Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z1L8

- MDS1_MOUSE

UniProt

Q9Z1L8 - MDS1_MOUSE

Protein

MDS1 and EVI1 complex locus protein MDS1

Gene

Mecom

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI

    GO - Biological processi

    1. embryonic forelimb morphogenesis Source: MGI
    2. embryonic hindlimb morphogenesis Source: MGI
    3. forebrain development Source: MGI
    4. inflammatory response Source: MGI
    5. in utero embryonic development Source: MGI
    6. neutrophil homeostasis Source: MGI
    7. pericardium development Source: MGI
    8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    9. post-embryonic development Source: MGI
    10. regulation of cell proliferation Source: MGI
    11. renal system development Source: MGI
    12. response to bacterium Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MDS1 and EVI1 complex locus protein MDS1
    Alternative name(s):
    Myelodysplasia syndrome 1 protein homolog
    Gene namesi
    Name:Mecom
    Synonyms:Mds1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95457. Mecom.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129MDS1 and EVI1 complex locus protein MDS1PRO_0000096339Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z1L8.

    PTM databases

    PhosphoSiteiQ9Z1L8.

    Expressioni

    Gene expression databases

    CleanExiMM_MDS1.
    GenevestigatoriQ9Z1L8.

    Interactioni

    Protein-protein interaction databases

    BioGridi199542. 2 interactions.
    STRINGi10090.ENSMUSP00000051057.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1L8.
    SMRiQ9Z1L8. Positions 76-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40641.
    HOVERGENiHBG031707.
    InParanoidiQ9Z1L8.
    KOiK04462.
    PhylomeDBiQ9Z1L8.

    Family and domain databases

    InterProiIPR026710. MDS1.
    [Graphical view]
    PANTHERiPTHR21652. PTHR21652. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 2 (identifier: Q9Z1L8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSKGRARKL ATSNECAYGN YPEIPLEEMP DADADGITSV PSLHIQEPCS    50
    PATSSESFTP KEGSPYKAPI YIPDDIPIPD EFELRESTMP GAGLGIWTKR 100
    KIEIGEKFGP YMGEQRSDLK DSSYGWENR 129

    Note: Produced by alternative promoter usage. May be due to intron retention.

    Length:129
    Mass (Da):14,329
    Last modified:May 1, 1999 - v1
    Checksum:i812CD5EB59C36A6E
    GO
    Isoform 1 (identifier: P14404-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P14404.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,042
    Mass (Da):116,848
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010015 mRNA. Translation: CAA08971.1.
    RefSeqiNP_067417.1. NM_021442.2. [Q9Z1L8-1]
    UniGeneiMm.426829.
    Mm.56965.

    Genome annotation databases

    GeneIDi14013.
    KEGGimmu:14013.
    UCSCiuc008ouv.1. mouse. [Q9Z1L8-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010015 mRNA. Translation: CAA08971.1 .
    RefSeqi NP_067417.1. NM_021442.2. [Q9Z1L8-1 ]
    UniGenei Mm.426829.
    Mm.56965.

    3D structure databases

    ProteinModelPortali Q9Z1L8.
    SMRi Q9Z1L8. Positions 76-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199542. 2 interactions.
    STRINGi 10090.ENSMUSP00000051057.

    PTM databases

    PhosphoSitei Q9Z1L8.

    Proteomic databases

    PRIDEi Q9Z1L8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14013.
    KEGGi mmu:14013.
    UCSCi uc008ouv.1. mouse. [Q9Z1L8-1 ]

    Organism-specific databases

    CTDi 2122.
    MGIi MGI:95457. Mecom.

    Phylogenomic databases

    eggNOGi NOG40641.
    HOVERGENi HBG031707.
    InParanoidi Q9Z1L8.
    KOi K04462.
    PhylomeDBi Q9Z1L8.

    Miscellaneous databases

    ChiTaRSi MECOM. mouse.
    NextBioi 284928.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MDS1.
    Genevestigatori Q9Z1L8.

    Family and domain databases

    InterProi IPR026710. MDS1.
    [Graphical view ]
    PANTHERi PTHR21652. PTHR21652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation."
      Wimmer K., Vinatzer U., Zwirn P., Fonatsch C., Wieser R.
      Biochem. Biophys. Res. Commun. 252:691-696(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMDS1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3