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Q9Z1S5 (SEPT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal-specific septin-3
Gene names
Name:Sept3
Synonyms:Sep3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.

Subunit structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity.

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity.

Post-translational modification

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 By similarity.

Sequence similarities

Belongs to the septin family.

Sequence caution

The sequence AAD02884.1 differs from that shown. Reason: Frameshift at position 344.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCell junction
Cytoplasm
Cytoskeleton
Synapse
   Coding sequence diversityAlternative splicing
   LigandGTP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

septin complex

Inferred from electronic annotation. Source: InterPro

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z1S5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z1S5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Neuronal-specific septin-3
PRO_0000173518

Regions

Nucleotide binding68 – 758GTP By similarity
Nucleotide binding208 – 2169GTP By similarity

Sites

Binding site1021GTP By similarity
Binding site2651GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2801GTP By similarity

Amino acid modifications

Modified residue911Phosphoserine By similarity

Natural variations

Alternative sequence1 – 1313Missing in isoform 2.
VSP_025400

Experimental info

Sequence conflict221 – 23515KQRVR…NGIEF → LPSEGI in AAD02884. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: AEF37C023AB21C0D

FASTA35040,038
        10         20         30         40         50         60 
MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ MRKKTMKTGF 

        70         80         90        100        110        120 
DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP KTVEIKAIGH VIEEGGVKMK 

       130        140        150        160        170        180 
LTVIDTPGFG DQINNENCWE PIEKYINEQY EKFLKEEVNI ARKKRIPDTR VHCCLYFISP 

       190        200        210        220        230        240 
TGHSLRPLDL EFMKHLSKVV NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE 

       250        260        270        280        290        300 
FDEDLEDKTE NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL 

       310        320        330        340        350 
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP 

« Hide

Isoform 2 [UniParc].

Checksum: C090F23E9C97B919
Show »

FASTA33738,709

References

« Hide 'large scale' references
[1]"Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development."
Xiong J.-W., Leahy A., Stuhlmann H.
Mech. Dev. 86:183-191(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Head and Spinal ganglion.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[4]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 132-139; 186-204 AND 314-325, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF104411 mRNA. Translation: AAD02884.1. Frameshift.
AK164861 mRNA. Translation: BAE37945.1.
AK169916 mRNA. Translation: BAE41456.1.
AK141915 mRNA. Translation: BAE24884.1.
BC055738 mRNA. Translation: AAH55738.1.
RefSeqNP_036019.2. NM_011889.2.
UniGeneMm.309707.

3D structure databases

ProteinModelPortalQ9Z1S5.
SMRQ9Z1S5. Positions 60-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204863. 2 interactions.
IntActQ9Z1S5. 3 interactions.
MINTMINT-4134132.
STRING10090.ENSMUSP00000076977.

PTM databases

PhosphoSiteQ9Z1S5.

2D gel databases

UCD-2DPAGEQ9Z1S5.

Proteomic databases

PaxDbQ9Z1S5.
PRIDEQ9Z1S5.

Protocols and materials databases

DNASU24050.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456. [Q9Z1S5-2]
GeneID24050.
KEGGmmu:24050.
UCSCuc007wyq.1. mouse. [Q9Z1S5-1]

Organism-specific databases

CTD55964.
MGIMGI:1345148. Sept3.

Phylogenomic databases

eggNOGCOG5019.
GeneTreeENSGT00640000091410.
HOGENOMHOG000233586.
HOVERGENHBG065093.
KOK16938.
OMARKELTAM.
OrthoDBEOG7KWSJ5.
PhylomeDBQ9Z1S5.
TreeFamTF101078.

Gene expression databases

BgeeQ9Z1S5.
CleanExMM_SEPT3.
GenevestigatorQ9Z1S5.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERPTHR18884. PTHR18884. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
PRINTSPR01741. SEPTIN3.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio303983.
PROQ9Z1S5.
SOURCESearch...

Entry information

Entry nameSEPT3_MOUSE
AccessionPrimary (citable) accession number: Q9Z1S5
Secondary accession number(s): Q3TNZ2, Q7TNT7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot