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Q9Z1N2

- ORC1_MOUSE

UniProt

Q9Z1N2 - ORC1_MOUSE

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Protein
Origin recognition complex subunit 1
Gene
Orc1, Orc1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931Histone H4K20me2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi513 – 5208ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: MGI
  3. chromatin binding Source: InterPro
  4. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. DNA replication Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198608. G1/S-Specific Transcription.
REACT_204269. E2F-enabled inhibition of pre-replication complex formation.
REACT_206830. E2F mediated regulation of DNA replication.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 1
Gene namesi
Name:Orc1
Synonyms:Orc1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1328337. Orc1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear origin of replication recognition complex Source: UniProtKB
  3. nucleolus Source: Ensembl
  4. nucleus Source: MGI
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Origin recognition complex subunit 1
PRO_0000127068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761Phosphoserine By similarity
Modified residuei291 – 2911Phosphoserine By similarity

Post-translational modificationi

Phosphorylated during mitosis By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z1N2.
PaxDbiQ9Z1N2.
PRIDEiQ9Z1N2.

PTM databases

PhosphoSiteiQ9Z1N2.

Expressioni

Gene expression databases

ArrayExpressiQ9Z1N2.
BgeeiQ9Z1N2.
GenevestigatoriQ9Z1N2.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity. Interacts with CDC6 and KAT7/HBO1 By similarity. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated By similarity.1 Publication

Protein-protein interaction databases

BioGridi201974. 9 interactions.
DIPiDIP-32115N.
IntActiQ9Z1N2. 7 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 186
Beta strandi28 – 3710
Beta strandi43 – 475
Beta strandi51 – 544
Beta strandi57 – 604
Beta strandi63 – 7311
Beta strandi76 – 783
Beta strandi80 – 9011
Helixi91 – 933
Turni96 – 983
Helixi99 – 1024
Beta strandi110 – 1145
Beta strandi117 – 1193
Beta strandi122 – 1243
Helixi125 – 1273
Beta strandi128 – 1369
Beta strandi151 – 1599
Beta strandi164 – 1663

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOVX-ray1.70A/C9-170[»]
4DOWX-ray1.95A/B9-170[»]
ProteinModelPortaliQ9Z1N2.
SMRiQ9Z1N2. Positions 13-169, 479-713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 170127BAH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni480 – 840361Necessary and sufficient for ORC complex assembly By similarity
Add
BLAST

Domaini

The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at replication origins.

Sequence similaritiesi

Belongs to the ORC1 family.
Contains 1 BAH domain.

Phylogenomic databases

eggNOGiCOG1474.
GeneTreeiENSGT00530000063498.
HOGENOMiHOG000231132.
HOVERGENiHBG007873.
InParanoidiA2A8R3.
KOiK02603.
OMAiIYSQHVA.
OrthoDBiEOG7QG44J.
TreeFamiTF313743.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C_dom.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1N2-1 [UniParc]FASTAAdd to Basket

