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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Gene

Dyrk1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Enzyme regulationi

Inhibited by RANBP9.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140ATPPROSITE-ProRule annotation1
Active sitei239Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 125ATPPROSITE-ProRule annotation9
Nucleotide bindingi190 – 193ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: UniProtKB
  • myoblast fusion Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC:2.7.12.1)
Gene namesi
Name:Dyrk1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1330302. Dyrk1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859351 – 629Dual specificity tyrosine-phosphorylation-regulated kinase 1BAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphotyrosineBy similarity1
Modified residuei92PhosphotyrosineBy similarity1
Modified residuei111PhosphotyrosineBy similarity1
Modified residuei129PhosphotyrosineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei271Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei273PhosphotyrosineBy similarity1
Modified residuei401PhosphotyrosineBy similarity1
Modified residuei624PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z188.
PeptideAtlasiQ9Z188.
PRIDEiQ9Z188.

PTM databases

iPTMnetiQ9Z188.
PhosphoSitePlusiQ9Z188.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level).1 Publication

Developmental stagei

Isoform 1 is present from 14 dpc. Isoform 3 is present from 18 dpc (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000002409.
GenevisibleiQ9Z188. MM.

Interactioni

Subunit structurei

Dimer. Interacts with DCOHM, MAP2K3/MKK3 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (By similarity). Interacts with DCAF7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083064.

Structurei

3D structure databases

ProteinModelPortaliQ9Z188.
SMRiQ9Z188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 431Protein kinasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni480 – 520Interaction with RANBP9By similarityAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 86Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi558 – 561Poly-Pro4
Compositional biasi577 – 584Poly-Pro8

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051425.
InParanoidiQ9Z188.
KOiK08825.
OMAiRAYRYSN.
OrthoDBiEOG091G03J7.
PhylomeDBiQ9Z188.
TreeFamiTF314624.

Family and domain databases

InterProiIPR033565. DYRK1B.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF27. PTHR24058:SF27. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z188-1) [UniParc]FASTAAdd to basket
Also known as: p69

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA ASAPLRKLSV
60 70 80 90 100
DLIKTYKHIN EVYYAKKKRR AQQAPPQDSS TKKEKKVLNH GYDDDNHDYI
110 120 130 140 150
VRSGERWLER YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN
160 170 180 190 200
QAQIELRLLE LMNQHDTEMK YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL
210 220 230 240 250
LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL KPENILLCNP
260 270 280 290 300
KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG
310 320 330 340 350
CILVEMHTGE PLFSGSNEVD QMSRIVEVLG IPPAPMLEQA PKARKYFERL
360 370 380 390 400
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD
410 420 430 440 450
YLRFQDLVLR MLEYEPAARI SPLGALQHGF FRRTADEATN TGPAGSSAST
460 470 480 490 500
SPAPLDTCPS SSTASSISSS GGSSGSSNDN RAYRYSNRYC GGPGPPITDC
510 520 530 540 550
EMNSPQVLPS QPLRPWAGGD VPHKTHQAPI SASTLPGTGA QLPPLPRCLG
560 570 580 590 600
RPPSPTSPPP PELMDVSLVG SPPDCSPPPP APAPQHPAAS ALRTRMTGGR
610 620
PPLPPPDDPA TLGPRLGLHG VPQSTAASS
Length:629
Mass (Da):69,178
Last modified:February 6, 2007 - v3
Checksum:i54FCE6DBD3918D1C
GO
Isoform 2 (identifier: Q9Z188-2) [UniParc]FASTAAdd to basket
Also known as: p65

The sequence of this isoform differs from the canonical sequence as follows:
     366-405: Missing.

