVF RRYQDEEEEE EDDSQDHTLE GQEETEEHFN SHYYEMQAWQ 


NTI 

« Hide

References

[1]"Tissue distribution of a novel cell binding protein, osteoadherin, in the rat."
Shen Z., Gantcheva S., Sommarin Y., Heinegaard D.
Matrix Biol. 18:533-542(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Calvaria.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF104362 mRNA. Translation: AAD04570.1.
RefSeqNP_114005.1. NM_031817.1.
UniGeneRn.30124.

3D structure databases

ProteinModelPortalQ9Z1S7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020648.

Proteomic databases

PaxDbQ9Z1S7.
PRIDEQ9Z1S7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID83717.
KEGGrno:83717.

Organism-specific databases

CTD4958.
RGD621818. Omd.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000234447.
HOVERGENHBG108061.
InParanoidQ9Z1S7.
KOK08124.
PhylomeDBQ9Z1S7.

Gene expression databases

GenevestigatorQ9Z1S7.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio616285.
PROQ9Z1S7.

Entry information

Entry nameOMD_RAT
AccessionPrimary (citable) accession number: Q9Z1S7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families