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Q9Z1S5

- SEPT3_MOUSE

UniProt

Q9Z1S5 - SEPT3_MOUSE

Protein

Neuronal-specific septin-3

Gene

Sept3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.By similarityCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021GTPBy similarity
    Binding sitei265 – 2651GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei280 – 2801GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758GTPBy similarity
    Nucleotide bindingi208 – 2169GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal-specific septin-3
    Gene namesi
    Name:Sept3
    Synonyms:Sep3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1345148. Sept3.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. septin complex Source: InterPro
    3. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Neuronal-specific septin-3PRO_0000173518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z1S5.
    PaxDbiQ9Z1S5.
    PRIDEiQ9Z1S5.

    2D gel databases

    UCD-2DPAGEQ9Z1S5.

    PTM databases

    PhosphoSiteiQ9Z1S5.

    Expressioni

    Gene expression databases

    BgeeiQ9Z1S5.
    CleanExiMM_SEPT3.
    GenevestigatoriQ9Z1S5.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204863. 2 interactions.
    IntActiQ9Z1S5. 3 interactions.
    MINTiMINT-4134132.
    STRINGi10090.ENSMUSP00000076977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1S5.
    SMRiQ9Z1S5. Positions 60-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 331274Septin-type GAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5019.
    GeneTreeiENSGT00640000091410.
    HOGENOMiHOG000233586.
    HOVERGENiHBG065093.
    KOiK16938.
    OMAiRKELTAM.
    OrthoDBiEOG7KWSJ5.
    PhylomeDBiQ9Z1S5.
    TreeFamiTF101078.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    IPR008114. Septin3.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    PRINTSiPR01741. SEPTIN3.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z1S5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ    50
    MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP 100
    KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY 150
    EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV 200
    NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE 250
    NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL 300
    RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP 350
    Length:350
    Mass (Da):40,038
    Last modified:May 15, 2007 - v2
    Checksum:iAEF37C023AB21C0D
    GO
    Isoform 2 (identifier: Q9Z1S5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Show »
    Length:337
    Mass (Da):38,709
    Checksum:iC090F23E9C97B919
    GO

    Sequence cautioni

    The sequence AAD02884.1 differs from that shown. Reason: Frameshift at position 344.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 23515KQRVR…NGIEF → LPSEGI in AAD02884. (PubMed:10446280)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313Missing in isoform 2. 2 PublicationsVSP_025400Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104411 mRNA. Translation: AAD02884.1. Frameshift.
    AK164861 mRNA. Translation: BAE37945.1.
    AK169916 mRNA. Translation: BAE41456.1.
    AK141915 mRNA. Translation: BAE24884.1.
    BC055738 mRNA. Translation: AAH55738.1.
    CCDSiCCDS37157.1. [Q9Z1S5-2]
    RefSeqiNP_036019.2. NM_011889.2. [Q9Z1S5-2]
    UniGeneiMm.309707.

    Genome annotation databases

    EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. [Q9Z1S5-2]
    ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456. [Q9Z1S5-2]
    GeneIDi24050.
    KEGGimmu:24050.
    UCSCiuc007wyq.1. mouse. [Q9Z1S5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104411 mRNA. Translation: AAD02884.1 . Frameshift.
    AK164861 mRNA. Translation: BAE37945.1 .
    AK169916 mRNA. Translation: BAE41456.1 .
    AK141915 mRNA. Translation: BAE24884.1 .
    BC055738 mRNA. Translation: AAH55738.1 .
    CCDSi CCDS37157.1. [Q9Z1S5-2 ]
    RefSeqi NP_036019.2. NM_011889.2. [Q9Z1S5-2 ]
    UniGenei Mm.309707.

    3D structure databases

    ProteinModelPortali Q9Z1S5.
    SMRi Q9Z1S5. Positions 60-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204863. 2 interactions.
    IntActi Q9Z1S5. 3 interactions.
    MINTi MINT-4134132.
    STRINGi 10090.ENSMUSP00000076977.

    PTM databases

    PhosphoSitei Q9Z1S5.

    2D gel databases

    UCD-2DPAGE Q9Z1S5.

    Proteomic databases

    MaxQBi Q9Z1S5.
    PaxDbi Q9Z1S5.
    PRIDEi Q9Z1S5.

    Protocols and materials databases

    DNASUi 24050.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023095 ; ENSMUSP00000023095 ; ENSMUSG00000022456 . [Q9Z1S5-2 ]
    ENSMUST00000116423 ; ENSMUSP00000112124 ; ENSMUSG00000022456 . [Q9Z1S5-2 ]
    GeneIDi 24050.
    KEGGi mmu:24050.
    UCSCi uc007wyq.1. mouse. [Q9Z1S5-1 ]

    Organism-specific databases

    CTDi 55964.
    MGIi MGI:1345148. Sept3.

    Phylogenomic databases

    eggNOGi COG5019.
    GeneTreei ENSGT00640000091410.
    HOGENOMi HOG000233586.
    HOVERGENi HBG065093.
    KOi K16938.
    OMAi RKELTAM.
    OrthoDBi EOG7KWSJ5.
    PhylomeDBi Q9Z1S5.
    TreeFami TF101078.

    Miscellaneous databases

    NextBioi 303983.
    PROi Q9Z1S5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z1S5.
    CleanExi MM_SEPT3.
    Genevestigatori Q9Z1S5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    IPR008114. Septin3.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    PRINTSi PR01741. SEPTIN3.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development."
      Xiong J.-W., Leahy A., Stuhlmann H.
      Mech. Dev. 86:183-191(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Head and Spinal ganglion.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 132-139; 186-204 AND 314-325, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiSEPT3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1S5
    Secondary accession number(s): Q3TNZ2, Q7TNT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3