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Q9Z1L8 (MDS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MDS1 and EVI1 complex locus protein MDS1
Alternative name(s):
Myelodysplasia syndrome 1 protein homolog
Gene names
Name:Mecom
Synonyms:Mds1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q9Z1L8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative promoter usage. May be due to intron retention.
Isoform 1 (identifier: P14404-1)

The sequence of this isoform can be found in the external entry P14404.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129MDS1 and EVI1 complex locus protein MDS1
PRO_0000096339

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 812CD5EB59C36A6E

FASTA12914,329
        10         20         30         40         50         60 
MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS PATSSESFTP 

        70         80         90        100        110        120 
KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR KIEIGEKFGP YMGEQRSDLK 


DSSYGWENR 

« Hide

Isoform 1 [UniParc].

See P14404.

References

[1]"Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation."
Wimmer K., Vinatzer U., Zwirn P., Fonatsch C., Wieser R.
Biochem. Biophys. Res. Commun. 252:691-696(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010015 mRNA. Translation: CAA08971.1.
RefSeqNP_067417.1. NM_021442.2. [Q9Z1L8-1]
UniGeneMm.426829.
Mm.56965.

3D structure databases

ProteinModelPortalQ9Z1L8.
SMRQ9Z1L8. Positions 76-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199542. 2 interactions.
STRING10090.ENSMUSP00000051057.

PTM databases

PhosphoSiteQ9Z1L8.

Proteomic databases

PRIDEQ9Z1L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID14013.
KEGGmmu:14013.
UCSCuc008ouv.1. mouse. [Q9Z1L8-1]

Organism-specific databases

CTD2122.
MGIMGI:95457. Mecom.

Phylogenomic databases

eggNOGNOG40641.
HOVERGENHBG031707.
InParanoidQ9Z1L8.
KOK04462.
PhylomeDBQ9Z1L8.

Gene expression databases

CleanExMM_MDS1.
GenevestigatorQ9Z1L8.

Family and domain databases

InterProIPR026710. MDS1.
[Graphical view]
PANTHERPTHR21652. PTHR21652. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMECOM. mouse.
NextBio284928.
SOURCESearch...

Entry information

Entry nameMDS1_MOUSE
AccessionPrimary (citable) accession number: Q9Z1L8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot