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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391FADBy similarity
Binding sitei178 – 1781FAD; via amide nitrogenBy similarity
Active sitei421 – 4211Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1 (EC:1.3.3.6)
Short name:
AOX
Alternative name(s):
Palmitoyl-CoA oxidase
Gene namesi
Name:ACOX1
Synonyms:PCOX1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Peroxisomal acyl-coenzyme A oxidase 1PRO_0000204676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity
Modified residuei65 – 651N6-acetyllysineBy similarity
Modified residuei89 – 891N6-succinyllysineBy similarity
Modified residuei159 – 1591N6-succinyllysineBy similarity
Modified residuei216 – 2161N6-acetyllysineBy similarity
Modified residuei241 – 2411N6-succinyllysineBy similarity
Modified residuei255 – 2551N6-acetyllysineBy similarity
Modified residuei267 – 2671N6-acetyllysineBy similarity
Modified residuei272 – 2721N6-acetyllysineBy similarity
Modified residuei349 – 3491N6-succinyllysineBy similarity
Modified residuei437 – 4371N6-acetyllysine; alternateBy similarity
Modified residuei437 – 4371N6-succinyllysine; alternateBy similarity
Modified residuei446 – 4461N6-acetyllysine; alternateBy similarity
Modified residuei446 – 4461N6-succinyllysine; alternateBy similarity
Modified residuei500 – 5001N6-acetyllysineBy similarity
Modified residuei512 – 5121N6-acetyllysine; alternateBy similarity
Modified residuei512 – 5121N6-succinyllysine; alternateBy similarity
Modified residuei542 – 5421N6-succinyllysineBy similarity
Modified residuei637 – 6371N6-acetyllysine; alternateBy similarity
Modified residuei637 – 6371N6-succinyllysine; alternateBy similarity
Modified residuei643 – 6431N6-succinyllysineBy similarity
Modified residuei649 – 6491PhosphoserineBy similarity
Modified residuei652 – 6521N6-acetyllysineBy similarity
Modified residuei655 – 6551N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9Z1N0.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014695.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1N0.
SMRiQ9Z1N0. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi659 – 6613Microbody targeting signalBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000181256.
HOVERGENiHBG050451.
InParanoidiQ9Z1N0.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLRRERA AATFNPELIT HLLDGSPEKT RRRREIENKI LSDPDFQHEN
60 70 80 90 100
HNFLTRSERY EAAIKKSAVM VKKMREFGIA DPDEIMWFKR LLLGNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWLHPSTGL QIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPKT QEFIINSPTV TSIKWWPGGL GKTSNHAIVL AQLITQGKCY
210 220 230 240 250
GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKYAQVK PDGTYVKPVS NKLTYGTMVF VRSFLVGAAA QSLSKACTIA
310 320 330 340 350
IRYSAVRHQS EIKPGEPEPQ VLDFQTQQYK LFPILATAYA FQFVGSYMKD
360 370 380 390 400
TYHRINESIG QGDLSELPEL HALTAGLKAF TTWTANAGIE ECRLACGGHG
410 420 430 440 450
YSHCSGIPNI YVTFTPACTF EGENTVMMLQ TARFLMKVYD QVQSGKLVHG
460 470 480 490 500
LVSYLNDLPS QRIQPQQVAV WPTVVDINNP DSLTEIYKLR AARLIDIAAK
510 520 530 540 550
SLQGEMSHRK SKEVAWNLTS VGLVRATDAH CHYVVVKLFA DKLLKIQDKT
560 570 580 590 600
IQAVLRNLFL LYSLYGISQK AGDFLQGNIM TGSQITQVNQ RVLELLAVIR
610 620 630 640 650
PNAVALVDAF DYKDITLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
HKYLKPLQSK L
Length:661
Mass (Da):74,390
Last modified:May 1, 1999 - v1
Checksum:iD360D9515259E76A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005112 mRNA. Translation: CAA06376.1.
RefSeqiNP_001166377.1. NM_001172906.1.

Genome annotation databases

GeneIDi100135467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005112 mRNA. Translation: CAA06376.1.
RefSeqiNP_001166377.1. NM_001172906.1.

3D structure databases

ProteinModelPortaliQ9Z1N0.
SMRiQ9Z1N0. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014695.

Proteomic databases

PRIDEiQ9Z1N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135467.

Organism-specific databases

CTDi51.

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000181256.
HOVERGENiHBG050451.
InParanoidiQ9Z1N0.

Enzyme and pathway databases

UniPathwayiUPA00661.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of guinea pig peroxisomal palmitoyl-CoA oxidase 1."
    Baumgart E., Van Veldhoven P.P., Althoff B., Mannaerts G.P., Voelkl A., Fahimi D.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiACOX1_CAVPO
AccessioniPrimary (citable) accession number: Q9Z1N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.