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Q9Z185 (PADI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-arginine deiminase type-1

EC=3.5.3.15
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene names
Name:Padi1
Synonyms:Pdi1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the deimination of arginine residues of proteins.

Catalytic activity

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactor

Calcium.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed only in the epidermis and uterus. Ref.3

Developmental stage

Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases.

Induction

By estrogen.

Sequence similarities

Belongs to the protein arginine deiminase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandCalcium
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein citrullination

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

protein-arginine deiminase activity

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Protein-arginine deiminase type-1
PRO_0000220024

Sequences

Sequence LengthMass (Da)Tools
Q9Z185 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F9A6C7DFF1031D8A

FASTA66273,824
        10         20         30         40         50         60 
MASPRAVQLS LRKPTHAVCV VGVETLVNVY SDVPKGAKTF GVSGSSEVKI YMVYDPSRVA 

        70         80         90        100        110        120 
EPAGWAHWPL DANVDVVVVA DTVSKDLYDF KVKVSYFESQ EAAALAHSVL YLTAVDVSLD 

       130        140        150        160        170        180 
VDTGRTGKVK KGSGDKKTWR WGPGGSGAIL LVNCDRDIHG SREDLHANHL KSLEDLQDMS 

       190        200        210        220        230        240 
PMVLSCGGPD ELFESHKLVL KASLSDSRRL KVFCARGGTS LSNYKQVLGP RHSSYEVERH 

       250        260        270        280        290        300 
SGERAIQFYV EGLAFPDASF SGLLSLSVSL VDTRPLSEVS VFTDSVTFRV APWIMTPNTQ 

       310        320        330        340        350        360 
PPLELYVCSV TDIHGRNDKF LEDMSHLATK ANCKLVVCPR AENRNDRWIQ DELEFGYIDA 

       370        380        390        400        410        420 
PHKSFPVVFD SPRNRGLRDF ALKRILGPDF GYVTREIEFA GASGLDSFGN LDVSPPVRVG 

       430        440        450        460        470        480 
NTDYPLGRIL IGGSFPKPSG RRMARVVRDF LQAQQVQSPV ELYSDWLSVG HVDEFLSFVP 

       490        500        510        520        530        540 
TSDQKGFRLL LASPSACLQL FQEKKEEGYG EAEQFDGLKH KAKRSINDIL ADKHLRRDSA 

       550        560        570        580        590        600 
HVQKCIDWNR EVLKRELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP 

       610        620        630        640        650        660 
FGPLINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR KPFTFKWWNS 


VP 

« Hide

References

[1]"Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epidermis and Uterus.
[2]"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
Terakawa H., Takahara H., Sugawara K.
J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013848 mRNA. Translation: BAA34181.1.
AB121692 Genomic DNA. Translation: BAD16625.1.
CCDSCCDS18856.1.
PIRPH0203.
RefSeqNP_035189.1. NM_011059.2.
UniGeneMm.20854.

3D structure databases

ProteinModelPortalQ9Z185.
SMRQ9Z185. Positions 7-662.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Z185.

Proteomic databases

MaxQBQ9Z185.
PRIDEQ9Z185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329.
GeneID18599.
KEGGmmu:18599.
UCSCuc008vnh.1. mouse.

Organism-specific databases

CTD29943.
MGIMGI:1338893. Padi1.

Phylogenomic databases

eggNOGNOG42085.
GeneTreeENSGT00390000008680.
HOGENOMHOG000220908.
HOVERGENHBG053016.
InParanoidQ9Z185.
KOK01481.
OMANCDRDSL.
OrthoDBEOG7P5T09.
PhylomeDBQ9Z185.
TreeFamTF331952.

Gene expression databases

BgeeQ9Z185.
CleanExMM_PADI1.
GenevestigatorQ9Z185.

Family and domain databases

InterProIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERPTHR10837. PTHR10837. 1 hit.
PfamPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetSearch...

Other

NextBio294498.
PROQ9Z185.
SOURCESearch...

Entry information

Entry namePADI1_MOUSE
AccessionPrimary (citable) accession number: Q9Z185
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot