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Protein

Death effector domain-containing protein

Gene

Dedd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro.By similarity1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • decidualization Source: MGI
  • extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: MGI
  • regulation of apoptotic process Source: InterPro
  • spermatogenesis Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Death effector domain-containing protein
Alternative name(s):
DEDPro1
Gene namesi
Name:Dedd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333874. Dedd.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912751 – 318Death effector domain-containing proteinAdd BLAST318

Post-translational modificationi

Exists predominantly in a mono- or diubiquitinated form.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9Z1L3.
PRIDEiQ9Z1L3.

PTM databases

iPTMnetiQ9Z1L3.
PhosphoSitePlusiQ9Z1L3.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000013973.
CleanExiMM_DEDD.
ExpressionAtlasiQ9Z1L3. baseline and differential.
GenevisibleiQ9Z1L3. MM.

Interactioni

Subunit structurei

Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204257. 1 interactor.
STRINGi10090.ENSMUSP00000068419.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 103DEDPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Contains 1 DED (death effector) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFFJ. Eukaryota.
ENOG410Z8U6. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ9Z1L3.
OMAiCPDPVDK.
OrthoDBiEOG091G07VX.
PhylomeDBiQ9Z1L3.
TreeFamiTF331807.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKRRASQ VWPEERGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV
60 70 80 90 100
DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY
110 120 130 140 150
VTLKKRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP
160 170 180 190 200
VVCCPTSGSQ MCSKRPARGR TTLGSQRKRR KSVTPDPKEK QTCDIRLRVR
210 220 230 240 250
AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF
260 270 280 290 300
SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
310
YELGRQKLLR NLMLQALP
Length:318
Mass (Da):36,805
Last modified:May 1, 1999 - v1
Checksum:iC9A31DFC4C0E57CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237K → N in AAD16415 (Ref. 2) Curated1
Sequence conflicti316A → V in AAH54445 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011386 mRNA. Translation: CAA09604.1.
AF100342 mRNA. Translation: AAD16415.1.
BC023668 mRNA. Translation: AAH23668.1.
BC054445 mRNA. Translation: AAH54445.1.
CCDSiCCDS15490.1.
RefSeqiNP_001122081.1. NM_001128609.1.
NP_035745.3. NM_011615.3.
XP_006496801.1. XM_006496738.3.
XP_006496802.1. XM_006496739.3.
XP_006496803.1. XM_006496740.3.
XP_006496804.1. XM_006496741.3.
XP_011237084.1. XM_011238782.2.
UniGeneiMm.270139.

Genome annotation databases

EnsembliENSMUST00000064950; ENSMUSP00000068419; ENSMUSG00000013973.
ENSMUST00000097467; ENSMUSP00000095075; ENSMUSG00000013973.
ENSMUST00000111299; ENSMUSP00000106930; ENSMUSG00000013973.
ENSMUST00000111300; ENSMUSP00000106931; ENSMUSG00000013973.
GeneIDi21945.
KEGGimmu:21945.
UCSCiuc007dnx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011386 mRNA. Translation: CAA09604.1.
AF100342 mRNA. Translation: AAD16415.1.
BC023668 mRNA. Translation: AAH23668.1.
BC054445 mRNA. Translation: AAH54445.1.
CCDSiCCDS15490.1.
RefSeqiNP_001122081.1. NM_001128609.1.
NP_035745.3. NM_011615.3.
XP_006496801.1. XM_006496738.3.
XP_006496802.1. XM_006496739.3.
XP_006496803.1. XM_006496740.3.
XP_006496804.1. XM_006496741.3.
XP_011237084.1. XM_011238782.2.
UniGeneiMm.270139.

3D structure databases

ProteinModelPortaliQ9Z1L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204257. 1 interactor.
STRINGi10090.ENSMUSP00000068419.

PTM databases

iPTMnetiQ9Z1L3.
PhosphoSitePlusiQ9Z1L3.

Proteomic databases

PaxDbiQ9Z1L3.
PRIDEiQ9Z1L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064950; ENSMUSP00000068419; ENSMUSG00000013973.
ENSMUST00000097467; ENSMUSP00000095075; ENSMUSG00000013973.
ENSMUST00000111299; ENSMUSP00000106930; ENSMUSG00000013973.
ENSMUST00000111300; ENSMUSP00000106931; ENSMUSG00000013973.
GeneIDi21945.
KEGGimmu:21945.
UCSCiuc007dnx.2. mouse.

Organism-specific databases

CTDi9191.
MGIiMGI:1333874. Dedd.

Phylogenomic databases

eggNOGiENOG410IFFJ. Eukaryota.
ENOG410Z8U6. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ9Z1L3.
OMAiCPDPVDK.
OrthoDBiEOG091G07VX.
PhylomeDBiQ9Z1L3.
TreeFamiTF331807.

Miscellaneous databases

ChiTaRSiDedd. mouse.
PROiQ9Z1L3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013973.
CleanExiMM_DEDD.
ExpressionAtlasiQ9Z1L3. baseline and differential.
GenevisibleiQ9Z1L3. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEDD_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1L3
Secondary accession number(s): Q7TQH8, Q9R227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.