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Q9Z1L5

- CA2D3_MOUSE

UniProt

Q9Z1L5 - CA2D3_MOUSE

Protein

Voltage-dependent calcium channel subunit alpha-2/delta-3

Gene

Cacna2d3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi262 – 2621Divalent metal cationBy similarity
    Metal bindingi264 – 2641Divalent metal cationBy similarity
    Metal bindingi266 – 2661Divalent metal cationBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. voltage-gated calcium channel activity Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel subunit alpha-2/delta-3
    Alternative name(s):
    Voltage-gated calcium channel subunit alpha-2/delta-3
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Cacna2d3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1338890. Cacna2d3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 1091Voltage-dependent calcium channel subunit delta-3Sequence AnalysisPRO_0000304651
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 10911058Voltage-dependent calcium channel subunit alpha-2/delta-3PRO_0000304649Add
    BLAST
    Chaini34 – ?Voltage-dependent calcium channel subunit alpha-2-3Sequence AnalysisPRO_0000304650

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi412 ↔ 1055Interchain (between alpha-2-3 and delta-3 chains)By similarity
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Modified residuei924 – 9241PhosphotyrosineBy similarity

    Post-translational modificationi

    N-glycosylated.1 Publication
    May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z1L5.
    PaxDbiQ9Z1L5.
    PRIDEiQ9Z1L5.

    PTM databases

    PhosphoSiteiQ9Z1L5.

    Expressioni

    Tissue specificityi

    Brain-specific. Predominantly expressed in the caudate putamen, entorhinal complex, hippocampus and cortex.2 Publications

    Gene expression databases

    BgeeiQ9Z1L5.
    GenevestigatoriQ9Z1L5.

    Interactioni

    Subunit structurei

    Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9Z1L5. 1 interaction.
    STRINGi10090.ENSMUSP00000022567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1L5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 1007974ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1090 – 10912CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1069 – 108921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini256 – 438183VWFAPROSITE-ProRule annotationAdd
    BLAST
    Domaini452 – 54998CacheAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi262 – 2665MIDAS-like motif

    Domaini

    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

    Sequence similaritiesi

    Contains 1 cache domain.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307080.
    GeneTreeiENSGT00530000062904.
    HOGENOMiHOG000010247.
    HOVERGENiHBG107124.
    InParanoidiQ9Z1L5.
    KOiK04860.
    OMAiKHEFDAD.
    OrthoDBiEOG7NSB1G.
    PhylomeDBiQ9Z1L5.
    TreeFamiTF315824.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004010. Cache_domain.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF02743. Cache_1. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z1L5-1 [UniParc]FASTAAdd to Basket

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    MAGPGSLCCA SRGASALLAT ALLYAALGDV VRSEQQIPLS VVKLWASAFG     50
    GEIKSIAAKY SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKIMEEMFH 100
    KKSEAVRRLV EAAEEAHLKH EFDADLQYEY FNAVLINERD KDGNFLELGK 150
    EFILAPNDHF NNLPVNISLS DVQVPTNMYN KDPAIVNGVY WSESLNKVFV 200
    DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD CRNRKWYIQA 250
    ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIITYNEE 300
    LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS 350
    DFNHTGQGSI CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE 400
    AAFADNLKWM ACANKGFFTQ ISTLADVQEN VMEYLHVLSR PKVIDQEHDV 450
    VWTEAYIDST LPQAQKLADD QGLVLMTTVA MPVFSKQNET RSKGILLGVV 500
    GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR PLYEEGKKRR 550
    KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 600
    TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA 650
    DEWSYCNTDL HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV 700
    SAPIEAYWTS LALNKSENSD KGVEVAFLGT RTGLSRINLF VGAEQLTNQD 750
    FLKAGDKENI FNADHFPLWY RRAAEQIAGS FVYSIPFSTG TVNKSNVVTA 800
    STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS LDGKCSISCD 850
    DETVNCYLID NNGFILVSED YTQTGDFFGE VEGAVMNKLL TMGSFKRITL 900
    YDYQAMCRAN KESSDSAHGL LDPYKAFLSA AKWIMTELVL FLVEFNLCSW 950
    WHSDMTAKAQ KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI 1000
    QQIPSSNLFM VVVDSSCLCE SVAPITMAPI EIRYNESLKC ERLKAQKIRR 1050
    RPESCHGFHP EENARECGGA SSLQAQAALL LLPLVSSLFS R 1091
    Length:1,091
    Mass (Da):122,778
    Last modified:May 1, 1999 - v1
    Checksum:i7AEE2BDA10077A0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010949 mRNA. Translation: CAA09423.1.
    PIRiT30256.
    RefSeqiNP_033915.1. NM_009785.1.
    UniGeneiMm.386754.

    Genome annotation databases

    EnsembliENSMUST00000022567; ENSMUSP00000022567; ENSMUSG00000021991.
    GeneIDi12294.
    KEGGimmu:12294.
    UCSCiuc007sui.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010949 mRNA. Translation: CAA09423.1 .
    PIRi T30256.
    RefSeqi NP_033915.1. NM_009785.1.
    UniGenei Mm.386754.

    3D structure databases

    ProteinModelPortali Q9Z1L5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z1L5. 1 interaction.
    STRINGi 10090.ENSMUSP00000022567.

    PTM databases

    PhosphoSitei Q9Z1L5.

    Proteomic databases

    MaxQBi Q9Z1L5.
    PaxDbi Q9Z1L5.
    PRIDEi Q9Z1L5.

    Protocols and materials databases

    DNASUi 12294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022567 ; ENSMUSP00000022567 ; ENSMUSG00000021991 .
    GeneIDi 12294.
    KEGGi mmu:12294.
    UCSCi uc007sui.1. mouse.

    Organism-specific databases

    CTDi 55799.
    MGIi MGI:1338890. Cacna2d3.

    Phylogenomic databases

    eggNOGi NOG307080.
    GeneTreei ENSGT00530000062904.
    HOGENOMi HOG000010247.
    HOVERGENi HBG107124.
    InParanoidi Q9Z1L5.
    KOi K04860.
    OMAi KHEFDAD.
    OrthoDBi EOG7NSB1G.
    PhylomeDBi Q9Z1L5.
    TreeFami TF315824.

    Miscellaneous databases

    NextBioi 280792.
    PROi Q9Z1L5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z1L5.
    Genevestigatori Q9Z1L5.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004010. Cache_domain.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF02743. Cache_1. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular diversity of the calcium channel alpha2delta subunit."
      Klugbauer N., Lacinova L., Marais E., Hobom M., Hofmann F.
      J. Neurosci. 19:684-691(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Absence of modulation of the expressed calcium channel alpha1G subunit by alpha2delta subunits."
      Lacinova L., Klugbauer N., Hofmann F.
      J. Physiol. (Lond.) 516:639-645(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes."
      Gong H.C., Hang J., Kohler W., Li L., Su T.-Z.
      J. Membr. Biol. 184:35-43(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Calcium channel alpha(2)delta subunits-structure and Gabapentin binding."
      Marais E., Klugbauer N., Hofmann F.
      Mol. Pharmacol. 59:1243-1248(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, GLYCOSYLATION, PROTEOLYTIC PROCESSING, LACK OF GABAPENTIN-BINDING.

    Entry informationi

    Entry nameiCA2D3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z1L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3