Q9Z173 (LPHN3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Latrophilin-3

Alternative name(s):
Calcium-independent alpha-latrotoxin receptor
Short name=CIRL-3

Gene names

Name:	Lphn3
Synonyms:	Cirl3, Cl3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1550 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Predominantly expressed in brain, followed by heart, placenta, pancreas, kidney and testis. Ref.2
Post-translational modification	Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 olfactomedin-like domain. Contains 1 SUEL-type lectin domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Ligand	Lectin
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z173-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z173-2)

Also known as: CL3AA;

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.
     1271-1284: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9Z173-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: Missing.
     1271-1284: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9Z173-4)

Also known as: CL3BB;

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: Missing.
     1271-1307: GSYLPCIQACVTYLEGLLNNARDTSVMDTLPLNGNHG → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1308-1550: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9Z173-5)

Also known as: CL3AB;

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.
     1271-1307: GSYLPCIQACVTYLEGLLNNARDTSVMDTLPLNGNHG → EPYRETSMGVKLNIAYQIGASEQCQGYKCHGYSTTEW
     1308-1550: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9Z173-6)

Also known as: CL3BC;

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: Missing.
     1272-1350: SYLPCIQACV...LKELTSNYIP → TMANHLMSNA...KCHGYSTTEW
     1351-1550: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9Z173-7)

Also known as: CL3AC;

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     1131-1139: Missing.
     1272-1350: SYLPCIQACV...LKELTSNYIP → TMANHLMSNA...KCHGYSTTEW
     1351-1550: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 1550	1531	Latrophilin-3		PRO_0000270141
Regions
	Topological domain	20 – 948	929	Extracellular Potential
	Transmembrane	949 – 969	21	Helical; Name=1; Potential
	Topological domain	970 – 977	8	Cytoplasmic Potential
	Transmembrane	978 – 998	21	Helical; Name=2; Potential
	Topological domain	999 – 1006	8	Extracellular Potential
	Transmembrane	1007 – 1027	21	Helical; Name=3; Potential
	Topological domain	1028 – 1048	21	Cytoplasmic Potential
	Transmembrane	1049 – 1069	21	Helical; Name=4; Potential
	Topological domain	1070 – 1087	18	Extracellular Potential
	Transmembrane	1088 – 1108	21	Helical; Name=5; Potential
	Topological domain	1109 – 1141	33	Cytoplasmic Potential
	Transmembrane	1142 – 1162	21	Helical; Name=6; Potential
	Topological domain	1163 – 1168	6	Extracellular Potential
	Transmembrane	1169 – 1189	21	Helical; Name=7; Potential
	Topological domain	1190 – 1550	361	Cytoplasmic Potential
	Domain	103 – 192	90	SUEL-type lectin
	Domain	202 – 461	260	Olfactomedin-like
	Domain	882 – 933	52	GPS
	Compositional bias	1483 – 1486	4	Poly-Ala
Amino acid modifications
	Modified residue	1548	1	Phosphothreonine By similarity
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	532	1	N-linked (GlcNAc...) Potential
	Glycosylation	616	1	N-linked (GlcNAc...) Potential
	Glycosylation	839	1	N-linked (GlcNAc...) Potential
	Glycosylation	884	1	N-linked (GlcNAc...) Potential
	Glycosylation	910	1	N-linked (GlcNAc...) Potential
	Glycosylation	999	1	N-linked (GlcNAc...) Potential
	Glycosylation	1165	1	N-linked (GlcNAc...) Potential
	Disulfide bond	203 ↔ 385		By similarity
Natural variations
	Alternative sequence	19 – 86	68	Missing in isoform 2, isoform 5 and isoform 7.		VSP_022127
	Alternative sequence	1131 – 1139	9	Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.		VSP_022128
	Alternative sequence	1271 – 1307	37	GSYLP…NGNHG → EPYRETSMGVKLNIAYQIGA SEQCQGYKCHGYSTTEW in isoform 4 and isoform 5.		VSP_022129
	Alternative sequence	1271 – 1284	14	Missing in isoform 2 and isoform 3.		VSP_022130
	Alternative sequence	1272 – 1350	79	SYLPC…SNYIP → TMANHLMSNALLRPHGTNNP YNTLLGEPAVCNNPSISMYN AQEPYRETSMGVKLNIAYQI GASEQCQGYKCHGYSTTEW in isoform 6 and isoform 7.		VSP_022131
	Alternative sequence	1308 – 1550	243	Missing in isoform 4 and isoform 5.		VSP_022132
	Alternative sequence	1351 – 1550	200	Missing in isoform 6 and isoform 7.		VSP_022133

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: A2E8091B2B34DB36	FASTA	1,550	172,442
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHGG KHNERHPALA APLRHAEHSP GGPLPPRHLL QQPAAERSTA 70 80 90 100 110 120 HRGQGPRGTA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM 130 140 150 160 170 180 IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG 190 200 210 220 230 240 TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM 250 260 270 280 290 300 PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 310 320 330 340 350 360 LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP 370 380 390 400 410 420 YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL 430 440 450 460 470 480 VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGPVH HGQVSYISPP 490 500 510 520 530 540 IHLDSDLERP PVRGISTTGP LGMGSTTTST TLRTTTWNLG RSTTPSLPGR RNRSTSTPSP 550 560 570 580 590 600 AIEVLDVTTH LPSAASQIPA MEESCEAVEA REIMWFKTRQ GQVAKQSCPA GTIGVSTYLC 610 620 630 640 650 660 LAPDGIWDPQ GPDLSNCSSP WVNHITQKLK SGETAANIAR ELAEQTRNHL NAGDITYSVR 670 680 690 700 710 720 AMDQLVGLLD VQLRNLTPGG KDSAARSLNK LQKRERSCRA YVQAMVETVN NLLQPQALNA 730 740 750 760 770 780 WRDLTTSDQL RAATMLLDTV EESAFVLADN LLKTDIVREN TDNIQLEVAR LSTEGNLEDL 790 800 810 820 830 840 KFPENTGHGS TIQLSANTLK QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEAMSTNH 850 860 870 880 890 900 SVIVNSPVIT AAINKEFSNK VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS 910 920 930 940 950 960 TQGCRLLTTN KTHTTCSCNH LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL 970 980 990 1000 1010 1020 ICIFTFCFFR GLQSDRNTIH KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA 1030 1040 1050 1060 1070 1080 AFTWMFLEGV QLYIMLVEVF ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW 1090 1100 1110 1120 1130 1140 LRLDTYFIWS FIGPATLIIM LNVIFLGIAL YKMFHHTAIL KPESGCLDNI NYEDNRPFIK 1150 1160 1170 1180 1190 1200 SWVIGAIALL CLLGLTWAFG LMYINESTVI MAYLFTIFNS LQGMFIFIFH CVLQKKVRKE 1210 1220 1230 1240 1250 1260 YGKCLRTHCC SGKSTESSIG SGKTSGSRTP GRYSTGSQSR IRRMWNDTVR KQSESSFITG 1270 1280 1290 1300 1310 1320 DINSSASLNR GSYLPCIQAC VTYLEGLLNN ARDTSVMDTL PLNGNHGNSY SIAGGEYLSN 1330 1340 1350 1360 1370 1380 CVQIIDRGYN HNETALEKKI LKELTSNYIP SYLNNHERSS EQNRNMMNKL VDNLGSGSED 1390 1400 1410 1420 1430 1440 DAIVLDDAAS FNHEESLGLE LIHEESDAPL LPPRVYSTDN HQPHHYSRRR LPQDHSESFF 1450 1460 1470 1480 1490 1500 PLLTDEHTED PQSPHRDSLY TSMPALAGVP AADSVTTSTQ TEAAAAKGGD AEDVYYKSMP 1510 1520 1530 1540 1550 NLGSRNHVHP LHAYYQLGRG SSDGFIVPPN KDGASPEGTS KGPAHLVTSL
	Isoform 2 (CL3AA) [UniParc]. Checksum: F083B7E81180E1A8	FASTA	1,459	162,831
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR 70 80 90 100 110 120 TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV AGPDVFPDPC PGTYKYLEVQ 130 140 150 160 170 180 YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE SDHQSGAWCK DPLQASDKIY YMPWTPYRTD 190 200 210 220 230 240 TLTEYSSKDD FIAGRPTTTY KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG 250 260 270 280 290 300 EAIIANANYH DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT 310 320 330 340 350 360 WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD SLVDVPFPNS 370 380 390 400 410 420 YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGP VHHGQVSYIS PPIHLDSDLE 430 440 450 460 470 480 RPPVRGISTT GPLGMGSTTT STTLRTTTWN LGRSTTPSLP GRRNRSTSTP SPAIEVLDVT 490 500 510 520 530 540 THLPSAASQI PAMEESCEAV EAREIMWFKT RQGQVAKQSC PAGTIGVSTY LCLAPDGIWD 550 560 570 580 590 600 PQGPDLSNCS SPWVNHITQK LKSGETAANI ARELAEQTRN HLNAGDITYS VRAMDQLVGL 610 620 630 640 650 660 LDVQLRNLTP GGKDSAARSL NKLQKRERSC RAYVQAMVET VNNLLQPQAL NAWRDLTTSD 670 680 690 700 710 720 QLRAATMLLD TVEESAFVLA DNLLKTDIVR ENTDNIQLEV ARLSTEGNLE DLKFPENTGH 730 740 750 760 770 780 GSTIQLSANT LKQNGRNGEI RVAFVLYNNL GPYLSTENAS MKLGTEAMST NHSVIVNSPV 790 800 810 820 830 840 ITAAINKEFS NKVYLADPVV FTVKHIKQSE ENFNPNCSFW SYSKRTMTGY WSTQGCRLLT 850 860 870 880 890 900 TNKTHTTCSC NHLTNFAVLM AHVEVKHSDA VHDLLLDVIT WVGILLSLVC LLICIFTFCF 910 920 930 940 950 960 FRGLQSDRNT IHKNLCISLF VAELLFLIGI NRTDQPIACA VFAALLHFFF LAAFTWMFLE 970 980 990 1000 1010 1020 GVQLYIMLVE VFESEHSRRK YFYLVGYGMP ALIVAVSAAV DYRSYGTDKV CWLRLDTYFI 1030 1040 1050 1060 1070 1080 WSFIGPATLI IMLNVIFLGI ALYKMFHHTA ILKPESGCLD NIKSWVIGAI ALLCLLGLTW 1090 1100 1110 1120 1130 1140 AFGLMYINES TVIMAYLFTI FNSLQGMFIF IFHCVLQKKV RKEYGKCLRT HCCSGKSTES 1150 1160 1170 1180 1190 1200 SIGSGKTSGS RTPGRYSTGS QSRIRRMWND TVRKQSESSF ITGDINSSAS LNREGLLNNA 1210 1220 1230 1240 1250 1260 RDTSVMDTLP LNGNHGNSYS IAGGEYLSNC VQIIDRGYNH NETALEKKIL KELTSNYIPS 1270 1280 1290 1300 1310 1320 YLNNHERSSE QNRNMMNKLV DNLGSGSEDD AIVLDDAASF NHEESLGLEL IHEESDAPLL 1330 1340 1350 1360 1370 1380 PPRVYSTDNH QPHHYSRRRL PQDHSESFFP LLTDEHTEDP QSPHRDSLYT SMPALAGVPA 1390 1400 1410 1420 1430 1440 ADSVTTSTQT EAAAAKGGDA EDVYYKSMPN LGSRNHVHPL HAYYQLGRGS SDGFIVPPNK 1450 DGASPEGTSK GPAHLVTSL
	Isoform 3 [UniParc]. Checksum: A0F1FFC2D9B50B9F	FASTA	1,527	169,780
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHGG KHNERHPALA APLRHAEHSP GGPLPPRHLL QQPAAERSTA 70 80 90 100 110 120 HRGQGPRGTA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM 130 140 150 160 170 180 IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG 190 200 210 220 230 240 TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM 250 260 270 280 290 300 PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 310 320 330 340 350 360 LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP 370 380 390 400 410 420 YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL 430 440 450 460 470 480 VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGPVH HGQVSYISPP 490 500 510 520 530 540 IHLDSDLERP PVRGISTTGP LGMGSTTTST TLRTTTWNLG RSTTPSLPGR RNRSTSTPSP 550 560 570 580 590 600 AIEVLDVTTH LPSAASQIPA MEESCEAVEA REIMWFKTRQ GQVAKQSCPA GTIGVSTYLC 610 620 630 640 650 660 LAPDGIWDPQ GPDLSNCSSP WVNHITQKLK SGETAANIAR ELAEQTRNHL NAGDITYSVR 670 680 690 700 710 720 AMDQLVGLLD VQLRNLTPGG KDSAARSLNK LQKRERSCRA YVQAMVETVN NLLQPQALNA 730 740 750 760 770 780 WRDLTTSDQL RAATMLLDTV EESAFVLADN LLKTDIVREN TDNIQLEVAR LSTEGNLEDL 790 800 810 820 830 840 KFPENTGHGS TIQLSANTLK QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEAMSTNH 850 860 870 880 890 900 SVIVNSPVIT AAINKEFSNK VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS 910 920 930 940 950 960 TQGCRLLTTN KTHTTCSCNH LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL 970 980 990 1000 1010 1020 ICIFTFCFFR GLQSDRNTIH KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA 1030 1040 1050 1060 1070 1080 AFTWMFLEGV QLYIMLVEVF ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW 1090 1100 1110 1120 1130 1140 LRLDTYFIWS FIGPATLIIM LNVIFLGIAL YKMFHHTAIL KPESGCLDNI KSWVIGAIAL 1150 1160 1170 1180 1190 1200 LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK EYGKCLRTHC 1210 1220 1230 1240 1250 1260 CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV RKQSESSFIT GDINSSASLN 1270 1280 1290 1300 1310 1320 REGLLNNARD TSVMDTLPLN GNHGNSYSIA GGEYLSNCVQ IIDRGYNHNE TALEKKILKE 1330 1340 1350 1360 1370 1380 LTSNYIPSYL NNHERSSEQN RNMMNKLVDN LGSGSEDDAI VLDDAASFNH EESLGLELIH 1390 1400 1410 1420 1430 1440 EESDAPLLPP RVYSTDNHQP HHYSRRRLPQ DHSESFFPLL TDEHTEDPQS PHRDSLYTSM 1450 1460 1470 1480 1490 1500 PALAGVPAAD SVTTSTQTEA AAAKGGDAED VYYKSMPNLG SRNHVHPLHA YYQLGRGSSD 1510 1520 GFIVPPNKDG ASPEGTSKGP AHLVTSL
	Isoform 4 (CL3BB) [UniParc]. Checksum: 26C05A298C6B1A02	FASTA	1,298	144,892
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHGG KHNERHPALA APLRHAEHSP GGPLPPRHLL QQPAAERSTA 70 80 90 100 110 120 HRGQGPRGTA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM 130 140 150 160 170 180 IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG 190 200 210 220 230 240 TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM 250 260 270 280 290 300 PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 310 320 330 340 350 360 LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP 370 380 390 400 410 420 YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL 430 440 450 460 470 480 VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGPVH HGQVSYISPP 490 500 510 520 530 540 IHLDSDLERP PVRGISTTGP LGMGSTTTST TLRTTTWNLG RSTTPSLPGR RNRSTSTPSP 550 560 570 580 590 600 AIEVLDVTTH LPSAASQIPA MEESCEAVEA REIMWFKTRQ GQVAKQSCPA GTIGVSTYLC 610 620 630 640 650 660 LAPDGIWDPQ GPDLSNCSSP WVNHITQKLK SGETAANIAR ELAEQTRNHL NAGDITYSVR 670 680 690 700 710 720 AMDQLVGLLD VQLRNLTPGG KDSAARSLNK LQKRERSCRA YVQAMVETVN NLLQPQALNA 730 740 750 760 770 780 WRDLTTSDQL RAATMLLDTV EESAFVLADN LLKTDIVREN TDNIQLEVAR LSTEGNLEDL 790 800 810 820 830 840 KFPENTGHGS TIQLSANTLK QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEAMSTNH 850 860 870 880 890 900 SVIVNSPVIT AAINKEFSNK VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS 910 920 930 940 950 960 TQGCRLLTTN KTHTTCSCNH LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL 970 980 990 1000 1010 1020 ICIFTFCFFR GLQSDRNTIH KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA 1030 1040 1050 1060 1070 1080 AFTWMFLEGV QLYIMLVEVF ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW 1090 1100 1110 1120 1130 1140 LRLDTYFIWS FIGPATLIIM LNVIFLGIAL YKMFHHTAIL KPESGCLDNI KSWVIGAIAL 1150 1160 1170 1180 1190 1200 LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK EYGKCLRTHC 1210 1220 1230 1240 1250 1260 CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV RKQSESSFIT GDINSSASLN 1270 1280 1290 REPYRETSMG VKLNIAYQIG ASEQCQGYKC HGYSTTEW
