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Protein

Unconventional myosin-IXa

Gene

Myo9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons, has a role in the regulation of neuronal morphology and function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi239 – 2468ATPSequence analysis
Zinc fingeri2067 – 211650Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Motor protein, Myosin

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-IXa
Alternative name(s):
Myr 7
Unconventional myosin-9a
Gene namesi
Name:Myo9a
Synonyms:Myr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621395. Myo9a.

Subcellular locationi

  • Membrane Curated; Single-pass membrane protein Curated
  • Cytoplasm 1 Publication

  • Note: Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26262626Unconventional myosin-IXaPRO_0000348442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei755 – 7551PhosphoserineCombined sources
Modified residuei1243 – 12431PhosphoserineBy similarity
Modified residuei1245 – 12451PhosphothreonineBy similarity
Modified residuei1259 – 12591PhosphoserineCombined sources
Modified residuei1300 – 13001PhosphoserineBy similarity
Modified residuei1318 – 13181PhosphoserineBy similarity
Modified residuei2016 – 20161PhosphoserineCombined sources
Modified residuei2380 – 23801PhosphoserineBy similarity
Modified residuei2542 – 25421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1N3.
PRIDEiQ9Z1N3.

PTM databases

iPTMnetiQ9Z1N3.
PhosphoSiteiQ9Z1N3.

Expressioni

Tissue specificityi

Expressed at high levels in brain, followed by testis and spleen. Expressed at very low levels, in kidney. Detected abundantly in brain and testis and at lower levels in adrenal gland, kidney, lung and spleen (at protein level). In adrenal gland it is mostly found in the medulla but not in the cortex. In brain, it is found in the cerebellum and the CA2-CA3 regions of the hippocampus.1 Publication

