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Q9Z1R3 (APOM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein M

Short name=Apo-M
Short name=ApoM
Gene names
Name:Apom
Synonyms:Ng20
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed by the liver; secreted in plasma.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family. Highly divergent.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentHDL
Secreted
   DomainSignal
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcholesterol efflux

Inferred from mutant phenotype PubMed 15793583. Source: BHF-UCL

high-density lipoprotein particle assembly

Inferred from mutant phenotype PubMed 15793583. Source: BHF-UCL

high-density lipoprotein particle clearance

Inferred from mutant phenotype PubMed 15793583. Source: BHF-UCL

high-density lipoprotein particle remodeling

Inferred from mutant phenotype PubMed 15793583. Source: BHF-UCL

lipoprotein metabolic process

Inferred from mutant phenotype PubMed 15793583. Source: MGI

negative regulation of plasma lipoprotein particle oxidation

Inferred from direct assay PubMed 22204862. Source: BHF-UCL

response to glucose

Inferred from electronic annotation. Source: Ensembl

reverse cholesterol transport

Inferred from mutant phenotype PubMed 15793583. Source: MGI

   Cellular_componentdiscoidal high-density lipoprotein particle

Inferred from direct assay PubMed 15793583. Source: BHF-UCL

extracellular region

Inferred from direct assay PubMed 15793583. Source: MGI

high-density lipoprotein particle

Inferred from direct assay PubMed 22204862. Source: BHF-UCL

low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

spherical high-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionantioxidant activity

Inferred from direct assay PubMed 22204862. Source: BHF-UCL

lipid transporter activity

Inferred from electronic annotation. Source: Ensembl

phospholipid binding

Inferred from sequence or structural similarity PubMed 22204862. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Apolipoprotein M
PRO_0000223279
Signal peptide1 – ?2222Not cleaved Potential

Sites

Binding site1381Fatty acid By similarity
Binding site1451Fatty acid By similarity

Amino acid modifications

Disulfide bond23 ↔ 169 By similarity
Disulfide bond95 ↔ 185 Ref.4
Disulfide bond130 ↔ 159 Ref.4

Secondary structure

........................ 190
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Z1R3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3D5614DADF2B77C4

FASTA19021,273
        10         20         30         40         50         60 
MFHQVWAALL SLYGLLFNSM NQCPEHSQLT ALGMDDTETP EPHLGLWYFI AGAASTTEEL 

        70         80         90        100        110        120 
ATFDPVDNIV FNMAAGSAPR QLQLRATIRT KSGVCVPRKW TYRLTEGKGN MELRTEGRPD 

       130        140        150        160        170        180 
MKTDLFSSSC PGGIMLKETG QGYQRFLLYN RSPHPPEKCV EEFQSLTSCL DFKAFLVTPR 

       190 
NQEACPLSSK 

« Hide

References

« Hide 'large scale' references
[1]Xu N., Dahlbaeck B.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[4]"Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold?"
Sevvana M., Kassler K., Ahnstrom J., Weiler S., Dahlback B., Sticht H., Muller Y.A.
J. Mol. Biol. 404:363-371(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 20-90, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF207820 mRNA. Translation: AAF23407.1.
AF109719 Genomic DNA. Translation: AAC82478.1.
AK004530 mRNA. Translation: BAB23349.1.
RefSeqNP_061286.1. NM_018816.1.
UniGeneMm.2161.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XKLX-ray2.50A20-190[»]
ProteinModelPortalQ9Z1R3.
SMRQ9Z1R3. Positions 24-189.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9Z1R3.
PRIDEQ9Z1R3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391.
GeneID55938.
KEGGmmu:55938.
UCSCuc008cga.1. mouse.

Organism-specific databases

CTD55937.
MGIMGI:1930124. Apom.

Phylogenomic databases

eggNOGNOG40194.
GeneTreeENSGT00390000001026.
HOGENOMHOG000034009.
HOVERGENHBG018735.
InParanoidQ9Z1R3.
OMASIYQCPE.
OrthoDBEOG7GJ6F5.
PhylomeDBQ9Z1R3.
TreeFamTF330771.

Gene expression databases

BgeeQ9Z1R3.
CleanExMM_APOM.
GenevestigatorQ9Z1R3.

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMSSF50814. SSF50814. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9Z1R3.
NextBio311616.
PROQ9Z1R3.
SOURCESearch...

Entry information

Entry nameAPOM_MOUSE
AccessionPrimary (citable) accession number: Q9Z1R3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot