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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.By similarity

Cofactori

FADBy similarity

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139FADBy similarity1
Binding sitei178FAD; via amide nitrogenBy similarity1
Active sitei421Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1By similarity (EC:1.3.3.6By similarity)
Short name:
AOXBy similarity
Alternative name(s):
Palmitoyl-CoA oxidase1 Publication
Gene namesi
Name:ACOX1By similarity
Synonyms:PCOX11 Publication
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Peroxisome By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046761 – 661Peroxisomal acyl-coenzyme A oxidase 1Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1
Modified residuei65N6-acetyllysineBy similarity1
Modified residuei89N6-succinyllysineBy similarity1
Modified residuei159N6-succinyllysineBy similarity1
Modified residuei216N6-acetyllysineBy similarity1
Modified residuei241N6-succinyllysineBy similarity1
Modified residuei255N6-acetyllysineBy similarity1
Modified residuei267N6-acetyllysineBy similarity1
Modified residuei272N6-acetyllysineBy similarity1
Modified residuei349N6-succinyllysineBy similarity1
Modified residuei437N6-acetyllysine; alternateBy similarity1
Modified residuei437N6-succinyllysine; alternateBy similarity1
Modified residuei446N6-acetyllysine; alternateBy similarity1
Modified residuei446N6-succinyllysine; alternateBy similarity1
Modified residuei500N6-acetyllysineBy similarity1
Modified residuei512N6-acetyllysine; alternateBy similarity1
Modified residuei512N6-succinyllysine; alternateBy similarity1
Modified residuei542N6-succinyllysineBy similarity1
Modified residuei637N6-acetyllysine; alternateBy similarity1
Modified residuei637N6-succinyllysine; alternateBy similarity1
Modified residuei643N6-succinyllysineBy similarity1
Modified residuei649PhosphoserineBy similarity1
Modified residuei652N6-acetyllysineBy similarity1
Modified residuei655N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9Z1N0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014695.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1N0.
SMRiQ9Z1N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi659 – 661Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000181256.
HOVERGENiHBG050451.
InParanoidiQ9Z1N0.
OrthoDBiEOG091G0A1P.

Family and domain databases

CDDicd01150. AXO. 1 hit.
Gene3Di1.10.540.10. 1 hit.
InterProiView protein in InterPro
IPR034171. ACO.
IPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
PfamiView protein in Pfam
PF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLRRERA AATFNPELIT HLLDGSPEKT RRRREIENKI LSDPDFQHEN
60 70 80 90 100
HNFLTRSERY EAAIKKSAVM VKKMREFGIA DPDEIMWFKR LLLGNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWLHPSTGL QIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPKT QEFIINSPTV TSIKWWPGGL GKTSNHAIVL AQLITQGKCY
210 220 230 240 250
GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKYAQVK PDGTYVKPVS NKLTYGTMVF VRSFLVGAAA QSLSKACTIA
310 320 330 340 350
IRYSAVRHQS EIKPGEPEPQ VLDFQTQQYK LFPILATAYA FQFVGSYMKD
360 370 380 390 400
TYHRINESIG QGDLSELPEL HALTAGLKAF TTWTANAGIE ECRLACGGHG
410 420 430 440 450
YSHCSGIPNI YVTFTPACTF EGENTVMMLQ TARFLMKVYD QVQSGKLVHG
460 470 480 490 500
LVSYLNDLPS QRIQPQQVAV WPTVVDINNP DSLTEIYKLR AARLIDIAAK
510 520 530 540 550
SLQGEMSHRK SKEVAWNLTS VGLVRATDAH CHYVVVKLFA DKLLKIQDKT
560 570 580 590 600
IQAVLRNLFL LYSLYGISQK AGDFLQGNIM TGSQITQVNQ RVLELLAVIR
610 620 630 640 650
PNAVALVDAF DYKDITLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
HKYLKPLQSK L
Length:661
Mass (Da):74,390
Last modified:May 1, 1999 - v1
Checksum:iD360D9515259E76A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005112 mRNA. Translation: CAA06376.1.
RefSeqiNP_001166377.1. NM_001172906.1.

Genome annotation databases

GeneIDi100135467.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACOX1_CAVPO
AccessioniPrimary (citable) accession number: Q9Z1N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families