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Protein

Ribosomal protein S6 kinase beta-2

Gene

Rps6kb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates specifically ribosomal protein S6.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 81ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translational initiation Source: MGI
  • protein kinase B signaling Source: MGI
  • protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-198693. AKT phosphorylates targets in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)
Short name:
S6K-beta-2
Short name:
S6K2
Alternative name(s):
70 kDa ribosomal protein S6 kinase 2
p70 ribosomal S6 kinase beta
Short name:
p70 S6 kinase beta
Short name:
p70 S6K-beta
Short name:
p70 S6KB
Gene namesi
Name:Rps6kb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1927343. Rps6kb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862151 – 485Ribosomal protein S6 kinase beta-2Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei476Phosphoserine; by PKCBy similarity1

Post-translational modificationi

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z1M4.
MaxQBiQ9Z1M4.
PaxDbiQ9Z1M4.
PRIDEiQ9Z1M4.

PTM databases

iPTMnetiQ9Z1M4.
PhosphoSitePlusiQ9Z1M4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024830.
ExpressionAtlasiQ9Z1M4. baseline and differential.
GenevisibleiQ9Z1M4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1M4.
SMRiQ9Z1M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 328Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini329 – 399AGC-kinase C-terminalAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 480Nuclear localization signalBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 485Pro-richAdd BLAST75

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133668.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9Z1M4.
KOiK04688.
OMAiYMKAERE.
OrthoDBiEOG091G05Z7.
PhylomeDBiQ9Z1M4.
TreeFamiTF313438.

Family and domain databases

CDDicd05584. STKc_p70S6K. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016238. Ribosomal_S6_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LGELRAAGLE TVGHYEEVEL
60 70 80 90 100
TESSVNLGPE RIGPHCFELL SVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVCSA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSHGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAITHTFC GTIEYMAPEI LVRTGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLA
310 320 330 340 350
KKFLKRNPTQ RIGGGLGDAA DVQRHPFFRH INWDDLLARR VDPPFRPSLQ
360 370 380 390 400
SEEDVSQFDA RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRT PISPLKFSPF EGFRPSPGPP EPMEPSLPPL
460 470 480
LPSPPSPPPT STAPLPIRPP SGTKKSKKGR GRSGR
Length:485
Mass (Da):53,538
Last modified:May 1, 1999 - v1
Checksum:i396929ADAB0F6CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA. Translation: CAA07774.1.
AK014412 mRNA. Translation: BAB29335.1.
CCDSiCCDS29419.1.
RefSeqiNP_067460.1. NM_021485.2.
UniGeneiMm.271937.

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830.
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721.
GeneIDi58988.
KEGGimmu:58988.
UCSCiuc008fzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA. Translation: CAA07774.1.
AK014412 mRNA. Translation: BAB29335.1.
CCDSiCCDS29419.1.
RefSeqiNP_067460.1. NM_021485.2.
UniGeneiMm.271937.

3D structure databases

ProteinModelPortaliQ9Z1M4.
SMRiQ9Z1M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749.

PTM databases

iPTMnetiQ9Z1M4.
PhosphoSitePlusiQ9Z1M4.

Proteomic databases

EPDiQ9Z1M4.
MaxQBiQ9Z1M4.
PaxDbiQ9Z1M4.
PRIDEiQ9Z1M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830.
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721.
GeneIDi58988.
KEGGimmu:58988.
UCSCiuc008fzb.1. mouse.

Organism-specific databases

CTDi6199.
MGIiMGI:1927343. Rps6kb2.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133668.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9Z1M4.
KOiK04688.
OMAiYMKAERE.
OrthoDBiEOG091G05Z7.
PhylomeDBiQ9Z1M4.
TreeFamiTF313438.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-198693. AKT phosphorylates targets in the nucleus.

Miscellaneous databases

PROiQ9Z1M4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024830.
ExpressionAtlasiQ9Z1M4. baseline and differential.
GenevisibleiQ9Z1M4. MM.

Family and domain databases

CDDicd05584. STKc_p70S6K. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016238. Ribosomal_S6_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKS6B2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.