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Q9Z1N7 (ARI3B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AT-rich interactive domain-containing protein 3B

Short name=ARID domain-containing protein 3B
Alternative name(s):
Bright and dead ringer protein
Bright-like protein
Gene names
Name:Arid3b
Synonyms:Bdp, Dril2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor involved in the production of cranial mesenchymal tissues. Favors nuclear targeting of ARID3A. Ref.4

Subunit structure

Heterodimer with ARID3A. Interacts with unphosphorylated RB1 By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed at high levels in testis. Also expressed in prostate, thyroid and thymus. Ref.4

Developmental stage

First detected at E7. Strongly expressed in cranial mesenchyme and caudal mesoderm. Expression in cranial mesenchyme decreases starting from E10.5. Ref.4

Disruption phenotype

Embryos die before E11.5 and display various abnormalities, including wavy neural tube, small branchial arches and defects of cardiovascular system. Ref.4

Sequence similarities

Contains 1 ARID domain.

Contains 1 REKLES domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z1N7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z1N7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     234-282: INRIPIMAKQ...TKGLNLPTSI → SGASPAGIVL...VIAHGSLGRD
     283-568: Missing.
Isoform 3 (identifier: Q9Z1N7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     232-287: TPINRIPIMA...LPTSITSAAF → DPAAAAECTA...QADPGPVHAV
     288-568: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568AT-rich interactive domain-containing protein 3B
PRO_0000295163

Regions

Domain213 – 30593ARID
Domain425 – 52298REKLES
Region201 – 374174Interaction with RB1 By similarity
Region495 – 51824Interaction with ARID3A By similarity
Compositional bias5 – 3733Gln-rich
Compositional bias88 – 936Poly-Glu
Compositional bias339 – 36224Ala-rich
Compositional bias528 – 56740Ser-rich

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue871Phosphoserine By similarity

Natural variations

Alternative sequence232 – 28756TPINR…TSAAF → DPAAAAECTAFLLPSLIVIK YPGTTQLSTIMQKGVWHPNQ PDSHHGQADPGPVHAV in isoform 3.
VSP_026775
Alternative sequence234 – 28249INRIP…LPTSI → SGASPAGIVLKATWPCGWPG QPPPLLCLVCILTRKKKKNV IAHGSLGRD in isoform 2.
VSP_026776
Alternative sequence283 – 568286Missing in isoform 2.
VSP_026777
Alternative sequence288 – 568281Missing in isoform 3.
VSP_026778

Experimental info

Sequence conflict991E → G in BAE24019. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 70250959E6EAF526

FASTA56861,015
        10         20         30         40         50         60 
MEPLQQQQQQ QQQKQPQQPL LQMDAREKQG PQTRESQFLY ASKLGTQPAL LSITPGRPSG 

        70         80         90        100        110        120 
SSVLGPLARV PPATPVARMS EQSNVNSEPE EEEGGLEDED GDDDVAEVAE KEAQAASKYF 

       130        140        150        160        170        180 
HMQKVTRQEP RATPMSSLLP VPGLSPQGQQ TKEDHTKDAS KAPPSVPTAG QPSWSLDEQL 

       190        200        210        220        230        240 
KQNGALAWSD DADGGRGREI SRDFAKLYEL DGDPERKEFL DDLFIFMQKR GTPINRIPIM 

       250        260        270        280        290        300 
AKQILDLYML YKLVTEKGGL VEIINKKIWR EITKGLNLPT SITSAAFTLR TQYMKYLYAY 

       310        320        330        340        350        360 
ECEKKALSSP AELQAAIDGN RREGRRPSYS SSLFGYSPAA AAAAAAAAAA AAASAASAGT 

       370        380        390        400        410        420 
PALLSSPKIR FSILGLGSSS GTSASSPRIP PASTLRKGDG VPVPVPNRLA VSGTLAGQQA 

       430        440        450        460        470        480 
GNRPGPLEHL RERLESGEPP EKKASRLSEE EQRLVQQAFQ RNLFSMARQL PMKIRINGRE 

       490        500        510        520        530        540 
DRAEPSAPAL NLTTSNIGSI NMSVDIDGTT YTGVLFAQKP VVHLIAGSTP QSIGSSASSS 

       550        560 
NSSSSHCSPS PTSSRGTPSA EPSTSWSL 

« Hide

Isoform 2 [UniParc].

Checksum: B18C5EB90DED77C4
Show »

FASTA28230,795
Isoform 3 [UniParc].

Checksum: 6DFB9E26A48E6A6C
Show »

FASTA28731,376

References

« Hide 'large scale' references
[1]"Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product."
Numata S., Claudio P.P., Dean C., Giordano A., Croce C.M.
Cancer Res. 59:3741-3747(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6J.
Tissue: Brain cortex.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo.
[4]"Microarray analysis of PDGFR alpha+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells."
Takebe A., Era T., Okada M., Martin Jakt L., Kuroda Y., Nishikawa S.
Dev. Biol. 293:25-37(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF116847 mRNA. Translation: AAD09134.1.
AK139455 mRNA. Translation: BAE24019.1.
BC049776 mRNA. Translation: AAH49776.1.
CCDSCCDS23233.1. [Q9Z1N7-1]
RefSeqNP_062663.1. NM_019689.2. [Q9Z1N7-1]
XP_006511354.1. XM_006511291.1. [Q9Z1N7-1]
UniGeneMm.425588.

3D structure databases

ProteinModelPortalQ9Z1N7.
SMRQ9Z1N7. Positions 174-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207941. 3 interactions.
IntActQ9Z1N7. 1 interaction.
STRING10090.ENSMUSP00000109802.

PTM databases

PhosphoSiteQ9Z1N7.

Proteomic databases

PRIDEQ9Z1N7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004780; ENSMUSP00000004780; ENSMUSG00000004661. [Q9Z1N7-1]
ENSMUST00000164035; ENSMUSP00000131677; ENSMUSG00000004661. [Q9Z1N7-3]
ENSMUST00000171444; ENSMUSP00000130173; ENSMUSG00000004661. [Q9Z1N7-1]
GeneID56380.
KEGGmmu:56380.
UCSCuc009pvt.2. mouse. [Q9Z1N7-1]

Organism-specific databases

CTD10620.
MGIMGI:1930768. Arid3b.

Phylogenomic databases

eggNOGNOG327790.
GeneTreeENSGT00550000074575.
HOGENOMHOG000236281.
HOVERGENHBG103680.
InParanoidQ9Z1N7.
OMAFHVQKVA.
OrthoDBEOG77DJ6W.
PhylomeDBQ9Z1N7.
TreeFamTF320364.

Gene expression databases

ArrayExpressQ9Z1N7.
BgeeQ9Z1N7.
CleanExMM_ARID3B.
GenevestigatorQ9Z1N7.

Family and domain databases

Gene3D1.10.150.60. 1 hit.
InterProIPR001606. ARID/BRIGHT_DNA-bd.
IPR023334. REKLES_domain.
[Graphical view]
PfamPF01388. ARID. 1 hit.
[Graphical view]
SMARTSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMSSF46774. SSF46774. 1 hit.
PROSITEPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312460.
PROQ9Z1N7.
SOURCESearch...

Entry information

Entry nameARI3B_MOUSE
AccessionPrimary (citable) accession number: Q9Z1N7
Secondary accession number(s): Q3UTG1, Q810L9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot