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Protein

Protein-arginine deiminase type-3

Gene

Padi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.By similarity

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-3247509 Chromatin modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15By similarity)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:Padi3
Synonyms:Pad3, Pdi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1338891 Padi3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. The skin of 7-week-old null mice appeared normal, but scanning electron microscopy revealed structural alterations in the whiskers and hair coat morphology (PubMed:27866708).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200301 – 664Protein-arginine deiminase type-3Add BLAST664

Proteomic databases

MaxQBiQ9Z184
PaxDbiQ9Z184
PRIDEiQ9Z184

PTM databases

iPTMnetiQ9Z184
PhosphoSitePlusiQ9Z184

Expressioni

Tissue specificityi

Epidermis and hair follicles.1 Publication

Gene expression databases

BgeeiENSMUSG00000025328
CleanExiMM_PADI3
ExpressionAtlasiQ9Z184 baseline and differential
GenevisibleiQ9Z184 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026377

Structurei

3D structure databases

ProteinModelPortaliQ9Z184
SMRiQ9Z184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOVERGENiHBG053016
InParanoidiQ9Z184
KOiK01481
OMAiTPGVDIY
OrthoDBiEOG091G02QG
TreeFamiTF331952

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQRIVRVS LEHPTSAVCV AGVETIVDIY GAVPEGTDMF EVYGTPGVDI
60 70 80 90 100
YVSPSMERSR ERADTRRWCF NKGLEIIVIM NSPSNDLNDS HVQIAYHSSR
110 120 130 140 150
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWV WGPDGYGAIL
160 170 180 190 200
LVNCDRDNVD SNAQDNCDQY VRCLQDLEDM SVMVLRTQGP EALFEDHRLI
210 220 230 240 250
LHTSSCDAER ARVFHVCGPE DSCESYKCVL GPDRMSYEVP RLKGYEERFF
260 270 280 290 300
VEGLSFPDAG FPGLISFHVT LLDDSNEDFS ETPIFTDTAV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CRVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYVQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPKDSS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRNFL
460 470 480 490 500
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF
510 520 530 540 550
QEKQKWGHGR SLLFEGVIGD RRVQTVSINQ ILNNQSLINF NKFAQSCIDW
560 570 580 590 600
NREVLKRELG LAEGDIIDIP QLFKTEKRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
RREPFAFKWW HMVP
Length:664
Mass (Da):75,073
Last modified:July 27, 2011 - v2
Checksum:iFA6E065DF5D9CB83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32A → S in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti52V → L in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti59S → N in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti79I → V in BAA34182 (PubMed:10092850).Curated1
Sequence conflicti225S → A in BAA34182 (PubMed:10092850).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013849 mRNA Translation: BAA34182.1
AL807805 Genomic DNA No translation available.
CCDSiCCDS18855.1
RefSeqiNP_035190.3, NM_011060.4
UniGeneiMm.20851

Genome annotation databases

EnsembliENSMUST00000026377; ENSMUSP00000026377; ENSMUSG00000025328
GeneIDi18601
KEGGimmu:18601
UCSCiuc008vng.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPADI3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z184
Secondary accession number(s): A2AMU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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