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Protein

Syntaxin-17

Gene

Stx17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • SNAP receptor activity Source: UniProtKB
  • SNARE binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-171 Publication
Gene namesi
Name:Stx17By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708499. Stx17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 227CytoplasmicSequence analysisAdd BLAST226
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 253LumenalSequence analysis5
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 301CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi156Y → E: Alters interaction with COPB1 but not with SEC24C. 2 Publications1
Mutagenesisi156Y → F: Prevents phosphorylation by ABL1 and impairs transport from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102302 – 301Syntaxin-17Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei41N6-acetyllysineBy similarity1
Modified residuei156Phosphotyrosine; by ABL11 Publication1
Modified residuei288PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Tyr-156 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z158.
PRIDEiQ9Z158.

PTM databases

iPTMnetiQ9Z158.
PhosphoSitePlusiQ9Z158.

Expressioni

Tissue specificityi

Detected in all tissues examined with higher expression in steroidogenic tissues including testis and adrenal gland (at protein level). Highly expressed in liver and testis. Also found in brain, heart, kidney, lung, placenta, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiENSRNOG00000005801.
GenevisibleiQ9Z158. RN.

Interactioni

Subunit structurei

Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (By similarity). May interact with VAMP7 (By similarity). May interact with VTI1B (By similarity). Probably interacts with BET1, SCFD1 and SEC22B (PubMed:10930465). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (PubMed:23006999). Interacts with COPB1 (PubMed:21545355). Interacts with TMED9 and TMED10; the interaction is direct (PubMed:21545355).By similarity3 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • SNAP receptor activity Source: UniProtKB
  • SNARE binding Source: UniProtKB

Protein-protein interaction databases

BioGridi251633. 1 interactor.
MINTiMINT-4998537.
STRINGi10116.ENSRNOP00000007641.

Structurei

3D structure databases

ProteinModelPortaliQ9Z158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 223t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni228 – 274Necessary and sufficient for localization to autophagosomeBy similarityAdd BLAST47
Regioni273 – 301Required for interaction with COPB1, TMED9 and TMED101 PublicationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 128Sequence analysisAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 301Endoplasmic reticulum retention signalSequence analysis4

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00390000013283.
HOGENOMiHOG000006905.
HOVERGENiHBG055257.
InParanoidiQ9Z158.
KOiK08491.
OMAiANMREME.
OrthoDBiEOG091G127M.
PhylomeDBiQ9Z158.
TreeFamiTF323947.

Family and domain databases

InterProiIPR028676. STX17.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF139. PTHR19957:SF139. 1 hit.
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDEEKVKL RRLEPAIQKF TKIVIPTDLE RLKKHQINIE KYQRCRIWDK
60 70 80 90 100
LHEEHINAGR TVQQLRSNIR EMEKLCLKVH KDDLILLKRM IDPMKEAAAA
110 120 130 140 150
ATAEFLQLHL ESVEELKKQV KNEEALLQPS LTRSTTIDGV HTGEAEAASQ
160 170 180 190 200
SLTQIYALPE IPRDQNAAES WETLEADLIE LSHLVTDMSL LVNSQQEKID
210 220 230 240 250
SIADHVNSAA VNVEEGTKNL QKAAKYKLAA LPVAGAVIGG VVGGPIGLLA
260 270 280 290 300
GFKVAGIAAA LGGGVLGFTG GKLIQRRKQK MMEKLTSSCP DLPSQSDKKC

S
Length:301
Mass (Da):33,182
Last modified:May 1, 1999 - v1
Checksum:i7C64C38961C5B8DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115435 mRNA. Translation: AAD11435.1.
RefSeqiNP_663775.1. NM_145723.1.
XP_006238086.1. XM_006238024.2.
XP_017448641.1. XM_017593152.1.
UniGeneiRn.204688.

Genome annotation databases

EnsembliENSRNOT00000007641; ENSRNOP00000007641; ENSRNOG00000005801.
GeneIDi252853.
KEGGirno:252853.
UCSCiRGD:708499. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115435 mRNA. Translation: AAD11435.1.
RefSeqiNP_663775.1. NM_145723.1.
XP_006238086.1. XM_006238024.2.
XP_017448641.1. XM_017593152.1.
UniGeneiRn.204688.

3D structure databases

ProteinModelPortaliQ9Z158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251633. 1 interactor.
MINTiMINT-4998537.
STRINGi10116.ENSRNOP00000007641.

PTM databases

iPTMnetiQ9Z158.
PhosphoSitePlusiQ9Z158.

Proteomic databases

PaxDbiQ9Z158.
PRIDEiQ9Z158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007641; ENSRNOP00000007641; ENSRNOG00000005801.
GeneIDi252853.
KEGGirno:252853.
UCSCiRGD:708499. rat.

Organism-specific databases

CTDi55014.
RGDi708499. Stx17.

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00390000013283.
HOGENOMiHOG000006905.
HOVERGENiHBG055257.
InParanoidiQ9Z158.
KOiK08491.
OMAiANMREME.
OrthoDBiEOG091G127M.
PhylomeDBiQ9Z158.
TreeFamiTF323947.

Miscellaneous databases

PROiQ9Z158.

Gene expression databases

BgeeiENSRNOG00000005801.
GenevisibleiQ9Z158. RN.

Family and domain databases

InterProiIPR028676. STX17.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF139. PTHR19957:SF139. 1 hit.
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX17_RAT
AccessioniPrimary (citable) accession number: Q9Z158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.