Note: Inactive.
Show »
Length:589
Mass (Da):64,914
Checksum:i48B4242AD6E8401E
GO
Isoform 3 (identifier: Q9Z188-3) [UniParc]FASTAAdd to basket
Also known as: p75

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLAARPPHWGPHRAPAPRGPSAIPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTM

Show »
Length:689
Mass (Da):75,095
Checksum:i8A1437EF65C65B50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459P → H in BAE28495 (PubMed:16141072).Curated1
Sequence conflicti531S → P in BAE28495 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229541M → MLAARPPHWGPHRAPAPRGP SAIPDPGLSGGGSRGAGCEK APPGRAPAPGLTPLRPSEPT M in isoform 3. 1 Publication1
Alternative sequenceiVSP_022955366 – 405Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18280 mRNA. Translation: CAA77101.2.
AJ252172 Genomic DNA. Translation: CAC20675.1.
AJ537610 mRNA. Translation: CAD61290.1.
BC019545 mRNA. Translation: AAH19545.1.
AK148342 mRNA. Translation: BAE28495.1.
CCDSiCCDS21037.1. [Q9Z188-1]
CCDS57532.1. [Q9Z188-2]
PIRiJG0196.
RefSeqiNP_001033046.1. NM_001037957.3. [Q9Z188-1]
NP_001258299.1. NM_001271370.1. [Q9Z188-3]
NP_034222.1. NM_010092.2. [Q9Z188-2]
UniGeneiMm.57249.

Genome annotation databases

EnsembliENSMUST00000085901; ENSMUSP00000083064; ENSMUSG00000002409. [Q9Z188-1]
ENSMUST00000172467; ENSMUSP00000133431; ENSMUSG00000002409. [Q9Z188-3]
ENSMUST00000172761; ENSMUSP00000133719; ENSMUSG00000002409. [Q9Z188-2]
GeneIDi13549.
KEGGimmu:13549.
UCSCiuc009fxz.2. mouse. [Q9Z188-2]
uc009fya.2. mouse. [Q9Z188-1]
uc009fyb.2. mouse. [Q9Z188-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18280 mRNA. Translation: CAA77101.2.
AJ252172 Genomic DNA. Translation: CAC20675.1.
AJ537610 mRNA. Translation: CAD61290.1.
BC019545 mRNA. Translation: AAH19545.1.
AK148342 mRNA. Translation: BAE28495.1.
CCDSiCCDS21037.1. [Q9Z188-1]
CCDS57532.1. [Q9Z188-2]
PIRiJG0196.
RefSeqiNP_001033046.1. NM_001037957.3. [Q9Z188-1]
NP_001258299.1. NM_001271370.1. [Q9Z188-3]
NP_034222.1. NM_010092.2. [Q9Z188-2]
UniGeneiMm.57249.

3D structure databases

ProteinModelPortaliQ9Z188.
SMRiQ9Z188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083064.

PTM databases

iPTMnetiQ9Z188.
PhosphoSitePlusiQ9Z188.

Proteomic databases

PaxDbiQ9Z188.
PeptideAtlasiQ9Z188.
PRIDEiQ9Z188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085901; ENSMUSP00000083064; ENSMUSG00000002409. [Q9Z188-1]
ENSMUST00000172467; ENSMUSP00000133431; ENSMUSG00000002409. [Q9Z188-3]
ENSMUST00000172761; ENSMUSP00000133719; ENSMUSG00000002409. [Q9Z188-2]
GeneIDi13549.
KEGGimmu:13549.
UCSCiuc009fxz.2. mouse. [Q9Z188-2]
uc009fya.2. mouse. [Q9Z188-1]
uc009fyb.2. mouse. [Q9Z188-3]

Organism-specific databases

CTDi9149.
MGIiMGI:1330302. Dyrk1b.

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051425.
InParanoidiQ9Z188.
KOiK08825.
OMAiRAYRYSN.
OrthoDBiEOG091G03J7.
PhylomeDBiQ9Z188.
TreeFamiTF314624.

Enzyme and pathway databases

BRENDAi2.7.12.1. 3474.

Miscellaneous databases

PROiQ9Z188.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002409.
GenevisibleiQ9Z188. MM.

Family and domain databases

InterProiIPR033565. DYRK1B.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF27. PTHR24058:SF27. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYR1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z188
Secondary accession number(s): Q3UFR5, Q70UR5, Q9EPM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.