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Reviewed, UniProtKB/Swiss-Prot Q9Z1N0 (ACOX1_CAVPO)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Peroxisomal acyl-coenzyme A oxidase 1
      Short name=AOX
    EC=1.3.3.6
Alternative name(s):
    Palmitoyl-CoA oxidase
Gene names
Name: ACOX1
Synonyms: PCOX1
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

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Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the desaturation of very long chain acyl-CoAs to 2-trans-enoyl-CoAs By similarity.

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 661661Peroxisomal acyl-coenzyme A oxidase 1
PRO_0000204676

Regions

Motif659 – 6613Microbody targeting signal By similarity

Sites

Active site4211Proton acceptor By similarity
Binding site1391FAD By similarity
Binding site1781FAD; via amide nitrogen By similarity

Amino acid modifications

Modified residue261Phosphoserine By similarity
Modified residue2671N6-acetyllysine By similarity
Modified residue3101Phosphoserine By similarity
Modified residue6431N6-acetyllysine By similarity
Modified residue6491Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9Z1N0-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D360D9515259E76A

FASTA66174,390
        10         20         30         40         50         60 
MNPDLRRERA AATFNPELIT HLLDGSPEKT RRRREIENKI LSDPDFQHEN HNFLTRSERY 

        70         80         90        100        110        120 
EAAIKKSAVM VKKMREFGIA DPDEIMWFKR LLLGNFVEPV GLNYSMFIPT LLNQGTTAQQ 

       130        140        150        160        170        180 
EKWLHPSTGL QIIGTYAQTE MGHGTHLRGL ETTATYDPKT QEFIINSPTV TSIKWWPGGL 

       190        200        210        220        230        240 
GKTSNHAIVL AQLITQGKCY GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL 

       250        260        270        280        290        300 
KMDNYRIPRE NMLMKYAQVK PDGTYVKPVS NKLTYGTMVF VRSFLVGAAA QSLSKACTIA 

       310        320        330        340        350        360 
IRYSAVRHQS EIKPGEPEPQ VLDFQTQQYK LFPILATAYA FQFVGSYMKD TYHRINESIG 

       370        380        390        400        410        420 
QGDLSELPEL HALTAGLKAF TTWTANAGIE ECRLACGGHG YSHCSGIPNI YVTFTPACTF 

       430        440        450        460        470        480 
EGENTVMMLQ TARFLMKVYD QVQSGKLVHG LVSYLNDLPS QRIQPQQVAV WPTVVDINNP 

       490        500        510        520        530        540 
DSLTEIYKLR AARLIDIAAK SLQGEMSHRK SKEVAWNLTS VGLVRATDAH CHYVVVKLFA 

       550        560        570        580        590        600 
DKLLKIQDKT IQAVLRNLFL LYSLYGISQK AGDFLQGNIM TGSQITQVNQ RVLELLAVIR 

       610        620        630        640        650        660 
PNAVALVDAF DYKDITLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY HKYLKPLQSK 


L

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References

[1]"Molecular characterization of guinea pig peroxisomal palmitoyl-CoA oxidase 1."
Baumgart E., Van Veldhoven P.P., Althoff B., Mannaerts G.P., Voelkl A., Fahimi D.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AJ005112 mRNA. Translation: CAA06376.1.

3D structure databases

HSSPHSSP built from PDB template 1IS2 based on UniProtKB P07872.
SMRQ9Z1N0. Positions 1-655.
ModBaseSearch...

Genome annotation databases

EnsemblENSCPOG00000015141. Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGENQ9Z1N0.

Enzyme and pathway databases

BRENDA1.3.3.6. 44.

Family and domain databases

InterProIPR006091. Acyl-CoA_Oxase/DH_M.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHERPTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameACOX1_CAVPO
AccessionPrimary (citable) accession number: Q9Z1N0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents