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Protein

Adenomatous polyposis coli protein 2

Gene

Apc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Adenomatous polyposis coli protein 2
Gene namesi
Name:Apc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346052. Apc2.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Golgi apparatus By similarity
  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Associated with actin filaments. Associated with microtubule network (By similarity).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22742274Adenomatous polyposis coli protein 2PRO_0000313687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1563 – 15631PhosphoserineCombined sources
Modified residuei1565 – 15651PhosphoserineCombined sources
Modified residuei1861 – 18611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z1K7.
PaxDbiQ9Z1K7.
PRIDEiQ9Z1K7.

PTM databases

iPTMnetiQ9Z1K7.
PhosphoSiteiQ9Z1K7.

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.1 Publication

Developmental stagei

Strongly expressed in fetal brain but expression decreases from P12 onward. Expressed in post-mitotic neurons.1 Publication

Gene expression databases

CleanExiMM_APC2.

Interactioni

Subunit structurei

Interacts with APC, CTNNB1, TP53BP2 and possibly with AXIN2 (By similarity). Interacts with MAPRE3, PSRC1 and probably MAPRE1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020349.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1K7.
SMRiQ9Z1K7. Positions 6-57, 131-233, 286-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati301 – 34141ARM 1Add
BLAST
Repeati472 – 51140ARM 2Add
BLAST
Repeati515 – 55541ARM 3Add
BLAST
Repeati557 – 60246ARM 4Add
BLAST
Repeati608 – 64740ARM 5Add
BLAST
Repeati650 – 68940ARM 6Add
BLAST
Repeati1049 – 1068201Add
BLAST
Repeati1140 – 1159202Add
BLAST
Repeati1250 – 1269203Add
BLAST
Repeati1375 – 1394204Add
BLAST
Repeati1546 – 1565205Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1049 – 15655175 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-SAdd
BLAST
Regioni1049 – 1565517Interaction with CTNNB1By similarityAdd
BLAST
Regioni2037 – 211478Interaction with MAPRE1 and MAPRE3By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5955Sequence analysisAdd
BLAST
Coiled coili832 – 85625Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1057 – 1186130Ser-richAdd
BLAST
Compositional biasi1829 – 192294Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ARM repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
HOGENOMiHOG000033986.
HOVERGENiHBG104821.
InParanoidiQ9Z1K7.
PhylomeDBiQ9Z1K7.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026837. APC2.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
PfamiPF05956. APC_basic. 1 hit.
PF05923. APC_crr. 2 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 1 hit.
PF05924. SAMP. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSMASYEQ LVRQVEALKA ENTHLRQELR DNSSHLSKLE TETSGMKEVL
60 70 80 90 100
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ TDISSLYNLK FHAPALGPEP
110 120 130 140 150
AARTPEGSPV HGSGPSKDSF GELSRATIRL LEELDQERCF LLSEIEKEEK
160 170 180 190 200
EKLWYYSQLQ GLSKRLDELP HVDTFSMQMD LIRQQLEFEA QHIRSLMEER
210 220 230 240 250
FGTSDEMVQR AQIRASRLEQ IDKELLEAQD RVQQTEPQAL LAVKPVAVEE
260 270 280 290 300
EQEAEVPTHP EDGTPQPGNS KVEVVFWLLS MLATRDQEDT ARTLLAMSSS
310 320 330 340 350
PESCVAMRRS GCLPLLLQIL HGTEAGSVGR AGIPGAPGAK DARMRANAAL
360 370 380 390 400
HNIVFSQPDQ GLARKEMRVL HVLEQIRAYC ETCWDWLQAR DSGTETPVPI
410 420 430 440 450
EPQICQATCA VMKLSFDEEY RRAMNELGGL QAVAELLQVD YEMHKMTRDP
460 470 480 490 500
LNLALRRYAG MTLTNLTFGD VANKATLCAR RGCMEAIVAQ LGSESEELHQ
510 520 530 540 550
VVSSILRNLS WRADINSKKV LREVGSMTAL MECVLRASKE STLKSVLSAL
560 570 580 590 600
WNLSAHSTEN KAAICQVDGA LGFLVSTLTY RCQGNSLAVI ESGGGILRNV
610 620 630 640 650
SSLIATREDY RQVLRDHNCL QTLLQHLTSH SLTIVSNACG TLWNLSARSP
660 670 680 690 700
RDQELLWDLG AVGMLRNLVH SKHKMIAMGS AAALRNLLAH RPAKYQAAAM
710 720 730 740 750
AVSPGTCVPS LYVRKQRALE AELDTRHLVH ALGHLEKQSL PEAETTSKKP
760 770 780 790 800
LPPLRHLDGL VQDYASDSGC FDDDDAPSLA AAATTAEPAS PAVMSMFLGG
810 820 830 840 850
PFLQGQALAR TPPARQGGLE AEKEAGGEAA VAAKAKAKLA LAVARIDRLV
860 870 880 890 900
EDISALHTSS DDSFSLSSGD PGQEAPREGR AQSCSPCRGT EGGRREAGSR
910 920 930 940 950
AHPLLRLKAA HTSLSNDSLN SGSTSDGYCT REHMTPCPLA ALAEHRDDPV
960 970 980 990 1000
RGQTRPRRLD LDLPSRAELP ARDTAATDAR VRTIKLSPTY QHVPLLDGAA
1010 1020 1030 1040 1050
GAGVRPLVGP GTSPGARKQA WIPADSLSKV PEKLVASPLP IASKVLQKLV
1060 1070 1080 1090 1100
AQDGPMSLSR CSSLSSLSST GHAVPSQAEN LDSDSSLEGL EEAGPGEAEL
1110 1120 1130 1140 1150
GRAWRASGST SLPVSIPAPQ RGRSRGLGVE DATPSSSSEN CVQETPLVLS
1160 1170 1180 1190 1200
RCSSVSSLGS FESRSIASSI PSDPCSGLGS GTVSPSELPD SPGQTMPPSR
1210 1220 1230 1240 1250
SKTPPAPPGQ PETSQFSLQW ESYVKRFLDI ADCRERCQPP SELDAGSVRF
1260 1270 1280 1290 1300
TVEKPDENFS CASSLSALAL HELYVQQDVE LRLRPPACPE RAVGGGGHRR
1310 1320 1330 1340 1350
RDEAASRLDG PAPAGSRARS ATDKELEALR ECLGAAMPAR LRKVASALVP
1360 1370 1380 1390 1400
GRRSLPVPVY MLVPAPARGD DSGTDSAEGT PVNFSSAASL SDETLQGPSR
1410 1420 1430 1440 1450
DKPAGPGDRQ KPTGRAAPAR QTRSHRPKAA GAGKSTEHTR GPCRNRAGLE
1460 1470 1480 1490 1500
LPLSRPQSAR SNRDSSCQTR TRGDGALQSL CLTTPTEEAV YCFYDSDEEP
1510 1520 1530 1540 1550
PATAPPPRRA SAIPRALKRE KPAGRKETPS RAAQPATLPV RAQPRLIVDE
1560 1570 1580 1590 1600
TPPCYSLTSS ASSLSEPEAP EQPANHARGP EQGSKQDSSP SPRAEEELLQ
1610 1620 1630 1640 1650
RCISLAMPRR RTQVPGSRRR KPRALRSDIR PTEITQKCQE EVAGSDPASD
1660 1670 1680 1690 1700
LDSVEWQAIQ EGANSIVTWL HQAAAKASLE ASSESDSLLS LVSGVSAGST
1710 1720 1730 1740 1750
LQPSKLRKGR KPAAEAGGAW RPEKRGTTST KINGSPRLPN GPEKAKGTQK
1760 1770 1780 1790 1800
MMAGESTMLR GRTVIYSAGP ASRTQSKGIS GPCTTPKKTG TSGTTQPETV
1810 1820 1830 1840 1850
TKAPSPEQQR SRSLHRPGKI SELAALRHPP RSATPPARLA KTPSSSSSQT
1860 1870 1880 1890 1900
SPASQPLPRR SPLATPTGGP LPGPGGSLVP KSPARALLAK QHKTQKSPVR
1910 1920 1930 1940 1950
IPFMQRPARR VPPPLARPSP EPGSRGRAGA EGTPGARGSR LGLVRMASAR
1960 1970 1980 1990 2000
SSGSESSDRS GFRRQLTFIK ESPGLLRRRR SELSSADSTA STSQAASPRR
2010 2020 2030 2040 2050
GRPALPAVFL CSSRCDELRV SPRQPLAAQR SPQAKPGLAP LAPRRTSSES
2060 2070 2080 2090 2100
PSRLPVRASP GRPETVKRYA SLPHISVSRR SDSAVSVPTT QANATRRGSD
2110 2120 2130 2140 2150
GEARPLPRVA PPGTTWRRIK DEDVPHILRS TLPATALPLR VSSPEDSPAG
2160 2170 2180 2190 2200
TPQRKTSDAV VQTEDVATSK TNSSTSPSLE SRDPPQAPAS GPVAPQGSDV
2210 2220 2230 2240 2250
DGPVLTKPPA SAPFPHEGLS AVIAGFPTSR HGSPSRAARV PPFNYVPSPM
2260 2270
AAATMASDSA VEKAPVSSPA SLLE
Length:2,274
Mass (Da):243,139
Last modified:May 1, 1999 - v1
Checksum:i75ABDA15D0F707F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130783
, AJ130784, AJ130785, AJ130786, AJ130787, AJ130788, AJ130789, AJ130790, AJ130791, AJ130792, AJ130793, AJ130794, AJ130795, AJ130796 Genomic DNA. Translation: CAA10207.1.
CCDSiCCDS24016.1.
PIRiT30258.
UniGeneiMm.57247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130783
, AJ130784, AJ130785, AJ130786, AJ130787, AJ130788, AJ130789, AJ130790, AJ130791, AJ130792, AJ130793, AJ130794, AJ130795, AJ130796 Genomic DNA. Translation: CAA10207.1.
CCDSiCCDS24016.1.
PIRiT30258.
UniGeneiMm.57247.

3D structure databases

ProteinModelPortaliQ9Z1K7.
SMRiQ9Z1K7. Positions 6-57, 131-233, 286-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020349.

PTM databases

iPTMnetiQ9Z1K7.
PhosphoSiteiQ9Z1K7.

Proteomic databases

MaxQBiQ9Z1K7.
PaxDbiQ9Z1K7.
PRIDEiQ9Z1K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346052. Apc2.

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
HOGENOMiHOG000033986.
HOVERGENiHBG104821.
InParanoidiQ9Z1K7.
PhylomeDBiQ9Z1K7.

Miscellaneous databases

ChiTaRSiApc2. mouse.
PROiQ9Z1K7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_APC2.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026837. APC2.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
PfamiPF05956. APC_basic. 1 hit.
PF05923. APC_crr. 2 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 1 hit.
PF05924. SAMP. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor."
    van Es J.H., Kirkpatrick C., van de Wetering M., Molenaar M., Miles A., Kuipers J., Destree O., Peifer M., Clevers H.
    Curr. Biol. 9:105-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway."
    Hsieh P.-C., Chang J.-C., Sun W.-T., Hsieh S.-C., Wang M.-C., Wang F.-F.
    Oncogene 26:4928-4940(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSRC1 AND MAPRE3.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1563; SER-1565 AND SER-1861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiAPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.