Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AT-rich interactive domain-containing protein 3B

Gene

Arid3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the production of cranial mesenchymal tissues. Favors nuclear targeting of ARID3A.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3B
Short name:
ARID domain-containing protein 3B
Alternative name(s):
Bright and dead ringer protein
Bright-like protein
Gene namesi
Name:Arid3b
Synonyms:Bdp, Dril2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930768. Arid3b.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos die before E11.5 and display various abnormalities, including wavy neural tube, small branchial arches and defects of cardiovascular system.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951631 – 568AT-rich interactive domain-containing protein 3BAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei370Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Z1N7.
PaxDbiQ9Z1N7.
PRIDEiQ9Z1N7.

PTM databases

iPTMnetiQ9Z1N7.
PhosphoSitePlusiQ9Z1N7.

Expressioni

Tissue specificityi

Expressed at high levels in testis. Also expressed in prostate, thyroid and thymus.1 Publication

Developmental stagei

First detected at E7. Strongly expressed in cranial mesenchyme and caudal mesoderm. Expression in cranial mesenchyme decreases starting from E10.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000004661.
CleanExiMM_ARID3B.
ExpressionAtlasiQ9Z1N7. baseline and differential.
GenevisibleiQ9Z1N7. MM.

Interactioni

Subunit structurei

Heterodimer with ARID3A. Interacts with unphosphorylated RB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207941. 3 interactors.
IntActiQ9Z1N7. 1 interactor.
STRINGi10090.ENSMUSP00000004780.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1N7.
SMRiQ9Z1N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 305ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini425 – 522REKLESPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 374Interaction with RB1By similarityAdd BLAST174
Regioni495 – 518Interaction with ARID3ABy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 37Gln-richAdd BLAST33
Compositional biasi88 – 93Poly-Glu6
Compositional biasi339 – 362Ala-richAdd BLAST24
Compositional biasi528 – 567Ser-richAdd BLAST40

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 REKLES domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000236281.
HOVERGENiHBG103680.
InParanoidiQ9Z1N7.
OMAiFSMARQI.
OrthoDBiEOG091G16XQ.
PhylomeDBiQ9Z1N7.
TreeFamiTF320364.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR023334. REKLES_domain.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z1N7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLQQQQQQ QQQKQPQQPL LQMDAREKQG PQTRESQFLY ASKLGTQPAL
60 70 80 90 100
LSITPGRPSG SSVLGPLARV PPATPVARMS EQSNVNSEPE EEEGGLEDED
110 120 130 140 150
GDDDVAEVAE KEAQAASKYF HMQKVTRQEP RATPMSSLLP VPGLSPQGQQ
160 170 180 190 200
TKEDHTKDAS KAPPSVPTAG QPSWSLDEQL KQNGALAWSD DADGGRGREI
210 220 230 240 250
SRDFAKLYEL DGDPERKEFL DDLFIFMQKR GTPINRIPIM AKQILDLYML
260 270 280 290 300
YKLVTEKGGL VEIINKKIWR EITKGLNLPT SITSAAFTLR TQYMKYLYAY
310 320 330 340 350
ECEKKALSSP AELQAAIDGN RREGRRPSYS SSLFGYSPAA AAAAAAAAAA
360 370 380 390 400
AAASAASAGT PALLSSPKIR FSILGLGSSS GTSASSPRIP PASTLRKGDG
410 420 430 440 450
VPVPVPNRLA VSGTLAGQQA GNRPGPLEHL RERLESGEPP EKKASRLSEE
460 470 480 490 500
EQRLVQQAFQ RNLFSMARQL PMKIRINGRE DRAEPSAPAL NLTTSNIGSI
510 520 530 540 550
NMSVDIDGTT YTGVLFAQKP VVHLIAGSTP QSIGSSASSS NSSSSHCSPS
560
PTSSRGTPSA EPSTSWSL
Length:568
Mass (Da):61,015
Last modified:May 1, 1999 - v1
Checksum:i70250959E6EAF526
GO
Isoform 2 (identifier: Q9Z1N7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-282: INRIPIMAKQ...TKGLNLPTSI → SGASPAGIVL...VIAHGSLGRD
     283-568: Missing.

