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Q9Z1L5

- CA2D3_MOUSE

UniProt

Q9Z1L5 - CA2D3_MOUSE

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Protein

Voltage-dependent calcium channel subunit alpha-2/delta-3

Gene
Cacna2d3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621Divalent metal cation By similarity
Metal bindingi264 – 2641Divalent metal cation By similarity
Metal bindingi266 – 2661Divalent metal cation By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. voltage-gated calcium channel activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-3
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-3
Cleaved into the following 2 chains:
Gene namesi
Name:Cacna2d3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1338890. Cacna2d3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 1007974Extracellular Reviewed predictionAdd
BLAST
Transmembranei1069 – 108921Helical; Reviewed predictionAdd
BLAST
Topological domaini1090 – 10912Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1091Voltage-dependent calcium channel subunit delta-3 Reviewed predictionPRO_0000304651
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 10911058Voltage-dependent calcium channel subunit alpha-2/delta-3PRO_0000304649Add
BLAST
Chaini34 – ?Voltage-dependent calcium channel subunit alpha-2-3 Reviewed predictionPRO_0000304650

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi412 ↔ 1055Interchain (between alpha-2-3 and delta-3 chains) By similarity
Glycosylationi553 – 5531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
Modified residuei924 – 9241Phosphotyrosine By similarity

Post-translational modificationi

N-glycosylated.1 Publication
May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z1L5.
PaxDbiQ9Z1L5.
PRIDEiQ9Z1L5.

PTM databases

PhosphoSiteiQ9Z1L5.

Expressioni

Tissue specificityi

Brain-specific. Predominantly expressed in the caudate putamen, entorhinal complex, hippocampus and cortex.2 Publications

Gene expression databases

BgeeiQ9Z1L5.
GenevestigatoriQ9Z1L5.

Interactioni

Subunit structurei

Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.

Protein-protein interaction databases

IntActiQ9Z1L5. 1 interaction.
STRINGi10090.ENSMUSP00000022567.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini256 – 438183VWFAAdd
BLAST
Domaini452 – 54998CacheAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi262 – 2665MIDAS-like motif

Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.

Sequence similaritiesi

Contains 1 cache domain.
Contains 1 VWFA domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307080.
GeneTreeiENSGT00530000062904.
HOGENOMiHOG000010247.
HOVERGENiHBG107124.
InParanoidiQ9Z1L5.
KOiK04860.
OMAiKHEFDAD.
OrthoDBiEOG7NSB1G.
PhylomeDBiQ9Z1L5.
TreeFamiTF315824.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004010. Cache_domain.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF02743. Cache_1. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1L5-1 [UniParc]FASTAAdd to Basket

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MAGPGSLCCA SRGASALLAT ALLYAALGDV VRSEQQIPLS VVKLWASAFG     50
GEIKSIAAKY SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKIMEEMFH 100
KKSEAVRRLV EAAEEAHLKH EFDADLQYEY FNAVLINERD KDGNFLELGK 150
EFILAPNDHF NNLPVNISLS DVQVPTNMYN KDPAIVNGVY WSESLNKVFV 200
DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD CRNRKWYIQA 250
ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIITYNEE 300
LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS 350
DFNHTGQGSI CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE 400
AAFADNLKWM ACANKGFFTQ ISTLADVQEN VMEYLHVLSR PKVIDQEHDV 450
VWTEAYIDST LPQAQKLADD QGLVLMTTVA MPVFSKQNET RSKGILLGVV 500
GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR PLYEEGKKRR 550
KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 600
TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA 650
DEWSYCNTDL HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV 700
SAPIEAYWTS LALNKSENSD KGVEVAFLGT RTGLSRINLF VGAEQLTNQD 750
FLKAGDKENI FNADHFPLWY RRAAEQIAGS FVYSIPFSTG TVNKSNVVTA 800
STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS LDGKCSISCD 850
DETVNCYLID NNGFILVSED YTQTGDFFGE VEGAVMNKLL TMGSFKRITL 900
YDYQAMCRAN KESSDSAHGL LDPYKAFLSA AKWIMTELVL FLVEFNLCSW 950
WHSDMTAKAQ KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI 1000
QQIPSSNLFM VVVDSSCLCE SVAPITMAPI EIRYNESLKC ERLKAQKIRR 1050
RPESCHGFHP EENARECGGA SSLQAQAALL LLPLVSSLFS R 1091
Length:1,091
Mass (Da):122,778
Last modified:May 1, 1999 - v1
Checksum:i7AEE2BDA10077A0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010949 mRNA. Translation: CAA09423.1.
PIRiT30256.
RefSeqiNP_033915.1. NM_009785.1.
UniGeneiMm.386754.

Genome annotation databases

EnsembliENSMUST00000022567; ENSMUSP00000022567; ENSMUSG00000021991.
GeneIDi12294.
KEGGimmu:12294.
UCSCiuc007sui.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010949 mRNA. Translation: CAA09423.1 .
PIRi T30256.
RefSeqi NP_033915.1. NM_009785.1.
UniGenei Mm.386754.

3D structure databases

ProteinModelPortali Q9Z1L5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Z1L5. 1 interaction.
STRINGi 10090.ENSMUSP00000022567.

PTM databases

PhosphoSitei Q9Z1L5.

Proteomic databases

MaxQBi Q9Z1L5.
PaxDbi Q9Z1L5.
PRIDEi Q9Z1L5.

Protocols and materials databases

DNASUi 12294.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022567 ; ENSMUSP00000022567 ; ENSMUSG00000021991 .
GeneIDi 12294.
KEGGi mmu:12294.
UCSCi uc007sui.1. mouse.

Organism-specific databases

CTDi 55799.
MGIi MGI:1338890. Cacna2d3.

Phylogenomic databases

eggNOGi NOG307080.
GeneTreei ENSGT00530000062904.
HOGENOMi HOG000010247.
HOVERGENi HBG107124.
InParanoidi Q9Z1L5.
KOi K04860.
OMAi KHEFDAD.
OrthoDBi EOG7NSB1G.
PhylomeDBi Q9Z1L5.
TreeFami TF315824.

Miscellaneous databases

NextBioi 280792.
PROi Q9Z1L5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z1L5.
Genevestigatori Q9Z1L5.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004010. Cache_domain.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF02743. Cache_1. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular diversity of the calcium channel alpha2delta subunit."
    Klugbauer N., Lacinova L., Marais E., Hobom M., Hofmann F.
    J. Neurosci. 19:684-691(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Absence of modulation of the expressed calcium channel alpha1G subunit by alpha2delta subunits."
    Lacinova L., Klugbauer N., Hofmann F.
    J. Physiol. (Lond.) 516:639-645(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes."
    Gong H.C., Hang J., Kohler W., Li L., Su T.-Z.
    J. Membr. Biol. 184:35-43(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Calcium channel alpha(2)delta subunits-structure and Gabapentin binding."
    Marais E., Klugbauer N., Hofmann F.
    Mol. Pharmacol. 59:1243-1248(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, GLYCOSYLATION, PROTEOLYTIC PROCESSING, LACK OF GABAPENTIN-BINDING.

Entry informationi

Entry nameiCA2D3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi