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Protein

Caveolae-associated protein 3

Gene

Cavin3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346).By similarity1 Publication

GO - Molecular functioni

  • protein kinase C binding Source: RGD

GO - Biological processi

Keywordsi

Biological processBiological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 3Imported
Alternative name(s):
Cavin-3
D3T-inducible gene 2 protein
Short name:
DIG-2
Dithiolethione-inducible gene 2 protein
Protein kinase C delta-binding protein
Serum deprivation response factor-related gene product that binds to C-kinase
Gene namesi
Name:Cavin3Imported
Synonyms:Dig2, Prkcdbp, Srbc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628755. Cavin3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314141 – 263Caveolae-associated protein 3Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei165PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9Z1H9.
PRIDEiQ9Z1H9.

PTM databases

iPTMnetiQ9Z1H9.
PhosphoSitePlusiQ9Z1H9.

Expressioni

Inductioni

Up-regulated by 1,2-dithiole-3-thione (D3T).1 Publication

Gene expression databases

BgeeiENSRNOG00000017914.
GenevisibleiQ9Z1H9. RN.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 and EPS15L1. Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner.By similarity

GO - Molecular functioni

  • protein kinase C binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024119.

Structurei

3D structure databases

SMRiQ9Z1H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Interaction with CAVIN1By similarityAdd BLAST84
Regioni20 – 78Leucine-zipperBy similarityAdd BLAST59
Regioni135 – 203Interaction with CAV1By similarityAdd BLAST69

Domaini

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.By similarity

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ9Z1H9.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ9Z1H9.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR033300. CAVIN3.
IPR026752. Cavin_fam.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z1H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALEPGP VPGAPAGGPV HAVTVVTLLE KLATMLEALR ERQGGLAERQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
HRAAQVQRLE ANHGLLVARG KLHVLLFKEE TEIPARAFQK APELLGPEDQ
160 170 180 190 200
LVLGPEQPED EVGESSDEEP VESRAQRLRR TGLQKVQSLK RAFSSRKGSE
210 220 230 240 250
AAQPTPVKPP RLGPVRNSEG PAEGQPAAQP AMEPVLPSAL EPEPPQPTKE
260
DPERPVLQIE SAA
Length:263
Mass (Da):27,910
Last modified:May 1, 1999 - v1
Checksum:i3F2FE5E3DCB1F750
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAB39982 (PubMed:8968041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85435 mRNA. Translation: BAA36277.1.
BC101398 mRNA. Translation: AAI01399.1.
U66323 mRNA. Translation: AAB39982.1.
RefSeqiNP_604444.1. NM_134449.1.
UniGeneiRn.12281.

Genome annotation databases

EnsembliENSRNOT00000024119; ENSRNOP00000024119; ENSRNOG00000017914.
GeneIDi85332.
KEGGirno:85332.
UCSCiRGD:628755. rat.

Similar proteinsi

Entry informationi

Entry nameiCAVN3_RAT
AccessioniPrimary (citable) accession number: Q9Z1H9
Secondary accession number(s): P97585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families