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Protein

Retinoschisin

Gene

Rs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be active in cell adhesion processes during retinal development.By similarity

GO - Molecular functioni

  • phosphatidylinositol-3,4,5-trisphosphate binding Source: MGI
  • phosphatidylinositol-3,4-bisphosphate binding Source: MGI
  • phosphatidylinositol-3,5-bisphosphate binding Source: MGI
  • phosphatidylinositol-3-phosphate binding Source: MGI
  • phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  • phosphatidylinositol-4-phosphate binding Source: MGI
  • phosphatidylinositol-5-phosphate binding Source: MGI
  • phosphatidylserine binding Source: MGI

GO - Biological processi

  • adaptation of rhodopsin mediated signaling Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • retina layer formation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoschisin
Alternative name(s):
X-linked juvenile retinoschisis protein homolog
Gene namesi
Name:Rs1
Synonyms:Rs1h, Xlrs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1336189. Rs1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extrinsic component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 224201RetinoschisinPRO_0000022696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 – 40InterchainPROSITE-ProRule annotation
Disulfide bondi59 – 59Interchain (with C-223)PROSITE-ProRule annotation
Disulfide bondi63 ↔ 219PROSITE-ProRule annotation
Disulfide bondi110 ↔ 142PROSITE-ProRule annotation
Disulfide bondi223 – 223Interchain (with C-59)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9Z1L4.
PaxDbiQ9Z1L4.
PRIDEiQ9Z1L4.

PTM databases

PhosphoSiteiQ9Z1L4.

Expressioni

Tissue specificityi

Restricted to the retina. At the mRNA level, detected only within the photoreceptor cell layer, most prominently within the inner segments of the photoreceptors. Undetectable in the inner plexiform layers and the inner nuclear layer. At the protein level, found in the inner segment of the photoreceptors, the inner nuclear layer, the inner plexiform layer and the ganglion cell layer (at protein level).1 Publication

Gene expression databases

BgeeiQ9Z1L4.
CleanExiMM_RS1.
ExpressionAtlasiQ9Z1L4. baseline and differential.
GenevisibleiQ9Z1L4. MM.

Interactioni

Subunit structurei

Homooctamer of 4 homodimers; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033650.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L4.
SMRiQ9Z1L4. Positions 68-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 219157F5/8 type CPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHQ. Eukaryota.
ENOG410YGW6. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000006700.
HOVERGENiHBG061301.
InParanoidiQ9Z1L4.
OMAiAWLSKYQ.
OrthoDBiEOG7SBNPV.
PhylomeDBiQ9Z1L4.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. FA58C.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
[Graphical view]
SMARTiSM00231. FA58C. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHKIEGFFL LLLFGYEATL GLSSTEDEGE DPWYQKACKC DCQVGANALW
60 70 80 90 100
SAGATSLDCI PECPYHKPLG FESGEVTPDQ ITCSNPEQYV GWYSSWTANK
110 120 130 140 150
ARLNSQGFGC AWLSKYQDSS QWLQIDLKEI KVISGILTQG RCDIDEWVTK
160 170 180 190 200
YSVQYRTDER LNWIYYKDQT GNNRVFYGNS DRSSTVQNLL RPPIISRFIR
210 220
LIPLGWHVRI AIRMELLECA SKCA
Length:224
Mass (Da):25,575
Last modified:May 1, 1999 - v1
Checksum:i4536203CC00E90E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084561 mRNA. Translation: AAD21808.1.
AF084567
, AF084562, AF084563, AF084564, AF084565, AF084566 Genomic DNA. Translation: AAD21809.1.
AJ011381 mRNA. Translation: CAA09601.1.
BC046422 mRNA. Translation: AAH46422.1.
CCDSiCCDS30505.1.
RefSeqiNP_035432.3. NM_011302.3.
UniGeneiMm.41982.

Genome annotation databases

EnsembliENSMUST00000033650; ENSMUSP00000033650; ENSMUSG00000031293.
GeneIDi20147.
KEGGimmu:20147.
UCSCiuc009utq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084561 mRNA. Translation: AAD21808.1.
AF084567
, AF084562, AF084563, AF084564, AF084565, AF084566 Genomic DNA. Translation: AAD21809.1.
AJ011381 mRNA. Translation: CAA09601.1.
BC046422 mRNA. Translation: AAH46422.1.
CCDSiCCDS30505.1.
RefSeqiNP_035432.3. NM_011302.3.
UniGeneiMm.41982.

3D structure databases

ProteinModelPortaliQ9Z1L4.
SMRiQ9Z1L4. Positions 68-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033650.

PTM databases

PhosphoSiteiQ9Z1L4.

Proteomic databases

MaxQBiQ9Z1L4.
PaxDbiQ9Z1L4.
PRIDEiQ9Z1L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033650; ENSMUSP00000033650; ENSMUSG00000031293.
GeneIDi20147.
KEGGimmu:20147.
UCSCiuc009utq.1. mouse.

Organism-specific databases

CTDi6247.
MGIiMGI:1336189. Rs1.

Phylogenomic databases

eggNOGiENOG410IIHQ. Eukaryota.
ENOG410YGW6. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000006700.
HOVERGENiHBG061301.
InParanoidiQ9Z1L4.
OMAiAWLSKYQ.
OrthoDBiEOG7SBNPV.
PhylomeDBiQ9Z1L4.

Miscellaneous databases

PROiQ9Z1L4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z1L4.
CleanExiMM_RS1.
ExpressionAtlasiQ9Z1L4. baseline and differential.
GenevisibleiQ9Z1L4. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. FA58C.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
[Graphical view]
SMARTiSM00231. FA58C. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the murine X-linked juvenile retinoschisis (Rs1h) gene."
    Gehrig A.E., Warneke-Wittstock R., Sauer C.G., Weber B.H.F.
    Mamm. Genome 10:303-307(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ.
  2. "Genomic structure and comparative analysis of seven contiguous genes disclose a large region with conserved gene order in human Xp22.2-p22.1."
    Brunner B., Todt T., Lenzner S., Stout K., Schulz U., Ropers H.-H., Kalscheuer V.M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "The mouse X-linked juvenile retinoschisis cDNA: expression in photoreceptors."
    Reid S.N., Akhmedov N.B., Piriev N.I., Kozak C.A., Danciger M., Farber D.B.
    Gene 227:257-266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  5. "Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells."
    Grayson C., Reid S.N., Ellis J.A., Rutherford A., Sowden J.C., Yates J.R., Farber D.B., Trump D.
    Hum. Mol. Genet. 9:1873-1879(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiXLRS1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.