Developmental stagei

Expressed at high levels in developing forebrain. This expression decreases slightly in embryonic and early postnatal days.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015963.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 11299Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini146 – 1017872Myosin motorAdd
BLAST
Domaini1021 – 104121IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 107230IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini1075 – 110430IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini1116 – 114530IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini1139 – 116830IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini2131 – 2319189Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni908 – 91912Actin-bindingBy similarityAdd
BLAST
Regioni1022 – 1163142Neck or regulatory domainBy similarityAdd
BLAST
Regioni1164 – 25891426TailBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1265 – 129228Sequence analysisAdd
BLAST
Coiled coili1493 – 154048Sequence analysisAdd
BLAST
Coiled coili2408 – 244437Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2067 – 211650Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
KOG4229. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000113707.
HOVERGENiHBG108165.
InParanoidiQ9Z1N3.
KOiK10360.
PhylomeDBiQ9Z1N3.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR028558. MYO9A.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
IPR002219. PE/DAG-bd.
IPR000159. RA_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR13140:SF9. PTHR13140:SF9. 8 hits.
PfamiPF00612. IQ. 4 hits.
PF00063. Myosin_head. 2 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00109. C1. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
SM00314. RA. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52540. SSF52540. 3 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSDGGRRR FEDNEHTLRI YPGTISEGTI YCPIPARKNS TAAEVIDSLI
60 70 80 90 100
NRLHLDKTKC YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG
110 120 130 140 150
EDYRFLLREK NLDGSIHYGS LQSWLRVTEE RRRMMERGFL PQPQQKDFDD
160 170 180 190 200
LCSLPDLNEK TLLENLRNRF KHEKIYTYVG SILIAINPFK FLPIYNPKYV
210 220 230 240 250
KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE SGSGKTQSTN
260 270 280 290 300
FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI
310 320 330 340 350
QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEEER
360 370 380 390 400
LAFHLKQPEE YHFLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE
410 420 430 440 450
RLQLAMEMVG FLPKTRRQIF SLLSAILHLG NISYKKKTYR DDSIDICNPE
460 470 480 490 500
VLPIVSELLE VKEEMLFEAL VTRKTVTVGE KLILPYKLAE AVTVRNSMAK
510 520 530 540 550
SLYSALFDWI VFRINHALLN SKDLEKDTKT LSIGVLDIFG FEDYENNSFE
560 570 580 590 600
QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS
610 620 630 640 650
KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEENSYIEF PAVMEPAFII
660 670 680 690 700
KHYAGKVKYG VKDFREKNTD HMRPDIVALL RSSRNAFVSG MTGIDPVAVF
710 720 730 740 750
RWAVLRAFFR AVVAFREAGK RHIQRKSGHD DTTPCTILKS MDSFSFLQHP
760 770 780 790 800
VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD LQGMNTLNEK NQHDTFDIAW
810 820 830 840 850
NVRTGIRQSR LPTNNTSLLD KDGIFANSAS SKLLERAHGI LTRNKNFRSK
860 870 880 890 900
PVLPKHLLEV NSLKHLTRLT LQDRITKSLL HLHKKKKPPS ISAQFQVSLS
910 920 930 940 950
KLMETLDQAE PYFVKCIRSN AEKLPLRFSD ALVLRQLRYT GMLETVRIRQ
960 970 980 990 1000
SGYSSKYSFQ DFVSHFHVLL PQHIIPSKFN IQDFFRKINI NPDNYQVGKT
1010 1020 1030 1040 1050
MVFLKEHERQ HLQDLLHQEV LRRIILLQRW FRVLLSRQQF LHLRQASVII
1060 1070 1080 1090 1100
QRFWRNYLNQ KQVRNAAVEK DAFIMASAAS LLQASWRAHL ERQRYLELRA
1110 1120 1130 1140 1150
AAVIIQQRWR ELCRRRHRAA TCIQSRWRGY RQSKKYKEQR NKIILLQSIY
1160 1170 1180 1190 1200
RGFRARQRYK ALKEERLKET KLEHGLAQIK TCGPLEIQGS DPSEWEDRSF
1210 1220 1230 1240 1250
ANRVKAIEEC KSVIESNRIS RESSMDFSKE SPDKQQERGR SQSGTDLQGD
1260 1270 1280 1290 1300
VIVRQRPKSL EDLHQKKVGR AKRESRRMRE LEQAIFSLEL LKVRSLGGMS
1310 1320 1330 1340 1350
PSEERRWSTE LMPEGLQSPQ GTPDSESSQG SLELLTCDEN QKSKPESLIL
1360 1370 1380 1390 1400
DDGELKISSP STFTNPKFDS QNNALSASSE TSSTFSGKGA SSDSEHLKNG
1410 1420 1430 1440 1450
TAEEKLVYSS QPITCKSQLR DSFVSSSLPT FFYIPHQEPL KTSSQLDTSI
1460 1470 1480 1490 1500
QRNKLPERET TLKTTLTLDI NREARKCQFS GQVTPLNPDS SCTVLKKLEK
1510 1520 1530 1540 1550
LNIEKEKRQK QLQQQNEKEM MEQIRQQTDI LEKERKAFKT IEQSRTEASL
1560 1570 1580 1590 1600
LAPSFYQSRQ KVERPSSLHI QNTPSKGEAG VLGSPSALAT KDSPSIHLPP
1610 1620 1630 1640 1650
KDRPVTLFFE RKGSPCQSRT VKELTKTERM GTQHDAACRL SNNHNTEREH
1660 1670 1680 1690 1700
FKSTHSYSHR SDDPSREGSS RPIFFTPKDN VITPLVHSGN PQVHKQDEPA
1710 1720 1730 1740 1750
WKSKLAGPGQ REVARPAHKK KARMARTRSD FLTRGTFADG EGDTEEDDYD
1760 1770 1780 1790 1800
DIIEPLLSLD QASHSELGPV SSLGQASHSD SEMTSQRFSS VDEQARLHKA
1810 1820 1830 1840 1850
MSQGEITKLA GRQKSSDLDI RPQRAKMRFW AKGKQGEKKT TRVKPAPQSE
1860 1870 1880 1890 1900
VSSLFAGSDV TPVHPFSDEL TQYHPTPPLS PELPGSCRKE FKENKEPSPK
1910 1920 1930 1940 1950
AKRKRGVKIS SVALDSMHWQ NDSVQIIASA NDLKSMDEFL LKKMNDLDNE
1960 1970 1980 1990 2000
DSKKDTLVDV VFKKALKEFR QNIFSSYSSA LAMDDGKSIR YKDLYALFEQ
2010 2020 2030 2040 2050
ILEKTMRFEQ RDWNESPVRV WVNTFKVFLD EYMNEFKTLD STAPKVLKTE
2060 2070 2080 2090 2100
RKKRRKKETD LVEEHNGHMF KATQYSIPTY CEYCSSLIWI MDRASVCKLC
2110 2120 2130 2140 2150
KYACHKKCCL KTTAKCSKKY DPELSSRQFG VELSRLTSED RAVPLVVEKL
2160 2170 2180 2190 2200
INYIEMHGLY TEGIYRKSGS TNKIKELRQG LDTDAESVNL DDYNIHVIAS
2210 2220 2230 2240 2250
VFKQWLRDLP NPLMTFELYE EFLRAMGLQE RKETIRGVYS VIDQLSRTHL
2260 2270 2280 2290 2300
STLERLIFHL VRIALQEDTN RMSANALAIV FAPCILRCPD TTDPLQSVQD
2310 2320 2330 2340 2350
ISKTTTCVEL IVVEQMNKYK ARLKDISSLE FAENKAKTRL SLIRRSMKPV
2360 2370 2380 2390 2400
LIAVRFMSIT RSSVSGKGRL HRGSHPNPSS PVIVRLPSMS DVPEETLTSE
2410 2420 2430 2440 2450
TAMDTDVTDQ QQAAMQQEEK VLTEQIENLQ KEKEELTFEM LVLEPRASDD
2460 2470 2480 2490 2500
EALESEASIG TADSSENLNM DPEERSLALS SLKAAGKSEP SSKFRKQLRK
2510 2520 2530 2540 2550
QPDSLDSVSS SVSSCLSNTT SSHGTRKRFQ IYSKSPFYRA ASACEAQGME
2560 2570 2580 2590 2600
GPLGQAKSLE DRPQFISRGT FNPEKGKQKL KNVKNSPQKT KETPEGTVSS
2610 2620
GRKKTVDSDC SSTQQLPLFG NNEFMV
Length:2,626
Mass (Da):301,382
Last modified:May 1, 1999 - v1
Checksum:i3F70610271E4D791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001713 mRNA. Translation: CAA04946.1.
PIRiT31099.
RefSeqiNP_599162.1. NM_134335.1.
UniGeneiRn.88901.

Genome annotation databases

GeneIDi171296.
KEGGirno:171296.
UCSCiRGD:621395. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001713 mRNA. Translation: CAA04946.1.
PIRiT31099.
RefSeqiNP_599162.1. NM_134335.1.
UniGeneiRn.88901.

3D structure databases

ProteinModelPortaliQ9Z1N3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015963.

PTM databases

iPTMnetiQ9Z1N3.
PhosphoSiteiQ9Z1N3.

Proteomic databases

PaxDbiQ9Z1N3.
PRIDEiQ9Z1N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171296.
KEGGirno:171296.
UCSCiRGD:621395. rat.

Organism-specific databases

CTDi4649.
RGDi621395. Myo9a.

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
KOG4229. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000113707.
HOVERGENiHBG108165.
InParanoidiQ9Z1N3.
KOiK10360.
PhylomeDBiQ9Z1N3.

Miscellaneous databases

PROiQ9Z1N3.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR028558. MYO9A.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
IPR002219. PE/DAG-bd.
IPR000159. RA_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR13140:SF9. PTHR13140:SF9. 8 hits.
PfamiPF00612. IQ. 4 hits.
PF00063. Myosin_head. 2 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00109. C1. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
SM00314. RA. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52540. SSF52540. 3 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO9A_RAT
AccessioniPrimary (citable) accession number: Q9Z1N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.