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Q9Z191 (EYA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eyes absent homolog 4

EC=3.1.3.48
Gene names
Name:Eya4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactor

Binds 1 Mg2+ ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb. Ref.1

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. EYA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Eyes absent homolog 4
PRO_0000218652

Sites

Active site3521Nucleophile By similarity
Active site3541Proton donor By similarity
Metal binding3521Magnesium By similarity
Metal binding3541Magnesium By similarity
Metal binding5801Magnesium By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue3381Phosphoserine By similarity

Experimental info

Sequence conflict3371P → L in CAA76637. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z191 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AC4B7E891AB7A6F3

FASTA61666,875
        10         20         30         40         50         60 
MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS SKLDKSGLSS 

        70         80         90        100        110        120 
TSVTTNGTGV SLLAVKTEPL HSSESTTTTG DGALDTFTGS VITSSGYSPR SAQQYSPQLY 

       130        140        150        160        170        180 
PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ QPAVYTAYSQ TGQPYSLPAY DLGVMLPAIK 

       190        200        210        220        230        240 
TESGLSQTQS PLQSGCLSYS PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF 

       250        260        270        280        290        300 
SSSQQDYPSY TAFGQNQYAQ YYSASTYGAY MTSNNTADGT SSSTSTYQLQ ESLQGLTSQP 

       310        320        330        340        350        360 
GEFDTVQSPS TPIKDLDDRT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV WDLDETIIVF 

       370        380        390        400        410        420 
HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF NDLEECDQVH IDDVSSDDNG 

       430        440        450        460        470        480 
QDLSTYSFAT DGFHAAASSA NLCLPTGVRG GVDWMRKLAF RYRRVKELYN TYKNNVGGLL 

       490        500        510        520        530        540 
GPAKRDAWLQ LRAEIEGLTD SWLTNALKSL SIISTRSNCV NVLVTTTQLI PALAKVLLYS 

       550        560        570        580        590        600 
LGGAFPIENI YSATKIGKES CFERIVSRFG TNITYVVIGD GRDEEHAANQ HNMPFWRISS 

       610 
HSDLLALHQA LELEYL 

« Hide

References

« Hide 'large scale' references
[1]"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S., Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R., Robertson M., Axton R., Brown A., van Heyningen V., Hanson I.
Hum. Mol. Genet. 8:11-23(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Embryo.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17115 mRNA. Translation: CAA76637.1.
AJ007997 mRNA. Translation: CAA07820.1.
CH466540 Genomic DNA. Translation: EDL04766.1.
BC120899 mRNA. Translation: AAI20900.1.
CCDSCCDS35867.1.
RefSeqXP_006512585.1. XM_006512522.1.
XP_006512586.1. XM_006512523.1.
XP_006512587.1. XM_006512524.1.
UniGeneMm.332128.
Mm.446298.

3D structure databases

ProteinModelPortalQ9Z191.
SMRQ9Z191. Positions 346-616.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8200583.

PTM databases

PhosphoSiteQ9Z191.

Proteomic databases

PRIDEQ9Z191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000074366; ENSMUSP00000073970; ENSMUSG00000010461.
GeneID14051.
KEGGmmu:14051.
UCSCuc007epu.1. mouse.

Organism-specific databases

CTD2070.
MGIMGI:1337104. Eya4.

Phylogenomic databases

eggNOGNOG297494.
GeneTreeENSGT00390000008860.
HOGENOMHOG000293149.
HOVERGENHBG002447.
KOK17622.

Gene expression databases

ArrayExpressQ9Z191.
BgeeQ9Z191.
CleanExMM_EYA4.
GenevestigatorQ9Z191.

Family and domain databases

InterProIPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsTIGR01658. EYA-cons_domain. 1 hit.
ProtoNetSearch...

Other

ChiTaRSEYA4. mouse.
PROQ9Z191.
SOURCESearch...

Entry information

Entry nameEYA4_MOUSE
AccessionPrimary (citable) accession number: Q9Z191
Secondary accession number(s): Q0VAV8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot