Eyes absent homolog 4 - Mus musculus (Mouse)

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Q9Z191 (EYA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Eyes absent homolog 4
EC=3.1.3.48

Gene names

Name:

Eya4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	616 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Cofactor	Binds 1 Mg²⁺ ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb. Ref.1
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. EYA family.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Activator Chromatin regulator Developmental protein Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW middle ear morphogenesis Inferred from mutant phenotype PubMed 18219393. Source: MGI peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of sound Inferred from mutant phenotype PubMed 18219393. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 616

616

Eyes absent homolog 4

PRO_0000218652

Sites

Active site

352

Nucleophile By similarity

Active site

354

Proton donor By similarity

Metal binding

352

Magnesium By similarity

Metal binding

354

Magnesium By similarity

Metal binding

580

Magnesium By similarity

Amino acid modifications

Modified residue

338

Phosphoserine By similarity

Experimental info

Sequence conflict

337

P → L in CAA76637. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Z191 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AC4B7E891AB7A6F3
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FASTA

616

66,875

        10         20         30         40         50         60 
MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS SKLDKSGLSS 

        70         80         90        100        110        120 
TSVTTNGTGV SLLAVKTEPL HSSESTTTTG DGALDTFTGS VITSSGYSPR SAQQYSPQLY 

       130        140        150        160        170        180 
PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ QPAVYTAYSQ TGQPYSLPAY DLGVMLPAIK 

       190        200        210        220        230        240 
TESGLSQTQS PLQSGCLSYS PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF 

       250        260        270        280        290        300 
SSSQQDYPSY TAFGQNQYAQ YYSASTYGAY MTSNNTADGT SSSTSTYQLQ ESLQGLTSQP 

       310        320        330        340        350        360 
GEFDTVQSPS TPIKDLDDRT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV WDLDETIIVF 

       370        380        390        400        410        420 
HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF NDLEECDQVH IDDVSSDDNG 

       430        440        450        460        470        480 
QDLSTYSFAT DGFHAAASSA NLCLPTGVRG GVDWMRKLAF RYRRVKELYN TYKNNVGGLL 

       490        500        510        520        530        540 
GPAKRDAWLQ LRAEIEGLTD SWLTNALKSL SIISTRSNCV NVLVTTTQLI PALAKVLLYS 

       550        560        570        580        590        600 
LGGAFPIENI YSATKIGKES CFERIVSRFG TNITYVVIGD GRDEEHAANQ HNMPFWRISS 

       610 
HSDLLALHQA LELEYL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EYA4, a novel vertebrate gene related to Drosophila eyes absent." Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S., Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R., Robertson M., Axton R., Brown A., van Heyningen V., Hanson I. Hum. Mol. Genet. 8:11-23(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Embryo.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17115 mRNA. Translation: CAA76637.1. AJ007997 mRNA. Translation: CAA07820.1. CH466540 Genomic DNA. Translation: EDL04766.1. BC120899 mRNA. Translation: AAI20900.1.
IPI	IPI00129695.
UniGene	Mm.332128. Mm.446298.
3D structure databases
ProteinModelPortal	Q9Z191.
SMR	Q9Z191. Positions 346-616.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z191.
Proteomic databases
PRIDE	Q9Z191.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000074366; ENSMUSP00000073970; ENSMUSG00000010461.
Organism-specific databases
MGI	MGI:1337104. Eya4.
Phylogenomic databases
eggNOG	NOG297494.
GeneTree	ENSGT00390000008860.
HOGENOM	HOG000293149.
HOVERGEN	HBG002447.
Gene expression databases
ArrayExpress	Q9Z191.
Bgee	Q9Z191.
CleanEx	MM_EYA4.
Genevestigator	Q9Z191.
GermOnline	ENSMUSG00000010461. Mus musculus.
Family and domain databases
InterPro	IPR006545. EYA. [Graphical view]
TIGRFAMs	TIGR01658. EYA-cons_domain. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	EYA4. mouse.
SOURCE	Search...

Entry information

Entry name

EYA4_MOUSE

Accession

Primary (citable) accession number: Q9Z191
Secondary accession number(s): Q0VAV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents