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Q9Z191

- EYA4_MOUSE

UniProt

Q9Z191 - EYA4_MOUSE

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Protein

Eyes absent homolog 4

Gene

Eya4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521NucleophileBy similarity
Metal bindingi352 – 3521MagnesiumBy similarity
Active sitei354 – 3541Proton donorBy similarity
Metal bindingi354 – 3541MagnesiumBy similarity
Metal bindingi580 – 5801MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. middle ear morphogenesis Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. sensory perception of sound Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 4 (EC:3.1.3.48)
Gene namesi
Name:Eya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1337104. Eya4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Eyes absent homolog 4PRO_0000218652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei338 – 3381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z191.
PRIDEiQ9Z191.

PTM databases

PhosphoSiteiQ9Z191.

Expressioni

Tissue specificityi

In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb.1 Publication

Gene expression databases

BgeeiQ9Z191.
CleanExiMM_EYA4.
ExpressionAtlasiQ9Z191. baseline and differential.
GenevestigatoriQ9Z191.

Interactioni

Subunit structurei

Interacts with SIX3; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes.By similarity

Protein-protein interaction databases

MINTiMINT-8200583.

Structurei

3D structure databases

ProteinModelPortaliQ9Z191.
SMRiQ9Z191. Positions 346-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG297494.
GeneTreeiENSGT00390000008860.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
InParanoidiQ9Z191.
KOiK17622.

Family and domain databases

InterProiIPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS
60 70 80 90 100
SKLDKSGLSS TSVTTNGTGV SLLAVKTEPL HSSESTTTTG DGALDTFTGS
110 120 130 140 150
VITSSGYSPR SAQQYSPQLY PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ
160 170 180 190 200
QPAVYTAYSQ TGQPYSLPAY DLGVMLPAIK TESGLSQTQS PLQSGCLSYS
210 220 230 240 250
PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF SSSQQDYPSY
260 270 280 290 300
TAFGQNQYAQ YYSASTYGAY MTSNNTADGT SSSTSTYQLQ ESLQGLTSQP
310 320 330 340 350
GEFDTVQSPS TPIKDLDDRT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV
360 370 380 390 400
WDLDETIIVF HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF
410 420 430 440 450
NDLEECDQVH IDDVSSDDNG QDLSTYSFAT DGFHAAASSA NLCLPTGVRG
460 470 480 490 500
GVDWMRKLAF RYRRVKELYN TYKNNVGGLL GPAKRDAWLQ LRAEIEGLTD
510 520 530 540 550
SWLTNALKSL SIISTRSNCV NVLVTTTQLI PALAKVLLYS LGGAFPIENI
560 570 580 590 600
YSATKIGKES CFERIVSRFG TNITYVVIGD GRDEEHAANQ HNMPFWRISS
610
HSDLLALHQA LELEYL
Length:616
Mass (Da):66,875
Last modified:July 27, 2011 - v2
Checksum:iAC4B7E891AB7A6F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371P → L in CAA76637. (PubMed:9887327)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17115 mRNA. Translation: CAA76637.1.
AJ007997 mRNA. Translation: CAA07820.1.
CH466540 Genomic DNA. Translation: EDL04766.1.
BC120899 mRNA. Translation: AAI20900.1.
CCDSiCCDS35867.1.
RefSeqiXP_006512585.1. XM_006512522.1.
XP_006512586.1. XM_006512523.1.
XP_006512587.1. XM_006512524.1.
UniGeneiMm.332128.
Mm.446298.

Genome annotation databases

EnsembliENSMUST00000074366; ENSMUSP00000073970; ENSMUSG00000010461.
GeneIDi14051.
KEGGimmu:14051.
UCSCiuc007epu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17115 mRNA. Translation: CAA76637.1 .
AJ007997 mRNA. Translation: CAA07820.1 .
CH466540 Genomic DNA. Translation: EDL04766.1 .
BC120899 mRNA. Translation: AAI20900.1 .
CCDSi CCDS35867.1.
RefSeqi XP_006512585.1. XM_006512522.1.
XP_006512586.1. XM_006512523.1.
XP_006512587.1. XM_006512524.1.
UniGenei Mm.332128.
Mm.446298.

3D structure databases

ProteinModelPortali Q9Z191.
SMRi Q9Z191. Positions 346-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8200583.

PTM databases

PhosphoSitei Q9Z191.

Proteomic databases

MaxQBi Q9Z191.
PRIDEi Q9Z191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074366 ; ENSMUSP00000073970 ; ENSMUSG00000010461 .
GeneIDi 14051.
KEGGi mmu:14051.
UCSCi uc007epu.1. mouse.

Organism-specific databases

CTDi 2070.
MGIi MGI:1337104. Eya4.

Phylogenomic databases

eggNOGi NOG297494.
GeneTreei ENSGT00390000008860.
HOGENOMi HOG000293149.
HOVERGENi HBG002447.
InParanoidi Q9Z191.
KOi K17622.

Miscellaneous databases

ChiTaRSi Eya4. mouse.
PROi Q9Z191.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z191.
CleanExi MM_EYA4.
ExpressionAtlasi Q9Z191. baseline and differential.
Genevestigatori Q9Z191.

Family and domain databases

InterProi IPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view ]
PANTHERi PTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsi TIGR01658. EYA-cons_domain. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiEYA4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z191
Secondary accession number(s): Q0VAV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3