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Q9Z185

- PADI1_MOUSE

UniProt

Q9Z185 - PADI1_MOUSE

Protein

Protein-arginine deiminase type-1

Gene

Padi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the deimination of arginine residues of proteins.

    Catalytic activityi

    Protein L-arginine + H2O = protein L-citrulline + NH3.

    Cofactori

    Calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein-arginine deiminase activity Source: MGI

    GO - Biological processi

    1. protein citrullination Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-arginine deiminase type-1 (EC:3.5.3.15)
    Alternative name(s):
    Peptidylarginine deiminase I
    Protein-arginine deiminase type I
    Gene namesi
    Name:Padi1
    Synonyms:Pdi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1338893. Padi1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662Protein-arginine deiminase type-1PRO_0000220024Add
    BLAST

    Proteomic databases

    MaxQBiQ9Z185.
    PRIDEiQ9Z185.

    PTM databases

    PhosphoSiteiQ9Z185.

    Expressioni

    Tissue specificityi

    Expressed only in the epidermis and uterus.1 Publication

    Developmental stagei

    Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases.

    Inductioni

    By estrogen.

    Gene expression databases

    BgeeiQ9Z185.
    CleanExiMM_PADI1.
    GenevestigatoriQ9Z185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z185.
    SMRiQ9Z185. Positions 7-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein arginine deiminase family.Curated

    Phylogenomic databases

    eggNOGiNOG42085.
    GeneTreeiENSGT00390000008680.
    HOGENOMiHOG000220908.
    HOVERGENiHBG053016.
    InParanoidiQ9Z185.
    KOiK01481.
    OMAiNCDRDSL.
    OrthoDBiEOG7P5T09.
    PhylomeDBiQ9Z185.
    TreeFamiTF331952.

    Family and domain databases

    InterProiIPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view]
    PANTHERiPTHR10837. PTHR10837. 1 hit.
    PfamiPF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMiSSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPRAVQLS LRKPTHAVCV VGVETLVNVY SDVPKGAKTF GVSGSSEVKI    50
    YMVYDPSRVA EPAGWAHWPL DANVDVVVVA DTVSKDLYDF KVKVSYFESQ 100
    EAAALAHSVL YLTAVDVSLD VDTGRTGKVK KGSGDKKTWR WGPGGSGAIL 150
    LVNCDRDIHG SREDLHANHL KSLEDLQDMS PMVLSCGGPD ELFESHKLVL 200
    KASLSDSRRL KVFCARGGTS LSNYKQVLGP RHSSYEVERH SGERAIQFYV 250
    EGLAFPDASF SGLLSLSVSL VDTRPLSEVS VFTDSVTFRV APWIMTPNTQ 300
    PPLELYVCSV TDIHGRNDKF LEDMSHLATK ANCKLVVCPR AENRNDRWIQ 350
    DELEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKRILGPDF GYVTREIEFA 400
    GASGLDSFGN LDVSPPVRVG NTDYPLGRIL IGGSFPKPSG RRMARVVRDF 450
    LQAQQVQSPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL 500
    FQEKKEEGYG EAEQFDGLKH KAKRSINDIL ADKHLRRDSA HVQKCIDWNR 550
    EVLKRELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP 600
    FGPLINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR 650
    KPFTFKWWNS VP 662
    Length:662
    Mass (Da):73,824
    Last modified:May 1, 1999 - v1
    Checksum:iF9A6C7DFF1031D8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013848 mRNA. Translation: BAA34181.1.
    AB121692 Genomic DNA. Translation: BAD16625.1.
    CCDSiCCDS18856.1.
    PIRiPH0203.
    RefSeqiNP_035189.1. NM_011059.2.
    UniGeneiMm.20854.

    Genome annotation databases

    EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329.
    GeneIDi18599.
    KEGGimmu:18599.
    UCSCiuc008vnh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013848 mRNA. Translation: BAA34181.1 .
    AB121692 Genomic DNA. Translation: BAD16625.1 .
    CCDSi CCDS18856.1.
    PIRi PH0203.
    RefSeqi NP_035189.1. NM_011059.2.
    UniGenei Mm.20854.

    3D structure databases

    ProteinModelPortali Q9Z185.
    SMRi Q9Z185. Positions 7-662.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z185.

    Proteomic databases

    MaxQBi Q9Z185.
    PRIDEi Q9Z185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026378 ; ENSMUSP00000026378 ; ENSMUSG00000025329 .
    GeneIDi 18599.
    KEGGi mmu:18599.
    UCSCi uc008vnh.1. mouse.

    Organism-specific databases

    CTDi 29943.
    MGIi MGI:1338893. Padi1.

    Phylogenomic databases

    eggNOGi NOG42085.
    GeneTreei ENSGT00390000008680.
    HOGENOMi HOG000220908.
    HOVERGENi HBG053016.
    InParanoidi Q9Z185.
    KOi K01481.
    OMAi NCDRDSL.
    OrthoDBi EOG7P5T09.
    PhylomeDBi Q9Z185.
    TreeFami TF331952.

    Miscellaneous databases

    NextBioi 294498.
    PROi Q9Z185.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z185.
    CleanExi MM_PADI1.
    Genevestigatori Q9Z185.

    Family and domain databases

    InterProi IPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view ]
    PANTHERi PTHR10837. PTHR10837. 1 hit.
    Pfami PF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMi SSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
      Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
      Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epidermis and Uterus.
    2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
      Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
      Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
      Terakawa H., Takahara H., Sugawara K.
      J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPADI1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z185
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3