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Protein

SET-binding protein

Gene

Setbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi575 – 58713A.T hook 1Add
BLAST
DNA bindingi1007 – 101913A.T hook 2Add
BLAST
DNA bindingi1440 – 145213A.T hook 3Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SET-binding protein
Short name:
SEB
Gene namesi
Name:Setbp1
Synonyms:Kiaa0437
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1933199. Setbp1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15821582SET-binding proteinPRO_0000097699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei808 – 8081N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Z180.
PaxDbiQ9Z180.
PRIDEiQ9Z180.

PTM databases

iPTMnetiQ9Z180.
PhosphoSiteiQ9Z180.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024548.
CleanExiMM_SETBP1.
ExpressionAtlasiQ9Z180. baseline and differential.

Interactioni

Subunit structurei

Interacts with SET.By similarity

Protein-protein interaction databases

BioGridi232199. 1 interaction.
IntActiQ9Z180. 1 interaction.
MINTiMINT-4968478.
STRINGi10090.ENSMUSP00000124497.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 29892Ser-richAdd
BLAST
Compositional biasi1509 – 156052Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 A.T hook DNA-binding domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1083. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000154293.
HOVERGENiHBG060433.
InParanoidiQ9Z180.
OMAiAVIHMAR.
OrthoDBiEOG091G02U7.
PhylomeDBiQ9Z180.
TreeFamiTF106416.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
[Graphical view]
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPREMLSSC RQRGSESEFL QGSSSRSPPA PGCSGEPLKG ISVGGERMEP
60 70 80 90 100
EEEDELGSGR DVDCNSNADS EKWVAGDGLE EQEFSIKEAN FTEGSLKLKI
110 120 130 140 150
QTTKRAKKPP KNLENYICPP EIKITIKQSG DQKVSRTGKN SKATKEDERN
160 170 180 190 200
HSKKKLLTAG DPTASDLKAF QTQAYERPQK HSTLQYDPGH SQGFTSDTLK
210 220 230 240 250
PKHQQKSSSQ SHMEWSSNSD SGPATQNCFI SPEAGRDTAS TSKVPALEPV
260 270 280 290 300
ASFAKAQSKK GSTGGAWSQL SSSSKDLLLG SVVPSPSSHN SPATPSSSAE
310 320 330 340 350
CNGLQPLGDQ DGGSTKDLPE PPTLSSKKKS SKKDMISQTL PNSDLDWVKS
360 370 380 390 400
AQKAFETTEG KREAYSADSA QEASPARQSI SSVSNPENDS SHVRITIPIK
410 420 430 440 450
TPSLDPSNHK RKKRQSIKAV VEKIVPEKAL ASGISMSSEV VNRILSNSEG
460 470 480 490 500
SKKDPRVPKL GKMIENETPS VGLETGGNAE KIVPGGASKQ RKPPMVMTSP
510 520 530 540 550
TRTEHAPSGK LSEIQHPKFA AKRRCSKAKP PAMLREAVLA TAEKLMVEPP
560 570 580 590 600
SAYPITPSSP LYTNTDSLTV ITPVKKKRGR PKKQPLLTVE TIHEGTSTSP
610 620 630 640 650
VSPISREFPG TKKRKRRRNL AKLAQLVPGE DKPMSEMKFH KKVGKLGVLD
660 670 680 690 700
KKTIKTINKM KTLKRKNILN QILSCSSSVA LKAKAPPETS PGAASIESKL
710 720 730 740 750
GKQINVSKRG TIYIGKKRGR KPRTELPPPS EEPKTAIKHP RPVSSQPDVP
760 770 780 790 800
AVPSSFQSPV ASSPAAMHPL STQLGGSNGN LSPASTETNF SELKTMPNLQ
810 820 830 840 850
PISALPTKTQ KGIHGGTWKL SPPRLMANSP SHLCEIGSLK EITLSPVSES
860 870 880 890 900
HSEETIPSDS GIGTDNNSTS DQAEKSSESR RRYSFDFCSL DNPEAIPSDT
910 920 930 940 950
STKNRHGHRQ KHLIVDTFLA HESLKKPKHK RKRKSLQNRD DLQFLAELEE
960 970 980 990 1000
LITKFQVFRI SHRGYTFYHE NPYPSIFRIN FDQYYPVPYI QYDPLLYLRR
1010 1020 1030 1040 1050
TSDLKSKKKR GRPAKTNDTM TKVPFLQGFS YPIPSGSYYA PYGMPYTSMP
1060 1070 1080 1090 1100
MMNLGYYGQY PAPLYLSHTL GAASPFMRPT VPPPQFHASS HVKISGATKH
1110 1120 1130 1140 1150
KAKHGVHLQG TVGMGLGDIQ PSLNPPKVGG ATLSSSRLHK RKHKHKRKHK
1160 1170 1180 1190 1200
EDRILGTHDN LSGLFAGKAT GFSSHLLSER LSGSDKELPL VSEKSKHKER
1210 1220 1230 1240 1250
QKHQHGEASH KVSKNNFEVD TLSTLSLSDA QHWTQAKDKG DLSSEPVESC
1260 1270 1280 1290 1300
AKRYSGSGGD STRSEGLDVF SEMNPSSDKW DSDMGGSKRR SFEGFGTYRE
1310 1320 1330 1340 1350
KDIQAFKMNR KERGSYESSM SPGMPSPHLK VDQTAAHSKS EGSISAMMAR
1360 1370 1380 1390 1400
KKPTAVDSVA IPSAPVLSLL AASAATSDAA SSSLKKRFKR REIEAIQCEV
1410 1420 1430 1440 1450
RKMCHYTKLL STKKNLDHVN KILKAKRLQR QSKTGNNFVK KRRGRPRKQP
1460 1470 1480 1490 1500
SQFDEDSRDQ MPVLEKCIDL PSKRGQKPSL SPLALEPASG QDAVMATIEA
1510 1520 1530 1540 1550
VIHMAREAPP LPPPPPPPLP PPPPPPPPPP PLPKTARGGK RKHRPQPPAQ
1560 1570 1580
PAQPTPQPLP QEEEVKAKRP RKSRASESDV LP
Length:1,582
Mass (Da):173,077
Last modified:April 20, 2010 - v4
Checksum:i783C1FEDFB5FE4F7
GO

