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Q9Z1L8

- MDS1_MOUSE

UniProt

Q9Z1L8 - MDS1_MOUSE

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Protein

MDS1 and EVI1 complex locus protein MDS1

Gene

Mecom

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI

GO - Biological processi

  1. embryonic forelimb morphogenesis Source: MGI
  2. embryonic hindlimb morphogenesis Source: MGI
  3. forebrain development Source: MGI
  4. inflammatory response Source: MGI
  5. in utero embryonic development Source: MGI
  6. neutrophil homeostasis Source: MGI
  7. pericardium development Source: MGI
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. post-embryonic development Source: MGI
  10. regulation of cell proliferation Source: MGI
  11. renal system development Source: MGI
  12. response to bacterium Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MDS1 and EVI1 complex locus protein MDS1
Alternative name(s):
Myelodysplasia syndrome 1 protein homolog
Gene namesi
Name:Mecom
Synonyms:Mds1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95457. Mecom.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129MDS1 and EVI1 complex locus protein MDS1PRO_0000096339Add
BLAST

Proteomic databases

MaxQBiQ9Z1L8.
PRIDEiQ9Z1L8.

PTM databases

PhosphoSiteiQ9Z1L8.

Expressioni

Gene expression databases

CleanExiMM_MDS1.
GenevestigatoriQ9Z1L8.

Interactioni

Protein-protein interaction databases

BioGridi199542. 2 interactions.
STRINGi10090.ENSMUSP00000051057.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L8.
SMRiQ9Z1L8. Positions 76-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40641.
HOVERGENiHBG031707.
KOiK04462.
PhylomeDBiQ9Z1L8.

Family and domain databases

InterProiIPR026710. MDS1.
[Graphical view]
PANTHERiPTHR21652. PTHR21652. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 2 (identifier: Q9Z1L8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS
60 70 80 90 100
PATSSESFTP KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR
110 120
KIEIGEKFGP YMGEQRSDLK DSSYGWENR

Note: Produced by alternative promoter usage. May be due to intron retention.

Length:129
Mass (Da):14,329
Last modified:May 1, 1999 - v1
Checksum:i812CD5EB59C36A6E
GO
Isoform 1 (identifier: P14404-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P14404.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,042
Mass (Da):116,848
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010015 mRNA. Translation: CAA08971.1.
RefSeqiNP_067417.1. NM_021442.2. [Q9Z1L8-1]
UniGeneiMm.426829.
Mm.56965.

Genome annotation databases

GeneIDi14013.
KEGGimmu:14013.
UCSCiuc008ouv.1. mouse. [Q9Z1L8-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010015 mRNA. Translation: CAA08971.1 .
RefSeqi NP_067417.1. NM_021442.2. [Q9Z1L8-1 ]
UniGenei Mm.426829.
Mm.56965.

3D structure databases

ProteinModelPortali Q9Z1L8.
SMRi Q9Z1L8. Positions 76-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199542. 2 interactions.
STRINGi 10090.ENSMUSP00000051057.

PTM databases

PhosphoSitei Q9Z1L8.

Proteomic databases

MaxQBi Q9Z1L8.
PRIDEi Q9Z1L8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14013.
KEGGi mmu:14013.
UCSCi uc008ouv.1. mouse. [Q9Z1L8-1 ]

Organism-specific databases

CTDi 2122.
MGIi MGI:95457. Mecom.

Phylogenomic databases

eggNOGi NOG40641.
HOVERGENi HBG031707.
KOi K04462.
PhylomeDBi Q9Z1L8.

Miscellaneous databases

ChiTaRSi MECOM. mouse.
NextBioi 284928.
SOURCEi Search...

Gene expression databases

CleanExi MM_MDS1.
Genevestigatori Q9Z1L8.

Family and domain databases

InterProi IPR026710. MDS1.
[Graphical view ]
PANTHERi PTHR21652. PTHR21652. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation."
    Wimmer K., Vinatzer U., Zwirn P., Fonatsch C., Wieser R.
    Biochem. Biophys. Res. Commun. 252:691-696(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMDS1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3