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Q9Z184

- PADI3_MOUSE

UniProt

Q9Z184 - PADI3_MOUSE

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Protein
Protein-arginine deiminase type-3
Gene
Padi3, Pdi3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

Calcium.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein-arginine deiminase activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. protein citrullination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:Padi3
Synonyms:Pdi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1338891. Padi3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Protein-arginine deiminase type-3
PRO_0000220030Add
BLAST

Proteomic databases

PRIDEiQ9Z184.

PTM databases

PhosphoSiteiQ9Z184.

Expressioni

Tissue specificityi

Epidermis and hair follicles.1 Publication

Gene expression databases

ArrayExpressiQ9Z184.
BgeeiQ9Z184.
CleanExiMM_PADI3.
GenevestigatoriQ9Z184.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026377.

Structurei

3D structure databases

ProteinModelPortaliQ9Z184.
SMRiQ9Z184. Positions 6-664.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOVERGENiHBG053016.
InParanoidiA2AMU4.
KOiK01481.
OMAiMSLQRIV.
OrthoDBiEOG7P5T09.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z184-1 [UniParc]FASTAAdd to Basket

« Hide

MSLQRIVRVS LEHPTSAVCV AGVETIVDIY GAVPEGTDMF EVYGTPGVDI    50
YVSPSMERSR ERADTRRWCF NKGLEIIVIM NSPSNDLNDS HVQIAYHSSR 100
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWV WGPDGYGAIL 150
LVNCDRDNVD SNAQDNCDQY VRCLQDLEDM SVMVLRTQGP EALFEDHRLI 200
LHTSSCDAER ARVFHVCGPE DSCESYKCVL GPDRMSYEVP RLKGYEERFF 250
VEGLSFPDAG FPGLISFHVT LLDDSNEDFS ETPIFTDTAV FRVAPWIMTP 300
STLPPLEVYV CRVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD 350
EMELGYVQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPKDSS 400
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRNFL 450
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF 500
QEKQKWGHGR SLLFEGVIGD RRVQTVSINQ ILNNQSLINF NKFAQSCIDW 550
NREVLKRELG LAEGDIIDIP QLFKTEKRKA VAFFPDLVNM LVLGKHLGIP 600
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV 650
RREPFAFKWW HMVP 664
Length:664
Mass (Da):75,073
Last modified:July 27, 2011 - v2
Checksum:iFA6E065DF5D9CB83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321A → S in BAA34182. 1 Publication
Sequence conflicti52 – 521V → L in BAA34182. 1 Publication
Sequence conflicti59 – 591S → N in BAA34182. 1 Publication
Sequence conflicti79 – 791I → V in BAA34182. 1 Publication
Sequence conflicti225 – 2251S → A in BAA34182. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013849 mRNA. Translation: BAA34182.1.
AL807805 Genomic DNA. Translation: CAM25733.1.
CCDSiCCDS18855.1.
RefSeqiNP_035190.3. NM_011060.4.
UniGeneiMm.20851.

Genome annotation databases

EnsembliENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328.
GeneIDi18601.
KEGGimmu:18601.
UCSCiuc008vng.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013849 mRNA. Translation: BAA34182.1 .
AL807805 Genomic DNA. Translation: CAM25733.1 .
CCDSi CCDS18855.1.
RefSeqi NP_035190.3. NM_011060.4.
UniGenei Mm.20851.

3D structure databases

ProteinModelPortali Q9Z184.
SMRi Q9Z184. Positions 6-664.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000026377.

PTM databases

PhosphoSitei Q9Z184.

Proteomic databases

PRIDEi Q9Z184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026377 ; ENSMUSP00000026377 ; ENSMUSG00000025328 .
GeneIDi 18601.
KEGGi mmu:18601.
UCSCi uc008vng.1. mouse.

Organism-specific databases

CTDi 51702.
MGIi MGI:1338891. Padi3.

Phylogenomic databases

eggNOGi NOG42085.
GeneTreei ENSGT00390000008680.
HOVERGENi HBG053016.
InParanoidi A2AMU4.
KOi K01481.
OMAi MSLQRIV.
OrthoDBi EOG7P5T09.
TreeFami TF331952.

Miscellaneous databases

NextBioi 294506.
PROi Q9Z184.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z184.
Bgeei Q9Z184.
CleanExi MM_PADI3.
Genevestigatori Q9Z184.

Family and domain databases

InterProi IPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view ]
PANTHERi PTHR10837. PTHR10837. 1 hit.
Pfami PF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMi SSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
    Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
    Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
    Terakawa H., Takahara H., Sugawara K.
    J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPADI3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z184
Secondary accession number(s): A2AMU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi