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Protein

Neuronal-specific septin-3

Gene

Sept3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102GTPBy similarity1
Binding sitei265GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei280GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTPBy similarity8
Nucleotide bindingi208 – 216GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:Sept3
Synonyms:Sep3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1345148. Sept3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735181 – 350Neuronal-specific septin-3Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1S5.
PeptideAtlasiQ9Z1S5.
PRIDEiQ9Z1S5.

2D gel databases

UCD-2DPAGEQ9Z1S5.

PTM databases

iPTMnetiQ9Z1S5.
PhosphoSitePlusiQ9Z1S5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022456.
CleanExiMM_SEPT3.
GenevisibleiQ9Z1S5. MM.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Protein-protein interaction databases

BioGridi204863. 2 interactors.
IntActiQ9Z1S5. 3 interactors.
MINTiMINT-4134132.
STRINGi10090.ENSMUSP00000023095.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1S5.
SMRiQ9Z1S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Septin-type GAdd BLAST274

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9Z1S5.
KOiK16938.
OMAiRWGVVNV.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9Z1S5.
TreeFamiTF101078.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z1S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGLPEART DAAMSELVPE PRPKPAVPMK PVSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPVSV DTEESHDSNP
Length:350
Mass (Da):40,038
Last modified:May 15, 2007 - v2
Checksum:iAEF37C023AB21C0D
GO
Isoform 2 (identifier: Q9Z1S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:337
Mass (Da):38,709
Checksum:iC090F23E9C97B919
GO

Sequence cautioni

The sequence AAD02884 differs from that shown. Reason: Frameshift at position 344.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221 – 235KQRVR…NGIEF → LPSEGI in AAD02884 (PubMed:10446280).CuratedAdd BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254001 – 13Missing in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA. Translation: AAD02884.1. Frameshift.
AK164861 mRNA. Translation: BAE37945.1.
AK169916 mRNA. Translation: BAE41456.1.
AK141915 mRNA. Translation: BAE24884.1.
BC055738 mRNA. Translation: AAH55738.1.
CCDSiCCDS37157.1. [Q9Z1S5-2]
RefSeqiNP_036019.2. NM_011889.2. [Q9Z1S5-2]
UniGeneiMm.309707.

Genome annotation databases

EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456. [Q9Z1S5-2]
GeneIDi24050.
KEGGimmu:24050.
UCSCiuc007wyq.1. mouse. [Q9Z1S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104411 mRNA. Translation: AAD02884.1. Frameshift.
AK164861 mRNA. Translation: BAE37945.1.
AK169916 mRNA. Translation: BAE41456.1.
AK141915 mRNA. Translation: BAE24884.1.
BC055738 mRNA. Translation: AAH55738.1.
CCDSiCCDS37157.1. [Q9Z1S5-2]
RefSeqiNP_036019.2. NM_011889.2. [Q9Z1S5-2]
UniGeneiMm.309707.

3D structure databases

ProteinModelPortaliQ9Z1S5.
SMRiQ9Z1S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204863. 2 interactors.
IntActiQ9Z1S5. 3 interactors.
MINTiMINT-4134132.
STRINGi10090.ENSMUSP00000023095.

PTM databases

iPTMnetiQ9Z1S5.
PhosphoSitePlusiQ9Z1S5.

2D gel databases

UCD-2DPAGEQ9Z1S5.

Proteomic databases

PaxDbiQ9Z1S5.
PeptideAtlasiQ9Z1S5.
PRIDEiQ9Z1S5.

Protocols and materials databases

DNASUi24050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023095; ENSMUSP00000023095; ENSMUSG00000022456. [Q9Z1S5-2]
ENSMUST00000116423; ENSMUSP00000112124; ENSMUSG00000022456. [Q9Z1S5-2]
GeneIDi24050.
KEGGimmu:24050.
UCSCiuc007wyq.1. mouse. [Q9Z1S5-1]

Organism-specific databases

CTDi55964.
MGIiMGI:1345148. Sept3.

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ9Z1S5.
KOiK16938.
OMAiRWGVVNV.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9Z1S5.
TreeFamiTF101078.

Miscellaneous databases

PROiQ9Z1S5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022456.
CleanExiMM_SEPT3.
GenevisibleiQ9Z1S5. MM.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1S5
Secondary accession number(s): Q3TNZ2, Q7TNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.