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Protein

Protein-arginine deiminase type-1

Gene

Padi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein-arginine deiminase activity Source: MGI

GO - Biological processi

  1. protein citrullination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:Padi1
Synonyms:Pdi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1338893. Padi1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Protein-arginine deiminase type-1PRO_0000220024Add
BLAST

Proteomic databases

MaxQBiQ9Z185.
PRIDEiQ9Z185.

PTM databases

PhosphoSiteiQ9Z185.

Expressioni

Tissue specificityi

Expressed only in the epidermis and uterus.1 Publication

Developmental stagei

Expressed during the estrus cycle. Expression is maximum at proestrus and moderate at estrus. Not expressed in diestrus and metaestrus phases.

Inductioni

By estrogen.

Gene expression databases

BgeeiQ9Z185.
CleanExiMM_PADI1.
ExpressionAtlasiQ9Z185. baseline and differential.
GenevestigatoriQ9Z185.

Structurei

3D structure databases

ProteinModelPortaliQ9Z185.
SMRiQ9Z185. Positions 7-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9Z185.
KOiK01481.
OMAiDIPQLFF.
OrthoDBiEOG7P5T09.
PhylomeDBiQ9Z185.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z185-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPRAVQLS LRKPTHAVCV VGVETLVNVY SDVPKGAKTF GVSGSSEVKI
60 70 80 90 100
YMVYDPSRVA EPAGWAHWPL DANVDVVVVA DTVSKDLYDF KVKVSYFESQ
110 120 130 140 150
EAAALAHSVL YLTAVDVSLD VDTGRTGKVK KGSGDKKTWR WGPGGSGAIL
160 170 180 190 200
LVNCDRDIHG SREDLHANHL KSLEDLQDMS PMVLSCGGPD ELFESHKLVL
210 220 230 240 250
KASLSDSRRL KVFCARGGTS LSNYKQVLGP RHSSYEVERH SGERAIQFYV
260 270 280 290 300
EGLAFPDASF SGLLSLSVSL VDTRPLSEVS VFTDSVTFRV APWIMTPNTQ
310 320 330 340 350
PPLELYVCSV TDIHGRNDKF LEDMSHLATK ANCKLVVCPR AENRNDRWIQ
360 370 380 390 400
DELEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKRILGPDF GYVTREIEFA
410 420 430 440 450
GASGLDSFGN LDVSPPVRVG NTDYPLGRIL IGGSFPKPSG RRMARVVRDF
460 470 480 490 500
LQAQQVQSPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL
510 520 530 540 550
FQEKKEEGYG EAEQFDGLKH KAKRSINDIL ADKHLRRDSA HVQKCIDWNR
560 570 580 590 600
EVLKRELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP
610 620 630 640 650
FGPLINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR
660
KPFTFKWWNS VP
Length:662
Mass (Da):73,824
Last modified:May 1, 1999 - v1
Checksum:iF9A6C7DFF1031D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013848 mRNA. Translation: BAA34181.1.
AB121692 Genomic DNA. Translation: BAD16625.1.
CCDSiCCDS18856.1.
PIRiPH0203.
RefSeqiNP_035189.1. NM_011059.2.
UniGeneiMm.20854.

Genome annotation databases

EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329.
GeneIDi18599.
KEGGimmu:18599.
UCSCiuc008vnh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013848 mRNA. Translation: BAA34181.1.
AB121692 Genomic DNA. Translation: BAD16625.1.
CCDSiCCDS18856.1.
PIRiPH0203.
RefSeqiNP_035189.1. NM_011059.2.
UniGeneiMm.20854.

3D structure databases

ProteinModelPortaliQ9Z185.
SMRiQ9Z185. Positions 7-662.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9Z185.

Proteomic databases

MaxQBiQ9Z185.
PRIDEiQ9Z185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026378; ENSMUSP00000026378; ENSMUSG00000025329.
GeneIDi18599.
KEGGimmu:18599.
UCSCiuc008vnh.1. mouse.

Organism-specific databases

CTDi29943.
MGIiMGI:1338893. Padi1.

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9Z185.
KOiK01481.
OMAiDIPQLFF.
OrthoDBiEOG7P5T09.
PhylomeDBiQ9Z185.
TreeFamiTF331952.

Miscellaneous databases

NextBioi294498.
PROiQ9Z185.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z185.
CleanExiMM_PADI1.
ExpressionAtlasiQ9Z185. baseline and differential.
GenevestigatoriQ9Z185.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
    Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
    Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis and Uterus.
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
    Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
    Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
    Terakawa H., Takahara H., Sugawara K.
    J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPADI1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.