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Protein

Claudin-7

Gene

Cldn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell adhesion Source: RGD
  • negative regulation of protein homooligomerization Source: RGD
  • positive regulation of cell motility Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of defense response to virus by host Source: Ensembl
  • xenophagy Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-7
Gene namesi
Name:Cldn7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68432. Cldn7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11917CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 16020ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 21130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apicolateral plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: RGD
  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Claudin-7PRO_0000144752Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1L1.
PRIDEiQ9Z1L1.

PTM databases

iPTMnetiQ9Z1L1.
SwissPalmiQ9Z1L1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9Z1L1. baseline and differential.
GenevisibleiQ9Z1L1. RN.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM.By similarity1 Publication

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023291.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2112Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z1L1.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z1L1.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSGLQLLG FSMAMLGWVG LIASTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMECVTQSTG MMSCKMYDSV LALPAATQAT RALMIVSLVL GFLAMFVATM
110 120 130 140 150
GMKCTRCGGD DKVKKARIAM TGGIIFIVAG LAALVACSWI GHQIVTDFYN
160 170 180 190 200
PLTPMNIKYE FGPAIFIGWA GSALVLLGGA LLSCSCPGSE SKAAYRAPRS
210
YPKSNSSKEY V
Length:211
Mass (Da):22,432
Last modified:March 29, 2005 - v2
Checksum:i7F90B644BAA472A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074542 Genomic DNA. No translation available.
BC101892 mRNA. Translation: AAI01893.1.
AJ011811 mRNA. Translation: CAA09790.1.
RefSeqiNP_113890.1. NM_031702.1.
XP_006246867.1. XM_006246805.2.
UniGeneiRn.32259.

Genome annotation databases

EnsembliENSRNOT00000023291; ENSRNOP00000023291; ENSRNOG00000017325.
ENSRNOT00000079237; ENSRNOP00000069209; ENSRNOG00000017325.
GeneIDi65132.
KEGGirno:65132.
UCSCiRGD:68432. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03074542 Genomic DNA. No translation available.
BC101892 mRNA. Translation: AAI01893.1.
AJ011811 mRNA. Translation: CAA09790.1.
RefSeqiNP_113890.1. NM_031702.1.
XP_006246867.1. XM_006246805.2.
UniGeneiRn.32259.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023291.

PTM databases

iPTMnetiQ9Z1L1.
SwissPalmiQ9Z1L1.

Proteomic databases

PaxDbiQ9Z1L1.
PRIDEiQ9Z1L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023291; ENSRNOP00000023291; ENSRNOG00000017325.
ENSRNOT00000079237; ENSRNOP00000069209; ENSRNOG00000017325.
GeneIDi65132.
KEGGirno:65132.
UCSCiRGD:68432. rat.

Organism-specific databases

CTDi1366.
RGDi68432. Cldn7.

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z1L1.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z1L1.
TreeFamiTF331936.

Miscellaneous databases

NextBioi613935.
PROiQ9Z1L1.

Gene expression databases

ExpressionAtlasiQ9Z1L1. baseline and differential.
GenevisibleiQ9Z1L1. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Keen T.J., Inglehearn C.F.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-211.
    Tissue: Pheochromocytoma.
  4. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
    Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
    Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, INTERACTION WITH CLDN7, PHOSPHORYLATION.

Entry informationi

Entry nameiCLD7_RAT
AccessioniPrimary (citable) accession number: Q9Z1L1
Secondary accession number(s): Q3T1J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.