Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Valine--tRNA ligase

Gene

Vars

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Enzyme regulationi

Can be regulated by protein kinase C-dependent phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei864ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase (EC:6.1.1.9)
Alternative name(s):
Protein G7a
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:Vars
Synonyms:Bat6, G7a, Vars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:90675 Vars

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001062542 – 1263Valine--tRNA ligaseAdd BLAST1262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei644N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z1Q9
MaxQBiQ9Z1Q9
PaxDbiQ9Z1Q9
PRIDEiQ9Z1Q9

PTM databases

iPTMnetiQ9Z1Q9
PhosphoSitePlusiQ9Z1Q9
SwissPalmiQ9Z1Q9

Expressioni

Gene expression databases

BgeeiENSMUSG00000007029
CleanExiMM_VARS
MM_VARS2
ExpressionAtlasiQ9Z1Q9 baseline and differential
GenevisibleiQ9Z1Q9 MM

Interactioni

Subunit structurei

Forms high-molecular-mass aggregates with elongation factor 1.By similarity

Protein-protein interaction databases

BioGridi204498, 2 interactors
IntActiQ9Z1Q9, 3 interactors
MINTiQ9Z1Q9
STRINGi10090.ENSMUSP00000084572

Structurei

3D structure databases

ProteinModelPortaliQ9Z1Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 219GST C-terminalAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi343 – 353"HIGH" regionAdd BLAST11
Motifi861 – 865"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0432 Eukaryota
KOG0867 Eukaryota
COG0525 LUCA
GeneTreeiENSGT00550000074727
HOGENOMiHOG000020094
HOVERGENiHBG017878
InParanoidiQ9Z1Q9
KOiK01873
PhylomeDBiQ9Z1Q9
TreeFamiTF300648

Family and domain databases

CDDicd07962 Anticodon_Ia_Val, 1 hit
Gene3Di1.10.287.380, 1 hit
3.40.50.620, 1 hit
3.90.740.10, 1 hit
HAMAPiMF_02004 Val_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033705 Anticodon_Ia_Val
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR037118 Val-tRNA_synth_C_sf
IPR009008 Val/Leu/Ile-tRNA-synth_edit
IPR002303 Valyl-tRNA_ligase
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00043 GST_C, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00986 TRNASYNTHVAL
SUPFAMiSSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00422 valS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILYVSPHP DAFPSLRALI AARYGEAGDG PGWGGPHPRI CLQPPPSSRT
60 70 80 90 100
PFPPPRLPAL EQGPGGLWVW GAPAVAQLLW PAGLGGPGGS RAAVLVQQWV
110 120 130 140 150
SYADTELIPA ACGATLPALG LRGPGQDPQA ALGALGKALN PLEDWLRLHT
160 170 180 190 200
YLAGDAPTLA DLAAVTALLL PFRYVLDPSA RRIWGNVTRW FNTCVRQPEF
210 220 230 240 250
RAVLGEVALY SGARSVTQQP GSEVIAPQKT PAQLKKEAKK REKLEKFQQK
260 270 280 290 300
QKTQQQPPHG EKKPKPEKKE KRDPGVITYD LPTPPGEKKD VSGAMPDSYS
310 320 330 340 350
PQYVEAAWYP WWERQGFFKP EYGRPSVSAP NPRGVFMMCI PPPNVTGSLH
360 370 380 390 400
LGHALTNAIQ DSLTRWHRMR GETTLWNPGC DHAGIATQVV VEKKLWKERG
410 420 430 440 450
LNRHQLGREA FLEEVWKWKA EKGDRIYHQL KKLGSSLDWD RACFTMDPKL
460 470 480 490 500
SATVTEAFVR LHEEGVIYRS TRLVNWSCTL NSAISDIEVD KKELTGRTLL
510 520 530 540 550
PVPGYKEKVE FGVLVSFAYK VQGSDSDEEV VVATTRIETM LGDVAVAVHP
560 570 580 590 600
KDPRYQHLKG KCVVHPFLSR SLPIVFDDFV DMEFGTGAVK ITPAHDQNDY
610 620 630 640 650
EVGQRHRLEA ISIMDSKGAL INVPPPFLGL PRFEARKAVL AALKERGLFR
660 670 680 690 700
GVKDNPMVVP LCNRSKDVVE PLLRPQWYVR CGEMAQAASA AVTRGDLRIL
710 720 730 740 750
PEAHQRTWHS WMDNIRDWCI SRQLWWGHRI PAYFITVHDP AVPPGEDPDG
760 770 780 790 800
RYWVSGRTEA EAREKAAREF GVSPDKISLQ QDEDVLDTWF SSGLFPFSIF
810 820 830 840 850
GWPNQSEDLS VFYPGTLLET GHDILFFWVA RMVMLGLKLT GKLPFREVYL
860 870 880 890 900
HAIVRDAHGR KMSKSLGNVI DPLDVIHGVS LQGLYDQLLN SNLDPSEVEK
910 920 930 940 950
AKEGQKADFP AGIPECGTDA LRFGLCAYTS QGRDINLDVN RILGYRHFCN
960 970 980 990 1000
KLWNATKFAL RGLGKGFVPS ATSKPEGHES LVDRWIRSRL TEAVRLSNEG
1010 1020 1030 1040 1050
FQAYDFPAIT TAQYSFWLYE LCDVYLECLK PVLNGVDQVA AECARQTLYT
1060 1070 1080 1090 1100
CLDVGLRLLS PFMPFVTEEL FQRLPRRTPK APASLCVTPY PEPSECSWKD
1110 1120 1130 1140 1150
PEAEAALELA LSITRAVRSL RADYNLTRTR PDCFLEVADE ATGALASAVS
1160 1170 1180 1190 1200
GYVQALASAG VVAVLALGAP APQGCAVAVA SDRCSIHLQL QGLVDPAREL
1210 1220 1230 1240 1250
GKLQAKRSEA QRQAQRLQER RAASSYSAKV PLEVQEADEA KLQQTEAELR
1260
KVDEAIALFQ KML
Length:1,263
Mass (Da):140,215
Last modified:May 1, 1999 - v1
Checksum:iB510E73284FCE26D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti959A → R in AAD26532 (PubMed:10199925).Curated1
Sequence conflicti959A → R in AAD26531 (PubMed:10199925).Curated1
Sequence conflicti1219E → K in AAD26532 (PubMed:10199925).Curated1
Sequence conflicti1219E → K in AAD26531 (PubMed:10199925).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087680 mRNA Translation: AAD26532.1
AF087141 Genomic DNA Translation: AAD26531.1
AF109905 Genomic DNA Translation: AAC84151.1
AF109906 Genomic DNA Translation: AAC84172.1
CCDSiCCDS37593.1
RefSeqiNP_035820.3, NM_011690.3
XP_017172884.1, XM_017317395.1
UniGeneiMm.28420

Genome annotation databases

EnsembliENSMUST00000087315; ENSMUSP00000084572; ENSMUSG00000007029
GeneIDi22321
KEGGimmu:22321
UCSCiuc008cez.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYVC_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1Q9
Secondary accession number(s): Q9QUN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health