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Q9Z191

- EYA4_MOUSE

UniProt

Q9Z191 - EYA4_MOUSE

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Protein

Eyes absent homolog 4

Gene
Eya4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Binds 1 Mg2+ ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521Nucleophile By similarity
Metal bindingi352 – 3521Magnesium By similarity
Active sitei354 – 3541Proton donor By similarity
Metal bindingi354 – 3541Magnesium By similarity
Metal bindingi580 – 5801Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. middle ear morphogenesis Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. sensory perception of sound Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eyes absent homolog 4 (EC:3.1.3.48)
Gene namesi
Name:Eya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1337104. Eya4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Eyes absent homolog 4PRO_0000218652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei338 – 3381Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9Z191.

PTM databases

PhosphoSiteiQ9Z191.

Expressioni

Tissue specificityi

In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb.1 Publication

Gene expression databases

ArrayExpressiQ9Z191.
BgeeiQ9Z191.
CleanExiMM_EYA4.
GenevestigatoriQ9Z191.

Interactioni

Protein-protein interaction databases

MINTiMINT-8200583.

Structurei

3D structure databases

ProteinModelPortaliQ9Z191.
SMRiQ9Z191. Positions 346-616.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG297494.
GeneTreeiENSGT00390000008860.
HOGENOMiHOG000293149.
HOVERGENiHBG002447.
KOiK17622.

Family and domain databases

InterProiIPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view]
PANTHERiPTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z191-1 [UniParc]FASTAAdd to Basket

« Hide

MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS    50
SKLDKSGLSS TSVTTNGTGV SLLAVKTEPL HSSESTTTTG DGALDTFTGS 100
VITSSGYSPR SAQQYSPQLY PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ 150
QPAVYTAYSQ TGQPYSLPAY DLGVMLPAIK TESGLSQTQS PLQSGCLSYS 200
PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF SSSQQDYPSY 250
TAFGQNQYAQ YYSASTYGAY MTSNNTADGT SSSTSTYQLQ ESLQGLTSQP 300
GEFDTVQSPS TPIKDLDDRT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV 350
WDLDETIIVF HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF 400
NDLEECDQVH IDDVSSDDNG QDLSTYSFAT DGFHAAASSA NLCLPTGVRG 450
GVDWMRKLAF RYRRVKELYN TYKNNVGGLL GPAKRDAWLQ LRAEIEGLTD 500
SWLTNALKSL SIISTRSNCV NVLVTTTQLI PALAKVLLYS LGGAFPIENI 550
YSATKIGKES CFERIVSRFG TNITYVVIGD GRDEEHAANQ HNMPFWRISS 600
HSDLLALHQA LELEYL 616
Length:616
Mass (Da):66,875
Last modified:July 27, 2011 - v2
Checksum:iAC4B7E891AB7A6F3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371P → L in CAA76637. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17115 mRNA. Translation: CAA76637.1.
AJ007997 mRNA. Translation: CAA07820.1.
CH466540 Genomic DNA. Translation: EDL04766.1.
BC120899 mRNA. Translation: AAI20900.1.
CCDSiCCDS35867.1.
RefSeqiXP_006512585.1. XM_006512522.1.
XP_006512586.1. XM_006512523.1.
XP_006512587.1. XM_006512524.1.
UniGeneiMm.332128.
Mm.446298.

Genome annotation databases

EnsembliENSMUST00000074366; ENSMUSP00000073970; ENSMUSG00000010461.
GeneIDi14051.
KEGGimmu:14051.
UCSCiuc007epu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17115 mRNA. Translation: CAA76637.1 .
AJ007997 mRNA. Translation: CAA07820.1 .
CH466540 Genomic DNA. Translation: EDL04766.1 .
BC120899 mRNA. Translation: AAI20900.1 .
CCDSi CCDS35867.1.
RefSeqi XP_006512585.1. XM_006512522.1.
XP_006512586.1. XM_006512523.1.
XP_006512587.1. XM_006512524.1.
UniGenei Mm.332128.
Mm.446298.

3D structure databases

ProteinModelPortali Q9Z191.
SMRi Q9Z191. Positions 346-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8200583.

PTM databases

PhosphoSitei Q9Z191.

Proteomic databases

PRIDEi Q9Z191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074366 ; ENSMUSP00000073970 ; ENSMUSG00000010461 .
GeneIDi 14051.
KEGGi mmu:14051.
UCSCi uc007epu.1. mouse.

Organism-specific databases

CTDi 2070.
MGIi MGI:1337104. Eya4.

Phylogenomic databases

eggNOGi NOG297494.
GeneTreei ENSGT00390000008860.
HOGENOMi HOG000293149.
HOVERGENi HBG002447.
KOi K17622.

Miscellaneous databases

ChiTaRSi EYA4. mouse.
PROi Q9Z191.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z191.
Bgeei Q9Z191.
CleanExi MM_EYA4.
Genevestigatori Q9Z191.

Family and domain databases

InterProi IPR028478. EYA4.
IPR006545. EYA_dom.
IPR028472. EYA_fam.
[Graphical view ]
PANTHERi PTHR10190. PTHR10190. 1 hit.
PTHR10190:SF17. PTHR10190:SF17. 1 hit.
TIGRFAMsi TIGR01658. EYA-cons_domain. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiEYA4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z191
Secondary accession number(s): Q0VAV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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