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Q9Z1R3

- APOM_MOUSE

UniProt

Q9Z1R3 - APOM_MOUSE

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Protein

Apolipoprotein M

Gene
Apom, Ng20
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Fatty acid By similarity
Binding sitei145 – 1451Fatty acid By similarity

GO - Molecular functioni

  1. antioxidant activity Source: BHF-UCL
  2. lipid transporter activity Source: Ensembl
  3. phospholipid binding Source: BHF-UCL

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. high-density lipoprotein particle assembly Source: BHF-UCL
  3. high-density lipoprotein particle clearance Source: BHF-UCL
  4. high-density lipoprotein particle remodeling Source: BHF-UCL
  5. lipoprotein metabolic process Source: MGI
  6. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
  7. response to glucose Source: Ensembl
  8. reverse cholesterol transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Gene namesi
Name:Apom
Synonyms:Ng20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1930124. Apom.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. discoidal high-density lipoprotein particle Source: BHF-UCL
  2. extracellular region Source: MGI
  3. high-density lipoprotein particle Source: BHF-UCL
  4. low-density lipoprotein particle Source: Ensembl
  5. spherical high-density lipoprotein particle Source: Ensembl
  6. very-low-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Apolipoprotein MPRO_0000223279Add
BLAST
Signal peptidei1 – ?2222Not cleaved Reviewed predictionAdd
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 169 By similarity
Disulfide bondi95 ↔ 1851 Publication
Disulfide bondi130 ↔ 1591 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z1R3.
PaxDbiQ9Z1R3.
PRIDEiQ9Z1R3.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

BgeeiQ9Z1R3.
CleanExiMM_APOM.
GenevestigatoriQ9Z1R3.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 347
Beta strandi47 – 5610
Helixi57 – 593
Helixi61 – 633
Beta strandi66 – 7510
Beta strandi81 – 9010
Beta strandi95 – 10410
Helixi125 – 1295
Beta strandi133 – 1408
Beta strandi143 – 15412
Helixi157 – 16913
Beta strandi174 – 1774

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XKLX-ray2.50A20-190[»]
ProteinModelPortaliQ9Z1R3.
SMRiQ9Z1R3. Positions 24-189.

Miscellaneous databases

EvolutionaryTraceiQ9Z1R3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40194.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiQ9Z1R3.
OMAiPRNQEAC.
OrthoDBiEOG7GJ6F5.
PhylomeDBiQ9Z1R3.
TreeFamiTF330771.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1R3-1 [UniParc]FASTAAdd to Basket

« Hide

MFHQVWAALL SLYGLLFNSM NQCPEHSQLT ALGMDDTETP EPHLGLWYFI    50
AGAASTTEEL ATFDPVDNIV FNMAAGSAPR QLQLRATIRT KSGVCVPRKW 100
TYRLTEGKGN MELRTEGRPD MKTDLFSSSC PGGIMLKETG QGYQRFLLYN 150
RSPHPPEKCV EEFQSLTSCL DFKAFLVTPR NQEACPLSSK 190
Length:190
Mass (Da):21,273
Last modified:May 1, 1999 - v1
Checksum:i3D5614DADF2B77C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207820 mRNA. Translation: AAF23407.1.
AF109719 Genomic DNA. Translation: AAC82478.1.
AK004530 mRNA. Translation: BAB23349.1.
CCDSiCCDS28687.1.
RefSeqiNP_061286.1. NM_018816.1.
UniGeneiMm.2161.

Genome annotation databases

EnsembliENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391.
GeneIDi55938.
KEGGimmu:55938.
UCSCiuc008cga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207820 mRNA. Translation: AAF23407.1 .
AF109719 Genomic DNA. Translation: AAC82478.1 .
AK004530 mRNA. Translation: BAB23349.1 .
CCDSi CCDS28687.1.
RefSeqi NP_061286.1. NM_018816.1.
UniGenei Mm.2161.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XKL X-ray 2.50 A 20-190 [» ]
ProteinModelPortali Q9Z1R3.
SMRi Q9Z1R3. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q9Z1R3.
PaxDbi Q9Z1R3.
PRIDEi Q9Z1R3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025249 ; ENSMUSP00000025249 ; ENSMUSG00000024391 .
GeneIDi 55938.
KEGGi mmu:55938.
UCSCi uc008cga.1. mouse.

Organism-specific databases

CTDi 55937.
MGIi MGI:1930124. Apom.

Phylogenomic databases

eggNOGi NOG40194.
GeneTreei ENSGT00390000001026.
HOGENOMi HOG000034009.
HOVERGENi HBG018735.
InParanoidi Q9Z1R3.
OMAi PRNQEAC.
OrthoDBi EOG7GJ6F5.
PhylomeDBi Q9Z1R3.
TreeFami TF330771.

Miscellaneous databases

EvolutionaryTracei Q9Z1R3.
NextBioi 311616.
PROi Q9Z1R3.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z1R3.
CleanExi MM_APOM.
Genevestigatori Q9Z1R3.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view ]
Pfami PF11032. ApoM. 1 hit.
[Graphical view ]
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Xu N., Dahlbaeck B.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "Mouse ApoM displays an unprecedented seven-stranded lipocalin fold: folding decoy or alternative native fold?"
    Sevvana M., Kassler K., Ahnstrom J., Weiler S., Dahlback B., Sticht H., Muller Y.A.
    J. Mol. Biol. 404:363-371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 20-90, DISULFIDE BONDS.

Entry informationi

Entry nameiAPOM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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