	Isoform 5 (CL3AB) [UniParc]. Checksum: 691DDCD1FE095C12	FASTA	1,230	137,943
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR 70 80 90 100 110 120 TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV AGPDVFPDPC PGTYKYLEVQ 130 140 150 160 170 180 YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE SDHQSGAWCK DPLQASDKIY YMPWTPYRTD 190 200 210 220 230 240 TLTEYSSKDD FIAGRPTTTY KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG 250 260 270 280 290 300 EAIIANANYH DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT 310 320 330 340 350 360 WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD SLVDVPFPNS 370 380 390 400 410 420 YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGP VHHGQVSYIS PPIHLDSDLE 430 440 450 460 470 480 RPPVRGISTT GPLGMGSTTT STTLRTTTWN LGRSTTPSLP GRRNRSTSTP SPAIEVLDVT 490 500 510 520 530 540 THLPSAASQI PAMEESCEAV EAREIMWFKT RQGQVAKQSC PAGTIGVSTY LCLAPDGIWD 550 560 570 580 590 600 PQGPDLSNCS SPWVNHITQK LKSGETAANI ARELAEQTRN HLNAGDITYS VRAMDQLVGL 610 620 630 640 650 660 LDVQLRNLTP GGKDSAARSL NKLQKRERSC RAYVQAMVET VNNLLQPQAL NAWRDLTTSD 670 680 690 700 710 720 QLRAATMLLD TVEESAFVLA DNLLKTDIVR ENTDNIQLEV ARLSTEGNLE DLKFPENTGH 730 740 750 760 770 780 GSTIQLSANT LKQNGRNGEI RVAFVLYNNL GPYLSTENAS MKLGTEAMST NHSVIVNSPV 790 800 810 820 830 840 ITAAINKEFS NKVYLADPVV FTVKHIKQSE ENFNPNCSFW SYSKRTMTGY WSTQGCRLLT 850 860 870 880 890 900 TNKTHTTCSC NHLTNFAVLM AHVEVKHSDA VHDLLLDVIT WVGILLSLVC LLICIFTFCF 910 920 930 940 950 960 FRGLQSDRNT IHKNLCISLF VAELLFLIGI NRTDQPIACA VFAALLHFFF LAAFTWMFLE 970 980 990 1000 1010 1020 GVQLYIMLVE VFESEHSRRK YFYLVGYGMP ALIVAVSAAV DYRSYGTDKV CWLRLDTYFI 1030 1040 1050 1060 1070 1080 WSFIGPATLI IMLNVIFLGI ALYKMFHHTA ILKPESGCLD NIKSWVIGAI ALLCLLGLTW 1090 1100 1110 1120 1130 1140 AFGLMYINES TVIMAYLFTI FNSLQGMFIF IFHCVLQKKV RKEYGKCLRT HCCSGKSTES 1150 1160 1170 1180 1190 1200 SIGSGKTSGS RTPGRYSTGS QSRIRRMWND TVRKQSESSF ITGDINSSAS LNREPYRETS 1210 1220 1230 MGVKLNIAYQ IGASEQCQGY KCHGYSTTEW
	Isoform 6 (CL3BC) [UniParc]. Checksum: F73C8CEB1B657008	FASTA	1,341	149,502
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHGG KHNERHPALA APLRHAEHSP GGPLPPRHLL QQPAAERSTA 70 80 90 100 110 120 HRGQGPRGTA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM 130 140 150 160 170 180 IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG 190 200 210 220 230 240 TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM 250 260 270 280 290 300 PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 310 320 330 340 350 360 LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP 370 380 390 400 410 420 YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL 430 440 450 460 470 480 VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGPVH HGQVSYISPP 490 500 510 520 530 540 IHLDSDLERP PVRGISTTGP LGMGSTTTST TLRTTTWNLG RSTTPSLPGR RNRSTSTPSP 550 560 570 580 590 600 AIEVLDVTTH LPSAASQIPA MEESCEAVEA REIMWFKTRQ GQVAKQSCPA GTIGVSTYLC 610 620 630 640 650 660 LAPDGIWDPQ GPDLSNCSSP WVNHITQKLK SGETAANIAR ELAEQTRNHL NAGDITYSVR 670 680 690 700 710 720 AMDQLVGLLD VQLRNLTPGG KDSAARSLNK LQKRERSCRA YVQAMVETVN NLLQPQALNA 730 740 