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Protein

SHC SH2 domain-binding protein 1

Gene

Shcbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.2 Publications

GO - Molecular functioni

  • SH2 domain binding Source: MGI

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • regulation of neural precursor cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SHC SH2 domain-binding protein 1
Alternative name(s):
Protein expressed in activated lymphocytes
Short name:
mPAL
SHC-binding protein
Gene namesi
Name:Shcbp1
Synonyms:Pal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338802. Shcbp1.

Subcellular locationi

  • Midbody By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis.By similarity

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 668667SHC SH2 domain-binding protein 1PRO_0000076316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei273 – 2731PhosphoserineBy similarity
Modified residuei630 – 6301PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z179.
MaxQBiQ9Z179.
PaxDbiQ9Z179.
PeptideAtlasiQ9Z179.
PRIDEiQ9Z179.

PTM databases

iPTMnetiQ9Z179.
PhosphoSiteiQ9Z179.

Expressioni

Tissue specificityi

Expressed in spleen, lung and heart with higher expression in testis. No expression in brain, liver and skeletal muscle. Elevated expression in actively cycling cells.1 Publication

Inductioni

Down-regulated upon growth inhibition.1 Publication

Gene expression databases

BgeeiENSMUSG00000022322.
CleanExiMM_SHCBP1.
GenevisibleiQ9Z179. MM.

Interactioni

Subunit structurei

Interacts directly with isoform p52shc of SHC1 via its SH2 domain (PubMed:10086341). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (PubMed:22508726). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Shc1P980835EBI-644352,EBI-300201

GO - Molecular functioni

  • SH2 domain binding Source: MGI

Protein-protein interaction databases

BioGridi203217. 19 interactions.
IntActiQ9Z179. 24 interactions.
MINTiMINT-1689423.
STRINGi10090.ENSMUSP00000022945.

Structurei

3D structure databases

ProteinModelPortaliQ9Z179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati428 – 45124PbH1 1Add
BLAST
Repeati452 – 47322PbH1 2Add
BLAST
Repeati474 – 49623PbH1 3Add
BLAST
Repeati497 – 51822PbH1 4Add
BLAST
Repeati526 – 54823PbH1 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 2166Poly-Glu

Sequence similaritiesi

Contains 5 PbH1 repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIV2. Eukaryota.
ENOG410XXTE. LUCA.
GeneTreeiENSGT00530000063807.
HOGENOMiHOG000154313.
HOVERGENiHBG060212.
InParanoidiQ9Z179.
OMAiPERTGWA.
OrthoDBiEOG091G0UP6.
PhylomeDBiQ9Z179.
TreeFamiTF329196.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLRAGGV LEPIAMVPPR PDLAAEKEPA SWKEGLFLDA DPCSDQGYHA
60 70 80 90 100
NPGATVKTLI PEGKTPFPRI IQTNELLFYE RFRAYQDYIL ADCKASEVKE
110 120 130 140 150
FTVSFLEKVL EPSGWWAVWH TNVFEVLVEV TNVDFPSLKA VVRLAEPCIY
160 170 180 190 200
ESKLSTFTLA NVKELLDLKE FHLPLQELWV VSDDSHEFHQ MALAIEHVRF
210 220 230 240 250
FYKHIWRSWD EEEEDEYDYF VRCVEPRLRL YYDILEDRVP SGLIVDYHNL
260 270 280 290 300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLNLYS EIEQLKQKLK
310 320 330 340 350
LIENPLLRYV FGYQKNSNIQ GKGTRQNGQK VIHVVSSTMK TGLLRSLFKD
360 370 380 390 400
RFCEESCKEE TEIKFHSDLL SGINACYDGD TVIICPGHYV VHGTCSIADS
410 420 430 440 450
IELEGYGLPD DIVIEKRGKG DTFVDCTGMD VKISGIKFIQ HDSVEGILII
460 470 480 490 500
HHGKTTLENC VLQCETTGVT VRTSAELFMK NSDVYGAKGA GIEIYPGSKC
510 520 530 540 550
TLTDNGIHHC KEGILIKDFL DEHYDIPKIS MINNVIHNNE GYGVVLVKPT
560 570 580 590 600
IFCDLQENTQ DEINDNMVQK NKEADVTEGL DLEEMLQCVA SKMEPYATAD
610 620 630 640 650
FNEQAKGNCE IINELLAISM QKGRMKKRLS ELGITQADDN IMSQEMFIEI
660
MGNQFKWNGK GSFGTFLY
Length:668
Mass (Da):75,917
Last modified:May 1, 1999 - v1
Checksum:iEC614A982B744591
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531G → D in BAE26159 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017152 mRNA. Translation: AAD01613.1.
AK144966 mRNA. Translation: BAE26159.1.
AK149580 mRNA. Translation: BAE28972.1.
BC070455 mRNA. Translation: AAH70455.1.
CCDSiCCDS22088.1.
RefSeqiNP_035499.1. NM_011369.2.
UniGeneiMm.37801.

Genome annotation databases

EnsembliENSMUST00000022945; ENSMUSP00000022945; ENSMUSG00000022322.
GeneIDi20419.
KEGGimmu:20419.
UCSCiuc009kua.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017152 mRNA. Translation: AAD01613.1.
AK144966 mRNA. Translation: BAE26159.1.
AK149580 mRNA. Translation: BAE28972.1.
BC070455 mRNA. Translation: AAH70455.1.
CCDSiCCDS22088.1.
RefSeqiNP_035499.1. NM_011369.2.
UniGeneiMm.37801.

3D structure databases

ProteinModelPortaliQ9Z179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203217. 19 interactions.
IntActiQ9Z179. 24 interactions.
MINTiMINT-1689423.
STRINGi10090.ENSMUSP00000022945.

PTM databases

iPTMnetiQ9Z179.
PhosphoSiteiQ9Z179.

Proteomic databases

EPDiQ9Z179.
MaxQBiQ9Z179.
PaxDbiQ9Z179.
PeptideAtlasiQ9Z179.
PRIDEiQ9Z179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022945; ENSMUSP00000022945; ENSMUSG00000022322.
GeneIDi20419.
KEGGimmu:20419.
UCSCiuc009kua.1. mouse.

Organism-specific databases

CTDi79801.
MGIiMGI:1338802. Shcbp1.

Phylogenomic databases

eggNOGiENOG410IIV2. Eukaryota.
ENOG410XXTE. LUCA.
GeneTreeiENSGT00530000063807.
HOGENOMiHOG000154313.
HOVERGENiHBG060212.
InParanoidiQ9Z179.
OMAiPERTGWA.
OrthoDBiEOG091G0UP6.
PhylomeDBiQ9Z179.
TreeFamiTF329196.

Miscellaneous databases

PROiQ9Z179.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022322.
CleanExiMM_SHCBP1.
GenevisibleiQ9Z179. MM.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSHCBP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z179
Secondary accession number(s): Q3UED9, Q3UMD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.