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Q9Z1S5

- SEPT3_MOUSE

UniProt

Q9Z1S5 - SEPT3_MOUSE

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Protein

Neuronal-specific septin-3

Gene

Sept3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021GTPBy similarity
Binding sitei265 – 2651GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei280 – 2801GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758GTPBy similarity
Nucleotide bindingi208 – 2169GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:Sept3
Synonyms:Sep3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1345148. Sept3.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. septin complex Source: InterPro
  3. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Neuronal-specific septin-3PRO_0000173518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z1S5.
PaxDbiQ9Z1S5.
PRIDEiQ9Z1S5.

2D gel databases

UCD-2DPAGEQ9Z1S5.

PTM databases

PhosphoSiteiQ9Z1S5.

Expressioni

Gene expression databases

BgeeiQ9Z1S5.
CleanExiMM_SEPT3.
GenevestigatoriQ9Z1S5.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Protein-protein interaction databases

BioGridi204863. 2 interactions.
IntActiQ9Z1S5. 3 interactions.
MINTiMINT-4134132.
STRINGi10090.ENSMUSP00000076977.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1S5.
SMRiQ9Z1S5. Positions 60-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 331274Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5019.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9Z1S5.
KOiK16938.
OMAiRKELTAM.
OrthoDBiEOG7KWSJ5.
PhylomeDBiQ9Z1S5.
TreeFamiTF101078.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z1S5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP
Length:350
Mass (Da):40,038
Last modified:May 15, 2007 - v2
Checksum:iAEF37C023AB21C0D
GO
Isoform 2 (identifier: Q9Z1S5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:337
Mass (Da):38,709
Checksum:iC090F23E9C97B919
GO

Sequence cautioni

The sequence AAD02884.1 differs from that shown. Reason: Frameshift at position 344. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 23515KQRVR…NGIEF → LPSEGI in AAD02884. (PubMed:10446280)CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313Missing in isoform 2. 2 PublicationsVSP_025400Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA. Translation: AAD02884.1. Frameshift.
AK164861 mRNA. Translation: BAE37945.1.
AK169916 mRNA. Translation: BAE41456.1.
AK141915 mRNA. Translation: BAE24884.1.
BC055738 mRNA. Translation: AAH55738.1.
CCDSiCCDS37157.1. [Q9Z1S5-2]
RefSeqiNP_036019.2. NM_011889.2. [Q9Z1S5-2]
UniGeneiMm.309707.

Genome annotation databases

EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456. [Q9Z1S5-2]
GeneIDi24050.
KEGGimmu:24050.
UCSCiuc007wyq.1. mouse. [Q9Z1S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA. Translation: AAD02884.1 . Frameshift.
AK164861 mRNA. Translation: BAE37945.1 .
AK169916 mRNA. Translation: BAE41456.1 .
AK141915 mRNA. Translation: BAE24884.1 .
BC055738 mRNA. Translation: AAH55738.1 .
CCDSi CCDS37157.1. [Q9Z1S5-2 ]
RefSeqi NP_036019.2. NM_011889.2. [Q9Z1S5-2 ]
UniGenei Mm.309707.

3D structure databases

ProteinModelPortali Q9Z1S5.
SMRi Q9Z1S5. Positions 60-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204863. 2 interactions.
IntActi Q9Z1S5. 3 interactions.
MINTi MINT-4134132.
STRINGi 10090.ENSMUSP00000076977.

PTM databases

PhosphoSitei Q9Z1S5.

2D gel databases

UCD-2DPAGE Q9Z1S5.

Proteomic databases

MaxQBi Q9Z1S5.
PaxDbi Q9Z1S5.
PRIDEi Q9Z1S5.

Protocols and materials databases

DNASUi 24050.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023095 ; ENSMUSP00000023095 ; ENSMUSG00000022456 . [Q9Z1S5-2 ]
ENSMUST00000116423 ; ENSMUSP00000112124 ; ENSMUSG00000022456 . [Q9Z1S5-2 ]
GeneIDi 24050.
KEGGi mmu:24050.
UCSCi uc007wyq.1. mouse. [Q9Z1S5-1 ]

Organism-specific databases

CTDi 55964.
MGIi MGI:1345148. Sept3.

Phylogenomic databases

eggNOGi COG5019.
GeneTreei ENSGT00760000118899.
HOGENOMi HOG000233586.
HOVERGENi HBG065093.
InParanoidi Q9Z1S5.
KOi K16938.
OMAi RKELTAM.
OrthoDBi EOG7KWSJ5.
PhylomeDBi Q9Z1S5.
TreeFami TF101078.

Miscellaneous databases

NextBioi 303983.
PROi Q9Z1S5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z1S5.
CleanExi MM_SEPT3.
Genevestigatori Q9Z1S5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
PRINTSi PR01741. SEPTIN3.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development."
    Xiong J.-W., Leahy A., Stuhlmann H.
    Mech. Dev. 86:183-191(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 132-139; 186-204 AND 314-325, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry nameiSEPT3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1S5
Secondary accession number(s): Q3TNZ2, Q7TNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3