750 760 770 780 WRDLTTSDQL RAATMLLDTV EESAFVLADN LLKTDIVREN TDNIQLEVAR LSTEGNLEDL 790 800 810 820 830 840 KFPENTGHGS TIQLSANTLK QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEAMSTNH 850 860 870 880 890 900 SVIVNSPVIT AAINKEFSNK VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS 910 920 930 940 950 960 TQGCRLLTTN KTHTTCSCNH LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL 970 980 990 1000 1010 1020 ICIFTFCFFR GLQSDRNTIH KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA 1030 1040 1050 1060 1070 1080 AFTWMFLEGV QLYIMLVEVF ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW 1090 1100 1110 1120 1130 1140 LRLDTYFIWS FIGPATLIIM LNVIFLGIAL YKMFHHTAIL KPESGCLDNI KSWVIGAIAL 1150 1160 1170 1180 1190 1200 LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK EYGKCLRTHC 1210 1220 1230 1240 1250 1260 CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV RKQSESSFIT GDINSSASLN 1270 1280 1290 1300 1310 1320 RGTMANHLMS NALLRPHGTN NPYNTLLGEP AVCNNPSISM YNAQEPYRET SMGVKLNIAY 1330 1340 QIGASEQCQG YKCHGYSTTE W
	Isoform 7 (CL3AC) [UniParc]. Checksum: AE10D88D147CF078	FASTA	1,273	142,554
	10 20 30 40 50 60 MCPPQLFILM MLLAPVVHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR 70 80 90 100 110 120 TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV AGPDVFPDPC PGTYKYLEVQ 130 140 150 160 170 180 YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE SDHQSGAWCK DPLQASDKIY YMPWTPYRTD 190 200 210 220 230 240 TLTEYSSKDD FIAGRPTTTY KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG 250 260 270 280 290 300 EAIIANANYH DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT 310 320 330 340 350 360 WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD SLVDVPFPNS 370 380 390 400 410 420 YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGP VHHGQVSYIS PPIHLDSDLE 430 440 450 460 470 480 RPPVRGISTT GPLGMGSTTT STTLRTTTWN LGRSTTPSLP GRRNRSTSTP SPAIEVLDVT 490 500 510 520 530 540 THLPSAASQI PAMEESCEAV EAREIMWFKT RQGQVAKQSC PAGTIGVSTY LCLAPDGIWD 550 560 570 580 590 600 PQGPDLSNCS SPWVNHITQK LKSGETAANI ARELAEQTRN HLNAGDITYS VRAMDQLVGL 610 620 630 640 650 660 LDVQLRNLTP GGKDSAARSL NKLQKRERSC RAYVQAMVET VNNLLQPQAL NAWRDLTTSD 670 680 690 700 710 720 QLRAATMLLD TVEESAFVLA DNLLKTDIVR ENTDNIQLEV ARLSTEGNLE DLKFPENTGH 730 740 750 760 770 780 GSTIQLSANT LKQNGRNGEI RVAFVLYNNL GPYLSTENAS MKLGTEAMST NHSVIVNSPV 790 800 810 820 830 840 ITAAINKEFS NKVYLADPVV FTVKHIKQSE ENFNPNCSFW SYSKRTMTGY WSTQGCRLLT 850 860 870 880 890 900 TNKTHTTCSC NHLTNFAVLM AHVEVKHSDA VHDLLLDVIT WVGILLSLVC LLICIFTFCF 910 920 930 940 950 960 FRGLQSDRNT IHKNLCISLF VAELLFLIGI NRTDQPIACA VFAALLHFFF LAAFTWMFLE 970 980 990 1000 1010 1020 GVQLYIMLVE VFESEHSRRK YFYLVGYGMP ALIVAVSAAV DYRSYGTDKV CWLRLDTYFI 1030 1040 1050 1060 1070 1080 WSFIGPATLI IMLNVIFLGI ALYKMFHHTA ILKPESGCLD NIKSWVIGAI ALLCLLGLTW 1090 1100 1110 1120 1130 1140 AFGLMYINES TVIMAYLFTI FNSLQGMFIF IFHCVLQKKV RKEYGKCLRT HCCSGKSTES 1150 1160 1170 1180 1190 1200 SIGSGKTSGS RTPGRYSTGS QSRIRRMWND TVRKQSESSF ITGDINSSAS LNRGTMANHL 1210 1220 1230 1240 1250 1260 MSNALLRPHG TNNPYNTLLG EPAVCNNPSI SMYNAQEPYR ETSMGVKLNI AYQIGASEQC 1270 QGYKCHGYST TEW

