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Q9Z184

- PADI3_MOUSE

UniProt

Q9Z184 - PADI3_MOUSE

Protein

Protein-arginine deiminase type-3

Gene

Padi3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the deimination of arginine residues of proteins.

    Catalytic activityi

    Protein L-arginine + H2O = protein L-citrulline + NH3.

    Cofactori

    Calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein-arginine deiminase activity Source: MGI

    GO - Biological processi

    1. protein citrullination Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-arginine deiminase type-3 (EC:3.5.3.15)
    Alternative name(s):
    Peptidylarginine deiminase III
    Protein-arginine deiminase type III
    Gene namesi
    Name:Padi3
    Synonyms:Pdi3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1338891. Padi3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664Protein-arginine deiminase type-3PRO_0000220030Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z184.

    PTM databases

    PhosphoSiteiQ9Z184.

    Expressioni

    Tissue specificityi

    Epidermis and hair follicles.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z184.
    BgeeiQ9Z184.
    CleanExiMM_PADI3.
    GenevestigatoriQ9Z184.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z184.
    SMRiQ9Z184. Positions 6-664.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein arginine deiminase family.Curated

    Phylogenomic databases

    eggNOGiNOG42085.
    GeneTreeiENSGT00390000008680.
    HOVERGENiHBG053016.
    InParanoidiA2AMU4.
    KOiK01481.
    OMAiMSLQRIV.
    OrthoDBiEOG7P5T09.
    TreeFamiTF331952.

    Family and domain databases

    InterProiIPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view]
    PANTHERiPTHR10837. PTHR10837. 1 hit.
    PfamiPF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMiSSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z184-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLQRIVRVS LEHPTSAVCV AGVETIVDIY GAVPEGTDMF EVYGTPGVDI    50
    YVSPSMERSR ERADTRRWCF NKGLEIIVIM NSPSNDLNDS HVQIAYHSSR 100
    EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWV WGPDGYGAIL 150
    LVNCDRDNVD SNAQDNCDQY VRCLQDLEDM SVMVLRTQGP EALFEDHRLI 200
    LHTSSCDAER ARVFHVCGPE DSCESYKCVL GPDRMSYEVP RLKGYEERFF 250
    VEGLSFPDAG FPGLISFHVT LLDDSNEDFS ETPIFTDTAV FRVAPWIMTP 300
    STLPPLEVYV CRVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD 350
    EMELGYVQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPKDSS 400
    VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRNFL 450
    HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF 500
    QEKQKWGHGR SLLFEGVIGD RRVQTVSINQ ILNNQSLINF NKFAQSCIDW 550
    NREVLKRELG LAEGDIIDIP QLFKTEKRKA VAFFPDLVNM LVLGKHLGIP 600
    KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV 650
    RREPFAFKWW HMVP 664
    Length:664
    Mass (Da):75,073
    Last modified:July 27, 2011 - v2
    Checksum:iFA6E065DF5D9CB83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321A → S in BAA34182. (PubMed:10092850)Curated
    Sequence conflicti52 – 521V → L in BAA34182. (PubMed:10092850)Curated
    Sequence conflicti59 – 591S → N in BAA34182. (PubMed:10092850)Curated
    Sequence conflicti79 – 791I → V in BAA34182. (PubMed:10092850)Curated
    Sequence conflicti225 – 2251S → A in BAA34182. (PubMed:10092850)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013849 mRNA. Translation: BAA34182.1.
    AL807805 Genomic DNA. Translation: CAM25733.1.
    CCDSiCCDS18855.1.
    RefSeqiNP_035190.3. NM_011060.4.
    UniGeneiMm.20851.

    Genome annotation databases

    EnsembliENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328.
    GeneIDi18601.
    KEGGimmu:18601.
    UCSCiuc008vng.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013849 mRNA. Translation: BAA34182.1 .
    AL807805 Genomic DNA. Translation: CAM25733.1 .
    CCDSi CCDS18855.1.
    RefSeqi NP_035190.3. NM_011060.4.
    UniGenei Mm.20851.

    3D structure databases

    ProteinModelPortali Q9Z184.
    SMRi Q9Z184. Positions 6-664.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026377.

    PTM databases

    PhosphoSitei Q9Z184.

    Proteomic databases

    PRIDEi Q9Z184.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026377 ; ENSMUSP00000026377 ; ENSMUSG00000025328 .
    GeneIDi 18601.
    KEGGi mmu:18601.
    UCSCi uc008vng.1. mouse.

    Organism-specific databases

    CTDi 51702.
    MGIi MGI:1338891. Padi3.

    Phylogenomic databases

    eggNOGi NOG42085.
    GeneTreei ENSGT00390000008680.
    HOVERGENi HBG053016.
    InParanoidi A2AMU4.
    KOi K01481.
    OMAi MSLQRIV.
    OrthoDBi EOG7P5T09.
    TreeFami TF331952.

    Miscellaneous databases

    NextBioi 294506.
    PROi Q9Z184.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z184.
    Bgeei Q9Z184.
    CleanExi MM_PADI3.
    Genevestigatori Q9Z184.

    Family and domain databases

    InterProi IPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view ]
    PANTHERi PTHR10837. PTHR10837. 1 hit.
    Pfami PF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMi SSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
      Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
      Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epidermis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
      Terakawa H., Takahara H., Sugawara K.
      J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPADI3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z184
    Secondary accession number(s): A2AMU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3