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Protein

Conserved oligomeric Golgi complex subunit 1

Gene

Cog1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 1
Short name:
COG complex subunit 1
Alternative name(s):
Component of oligomeric Golgi complex 1
Low density lipoprotein receptor defect B-complementing protein
Gene namesi
Name:Cog1
Synonyms:Ldlb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333873. Cog1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002134922 – 980Conserved oligomeric Golgi complex subunit 1Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei598N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z160.
MaxQBiQ9Z160.
PaxDbiQ9Z160.
PRIDEiQ9Z160.

PTM databases

iPTMnetiQ9Z160.
PhosphoSitePlusiQ9Z160.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018661.
CleanExiMM_COG1.
ExpressionAtlasiQ9Z160. baseline and differential.
GenevisibleiQ9Z160. MM.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

BioGridi201132. 1 interactor.
STRINGi10090.ENSMUSP00000018805.

Structurei

3D structure databases

ProteinModelPortaliQ9Z160.
SMRiQ9Z160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG1 family.Curated

Phylogenomic databases

eggNOGiKOG2033. Eukaryota.
ENOG410XR7E. LUCA.
GeneTreeiENSGT00390000017136.
HOGENOMiHOG000231051.
HOVERGENiHBG031402.
InParanoidiQ9Z160.
KOiK20288.
OMAiCPHLKQC.
OrthoDBiEOG091G02C8.
PhylomeDBiQ9Z160.
TreeFamiTF314678.

Family and domain databases

InterProiView protein in InterPro
IPR033370. COG1.
PANTHERiPTHR31658. PTHR31658. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATASSAL KRLDLRDPNA LFETHGAEEI RGLERQVRAE IEHKKEELRQ
60 70 80 90 100
MVGERYRDLI EAADTIGQMR RCAEGLVDAV QATDQYCARL RQAGSVAPRV
110 120 130 140 150
PRAPQPQPPS EKFYSMAAQI KLLLEIPEKI WSAMEASQHL QATQLYLLCC
160 170 180 190 200
HLHSLLQLDS SNSRYSPILS RFPILIRQVA AASHFRSTIL HESKMLLKCQ
210 220 230 240 250
AVSDQAVAEA LCSIMLLEES SPRQALTDFL LARKATIQTL LNQSHHGAGI
260 270 280 290 300
KAQICSLVEL LATTLNQAHA LFYTLPEGVL PDPSLPCGLL FSTLETVTRQ
310 320 330 340 350
HPTGKGIGAL QGEMKLCSWF RHLPTSIIEF QPTLRTLAHP ISQEYLKDTL
360 370 380 390 400
QKWIDMCNED IKNGIGNLLM YVKSMKGLAG IRDAIWDLLS NESASHSWEV
410 420 430 440 450
VCQRLLEKPL LFWEDLMQQL FLDRLQTLTR EGFESISNSS KELLVSALQE
460 470 480 490 500
LETNNSTSNK HVHFEQNMSF FLWSESPNDL PSDAAWVSVA NRAQFASSGL
510 520 530 540 550
SMKAQAISPC VQNFCSALDS KLKVKLDDLL AYLPSSDTPL LKDTTPTHQP
560 570 580 590 600
KNSAFDRYAD AGTVQDMLRT QSVACIKSVV GCIQAELCTI EEVTREQKDV
610 620 630 640 650
LHSTKLHAVL FMARLCQSLG ELCPHLKQCV VGQCGGSEKP AREARALKKQ
660 670 680 690 700
GKGRAQDVLP AQAQWQGVKE VLLQQSVMAY RVWSTALVKF LICGFTRSLL
710 720 730 740 750
LRDAGSVLAT ATNWDELEIQ EETESGSSVT SKIRLPTQPS WYVQSFLFSL
760 770 780 790 800
CQEVNRVGGH ALPKVTLQEM LKTCMAQVIA AYEQLTEENQ IKKEGAFPMT
810 820 830 840 850
QNRALQLLYD LRYLTMVLSS KGEEVKSGRS KADSRMEKMT ERLEALIDPF
860 870 880 890 900
DLDVFTPHLN SNLNRLVQRT SVLFGLVTGT ENQFASRSST FNSQEPHNIL
910 920 930 940 950
PLASSQIRFG LLPLSMTSTR KARATSRSVE TQAQVGPPAL SRVGDPTTHP
960 970 980
GSLFRQLASE EDDSPAPSLF KLAWLSSMTK
Length:980
Mass (Da):109,050
Last modified:May 2, 2006 - v3
Checksum:iF0CDC1104663FAD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320F → L in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti561A → T in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti630V → I in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti722E → G in AAD13780 (PubMed:9927668).Curated1
Sequence conflicti772K → E in AAD13780 (PubMed:9927668).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109377 mRNA. Translation: AAD13780.2.
AK034636 mRNA. Translation: BAE43288.1.
BC063056 mRNA. Translation: AAH63056.1.
CCDSiCCDS25599.1.
RefSeqiNP_038609.3. NM_013581.3.
UniGeneiMm.261620.
Mm.351688.

Genome annotation databases

EnsembliENSMUST00000018805; ENSMUSP00000018805; ENSMUSG00000018661.
GeneIDi16834.
KEGGimmu:16834.
UCSCiuc007mer.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCOG1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z160
Secondary accession number(s): Q6P567
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 2, 2006
Last modified: December 20, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families