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Protein

Apolipoprotein M

Gene

Apom

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138Fatty acidBy similarity1
Binding sitei145Fatty acidBy similarity1

GO - Molecular functioni

  • antioxidant activity Source: BHF-UCL
  • lipid transporter activity Source: MGI
  • phospholipid binding Source: BHF-UCL

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • high-density lipoprotein particle assembly Source: BHF-UCL
  • high-density lipoprotein particle clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipoprotein metabolic process Source: MGI
  • negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
  • response to glucose Source: Ensembl
  • reverse cholesterol transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Gene namesi
Name:Apom
Synonyms:Ng20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930124. Apom.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232791 – 190Apolipoprotein MAdd BLAST190
Signal peptidei1 – ?22Not cleavedSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 169By similarity
Disulfide bondi95 ↔ 1851 Publication
Disulfide bondi130 ↔ 1591 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z1R3.
PaxDbiQ9Z1R3.
PeptideAtlasiQ9Z1R3.
PRIDEiQ9Z1R3.

PTM databases

iPTMnetiQ9Z1R3.
PhosphoSitePlusiQ9Z1R3.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000024391.
CleanExiMM_APOM.
GenevisibleiQ9Z1R3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025249.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 34Combined sources7
Beta strandi47 – 56Combined sources10
Helixi57 – 59Combined sources3
Helixi61 – 63Combined sources3
Beta strandi66 – 75Combined sources10
Beta strandi81 – 90Combined sources10
Beta strandi95 – 104Combined sources10
Helixi125 – 129Combined sources5
Beta strandi133 – 140Combined sources8
Beta strandi143 – 154Combined sources12
Helixi157 – 169Combined sources13
Beta strandi174 – 177Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XKLX-ray2.50A20-190[»]
ProteinModelPortaliQ9Z1R3.
SMRiQ9Z1R3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z1R3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiQ9Z1R3.
OMAiWYFIAGA.
OrthoDBiEOG091G0L0Y.
PhylomeDBiQ9Z1R3.
TreeFamiTF330771.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHQVWAALL SLYGLLFNSM NQCPEHSQLT ALGMDDTETP EPHLGLWYFI
60 70 80 90 100
AGAASTTEEL ATFDPVDNIV FNMAAGSAPR QLQLRATIRT KSGVCVPRKW
110 120 130 140 150
TYRLTEGKGN MELRTEGRPD MKTDLFSSSC PGGIMLKETG QGYQRFLLYN
160 170 180 190
RSPHPPEKCV EEFQSLTSCL DFKAFLVTPR NQEACPLSSK
Length:190
Mass (Da):21,273
Last modified:May 1, 1999 - v1
Checksum:i3D5614DADF2B77C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207820 mRNA. Translation: AAF23407.1.
AF109719 Genomic DNA. Translation: AAC82478.1.
AK004530 mRNA. Translation: BAB23349.1.
CCDSiCCDS28687.1.
RefSeqiNP_061286.1. NM_018816.1.
UniGeneiMm.2161.

Genome annotation databases

EnsembliENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391.
GeneIDi55938.
KEGGimmu:55938.
UCSCiuc008cga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207820 mRNA. Translation: AAF23407.1.
AF109719 Genomic DNA. Translation: AAC82478.1.
AK004530 mRNA. Translation: BAB23349.1.
CCDSiCCDS28687.1.
RefSeqiNP_061286.1. NM_018816.1.
UniGeneiMm.2161.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XKLX-ray2.50A20-190[»]
ProteinModelPortaliQ9Z1R3.
SMRiQ9Z1R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025249.

PTM databases

iPTMnetiQ9Z1R3.
PhosphoSitePlusiQ9Z1R3.

Proteomic databases

MaxQBiQ9Z1R3.
PaxDbiQ9Z1R3.
PeptideAtlasiQ9Z1R3.
PRIDEiQ9Z1R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025249; ENSMUSP00000025249; ENSMUSG00000024391.
GeneIDi55938.
KEGGimmu:55938.
UCSCiuc008cga.1. mouse.

Organism-specific databases

CTDi55937.
MGIiMGI:1930124. Apom.

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiQ9Z1R3.
OMAiWYFIAGA.
OrthoDBiEOG091G0L0Y.
PhylomeDBiQ9Z1R3.
TreeFamiTF330771.

Enzyme and pathway databases

ReactomeiR-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiQ9Z1R3.
PROiQ9Z1R3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024391.
CleanExiMM_APOM.
GenevisibleiQ9Z1R3. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOM_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.