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Protein
Submitted name:

Protocadherin 2C

Gene

Pcdhga12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin 2CImported
Gene namesi
Name:Pcdhga12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1935229. Pcdhga12.

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei685 – 71026HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliQ9Z1B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13059CadherinInterPro annotationAdd
BLAST
Domaini131 – 239109CadherinInterPro annotationAdd
BLAST
Domaini249 – 34395CadherinInterPro annotationAdd
BLAST
Domaini344 – 448105CadherinInterPro annotationAdd
BLAST
Domaini449 – 558110CadherinInterPro annotationAdd
BLAST
Domaini575 – 679105CadherinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z1B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRREDCKGL VFLGVLLGML WKAGSTQIRY SVPEELEKGS RVGNISKDLG
60 70 80 90 100
LKSCELAERG VRIVSRGRAQ LFALNPRSGS LVTAGRIDRE ELCMGSIKCQ
110 120 130 140 150
LNLEILMEDI GKIYGVEIEV RDINDNAPYF RESELEIKMS ENAAAGMRFP
160 170 180 190 200
LPHAWDPDIG KNSLQSYQLS PNAHFSLEVQ NGADGNKYPE LVLESSLDRE
210 220 230 240 250
EKAAHLLVLT ASDAGDPVRT GTARIRVMVV DANDNAPAFA RSEYRVSWEN
260 270 280 290 300
VAVGTQLLLV NATDPDEGAN AEVIYSFRYV DDKAAKVFKL DSNLGTISTI
310 320 330 340 350
GELNHEESGF YEMEVQATDN AGYSARAKVL VTVLDVNDNA PEVAITSLTN
360 370 380 390 400
SVPENSPQGT LIALLNVNDQ DSGENGQVIC SIQENLPFKL EKSYGNYYRL
410 420 430 440 450
VTDAVLDREE VPSYNITMTA TDRGSPPLTT ETHLALDIAD TNDNSPVFLQ
460 470 480 490 500
ASYWAYIPEN NPRGASIASV TAHDPDSDKN AQVTYSLAED THQGVPLSSY
510 520 530 540 550
VSINSDTGVL YALHSFDYEQ FPDLQLQVIA RDSGDPPLSS NVSLSLFVLD
560 570 580 590 600
QNDNVPEILY PTLPTDGSTG VELAPRSAEP GYLVTKVVAV DRDSGQNAWL
610 620 630 640 650
SYRLLKASEP GLFSVGLHTG EISTARALMD RDALKQNLVV SVQDHGQPPL
660 670 680 690 700
SATVTLTVAI ADSIPDVLAD LDNLESPSTS ETSGLTLYLV VAVAAVSTVF
710 720 730 740 750
LVFVLVLLAL RLRRWHSLRL LRAGGPGLAD VAASHFVGVD GVQAFLQTYS
760 770 780 790 800
HEVSLTAGSR KSHLIFPQPN YADTLISQES CEKTEPLLPS GDSVFSKDNH
810 820 830 840 850
ALNQQAPPNT DWRFSQAQRP GTSGSQNGDE TGTWPNNQFD TEMLQAMILA
860 870 880 890 900
SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN VYIPGSNATL
910 920
TNAAGKRDGK APAGGNGNKK KSGKKEKK
Length:928
Mass (Da):100,302
Last modified:May 1, 1999 - v1
Checksum:i4D0595DBC6725738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88550 mRNA. Translation: AAD00652.1.
UniGeneiMm.247203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88550 mRNA. Translation: AAD00652.1.
UniGeneiMm.247203.

3D structure databases

ProteinModelPortaliQ9Z1B0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1935229. Pcdhga12.

Phylogenomic databases

HOVERGENiHBG054878.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9Z1B0_MOUSE
AccessioniPrimary (citable) accession number: Q9Z1B0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.