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Q9Z1K8

- YLAT1_MOUSE

UniProt

Q9Z1K8 - YLAT1_MOUSE

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Protein

Y+L amino acid transporter 1

Gene

Slc7a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes.1 Publication

Kineticsi

  1. KM=91.5 µM for L-arginine (in the absence of NaCl)1 Publication
  2. KM=340.8 µM for L-arginine (in the presence of 0.1 M NaCl)1 Publication
  3. KM=21.7 µM for L-leucine (in the presence of 0.1 M NaCl)1 Publication
  4. KM=1.36 mM for L-alanine (in the presence of 0.1 M NaCl)1 Publication
  5. KM=47.9 µM for L-leucine (in the presence of 0.1 M LiCl)1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Y+L amino acid transporter 1
Alternative name(s):
Solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
Short name:
Y+LAT1
Short name:
y+LAT-1
Gene namesi
Name:Slc7a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1337120. Slc7a7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Y+L amino acid transporter 1PRO_0000304935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Modified residuei19 – 191Phosphoserine2 Publications
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z1K8.
PRIDEiQ9Z1K8.

PTM databases

PhosphoSiteiQ9Z1K8.

Expressioni

Tissue specificityi

Strongly expressed in kidney and intestine. Weaker expression observed in epididymis, testis, ovary, thyroid pancreas, sub-gland and liver.1 Publication

Gene expression databases

BgeeiQ9Z1K8.
GenevestigatoriQ9Z1K8.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Protein-protein interaction databases

BioGridi203319. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1K8.
SMRiQ9Z1K8. Positions 46-373.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9Z1K8.
KOiK13867.
OMAiCLAPYAA.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9Z1K8.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNSTKYEVA AQHEADDGSA LGDGASPVAE QVKLKKEISL LNGVCLIVGN
60 70 80 90 100
MIGSGIFVSP KGVLMYSASF GLSLVIWAVG GIFSVFGALC YAELGTTIKK
110 120 130 140 150
SGASYAYILE AFGGFLAFIR LWTSLLIIEP TSQAVIAITF ANYMVQPLFP
160 170 180 190 200
SCGAPYAAGR LLAAACICLL TFINCAYVKW GTLVQDIFTY AKVLALIAVI
210 220 230 240 250
IAGIVRLGQG ATANFENSFE GSSFAMGDIA LALYSALFSY SGWDTLNYVT
260 270 280 290 300
EEIRNPERNL PLSIGISMPI VTIIYLLTNV AYYSVLDIKE ILASDAVAVT
310 320 330 340 350
FADQIFGVFN WIIPVAVAFS CFGGLNASIV AASRLLFVGS REGHLPDAIC
360 370 380 390 400
MVHVERFTPV PSLLFNGVLS LVYLCVEDIF QLINYYSFSY WFFVGLSIVG
410 420 430 440 450
QLYLRWKDPD RPRPLKLSLF FPIIFCLCTI FLVAVPLYSD TINSLIGIGI
460 470 480 490 500
ALSGLPFYFF IIRVPEHKRP LFLRRIVASI TRYLQILCMS VAAEMDLEDG
510
ELSKQDPKSK
Length:510
Mass (Da):55,677
Last modified:May 1, 1999 - v1
Checksum:i9F30FB1B88126F6C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41S → T.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012754 mRNA. Translation: CAA10170.1.
AJ130943 mRNA. Translation: CAA10255.1.
AK150950 mRNA. Translation: BAE29983.1.
AK151718 mRNA. Translation: BAE30637.1.
AK152637 mRNA. Translation: BAE31379.1.
AK170851 mRNA. Translation: BAE42073.1.
BC014709 mRNA. Translation: AAH14709.1.
CCDSiCCDS27087.1.
RefSeqiNP_001240608.1. NM_001253679.1.
NP_001240609.1. NM_001253680.1.
NP_035535.2. NM_011405.4.
XP_006518811.1. XM_006518748.1.
XP_006518812.1. XM_006518749.1.
XP_006518813.1. XM_006518750.1.
XP_006518814.1. XM_006518751.1.
XP_006518815.1. XM_006518752.1.
XP_006518816.1. XM_006518753.1.
XP_006518817.1. XM_006518754.1.
XP_006518818.1. XM_006518755.1.
UniGeneiMm.142455.
Mm.489701.

Genome annotation databases

EnsembliENSMUST00000000984; ENSMUSP00000000984; ENSMUSG00000000958.
GeneIDi20540.
KEGGimmu:20540.
UCSCiuc007tvv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012754 mRNA. Translation: CAA10170.1 .
AJ130943 mRNA. Translation: CAA10255.1 .
AK150950 mRNA. Translation: BAE29983.1 .
AK151718 mRNA. Translation: BAE30637.1 .
AK152637 mRNA. Translation: BAE31379.1 .
AK170851 mRNA. Translation: BAE42073.1 .
BC014709 mRNA. Translation: AAH14709.1 .
CCDSi CCDS27087.1.
RefSeqi NP_001240608.1. NM_001253679.1.
NP_001240609.1. NM_001253680.1.
NP_035535.2. NM_011405.4.
XP_006518811.1. XM_006518748.1.
XP_006518812.1. XM_006518749.1.
XP_006518813.1. XM_006518750.1.
XP_006518814.1. XM_006518751.1.
XP_006518815.1. XM_006518752.1.
XP_006518816.1. XM_006518753.1.
XP_006518817.1. XM_006518754.1.
XP_006518818.1. XM_006518755.1.
UniGenei Mm.142455.
Mm.489701.

3D structure databases

ProteinModelPortali Q9Z1K8.
SMRi Q9Z1K8. Positions 46-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203319. 1 interaction.

PTM databases

PhosphoSitei Q9Z1K8.

Proteomic databases

PaxDbi Q9Z1K8.
PRIDEi Q9Z1K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000984 ; ENSMUSP00000000984 ; ENSMUSG00000000958 .
GeneIDi 20540.
KEGGi mmu:20540.
UCSCi uc007tvv.2. mouse.

Organism-specific databases

CTDi 9056.
MGIi MGI:1337120. Slc7a7.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119037.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi Q9Z1K8.
KOi K13867.
OMAi CLAPYAA.
OrthoDBi EOG73BVCR.
PhylomeDBi Q9Z1K8.
TreeFami TF313355.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.

Miscellaneous databases

NextBioi 298823.
PROi Q9Z1K8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z1K8.
Genevestigatori Q9Z1K8.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family."
    Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.
    EMBO J. 18:49-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, TISSUE SPECIFICITY, VARIANT THR-4.
    Strain: BALB/c and NIH Swiss.
    Tissue: Heart and Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYLAT1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1K8
Secondary accession number(s): Q9QWS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3