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Q9Z191

- EYA4_MOUSE

UniProt

Q9Z191 - EYA4_MOUSE

Protein

Eyes absent homolog 4

Gene

Eya4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Binds 1 Mg2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei352 – 3521NucleophileBy similarity
    Metal bindingi352 – 3521MagnesiumBy similarity
    Active sitei354 – 3541Proton donorBy similarity
    Metal bindingi354 – 3541MagnesiumBy similarity
    Metal bindingi580 – 5801MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. middle ear morphogenesis Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. sensory perception of sound Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eyes absent homolog 4 (EC:3.1.3.48)
    Gene namesi
    Name:Eya4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1337104. Eya4.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616Eyes absent homolog 4PRO_0000218652Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei338 – 3381PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ9Z191.

    PTM databases

    PhosphoSiteiQ9Z191.

    Expressioni

    Tissue specificityi

    In the embryo, expressed mainly in the craniofacial mesenchyme, dermamyotome and limb.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z191.
    BgeeiQ9Z191.
    CleanExiMM_EYA4.
    GenevestigatoriQ9Z191.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8200583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z191.
    SMRiQ9Z191. Positions 346-616.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG297494.
    GeneTreeiENSGT00390000008860.
    HOGENOMiHOG000293149.
    HOVERGENiHBG002447.
    KOiK17622.

    Family and domain databases

    InterProiIPR028478. EYA4.
    IPR006545. EYA_dom.
    IPR028472. EYA_fam.
    [Graphical view]
    PANTHERiPTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF17. PTHR10190:SF17. 1 hit.
    TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS    50
    SKLDKSGLSS TSVTTNGTGV SLLAVKTEPL HSSESTTTTG DGALDTFTGS 100
    VITSSGYSPR SAQQYSPQLY PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ 150
    QPAVYTAYSQ TGQPYSLPAY DLGVMLPAIK TESGLSQTQS PLQSGCLSYS 200
    PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF SSSQQDYPSY 250
    TAFGQNQYAQ YYSASTYGAY MTSNNTADGT SSSTSTYQLQ ESLQGLTSQP 300
    GEFDTVQSPS TPIKDLDDRT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV 350
    WDLDETIIVF HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF 400
    NDLEECDQVH IDDVSSDDNG QDLSTYSFAT DGFHAAASSA NLCLPTGVRG 450
    GVDWMRKLAF RYRRVKELYN TYKNNVGGLL GPAKRDAWLQ LRAEIEGLTD 500
    SWLTNALKSL SIISTRSNCV NVLVTTTQLI PALAKVLLYS LGGAFPIENI 550
    YSATKIGKES CFERIVSRFG TNITYVVIGD GRDEEHAANQ HNMPFWRISS 600
    HSDLLALHQA LELEYL 616
    Length:616
    Mass (Da):66,875
    Last modified:July 27, 2011 - v2
    Checksum:iAC4B7E891AB7A6F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti337 – 3371P → L in CAA76637. (PubMed:9887327)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17115 mRNA. Translation: CAA76637.1.
    AJ007997 mRNA. Translation: CAA07820.1.
    CH466540 Genomic DNA. Translation: EDL04766.1.
    BC120899 mRNA. Translation: AAI20900.1.
    CCDSiCCDS35867.1.
    RefSeqiXP_006512585.1. XM_006512522.1.
    XP_006512586.1. XM_006512523.1.
    XP_006512587.1. XM_006512524.1.
    UniGeneiMm.332128.
    Mm.446298.

    Genome annotation databases

    EnsembliENSMUST00000074366; ENSMUSP00000073970; ENSMUSG00000010461.
    GeneIDi14051.
    KEGGimmu:14051.
    UCSCiuc007epu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17115 mRNA. Translation: CAA76637.1 .
    AJ007997 mRNA. Translation: CAA07820.1 .
    CH466540 Genomic DNA. Translation: EDL04766.1 .
    BC120899 mRNA. Translation: AAI20900.1 .
    CCDSi CCDS35867.1.
    RefSeqi XP_006512585.1. XM_006512522.1.
    XP_006512586.1. XM_006512523.1.
    XP_006512587.1. XM_006512524.1.
    UniGenei Mm.332128.
    Mm.446298.

    3D structure databases

    ProteinModelPortali Q9Z191.
    SMRi Q9Z191. Positions 346-616.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8200583.

    PTM databases

    PhosphoSitei Q9Z191.

    Proteomic databases

    PRIDEi Q9Z191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074366 ; ENSMUSP00000073970 ; ENSMUSG00000010461 .
    GeneIDi 14051.
    KEGGi mmu:14051.
    UCSCi uc007epu.1. mouse.

    Organism-specific databases

    CTDi 2070.
    MGIi MGI:1337104. Eya4.

    Phylogenomic databases

    eggNOGi NOG297494.
    GeneTreei ENSGT00390000008860.
    HOGENOMi HOG000293149.
    HOVERGENi HBG002447.
    KOi K17622.

    Miscellaneous databases

    ChiTaRSi EYA4. mouse.
    PROi Q9Z191.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z191.
    Bgeei Q9Z191.
    CleanExi MM_EYA4.
    Genevestigatori Q9Z191.

    Family and domain databases

    InterProi IPR028478. EYA4.
    IPR006545. EYA_dom.
    IPR028472. EYA_fam.
    [Graphical view ]
    PANTHERi PTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF17. PTHR10190:SF17. 1 hit.
    TIGRFAMsi TIGR01658. EYA-cons_domain. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiEYA4_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z191
    Secondary accession number(s): Q0VAV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3