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Protein
Submitted name:

Son of sevenless 1

Gene

Sos2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. positive regulation of small GTPase mediated signal transduction Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_288944. SOS-mediated signalling.
REACT_316581. Signalling to RAS.
REACT_319562. SHC-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
Son of sevenless 1Imported
Gene namesi
Name:Sos2Imported
Synonyms:Sos1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620435. Sos2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9Z1I1.

Expressioni

Gene expression databases

GenevestigatoriQ9Z1I1.

Interactioni

Protein-protein interaction databases

IntActiQ9Z1I1. 1 interaction.
MINTiMINT-4508448.
STRINGi10116.ENSRNOP00000006425.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG265981.
HOGENOMiHOG000013040.
HOVERGENiHBG103663.
PhylomeDBiQ9Z1I1.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9Z1I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY
60 70 80 90 100
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK
110 120 130 140 150
VLMDMFDQDD DIGLVSLCEE EPCSSGELNY YDLVRTEIAE ERQYLRELNM
160 170 180 190 200
IIKVFREAFL SDKKLFKSSE IEKIFSNISD IHELTVKLLG LIEDTVEMTD

EGSP
Length:204
Mass (Da):23,589
Last modified:May 1, 1999 - v1
Checksum:iEA5A123AE610CD52
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei204 – 2041Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83014 mRNA. Translation: BAA74949.1.
UniGeneiRn.4226.

Genome annotation databases

UCSCiRGD:620435. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83014 mRNA. Translation: BAA74949.1.
UniGeneiRn.4226.

3D structure databases

ProteinModelPortaliQ9Z1I1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z1I1. 1 interaction.
MINTiMINT-4508448.
STRINGi10116.ENSRNOP00000006425.

Proteomic databases

PaxDbiQ9Z1I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620435. rat.

Organism-specific databases

RGDi620435. Sos2.

Phylogenomic databases

eggNOGiNOG265981.
HOGENOMiHOG000013040.
HOVERGENiHBG103663.
PhylomeDBiQ9Z1I1.

Enzyme and pathway databases

ReactomeiREACT_288944. SOS-mediated signalling.
REACT_316581. Signalling to RAS.
REACT_319562. SHC-mediated signalling.

Gene expression databases

GenevestigatoriQ9Z1I1.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle."
    Kim Y.-B., Inoue T., Nakajima R., Shirai-Morishita Y., Tokuyama K., Suzuki M.
    Biochem. Biophys. Res. Commun. 254:720-727(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Spraque-DawleyImported.
    Tissue: Skeletal muscleImported.

Entry informationi

Entry nameiQ9Z1I1_RAT
AccessioniPrimary (citable) accession number: Q9Z1I1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.