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Protein

Death effector domain-containing protein

Gene

Dedd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro.By similarity1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • decidualization Source: MGI
  • extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: MGI
  • regulation of apoptotic process Source: InterPro
  • spermatogenesis Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Death effector domain-containing protein
Alternative name(s):
DEDPro1
Gene namesi
Name:Dedd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333874 Dedd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912751 – 318Death effector domain-containing proteinAdd BLAST318

Post-translational modificationi

Exists predominantly in a mono- or diubiquitinated form.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9Z1L3
PaxDbiQ9Z1L3
PRIDEiQ9Z1L3

PTM databases

iPTMnetiQ9Z1L3
PhosphoSitePlusiQ9Z1L3

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000013973
CleanExiMM_DEDD
ExpressionAtlasiQ9Z1L3 baseline and differential
GenevisibleiQ9Z1L3 MM

Interactioni

Subunit structurei

Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204257, 1 interactor
STRINGi10090.ENSMUSP00000068419

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 103DEDPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IFFJ Eukaryota
ENOG410Z8U6 LUCA
GeneTreeiENSGT00390000008714
HOGENOMiHOG000049120
HOVERGENiHBG007220
InParanoidiQ9Z1L3
OMAiCPDPVDK
OrthoDBiEOG091G07VX
PhylomeDBiQ9Z1L3
TreeFamiTF331807

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z1L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKRRASQ VWPEERGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV
60 70 80 90 100
DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY
110 120 130 140 150
VTLKKRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP
160 170 180 190 200
VVCCPTSGSQ MCSKRPARGR TTLGSQRKRR KSVTPDPKEK QTCDIRLRVR
210 220 230 240 250
AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF
260 270 280 290 300
SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
310
YELGRQKLLR NLMLQALP
Length:318
Mass (Da):36,805
Last modified:May 1, 1999 - v1
Checksum:iC9A31DFC4C0E57CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237K → N in AAD16415 (Ref. 2) Curated1
Sequence conflicti316A → V in AAH54445 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011386 mRNA Translation: CAA09604.1
AF100342 mRNA Translation: AAD16415.1
BC023668 mRNA Translation: AAH23668.1
BC054445 mRNA Translation: AAH54445.1
CCDSiCCDS15490.1
RefSeqiNP_001122081.1, NM_001128609.1
NP_035745.3, NM_011615.3
XP_006496801.1, XM_006496738.3
XP_006496802.1, XM_006496739.3
XP_006496803.1, XM_006496740.3
XP_006496804.1, XM_006496741.3
XP_011237084.1, XM_011238782.2
UniGeneiMm.270139

Genome annotation databases

EnsembliENSMUST00000064950; ENSMUSP00000068419; ENSMUSG00000013973
ENSMUST00000097467; ENSMUSP00000095075; ENSMUSG00000013973
ENSMUST00000111299; ENSMUSP00000106930; ENSMUSG00000013973
ENSMUST00000111300; ENSMUSP00000106931; ENSMUSG00000013973
GeneIDi21945
KEGGimmu:21945
UCSCiuc007dnx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDEDD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L3
Secondary accession number(s): Q7TQH8, Q9R227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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