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Protein

Claudin-7

Gene

Cldn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell adhesion Source: RGD
  • negative regulation of protein homooligomerization Source: RGD
  • positive regulation of cell motility Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of defense response to virus by host Source: Ensembl
  • response to ethanol Source: RGD
  • xenophagy Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-7
Gene namesi
Name:Cldn7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68432. Cldn7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 119CytoplasmicSequence analysisAdd BLAST17
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 160ExtracellularSequence analysisAdd BLAST20
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 211CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • apicolateral plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: RGD
  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447521 – 211Claudin-7Add BLAST211

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1L1.
PRIDEiQ9Z1L1.

PTM databases

iPTMnetiQ9Z1L1.
PhosphoSitePlusiQ9Z1L1.
SwissPalmiQ9Z1L1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017325.
ExpressionAtlasiQ9Z1L1. baseline and differential.
GenevisibleiQ9Z1L1. RN.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM.By similarity1 Publication

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023291.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 211Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z1L1.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ9Z1L1.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSGLQLLG FSMAMLGWVG LIASTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMECVTQSTG MMSCKMYDSV LALPAATQAT RALMIVSLVL GFLAMFVATM
110 120 130 140 150
GMKCTRCGGD DKVKKARIAM TGGIIFIVAG LAALVACSWI GHQIVTDFYN
160 170 180 190 200
PLTPMNIKYE FGPAIFIGWA GSALVLLGGA LLSCSCPGSE SKAAYRAPRS
210
YPKSNSSKEY V
Length:211
Mass (Da):22,432
Last modified:March 29, 2005 - v2
Checksum:i7F90B644BAA472A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074542 Genomic DNA. No translation available.
BC101892 mRNA. Translation: AAI01893.1.
AJ011811 mRNA. Translation: CAA09790.1.
RefSeqiNP_113890.1. NM_031702.1.
XP_006246867.1. XM_006246805.3.
UniGeneiRn.32259.

Genome annotation databases

EnsembliENSRNOT00000023291; ENSRNOP00000023291; ENSRNOG00000017325.
ENSRNOT00000079237; ENSRNOP00000069209; ENSRNOG00000017325.
GeneIDi65132.
KEGGirno:65132.
UCSCiRGD:68432. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074542 Genomic DNA. No translation available.
BC101892 mRNA. Translation: AAI01893.1.
AJ011811 mRNA. Translation: CAA09790.1.
RefSeqiNP_113890.1. NM_031702.1.
XP_006246867.1. XM_006246805.3.
UniGeneiRn.32259.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023291.

PTM databases

iPTMnetiQ9Z1L1.
PhosphoSitePlusiQ9Z1L1.
SwissPalmiQ9Z1L1.

Proteomic databases

PaxDbiQ9Z1L1.
PRIDEiQ9Z1L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023291; ENSRNOP00000023291; ENSRNOG00000017325.
ENSRNOT00000079237; ENSRNOP00000069209; ENSRNOG00000017325.
GeneIDi65132.
KEGGirno:65132.
UCSCiRGD:68432. rat.

Organism-specific databases

CTDi1366.
RGDi68432. Cldn7.

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z1L1.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ9Z1L1.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9Z1L1.

Gene expression databases

BgeeiENSRNOG00000017325.
ExpressionAtlasiQ9Z1L1. baseline and differential.
GenevisibleiQ9Z1L1. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD7_RAT
AccessioniPrimary (citable) accession number: Q9Z1L1
Secondary accession number(s): Q3T1J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.