References

[1]	"Alpha-latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis." Sugita S., Ichtchenko K., Khvotchev M., Suedhof T.C. J. Biol. Chem. 273:32715-32724(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6 AND 7).
[2]	"A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors." Ichtchenko K., Bittner M.A., Krasnoperov V., Little A.R., Chepurny O., Holz R.W., Petrenko A.G. J. Biol. Chem. 274:5491-5498(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081154 mRNA. Translation: AAC62660.1. AF081155 mRNA. Translation: AAC62661.1. AF081156 mRNA. Translation: AAC62662.1. AF081157 mRNA. Translation: AAC62663.1. AF081158 mRNA. Translation: AAC62664.1. AF081159 mRNA. Translation: AAC62665.1. AF063103 mRNA. Translation: AAC77816.1.
IPI	IPI00208264. IPI00214226. IPI00561212. IPI00562968. IPI00817056. IPI00817103. IPI00817119.
PIR	T14327. T17186. T17187. T17188. T17198. T17199. T17200.
RefSeq	NP_570835.1. NM_130822.1.
UniGene	Rn.203386.
3D structure databases
ProteinModelPortal	Q9Z173.
SMR	Q9Z173. Positions 93-197.
ModBase	Search...
Protein family/group databases
MEROPS	S63.014.
GPCRDB	Search...
PTM databases
PhosphoSite	Q9Z173.
Proteomic databases
PaxDb	Q9Z173.
PRIDE	Q9Z173.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	170641.
KEGG	rno:170641.
Organism-specific databases
CTD	23284.
RGD	620836. Lphn3.
Phylogenomic databases
eggNOG	NOG253931.
HOVERGEN	HBG052337.
InParanoid	Q9Z173.
KO	K04594.
Gene expression databases
ArrayExpress	Q9Z173.
Genevestigator	Q9Z173.
Family and domain databases
InterPro	IPR022624. DUF3497. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR003924. GPCR_2_latrophilin. IPR015630. GPCR_2_latrophilin3. IPR003334. GPCR_2_latrophilin_rcpt_C. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. IPR000922. Lectin_gal-bd_dom. IPR003112. Olfac-like. [Graphical view]
PANTHER	PTHR12011:SF60. PTHR12011:SF60. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF12003. DUF3497. 1 hit. PF02140. Gal_Lectin. 1 hit. PF01825. GPS. 1 hit. PF02793. HRM. 1 hit. PF02354. Latrophilin. 2 hits. PF02191. OLF. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR01444. LATROPHILIN.
SMART	SM00303. GPS. 1 hit. SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS51132. OLF. 1 hit. PS50228. SUEL_LECTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	621147.

Entry information

Entry name

LPHN3_RAT

Accession

Primary (citable) accession number: Q9Z173
Secondary accession number(s): O88924 , O88925, O88926, O88927, O88928, O88929, Q4LDM4, Q4LDM5, Q4LDM6, Q4LDM7, Q4LDM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program