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Protein

Claudin-7

Gene

Cldn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell adhesion Source: RGD
  • negative regulation of protein homooligomerization Source: RGD
  • positive regulation of cell motility Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • response to ethanol Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-7
Gene namesi
Name:Cldn7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68432 Cldn7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 119CytoplasmicSequence analysisAdd BLAST17
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 160ExtracellularSequence analysisAdd BLAST20
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 211CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447521 – 211Claudin-7Add BLAST211

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1L1

PTM databases

iPTMnetiQ9Z1L1
PhosphoSitePlusiQ9Z1L1
SwissPalmiQ9Z1L1

Expressioni

Gene expression databases

BgeeiENSRNOG00000017325
ExpressionAtlasiQ9Z1L1 baseline and differential
GenevisibleiQ9Z1L1 RN

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023291

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 211Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHPN Eukaryota
ENOG4111GPP LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z1L1
KOiK06087
OMAiNTKYEFG
OrthoDBiEOG091G0MX2
PhylomeDBiQ9Z1L1
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003552 Claudin7
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01381 CLAUDIN7
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z1L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSGLQLLG FSMAMLGWVG LIASTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMECVTQSTG MMSCKMYDSV LALPAATQAT RALMIVSLVL GFLAMFVATM
110 120 130 140 150
GMKCTRCGGD DKVKKARIAM TGGIIFIVAG LAALVACSWI GHQIVTDFYN
160 170 180 190 200
PLTPMNIKYE FGPAIFIGWA GSALVLLGGA LLSCSCPGSE SKAAYRAPRS
210
YPKSNSSKEY V
Length:211
Mass (Da):22,432
Last modified:March 29, 2005 - v2
Checksum:i7F90B644BAA472A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074542 Genomic DNA No translation available.
BC101892 mRNA Translation: AAI01893.1
AJ011811 mRNA Translation: CAA09790.1
RefSeqiNP_113890.1, NM_031702.1
XP_006246867.1, XM_006246805.3
UniGeneiRn.32259

Genome annotation databases

EnsembliENSRNOT00000023291; ENSRNOP00000023291; ENSRNOG00000017325
ENSRNOT00000079237; ENSRNOP00000069209; ENSRNOG00000017325
GeneIDi65132
KEGGirno:65132
UCSCiRGD:68432 rat

Similar proteinsi

Entry informationi

Entry nameiCLD7_RAT
AccessioniPrimary (citable) accession number: Q9Z1L1
Secondary accession number(s): Q3T1J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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