Show »
Length:282
Mass (Da):30,795
Checksum:iB18C5EB90DED77C4
GO
Isoform 3 (identifier: Q9Z1N7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-287: TPINRIPIMA...LPTSITSAAF → DPAAAAECTA...QADPGPVHAV
     288-568: Missing.

Show »
Length:287
Mass (Da):31,376
Checksum:i6DFB9E26A48E6A6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99E → G in BAE24019 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026775232 – 287TPINR…TSAAF → DPAAAAECTAFLLPSLIVIK YPGTTQLSTIMQKGVWHPNQ PDSHHGQADPGPVHAV in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_026776234 – 282INRIP…LPTSI → SGASPAGIVLKATWPCGWPG QPPPLLCLVCILTRKKKKNV IAHGSLGRD in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_026777283 – 568Missing in isoform 2. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_026778288 – 568Missing in isoform 3. 1 PublicationAdd BLAST281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116847 mRNA. Translation: AAD09134.1.
AK139455 mRNA. Translation: BAE24019.1.
BC049776 mRNA. Translation: AAH49776.1.
CCDSiCCDS23233.1. [Q9Z1N7-1]
RefSeqiNP_062663.1. NM_019689.2. [Q9Z1N7-1]
XP_006511354.1. XM_006511291.3. [Q9Z1N7-1]
UniGeneiMm.425588.

Genome annotation databases

EnsembliENSMUST00000004780; ENSMUSP00000004780; ENSMUSG00000004661. [Q9Z1N7-1]
ENSMUST00000164035; ENSMUSP00000131677; ENSMUSG00000004661. [Q9Z1N7-3]
ENSMUST00000171444; ENSMUSP00000130173; ENSMUSG00000004661. [Q9Z1N7-1]
GeneIDi56380.
KEGGimmu:56380.
UCSCiuc009pvt.2. mouse. [Q9Z1N7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116847 mRNA. Translation: AAD09134.1.
AK139455 mRNA. Translation: BAE24019.1.
BC049776 mRNA. Translation: AAH49776.1.
CCDSiCCDS23233.1. [Q9Z1N7-1]
RefSeqiNP_062663.1. NM_019689.2. [Q9Z1N7-1]
XP_006511354.1. XM_006511291.3. [Q9Z1N7-1]
UniGeneiMm.425588.

3D structure databases

ProteinModelPortaliQ9Z1N7.
SMRiQ9Z1N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207941. 3 interactors.
IntActiQ9Z1N7. 1 interactor.
STRINGi10090.ENSMUSP00000004780.

PTM databases

iPTMnetiQ9Z1N7.
PhosphoSitePlusiQ9Z1N7.

Proteomic databases

EPDiQ9Z1N7.
PaxDbiQ9Z1N7.
PRIDEiQ9Z1N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004780; ENSMUSP00000004780; ENSMUSG00000004661. [Q9Z1N7-1]
ENSMUST00000164035; ENSMUSP00000131677; ENSMUSG00000004661. [Q9Z1N7-3]
ENSMUST00000171444; ENSMUSP00000130173; ENSMUSG00000004661. [Q9Z1N7-1]
GeneIDi56380.
KEGGimmu:56380.
UCSCiuc009pvt.2. mouse. [Q9Z1N7-1]

Organism-specific databases

CTDi10620.
MGIiMGI:1930768. Arid3b.

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000236281.
HOVERGENiHBG103680.
InParanoidiQ9Z1N7.
OMAiFSMARQI.
OrthoDBiEOG091G16XQ.
PhylomeDBiQ9Z1N7.
TreeFamiTF320364.

Miscellaneous databases

ChiTaRSiArid3b. mouse.
PROiQ9Z1N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004661.
CleanExiMM_ARID3B.
ExpressionAtlasiQ9Z1N7. baseline and differential.
GenevisibleiQ9Z1N7. MM.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR023334. REKLES_domain.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARI3B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1N7
Secondary accession number(s): Q3UTG1, Q810L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.