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Protein

Protein kinase C delta-binding protein

Gene

Prkcdbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein kinase C binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C delta-binding protein
Alternative name(s):
Cavin-3
D3T-inducible gene 2 protein
Short name:
DIG-2
Dithiolethione-inducible gene 2 protein
Serum deprivation response factor-related gene product that binds to C-kinase
Gene namesi
Name:Prkcdbp
Synonyms:Dig2, Srbc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628755. Prkcdbp.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314141 – 263Protein kinase C delta-binding proteinAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z1H9.
PRIDEiQ9Z1H9.

PTM databases

iPTMnetiQ9Z1H9.
PhosphoSitePlusiQ9Z1H9.

Expressioni

Inductioni

Up-regulated by 1,2-dithiole-3-thione (D3T).1 Publication

Gene expression databases

BgeeiENSRNOG00000017914.
GenevisibleiQ9Z1H9. RN.

Interactioni

Subunit structurei

Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.By similarity

GO - Molecular functioni

  • protein kinase C binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024119.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ9Z1H9.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ9Z1H9.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALEPGP VPGAPAGGPV HAVTVVTLLE KLATMLEALR ERQGGLAERQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
HRAAQVQRLE ANHGLLVARG KLHVLLFKEE TEIPARAFQK APELLGPEDQ
160 170 180 190 200
LVLGPEQPED EVGESSDEEP VESRAQRLRR TGLQKVQSLK RAFSSRKGSE
210 220 230 240 250
AAQPTPVKPP RLGPVRNSEG PAEGQPAAQP AMEPVLPSAL EPEPPQPTKE
260
DPERPVLQIE SAA
Length:263
Mass (Da):27,910
Last modified:May 1, 1999 - v1
Checksum:i3F2FE5E3DCB1F750
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAB39982 (PubMed:8968041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85435 mRNA. Translation: BAA36277.1.
BC101398 mRNA. Translation: AAI01399.1.
U66323 mRNA. Translation: AAB39982.1.
RefSeqiNP_604444.1. NM_134449.1.
UniGeneiRn.12281.

Genome annotation databases

EnsembliENSRNOT00000024119; ENSRNOP00000024119; ENSRNOG00000017914.
GeneIDi85332.
KEGGirno:85332.
UCSCiRGD:628755. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85435 mRNA. Translation: BAA36277.1.
BC101398 mRNA. Translation: AAI01399.1.
U66323 mRNA. Translation: AAB39982.1.
RefSeqiNP_604444.1. NM_134449.1.
UniGeneiRn.12281.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024119.

PTM databases

iPTMnetiQ9Z1H9.
PhosphoSitePlusiQ9Z1H9.

Proteomic databases

PaxDbiQ9Z1H9.
PRIDEiQ9Z1H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024119; ENSRNOP00000024119; ENSRNOG00000017914.
GeneIDi85332.
KEGGirno:85332.
UCSCiRGD:628755. rat.

Organism-specific databases

CTDi112464.
RGDi628755. Prkcdbp.

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ9Z1H9.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ9Z1H9.
TreeFamiTF331031.

Miscellaneous databases

PROiQ9Z1H9.

Gene expression databases

BgeeiENSRNOG00000017914.
GenevisibleiQ9Z1H9. RN.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRDBP_RAT
AccessioniPrimary (citable) accession number: Q9Z1H9
Secondary accession number(s): P97585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.