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Q9Z1I1

- Q9Z1I1_RAT

UniProt

Q9Z1I1 - Q9Z1I1_RAT

Protein
Submitted name:

Son of sevenless 1

Gene

Sos2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of small GTPase mediated signal transduction Source: RGD

    Enzyme and pathway databases

    ReactomeiREACT_204559. SOS-mediated signalling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Son of sevenless 1Imported
    Gene namesi
    Name:Sos2Imported
    Synonyms:Sos1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi620435. Sos2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. protein complex Source: RGD

    PTM / Processingi

    Proteomic databases

    PaxDbiQ9Z1I1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z1I1.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Z1I1. 1 interaction.
    MINTiMINT-4508448.
    STRINGi10116.ENSRNOP00000006425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z1I1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG265981.
    HOGENOMiHOG000013040.
    HOVERGENiHBG103663.
    InParanoidiQ9Z1I1.
    PhylomeDBiQ9Z1I1.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    1.20.900.10. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    SSF48065. SSF48065. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9Z1I1-1 [UniParc]FASTAAdd to Basket

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    EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY    50
    KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK 100
    VLMDMFDQDD DIGLVSLCEE EPCSSGELNY YDLVRTEIAE ERQYLRELNM 150
    IIKVFREAFL SDKKLFKSSE IEKIFSNISD IHELTVKLLG LIEDTVEMTD 200
    EGSP 204
    Length:204
    Mass (Da):23,589
    Last modified:May 1, 1999 - v1
    Checksum:iEA5A123AE610CD52
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei204 – 2041Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83014 mRNA. Translation: BAA74949.1.
    UniGeneiRn.4226.

    Genome annotation databases

    UCSCiRGD:620435. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83014 mRNA. Translation: BAA74949.1 .
    UniGenei Rn.4226.

    3D structure databases

    ProteinModelPortali Q9Z1I1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z1I1. 1 interaction.
    MINTi MINT-4508448.
    STRINGi 10116.ENSRNOP00000006425.

    Proteomic databases

    PaxDbi Q9Z1I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620435. rat.

    Organism-specific databases

    RGDi 620435. Sos2.

    Phylogenomic databases

    eggNOGi NOG265981.
    HOGENOMi HOG000013040.
    HOVERGENi HBG103663.
    InParanoidi Q9Z1I1.
    PhylomeDBi Q9Z1I1.

    Enzyme and pathway databases

    Reactomei REACT_204559. SOS-mediated signalling.

    Gene expression databases

    Genevestigatori Q9Z1I1.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    1.20.900.10. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    SSF48065. SSF48065. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle."
      Kim Y.-B., Inoue T., Nakajima R., Shirai-Morishita Y., Tokuyama K., Suzuki M.
      Biochem. Biophys. Res. Commun. 254:720-727(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Spraque-DawleyImported.
      Tissue: Skeletal muscleImported.

    Entry informationi

    Entry nameiQ9Z1I1_RAT
    AccessioniPrimary (citable) accession number: Q9Z1I1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)