« Hide

MPSYLTRQKT RQTFSWVGRP LPNRKQFQQM YREICMKIND GSEIHIKVGQ    50
FVLIQGEDNK KPYVAKLIEL FQNGAEVPPK KCARVQWFVR FLEIPVSKRH 100
LLGRSPPAQE IFWYDCSDWD NKINVETIIG PVQVVALAPE EVIPVDQKSE 150
ETLFVKLSWN KKDFAPLPPE VLAALREQED SPEWQKPLKA KIKNVKSPAR 200
NTTEQEVKGI KSNHSTSKFH QTPANIVIPN AKKSLELDGL GFTRKPNTRW 250
SKKSSCDSLD YQKTSKRRAA FSETTSPPKK PNKPREIKPS SALETRVKNG 300
QTQPFCAKSS VVLRARNPAM TTTKLGVDNT LSPIRNGLRS SVVPSGGLTP 350
VYIRRKAKEQ ETHKEPIRTS RVHRKSSLLT LKRIRQQLCL LDGDDRDQEE 400
EESVDSESEE EDEFISSLPT RNSLGQSRTR QTPSKSPQKN PKPRTPHRAT 450
PQIRDRNLAV QEPASALEEA RLRLHVSAVP DSLPCREQEF QDIYSFVESK 500
LLDGTGGCMY ISGVPGTGKT ATVHEVIRCL QQAAETDDVP PFQYVEVNGM 550
KLTEPHQVYV QILKKLTGQK ATANHAAELL AKQFCGQGSQ KETTVLLVDE 600
LDLLWTHKQD VMYNLFDWPT HKGAHLIVLT IANTMDLPER IMMNRVSSRL 650
GLTRMSFQPY SHSQLKQILV SRLRNLRAFE DDAIQLVARK VAALSGDARR 700
CLDICRRATE ICELSHLRGD SLSLVTVAHL MEAIDEMFSS SYITAIKNSS 750
VVEQSFLRAI IAEFRRSGLE EATFQQIYSQ HVALCRMEGL PYPTMSETMA 800
VCSRLGSCRL LLVEPSRNDL LLRVRLNVSQ NDVLFALKEE 840
Length:840
Mass (Da):95,103
Last modified:July 27, 2011 - v2
Checksum:i12769943A354CA8B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301N → S in CAA05890. 1 Publication
Sequence conflicti230 – 2301N → S in AAH15073. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ003133 mRNA. Translation: CAA05890.1.
AL626783 Genomic DNA. Translation: CAM23501.1.
BC015073 mRNA. Translation: AAH15073.1.
CCDSiCCDS18453.1.
RefSeqiNP_035145.2. NM_011015.2.
UniGeneiMm.294154.

Genome annotation databases

EnsembliENSMUST00000102744; ENSMUSP00000099805; ENSMUSG00000028587.
GeneIDi18392.
KEGGimmu:18392.
UCSCiuc008ubh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ003133 mRNA. Translation: CAA05890.1 .
AL626783 Genomic DNA. Translation: CAM23501.1 .
BC015073 mRNA. Translation: AAH15073.1 .
CCDSi CCDS18453.1.
RefSeqi NP_035145.2. NM_011015.2.
UniGenei Mm.294154.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DOV X-ray 1.70 A/C 9-170 [» ]
4DOW X-ray 1.95 A/B 9-170 [» ]
ProteinModelPortali Q9Z1N2.
SMRi Q9Z1N2. Positions 13-169, 479-713.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201974. 9 interactions.
DIPi DIP-32115N.
IntActi Q9Z1N2. 7 interactions.

PTM databases

PhosphoSitei Q9Z1N2.

Proteomic databases

MaxQBi Q9Z1N2.
PaxDbi Q9Z1N2.
PRIDEi Q9Z1N2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102744 ; ENSMUSP00000099805 ; ENSMUSG00000028587 .
GeneIDi 18392.
KEGGi mmu:18392.
UCSCi uc008ubh.2. mouse.

Organism-specific databases

CTDi 4998.
MGIi MGI:1328337. Orc1.

Phylogenomic databases

eggNOGi COG1474.
GeneTreei ENSGT00530000063498.
HOGENOMi HOG000231132.
HOVERGENi HBG007873.
InParanoidi A2A8R3.
KOi K02603.
OMAi IYSQHVA.
OrthoDBi EOG7QG44J.
TreeFami TF313743.

Enzyme and pathway databases

Reactomei REACT_198608. G1/S-Specific Transcription.
REACT_204269. E2F-enabled inhibition of pre-replication complex formation.
REACT_206830. E2F mediated regulation of DNA replication.

Miscellaneous databases

NextBioi 293996.
PROi Q9Z1N2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z1N2.
Bgeei Q9Z1N2.
Genevestigatori Q9Z1N2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C_dom.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1."
    Zisimopoulou P., Staib C., Nanda I., Schmid M., Grummt F.
    Mol. Gen. Genet. 260:295-299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  4. "The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome."
    Kuo A.J., Song J., Cheung P., Ishibe-Murakami S., Yamazoe S., Chen J.K., Patel D.J., Gozani O.
    Nature 484:115-119(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 9-170, INTERACTION WITH H4K20ME2.

Entry informationi

Entry nameiORC1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1N2
Secondary accession number(s): A2A8R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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