Sequence cautioni

The sequence AAH80865 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1281 – 12811D → L in BAA36338 (PubMed:11231286).Curated
Sequence conflicti1433 – 14331K → N in AAH80865 (PubMed:15489334).Curated
Sequence conflicti1467 – 14671C → W in BAA36338 (PubMed:11231286).Curated
Sequence conflicti1476 – 14772QK → PE in BAA36338 (PubMed:11231286).Curated
Sequence conflicti1509 – 152921Missing in BAC97953 (PubMed:14621295).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114924 Genomic DNA. No translation available.
AC131736 Genomic DNA. No translation available.
AC140455 Genomic DNA. No translation available.
AC146613 Genomic DNA. No translation available.
BC080865 mRNA. Translation: AAH80865.1. Different initiation.
AK129143 mRNA. Translation: BAC97953.1.
AB015614 mRNA. Translation: BAA36338.1.
CCDSiCCDS29362.2.
RefSeqiNP_444329.2. NM_053099.2.
UniGeneiMm.312871.

Genome annotation databases

EnsembliENSMUST00000025430; ENSMUSP00000025430; ENSMUSG00000024548.
GeneIDi240427.
KEGGimmu:240427.
UCSCiuc008fsi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114924 Genomic DNA. No translation available.
AC131736 Genomic DNA. No translation available.
AC140455 Genomic DNA. No translation available.
AC146613 Genomic DNA. No translation available.
BC080865 mRNA. Translation: AAH80865.1. Different initiation.
AK129143 mRNA. Translation: BAC97953.1.
AB015614 mRNA. Translation: BAA36338.1.
CCDSiCCDS29362.2.
RefSeqiNP_444329.2. NM_053099.2.
UniGeneiMm.312871.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232199. 1 interaction.
IntActiQ9Z180. 1 interaction.
MINTiMINT-4968478.
STRINGi10090.ENSMUSP00000124497.

PTM databases

iPTMnetiQ9Z180.
PhosphoSiteiQ9Z180.

Proteomic databases

MaxQBiQ9Z180.
PaxDbiQ9Z180.
PRIDEiQ9Z180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025430; ENSMUSP00000025430; ENSMUSG00000024548.
GeneIDi240427.
KEGGimmu:240427.
UCSCiuc008fsi.2. mouse.

Organism-specific databases

CTDi26040.
MGIiMGI:1933199. Setbp1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1083. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000154293.
HOVERGENiHBG060433.
InParanoidiQ9Z180.
OMAiAVIHMAR.
OrthoDBiEOG091G02U7.
PhylomeDBiQ9Z180.
TreeFamiTF106416.

Miscellaneous databases

ChiTaRSiSetbp1. mouse.
PROiQ9Z180.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024548.
CleanExiMM_SETBP1.
ExpressionAtlasiQ9Z180. baseline and differential.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
[Graphical view]
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETBP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z180
Secondary accession number(s): Q66JL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.