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Q9Z184 (PADI3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-arginine deiminase type-3

EC=3.5.3.15
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene names
Name:Padi3
Synonyms:Pdi3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the deimination of arginine residues of proteins.

Catalytic activity

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactor

Calcium.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Epidermis and hair follicles. Ref.3

Sequence similarities

Belongs to the protein arginine deiminase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandCalcium
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein citrullination

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

protein-arginine deiminase activity

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 664664Protein-arginine deiminase type-3
PRO_0000220030

Experimental info

Sequence conflict321A → S in BAA34182. Ref.1
Sequence conflict521V → L in BAA34182. Ref.1
Sequence conflict591S → N in BAA34182. Ref.1
Sequence conflict791I → V in BAA34182. Ref.1
Sequence conflict2251S → A in BAA34182. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z184 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: FA6E065DF5D9CB83

FASTA66475,073
        10         20         30         40         50         60 
MSLQRIVRVS LEHPTSAVCV AGVETIVDIY GAVPEGTDMF EVYGTPGVDI YVSPSMERSR 

        70         80         90        100        110        120 
ERADTRRWCF NKGLEIIVIM NSPSNDLNDS HVQIAYHSSR EHLPLAYAVL YLTCVDITLD 

       130        140        150        160        170        180 
CDMNCADRQD RSFVDKRQWV WGPDGYGAIL LVNCDRDNVD SNAQDNCDQY VRCLQDLEDM 

       190        200        210        220        230        240 
SVMVLRTQGP EALFEDHRLI LHTSSCDAER ARVFHVCGPE DSCESYKCVL GPDRMSYEVP 

       250        260        270        280        290        300 
RLKGYEERFF VEGLSFPDAG FPGLISFHVT LLDDSNEDFS ETPIFTDTAV FRVAPWIMTP 

       310        320        330        340        350        360 
STLPPLEVYV CRVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD EMELGYVQAP 

       370        380        390        400        410        420 
HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPKDSS VSGLDSFGNL EVSPPVVANG 

       430        440        450        460        470        480 
KEYPLGRILI GGNLPGSRGR RVTQVVRNFL HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA 

       490        500        510        520        530        540 
PDGKGFRLLL ASPGACFRLF QEKQKWGHGR SLLFEGVIGD RRVQTVSINQ ILNNQSLINF 

       550        560        570        580        590        600 
NKFAQSCIDW NREVLKRELG LAEGDIIDIP QLFKTEKRKA VAFFPDLVNM LVLGKHLGIP 

       610        620        630        640        650        660 
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV RREPFAFKWW 


HMVP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse."
Rusd A.A., Ikejiri Y., Ono H., Yonekawa T., Shiraiwa M., Kawada A., Takahara H.
Eur. J. Biochem. 259:660-669(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epidermis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Three types of mouse peptidylarginine deiminase: characterization and tissue distribution."
Terakawa H., Takahara H., Sugawara K.
J. Biochem. 110:661-666(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013849 mRNA. Translation: BAA34182.1.
AL807805 Genomic DNA. Translation: CAM25733.1.
RefSeqNP_035190.3. NM_011060.4.
UniGeneMm.20851.

3D structure databases

ProteinModelPortalQ9Z184.
SMRQ9Z184. Positions 6-664.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000026377.

PTM databases

PhosphoSiteQ9Z184.

Proteomic databases

PRIDEQ9Z184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328.
GeneID18601.
KEGGmmu:18601.
UCSCuc008vng.1. mouse.

Organism-specific databases

CTD51702.
MGIMGI:1338891. Padi3.

Phylogenomic databases

eggNOGNOG42085.
GeneTreeENSGT00390000008680.
HOVERGENHBG053016.
InParanoidA2AMU4.
KOK01481.
OMAMSLQRIV.
OrthoDBEOG7P5T09.
TreeFamTF331952.

Gene expression databases

ArrayExpressQ9Z184.
BgeeQ9Z184.
CleanExMM_PADI3.
GenevestigatorQ9Z184.

Family and domain databases

InterProIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERPTHR10837. PTHR10837. 1 hit.
PfamPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetSearch...

Other

NextBio294506.
PROQ9Z184.
SOURCESearch...

Entry information

Entry namePADI3_MOUSE
AccessionPrimary (citable) accession number: Q9Z184
Secondary accession number(s): A2AMU4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot