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Protein

Secreted frizzled-related sequence protein 4

Gene

Sfrp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related sequence protein 4
Short name:
FRP-4
Short name:
sFRP-4
Gene namesi
Name:Sfrp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:892010. Sfrp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 351333Secreted frizzled-related sequence protein 4PRO_0000032552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 85By similarity
Disulfide bondi32 ↔ 78By similarity
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi69 ↔ 108By similarity
Disulfide bondi97 ↔ 136By similarity
Disulfide bondi101 ↔ 125By similarity
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z1N6.
PRIDEiQ9Z1N6.

PTM databases

PhosphoSiteiQ9Z1N6.

Expressioni

Tissue specificityi

Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung.1 Publication

Developmental stagei

Only weakly expressed in developing embryo except for developing teeth, eye and salivary gland. In the developing eye, from E12.5, expressed in the future neural retina, in both the inner and outer cell layers. In the developing teeth, strong expression detected in the developing incisor teeth at E14.5. Expression localized to the mesenchyme of the dental follicle surrounding the enamel organ only at the early cap stage. Highly expressed in the branching epithelium of the salivary gland.1 Publication

Inductioni

Induced in ovaries by chorionic gonadotropin (CG).1 Publication

Gene expression databases

BgeeiENSMUSG00000021319.
CleanExiMM_SFRP4.
GenevisibleiQ9Z1N6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203187. 1 interaction.
STRINGi10090.ENSMUSP00000002883.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1N6.
SMRiQ9Z1N6. Positions 22-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 139121FZPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 306129NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231879.
HOVERGENiHBG070536.
InParanoidiQ9Z1N6.
KOiK02185.
OMAiNITRMPN.
OrthoDBiEOG091G0BGB.
PhylomeDBiQ9Z1N6.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026560. SFRP4.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF7. PTHR11309:SF7. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSILVALC LWLRLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST
60 70 80 90 100
QENAILAIEQ YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV
110 120 130 140 150
CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV
160 170 180 190 200
KWIDITPDMM VQERSFDADC KRLSPDRCKC KKVKPTLATY LSKNYSYVIH
210 220 230 240 250
AKIKAVQRSG CNEVTTVVDV KEIFKSLSPI PRTQVPLITN SSCQCPHILP
260 270 280 290 300
HQDVLIMCYE WRSRMMLLEN CLVEKWRDQL SRRSIQWEER LQEQQRTIQD
310 320 330 340 350
KKQIASRTSR TSRSNPPKSK GRPPAPKPAS PKKNIKARSA PKKSNLKKSA

S
Length:351
Mass (Da):40,342
Last modified:May 1, 1999 - v1
Checksum:i6CB0B625920A54FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991S → F (PubMed:9096311).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117709 mRNA. Translation: AAD12306.1.
AK080766 mRNA. Translation: BAC38013.1.
BC034853 mRNA. Translation: AAH34853.1.
U88569 Genomic DNA. No translation available.
AF364906 Genomic DNA. Translation: AAL14904.1.
CCDSiCCDS26261.1.
RefSeqiNP_057896.1. NM_016687.3.
UniGeneiMm.42095.

Genome annotation databases

EnsembliENSMUST00000002883; ENSMUSP00000002883; ENSMUSG00000021319.
GeneIDi20379.
KEGGimmu:20379.
UCSCiuc007ppg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117709 mRNA. Translation: AAD12306.1.
AK080766 mRNA. Translation: BAC38013.1.
BC034853 mRNA. Translation: AAH34853.1.
U88569 Genomic DNA. No translation available.
AF364906 Genomic DNA. Translation: AAL14904.1.
CCDSiCCDS26261.1.
RefSeqiNP_057896.1. NM_016687.3.
UniGeneiMm.42095.

3D structure databases

ProteinModelPortaliQ9Z1N6.
SMRiQ9Z1N6. Positions 22-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203187. 1 interaction.
STRINGi10090.ENSMUSP00000002883.

PTM databases

PhosphoSiteiQ9Z1N6.

Proteomic databases

PaxDbiQ9Z1N6.
PRIDEiQ9Z1N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002883; ENSMUSP00000002883; ENSMUSG00000021319.
GeneIDi20379.
KEGGimmu:20379.
UCSCiuc007ppg.2. mouse.

Organism-specific databases

CTDi6424.
MGIiMGI:892010. Sfrp4.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231879.
HOVERGENiHBG070536.
InParanoidiQ9Z1N6.
KOiK02185.
OMAiNITRMPN.
OrthoDBiEOG091G0BGB.
PhylomeDBiQ9Z1N6.

Miscellaneous databases

PROiQ9Z1N6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021319.
CleanExiMM_SFRP4.
GenevisibleiQ9Z1N6. MM.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026560. SFRP4.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF7. PTHR11309:SF7. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFRP4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1N6
Secondary accession number(s): Q91ZX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.