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Protein

Ribosomal protein S6 kinase beta-2

Gene

Rps6kb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates specifically ribosomal protein S6.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991ATPPROSITE-ProRule annotation
Active sitei194 – 1941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 819ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. peptide binding Source: Ensembl
  3. protein kinase activity Source: MGI
  4. ribosomal protein S6 kinase activity Source: GO_Central

GO - Biological processi

  1. positive regulation of translational initiation Source: MGI
  2. protein kinase B signaling Source: MGI
  3. protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiREACT_308448. AKT phosphorylates targets in the nucleus.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)
Short name:
S6K-beta-2
Short name:
S6K2
Alternative name(s):
70 kDa ribosomal protein S6 kinase 2
p70 ribosomal S6 kinase beta
Short name:
p70 S6 kinase beta
Short name:
p70 S6K-beta
Short name:
p70 S6KB
Gene namesi
Name:Rps6kb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

MGIiMGI:1927343. Rps6kb2.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Ribosomal protein S6 kinase beta-2PRO_0000086215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei420 – 4201Phosphothreonine1 Publication
Modified residuei423 – 4231Phosphoserine1 Publication
Modified residuei476 – 4761Phosphoserine; by PKCBy similarity

Post-translational modificationi

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z1M4.
PaxDbiQ9Z1M4.
PRIDEiQ9Z1M4.

PTM databases

PhosphoSiteiQ9Z1M4.

Expressioni

Gene expression databases

BgeeiQ9Z1M4.
ExpressionAtlasiQ9Z1M4. baseline and differential.
GenevestigatoriQ9Z1M4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1M4.
SMRiQ9Z1M4. Positions 58-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 328262Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini329 – 39971AGC-kinase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi474 – 4807Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi411 – 48575Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120449.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9Z1M4.
KOiK04688.
OMAiNATTENE.
OrthoDBiEOG7B8S38.
PhylomeDBiQ9Z1M4.
TreeFamiTF313438.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LGELRAAGLE TVGHYEEVEL
60 70 80 90 100
TESSVNLGPE RIGPHCFELL SVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVCSA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSHGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAITHTFC GTIEYMAPEI LVRTGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLA
310 320 330 340 350
KKFLKRNPTQ RIGGGLGDAA DVQRHPFFRH INWDDLLARR VDPPFRPSLQ
360 370 380 390 400
SEEDVSQFDA RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRT PISPLKFSPF EGFRPSPGPP EPMEPSLPPL
460 470 480
LPSPPSPPPT STAPLPIRPP SGTKKSKKGR GRSGR
Length:485
Mass (Da):53,538
Last modified:May 1, 1999 - v1
Checksum:i396929ADAB0F6CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA. Translation: CAA07774.1.
AK014412 mRNA. Translation: BAB29335.1.
CCDSiCCDS29419.1.
RefSeqiNP_067460.1. NM_021485.2.
UniGeneiMm.271937.

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830.
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721.
GeneIDi58988.
KEGGimmu:58988.
UCSCiuc008fzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007938 mRNA. Translation: CAA07774.1.
AK014412 mRNA. Translation: BAB29335.1.
CCDSiCCDS29419.1.
RefSeqiNP_067460.1. NM_021485.2.
UniGeneiMm.271937.

3D structure databases

ProteinModelPortaliQ9Z1M4.
SMRiQ9Z1M4. Positions 58-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025749.

PTM databases

PhosphoSiteiQ9Z1M4.

Proteomic databases

MaxQBiQ9Z1M4.
PaxDbiQ9Z1M4.
PRIDEiQ9Z1M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025749; ENSMUSP00000025749; ENSMUSG00000024830.
ENSMUST00000181245; ENSMUSP00000137802; ENSMUSG00000097721.
GeneIDi58988.
KEGGimmu:58988.
UCSCiuc008fzb.1. mouse.

Organism-specific databases

CTDi6199.
MGIiMGI:1927343. Rps6kb2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120449.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9Z1M4.
KOiK04688.
OMAiNATTENE.
OrthoDBiEOG7B8S38.
PhylomeDBiQ9Z1M4.
TreeFamiTF313438.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiREACT_308448. AKT phosphorylates targets in the nucleus.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi314486.
PROiQ9Z1M4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z1M4.
ExpressionAtlasiQ9Z1M4. baseline and differential.
GenevestigatoriQ9Z1M4.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase."
    Shima H., Pende M., Chen Y., Fumagalli S., Thomas G., Kozma S.C.
    EMBO J. 17:6649-6659(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-420 AND SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKS6B2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.