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Q9Z185

- PADI1_MOUSE

UniProt

Q9Z185 - PADI1_MOUSE

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Protein

Protein-arginine deiminase type-1

Gene
Padi1, Pdi1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

Calcium.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein-arginine deiminase activity Source: MGI

GO - Biological processi

  1. protein citrullination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:Padi1
Synonyms:Pdi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1338893. Padi1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Protein-arginine deiminase type-1PRO_0000220024Add
BLAST

Proteomic databases

MaxQBiQ9Z185.
PRIDEiQ9Z185.

PTM databases

PhosphoSiteiQ9Z185.

Expressioni

Tissue specificityi

Expressed only in the epidermis and uterus.1 Publication

Developmental stagei

Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases.

Inductioni

By estrogen.

Gene expression databases

BgeeiQ9Z185.
CleanExiMM_PADI1.
GenevestigatoriQ9Z185.

Structurei

3D structure databases

ProteinModelPortaliQ9Z185.
SMRiQ9Z185. Positions 7-662.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9Z185.
KOiK01481.
OMAiNCDRDSL.
OrthoDBiEOG7P5T09.
PhylomeDBiQ9Z185.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z185-1 [UniParc]FASTAAdd to Basket

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MASPRAVQLS LRKPTHAVCV VGVETLVNVY SDVPKGAKTF GVSGSSEVKI    50
YMVYDPSRVA EPAGWAHWPL DANVDVVVVA DTVSKDLYDF KVKVSYFESQ 100
EAAALAHSVL YLTAVDVSLD VDTGRTGKVK KGSGDKKTWR WGPGGSGAIL 150
LVNCDRDIHG SREDLHANHL KSLEDLQDMS PMVLSCGGPD ELFESHKLVL 200
KASLSDSRRL KVFCARGGTS LSNYKQVLGP RHSSYEVERH SGERAIQFYV 250
EGLAFPDASF SGLLSLSVSL VDTRPLSEVS VFTDSVTFRV APWIMTPNTQ 300
PPLELYVCSV TDIHGRNDKF LEDMSHLATK ANCKLVVCPR AENRNDRWIQ 350
DELEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKRILGPDF GYVTREIEFA 400
GASGLDSFGN LDVSPPVRVG NTDYPLGRIL IGGSFPKPSG RRMARVVRDF 450
LQAQQVQSPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL 500
FQEKKEEGYG EAEQFDGLKH KAKRSINDIL ADKHLRRDSA HVQKCIDWNR 550
EVLKRELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP 600
FGPLINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR 650
KPFTFKWWNS VP 662
Length:662
Mass (Da):73,824
Last modified:May 1, 1999 - v1
Checksum:iF9A6C7DFF1031D8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013848 mRNA. Translation: BAA34181.1.
AB121692 Genomic DNA. Translation: BAD16625.1.
CCDSiCCDS18856.1.
PIRiPH0203.
RefSeqiNP_035189.1. NM_011059.2.
UniGeneiMm.20854.

Genome annotation databases

EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329.
GeneIDi18599.
KEGGimmu:18599.
UCSCiuc008vnh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013848 mRNA. Translation: BAA34181.1 .
AB121692 Genomic DNA. Translation: BAD16625.1 .
CCDSi CCDS18856.1.
PIRi PH0203.
RefSeqi NP_035189.1. NM_011059.2.
UniGenei Mm.20854.

3D structure databases

ProteinModelPortali Q9Z185.
SMRi Q9Z185. Positions 7-662.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z185.

Proteomic databases

MaxQBi Q9Z185.
PRIDEi Q9Z185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026378 ; ENSMUSP00000026378 ; ENSMUSG00000025329 .
GeneIDi 18599.
KEGGi mmu:18599.
UCSCi uc008vnh.1. mouse.

Organism-specific databases

CTDi 29943.
MGIi MGI:1338893. Padi1.

Phylogenomic databases

eggNOGi NOG42085.
GeneTreei ENSGT00390000008680.
HOGENOMi HOG000220908.
HOVERGENi HBG053016.
InParanoidi Q9Z185.
KOi K01481.
OMAi NCDRDSL.
OrthoDBi EOG7P5T09.
PhylomeDBi Q9Z185.
TreeFami TF331952.

Miscellaneous databases

NextBioi 294498.
PROi Q9Z185.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z185.
CleanExi MM_PADI1.
Genevestigatori Q9Z185.

Family and domain databases

InterProi IPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view ]
PANTHERi PTHR10837. PTHR10837. 1 hit.
Pfami PF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMi SSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
    Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
    Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis and Uterus.
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
    Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
    Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
    Terakawa H., Takahara H., Sugawara K.
    J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPADI1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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