Q9Z1S5 (SEPT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronal-specific septin-3

Gene names

Name:	Sept3
Synonyms:	Sep3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity.
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton By similarity. Cell junction › synapse By similarity.
Post-translational modification	Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 By similarity.
Sequence similarities	Belongs to the septin family.
Sequence caution	The sequence AAD02884.1 differs from that shown. Reason: Frameshift at position 344.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell junction Cytoplasm Cytoskeleton Synapse
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW septin complex Inferred from electronic annotation. Source: InterPro synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z1S5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z1S5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Neuronal-specific septin-3		PRO_0000173518
Regions
	Nucleotide binding	68 – 75	8	GTP By similarity
	Nucleotide binding	208 – 216	9	GTP By similarity
Sites
	Binding site	102	1	GTP By similarity
	Binding site	265	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	280	1	GTP By similarity
Amino acid modifications
	Modified residue	91	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 13	13	Missing in isoform 2.		VSP_025400
Experimental info
	Sequence conflict	221 – 235	15	KQRVR…NGIEF → LPSEGI in AAD02884. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: AEF37C023AB21C0D	FASTA	350	40,038
	10 20 30 40 50 60 MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ MRKKTMKTGF 70 80 90 100 110 120 DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP KTVEIKAIGH VIEEGGVKMK 130 140 150 160 170 180 LTVIDTPGFG DQINNENCWE PIEKYINEQY EKFLKEEVNI ARKKRIPDTR VHCCLYFISP 190 200 210 220 230 240 TGHSLRPLDL EFMKHLSKVV NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE 250 260 270 280 290 300 FDEDLEDKTE NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL 310 320 330 340 350 RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP
	Isoform 2 [UniParc]. Checksum: C090F23E9C97B919	FASTA	337	38,709
	10 20 30 40 50 60 MSELVPEPRP KPAVPMKPVS INSNLLGYIG IDTIIEQMRK KTMKTGFDFN IMVVGQSGLG 70 80 90 100 110 120 KSTLVNTLFK SQVSRKASSW NREEKIPKTV EIKAIGHVIE EGGVKMKLTV IDTPGFGDQI 130 140 150 160 170 180 NNENCWEPIE KYINEQYEKF LKEEVNIARK KRIPDTRVHC CLYFISPTGH SLRPLDLEFM 190 200 210 220 230 240 KHLSKVVNII PVIAKADTMT LEEKSEFKQR VRKELEVNGI EFYPQKEFDE DLEDKTENDK 250 260 270 280 290 300 IRQESMPFAV VGSDKEYQVN GKRVLGRKTP WGIIEVENLN HCEFALLRDF VIRTHLQDLK 310 320 330 EVTHNIHYET YRAKRLNDNG GLPPVSVDTE ESHDSNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development." Xiong J.-W., Leahy A., Stuhlmann H. Mech. Dev. 86:183-191(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J and NOD. Tissue: Head and Spinal ganglion.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[4]	Lubec G., Klug S., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 132-139; 186-204 AND 314-325, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain and Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF104411 mRNA. Translation: AAD02884.1. Frameshift. AK164861 mRNA. Translation: BAE37945.1. AK169916 mRNA. Translation: BAE41456.1. AK141915 mRNA. Translation: BAE24884.1. BC055738 mRNA. Translation: AAH55738.1.
IPI	IPI00808312. IPI00845776.
RefSeq	NP_036019.2. NM_011889.2.
UniGene	Mm.309707.
3D structure databases
ProteinModelPortal	Q9Z1S5.
SMR	Q9Z1S5. Positions 60-329.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z1S5. 2 interactions.
STRING	10090.ENSMUSP00000076977.
PTM databases
PhosphoSite	Q9Z1S5.
2D gel databases
UCD-2DPAGE	Q9Z1S5.
Proteomic databases
PaxDb	Q9Z1S5.
PRIDE	Q9Z1S5.
Protocols and materials databases
DNASU	24050.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456.
GeneID	24050.
KEGG	mmu:24050.
UCSC	uc007wyq.1. mouse.
Organism-specific databases
CTD	55964.
MGI	MGI:1345148. Sept3.
Phylogenomic databases
eggNOG	COG5019.
GeneTree	ENSGT00640000091410.
HOGENOM	HOG000233586.
HOVERGEN	HBG065093.
OMA	SQYLRKE.
OrthoDB	EOG4WDDBR.
Gene expression databases
Bgee	Q9Z1S5.
CleanEx	MM_SEPT3.
Genevestigator	Q9Z1S5.
GermOnline	ENSMUSG00000022456. Mus musculus.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. IPR008114. Septin3. [Graphical view]
PANTHER	PTHR18884. PTHR18884. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
PRINTS	PR01741. SEPTIN3.
ProtoNet	Search...
Other
NextBio	303983.
SOURCE	Search...

Entry information

Entry name

SEPT3_MOUSE

Accession

Primary (citable) accession number: Q9Z1S5
Secondary accession number(s): Q3TNZ2, Q7TNT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program