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Protein

Leukocyte cell-derived chemotaxin 1

Gene

Lect1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.By similarity1 Publication

GO - Biological processi

  • cartilage development Source: UniProtKB-KW
  • endothelial cell morphogenesis Source: MGI
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of endothelial cell proliferation Source: MGI
  • negative regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin 1
Cleaved into the following 2 chains:
Chondrosurfactant protein
Short name:
CH-SP
Alternative name(s):
Chondromodulin-I
Short name:
ChM-I
Gene namesi
Name:Lect1
Synonyms:Chmi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1341171. Lect1.

Subcellular locationi

Chondromodulin-1 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Aged mice show enhanced VEGFA expression, angiogenesis, inflammatory cell infiltration, aortic stenosis, lipid deposition and calcification in the cardiac valves.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000053491 – 210Chondrosurfactant proteinBy similarityAdd BLAST210
PropeptideiPRO_0000005350211 – 214By similarity4
ChainiPRO_0000005351215 – 334Chondromodulin-1By similarityAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 193By similarity
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi282 ↔ 286By similarity
Disulfide bondi283 ↔ 323By similarity
Disulfide bondi293 ↔ 317By similarity
Disulfide bondi297 ↔ 313By similarity

Post-translational modificationi

After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z1F6.
PRIDEiQ9Z1F6.

PTM databases

PhosphoSitePlusiQ9Z1F6.

Expressioni

Tissue specificityi

Detected in the four cardiac valves, valvular interstitial cells and extracellular matrix (at protein level).1 Publication

Developmental stagei

Detected from E9.5 in the cardiac valve precursor cells from the atrioventricular cushions and outflow. At E10 expressed in the cardiac jelly covering the trabeculating cardiomyocytes of the left ventricle, the outer curvature of the right ventricle and the outflow tract. Expression in the ventricles decreased gradually as development progressed, and disappeared by mid-embryogenesis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022025.
CleanExiMM_LECT1.
ExpressionAtlasiQ9Z1F6. baseline and differential.
GenevisibleiQ9Z1F6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022603.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1F6.
SMRiQ9Z1F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 201BRICHOSPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the chondromodulin-1 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAS. Eukaryota.
ENOG410YVHU. LUCA.
GeneTreeiENSGT00480000042679.
HOGENOMiHOG000234812.
HOVERGENiHBG004387.
InParanoidiQ9Z1F6.
TreeFamiTF329712.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z1F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENSDKVPI TMVGPEDVEF CSPPAYTTVT VKPSGSPTRL LKVGAVVLIS
60 70 80 90 100
GAVLLLFGAI GAFYFWKGND NHIYNVHYSM SINGKLQDGS MEIDAVNNLE
110 120 130 140 150
TFKMGSGAEE AIEVNDFKNG ITGIRFAGGE KCYIKAQVKA RIPEVGTVTK
160 170 180 190 200
QSISELEGKI MPANYEENSL IWVAVDQPVK DSSFLSSKIL ELCGDLPIFW
210 220 230 240 250
LKPMYPKEIQ RERREVVRNS APSTTRRPHS EPRGNAGPGR LSNGTRPNVQ
260 270 280 290 300
DDAEPFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL
310 320 330
GGYYPWPYNY QGCRSACRVV MPCSWWVARI LGMV
Length:334
Mass (Da):37,225
Last modified:July 27, 2011 - v2
Checksum:iBFAAA0B224DC9944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108A → R in BAB29095 (PubMed:16141072).Curated1
Sequence conflicti109E → K in AAD00027 (Ref. 1) Curated1
Sequence conflicti163A → V in AAD00027 (Ref. 1) Curated1
Sequence conflicti207K → KANFA in BAB29095 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43509 mRNA. Translation: AAD00027.1.
AK013975 mRNA. Translation: BAB29095.1.
CH466535 Genomic DNA. Translation: EDL35758.1.
BC045152 mRNA. Translation: AAH45152.1.
CCDSiCCDS27302.1.
RefSeqiNP_001297584.1. NM_001310655.1.
NP_034831.2. NM_010701.3.
UniGeneiMm.46561.

Genome annotation databases

EnsembliENSMUST00000022603; ENSMUSP00000022603; ENSMUSG00000022025.
GeneIDi16840.
KEGGimmu:16840.
UCSCiuc007utg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43509 mRNA. Translation: AAD00027.1.
AK013975 mRNA. Translation: BAB29095.1.
CH466535 Genomic DNA. Translation: EDL35758.1.
BC045152 mRNA. Translation: AAH45152.1.
CCDSiCCDS27302.1.
RefSeqiNP_001297584.1. NM_001310655.1.
NP_034831.2. NM_010701.3.
UniGeneiMm.46561.

3D structure databases

ProteinModelPortaliQ9Z1F6.
SMRiQ9Z1F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022603.

PTM databases

PhosphoSitePlusiQ9Z1F6.

Proteomic databases

PaxDbiQ9Z1F6.
PRIDEiQ9Z1F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022603; ENSMUSP00000022603; ENSMUSG00000022025.
GeneIDi16840.
KEGGimmu:16840.
UCSCiuc007utg.2. mouse.

Organism-specific databases

CTDi11061.
MGIiMGI:1341171. Lect1.

Phylogenomic databases

eggNOGiENOG410IFAS. Eukaryota.
ENOG410YVHU. LUCA.
GeneTreeiENSGT00480000042679.
HOGENOMiHOG000234812.
HOVERGENiHBG004387.
InParanoidiQ9Z1F6.
TreeFamiTF329712.

Miscellaneous databases

PROiQ9Z1F6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022025.
CleanExiMM_LECT1.
ExpressionAtlasiQ9Z1F6. baseline and differential.
GenevisibleiQ9Z1F6. MM.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLECT1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1F6
Secondary accession number(s): Q80UX1, Q9CXU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.