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Protein

MDS1 and EVI1 complex locus protein MDS1

Gene

Mecom

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. embryonic forelimb morphogenesis Source: MGI
  2. embryonic hindlimb morphogenesis Source: MGI
  3. forebrain development Source: MGI
  4. inflammatory response Source: MGI
  5. in utero embryonic development Source: MGI
  6. negative regulation of JNK cascade Source: MGI
  7. negative regulation of programmed cell death Source: MGI
  8. negative regulation of transcription, DNA-templated Source: MGI
  9. neutrophil homeostasis Source: MGI
  10. pericardium development Source: MGI
  11. positive regulation of brown fat cell differentiation Source: MGI
  12. positive regulation of transcription, DNA-templated Source: MGI
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. post-embryonic development Source: MGI
  15. regulation of cell cycle Source: MGI
  16. regulation of cell proliferation Source: MGI
  17. renal system development Source: MGI
  18. response to bacterium Source: MGI
  19. stem cell maintenance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MDS1 and EVI1 complex locus protein MDS1
Alternative name(s):
Myelodysplasia syndrome 1 protein homolog
Gene namesi
Name:Mecom
Synonyms:Mds1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95457. Mecom.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: MGI
  2. cytoplasm Source: MGI
  3. Golgi apparatus Source: MGI
  4. intracellular membrane-bounded organelle Source: MGI
  5. nuclear speck Source: MGI
  6. nucleoplasm Source: MGI
  7. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129MDS1 and EVI1 complex locus protein MDS1PRO_0000096339Add
BLAST

Proteomic databases

MaxQBiQ9Z1L8.
PRIDEiQ9Z1L8.

PTM databases

PhosphoSiteiQ9Z1L8.

Expressioni

Gene expression databases

CleanExiMM_MDS1.
GenevestigatoriQ9Z1L8.

Interactioni

Protein-protein interaction databases

BioGridi199542. 2 interactions.
STRINGi10090.ENSMUSP00000051057.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L8.
SMRiQ9Z1L8. Positions 76-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40641.
HOVERGENiHBG031707.
KOiK04462.
PhylomeDBiQ9Z1L8.

Family and domain databases

InterProiIPR026710. MDS1.
[Graphical view]
PANTHERiPTHR21652. PTHR21652. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9Z1L8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS
60 70 80 90 100
PATSSESFTP KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR
110 120
KIEIGEKFGP YMGEQRSDLK DSSYGWENR

Note: Produced by alternative promoter usage. May be due to intron retention.

Length:129
Mass (Da):14,329
Last modified:May 1, 1999 - v1
Checksum:i812CD5EB59C36A6E
GO
Isoform 1 (identifier: P14404-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P14404.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,042
Mass (Da):116,848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010015 mRNA. Translation: CAA08971.1.
RefSeqiNP_067417.1. NM_021442.2. [Q9Z1L8-1]
UniGeneiMm.426829.
Mm.56965.

Genome annotation databases

GeneIDi14013.
KEGGimmu:14013.
UCSCiuc008ouv.1. mouse. [Q9Z1L8-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010015 mRNA. Translation: CAA08971.1.
RefSeqiNP_067417.1. NM_021442.2. [Q9Z1L8-1]
UniGeneiMm.426829.
Mm.56965.

3D structure databases

ProteinModelPortaliQ9Z1L8.
SMRiQ9Z1L8. Positions 76-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199542. 2 interactions.
STRINGi10090.ENSMUSP00000051057.

PTM databases

PhosphoSiteiQ9Z1L8.

Proteomic databases

MaxQBiQ9Z1L8.
PRIDEiQ9Z1L8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14013.
KEGGimmu:14013.
UCSCiuc008ouv.1. mouse. [Q9Z1L8-1]

Organism-specific databases

CTDi2122.
MGIiMGI:95457. Mecom.

Phylogenomic databases

eggNOGiNOG40641.
HOVERGENiHBG031707.
KOiK04462.
PhylomeDBiQ9Z1L8.

Miscellaneous databases

ChiTaRSiMecom. mouse.
NextBioi284928.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MDS1.
GenevestigatoriQ9Z1L8.

Family and domain databases

InterProiIPR026710. MDS1.
[Graphical view]
PANTHERiPTHR21652. PTHR21652. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation."
    Wimmer K., Vinatzer U., Zwirn P., Fonatsch C., Wieser R.
    Biochem. Biophys. Res. Commun. 252:691-696(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMDS1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.