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Protein

Zinc finger protein 394

Gene

Znf394

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 349C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 394
Alternative name(s):
Zinc finger protein 94
Short name:
Zfp-94
Zinc finger protein with KRAB and SCAN domains 14
Gene namesi
Name:Znf394
Synonyms:Zfp94, Zfp99, Zkscan14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914485. Zkscan14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475581 – 521Zinc finger protein 394Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9Z1D9.
PRIDEiQ9Z1D9.

PTM databases

iPTMnetiQ9Z1D9.
PhosphoSitePlusiQ9Z1D9.

Expressioni

Tissue specificityi

Expressed at high level in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000029627.
CleanExiMM_ZKSCAN14.
ExpressionAtlasiQ9Z1D9. baseline and differential.
GenevisibleiQ9Z1D9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031632.

Structurei

3D structure databases

ProteinModelPortaliQ9Z1D9.
SMRiQ9Z1D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST96
Domaini135 – 196KRABAdd BLAST62

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 349C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Z1D9.
KOiK09229.
OMAiCGETCHI.
OrthoDBiEOG091G02KC.
TreeFamiTF338304.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

Q9Z1D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSGVVPP PLGAGLCTVK VEEDSPGNQE SSGSGDWQNP ETSRKQFRQL
60 70 80 90 100
RYQEVAGPEE ALSRLWELCR RWLRPELLSK EQIMELLVLE QFLTILPQEL
110 120 130 140 150
QAYVRDHSPE SGEEAAALAR TLQRALDRAS PQGFMTFKDV AESLTWEEWE
160 170 180 190 200
QLAAARKGFC EESTKDAGST VVPGLETRTV NTDVILKQEI LKEAEPQAWL
210 220 230 240 250
QEVSQGMVPA LTKCGDPSED WEEKLPKAAV LLQLQGSEEQ GRTAIPLLIG
260 270 280 290 300
VSREERDSKN NESENSGSSV LGQHIQTAEG LGTNSQCGDD HKQGFHVKCH
310 320 330 340 350
SVKPHSSVDS AVGLLETQRQ FQEDKPYKCD SCEKGFRQRS DLFKHQRIHT
360 370 380 390 400
GEKPYQCQEC GKRFSQSAAL VKHQRTHTGE KPYACPECGE CFRQSSHLSR
410 420 430 440 450
HQRTHASEKY YKCEECGEIV HVSSLFRHQR LHRGERPYKC GDCEKSFRQR
460 470 480 490 500
SDLFKHQRTH TGEKPYACVV CGRRFSQSAT LIKHQRTHTG EKPYKCFQCG
510 520
ERFRQSTHLV RHQRIHQNSV S
Length:521
Mass (Da):59,038
Last modified:July 27, 2011 - v3
Checksum:iBFA0C7F21761A2EB
GO

Sequence cautioni

The sequence BAB28368 differs from that shown. Reason: Frameshift at position 170.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112G → R in AAD00102 (PubMed:12860387).Curated1
Sequence conflicti118 – 119LA → W in AAD00102 (PubMed:12860387).Curated2
Sequence conflicti194 – 199AEPQAW → QSHRSC in AAD00102 (PubMed:12860387).Curated6
Sequence conflicti483K → R in BAB28368 (PubMed:16141072).Curated1
Sequence conflicti483K → R in BAB28752 (PubMed:16141072).Curated1
Sequence conflicti484 – 486HQR → NQS in BAE32289 (PubMed:16141072).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62906 mRNA. Translation: AAD00102.1.
AK012630 mRNA. Translation: BAB28368.1. Frameshift.
AK013258 mRNA. Translation: BAB28752.1.
AK153972 mRNA. Translation: BAE32289.1.
CH466529 Genomic DNA. Translation: EDL18989.1.
BC141244 mRNA. Translation: AAI41245.1.
CCDSiCCDS19860.1.
RefSeqiNP_075811.2. NM_023322.2.
UniGeneiMm.432480.

Genome annotation databases

EnsembliENSMUST00000031632; ENSMUSP00000031632; ENSMUSG00000029627.
GeneIDi67235.
KEGGimmu:67235.
UCSCiuc009amm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN394_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1D9
Secondary accession number(s): B9EIZ4
, Q3U4Z1, Q9CYV9, Q9CZG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families