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Q9Z1R3

- APOM_MOUSE

UniProt

Q9Z1R3 - APOM_MOUSE

Protein

Apolipoprotein M

Gene

Apom

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei138 – 1381Fatty acidBy similarity
    Binding sitei145 – 1451Fatty acidBy similarity

    GO - Molecular functioni

    1. antioxidant activity Source: BHF-UCL
    2. lipid transporter activity Source: Ensembl
    3. phospholipid binding Source: BHF-UCL

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. high-density lipoprotein particle assembly Source: BHF-UCL
    3. high-density lipoprotein particle clearance Source: BHF-UCL
    4. high-density lipoprotein particle remodeling Source: BHF-UCL
    5. lipoprotein metabolic process Source: MGI
    6. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
    7. response to glucose Source: Ensembl
    8. reverse cholesterol transport Source: MGI

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein M
    Short name:
    Apo-M
    Short name:
    ApoM
    Gene namesi
    Name:Apom
    Synonyms:Ng20
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1930124. Apom.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. discoidal high-density lipoprotein particle Source: BHF-UCL
    2. extracellular region Source: MGI
    3. high-density lipoprotein particle Source: BHF-UCL
    4. low-density lipoprotein particle Source: Ensembl
    5. spherical high-density lipoprotein particle Source: Ensembl
    6. very-low-density lipoprotein particle Source: Ensembl

    Keywords - Cellular componenti

    HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Apolipoprotein MPRO_0000223279Add
    BLAST
    Signal peptidei1 – ?2222Not cleavedSequence AnalysisAdd
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 169By similarity
    Disulfide bondi95 ↔ 1851 Publication
    Disulfide bondi130 ↔ 1591 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9Z1R3.
    PaxDbiQ9Z1R3.
    PRIDEiQ9Z1R3.

    Expressioni

    Tissue specificityi

    Expressed by the liver; secreted in plasma.

    Gene expression databases

    BgeeiQ9Z1R3.
    CleanExiMM_APOM.
    GenevestigatoriQ9Z1R3.

    Structurei

    Secondary structure

    1
    190
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 347
    Beta strandi47 – 5610
    Helixi57 – 593
    Helixi61 – 633
    Beta strandi66 – 7510
    Beta strandi81 – 9010
    Beta strandi95 – 10410
    Helixi125 – 1295
    Beta strandi133 – 1408
    Beta strandi143 – 15412
    Helixi157 – 16913
    Beta strandi174 – 1774

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XKLX-ray2.50A20-190[»]
    ProteinModelPortaliQ9Z1R3.
    SMRiQ9Z1R3. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Z1R3.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40194.
    GeneTreeiENSGT00390000001026.
    HOGENOMiHOG000034009.
    HOVERGENiHBG018735.
    InParanoidiQ9Z1R3.
    OMAiPRNQEAC.
    OrthoDBiEOG7GJ6F5.
    PhylomeDBiQ9Z1R3.
    TreeFamiTF330771.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR022734. ApoM.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    [Graphical view]
    PfamiPF11032. ApoM. 1 hit.
    [Graphical view]
    SUPFAMiSSF50814. SSF50814. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z1R3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHQVWAALL SLYGLLFNSM NQCPEHSQLT ALGMDDTETP EPHLGLWYFI    50
    AGAASTTEEL ATFDPVDNIV FNMAAGSAPR QLQLRATIRT KSGVCVPRKW 100
    TYRLTEGKGN MELRTEGRPD MKTDLFSSSC PGGIMLKETG QGYQRFLLYN 150
    RSPHPPEKCV EEFQSLTSCL DFKAFLVTPR NQEACPLSSK 190
    Length:190
    Mass (Da):21,273
    Last modified:May 1, 1999 - v1
    Checksum:i3D5614DADF2B77C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207820 mRNA. Translation: AAF23407.1.
    AF109719 Genomic DNA. Translation: AAC82478.1.
    AK004530 mRNA. Translation: BAB23349.1.
    CCDSiCCDS28687.1.
    RefSeqiNP_061286.1. NM_018816.1.
    UniGeneiMm.2161.

    Genome annotation databases

    EnsembliENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391.
    GeneIDi55938.
    KEGGimmu:55938.
    UCSCiuc008cga.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207820 mRNA. Translation: AAF23407.1 .
    AF109719 Genomic DNA. Translation: AAC82478.1 .
    AK004530 mRNA. Translation: BAB23349.1 .
    CCDSi CCDS28687.1.
    RefSeqi NP_061286.1. NM_018816.1.
    UniGenei Mm.2161.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XKL X-ray 2.50 A 20-190 [» ]
    ProteinModelPortali Q9Z1R3.
    SMRi Q9Z1R3. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q9Z1R3.
    PaxDbi Q9Z1R3.
    PRIDEi Q9Z1R3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025249 ; ENSMUSP00000025249 ; ENSMUSG00000024391 .
    GeneIDi 55938.
    KEGGi mmu:55938.
    UCSCi uc008cga.1. mouse.

    Organism-specific databases

    CTDi 55937.
    MGIi MGI:1930124. Apom.

    Phylogenomic databases

    eggNOGi NOG40194.
    GeneTreei ENSGT00390000001026.
    HOGENOMi HOG000034009.
    HOVERGENi HBG018735.
    InParanoidi Q9Z1R3.
    OMAi PRNQEAC.
    OrthoDBi EOG7GJ6F5.
    PhylomeDBi Q9Z1R3.
    TreeFami TF330771.

    Miscellaneous databases

    EvolutionaryTracei Q9Z1R3.
    NextBioi 311616.
    PROi Q9Z1R3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z1R3.
    CleanExi MM_APOM.
    Genevestigatori Q9Z1R3.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR022734. ApoM.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    [Graphical view ]
    Pfami PF11032. ApoM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50814. SSF50814. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Xu N., Dahlbaeck B.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold?"
      Sevvana M., Kassler K., Ahnstrom J., Weiler S., Dahlback B., Sticht H., Muller Y.A.
      J. Mol. Biol. 404:363-371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 20-90, DISULFIDE BONDS.

    Entry informationi

    Entry nameiAPOM_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3