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Protein

Galectin-2

Gene

Lgals2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds beta-galactoside. Its physiological function is not yet known.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • galactoside binding Source: RGD
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-2
Short name:
Gal-2
Gene namesi
Name:Lgals2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621269. Lgals2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769271 – 130Galectin-2Add BLAST130

Proteomic databases

PaxDbiQ9Z144.

PTM databases

iPTMnetiQ9Z144.
PhosphoSitePlusiQ9Z144.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008539.
GenevisibleiQ9Z144. RN.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011750.

Structurei

3D structure databases

ProteinModelPortaliQ9Z144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 130GalectinPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 71Beta-galactoside bindingSequence analysis7

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiQ9Z144.
KOiK10090.
OMAiLNLHFNP.
OrthoDBiEOG091G0S7H.
PhylomeDBiQ9Z144.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKFEVTNL NMKSGMSLKI KGKIHNDVNS FTINLGQGKE TLNLHFNPRF
60 70 80 90 100
NESTIVCNTL DGSSWGQEQR ENHSCFSPGS EVKLTLTFQD KDFKVTLPDG
110 120 130
HSLTFPNRLG HNHLRYLSMD GLQISSFKLE
Length:130
Mass (Da):14,733
Last modified:May 1, 1999 - v1
Checksum:iE4641D804C9CA7E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001075 mRNA. Translation: BAA74954.1.
RefSeqiNP_598283.1. NM_133599.1.
UniGeneiRn.2982.

Genome annotation databases

EnsembliENSRNOT00000011750; ENSRNOP00000011750; ENSRNOG00000008539.
GeneIDi171134.
KEGGirno:171134.
UCSCiRGD:621269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001075 mRNA. Translation: BAA74954.1.
RefSeqiNP_598283.1. NM_133599.1.
UniGeneiRn.2982.

3D structure databases

ProteinModelPortaliQ9Z144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011750.

PTM databases

iPTMnetiQ9Z144.
PhosphoSitePlusiQ9Z144.

Proteomic databases

PaxDbiQ9Z144.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011750; ENSRNOP00000011750; ENSRNOG00000008539.
GeneIDi171134.
KEGGirno:171134.
UCSCiRGD:621269. rat.

Organism-specific databases

CTDi3957.
RGDi621269. Lgals2.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiQ9Z144.
KOiK10090.
OMAiLNLHFNP.
OrthoDBiEOG091G0S7H.
PhylomeDBiQ9Z144.
TreeFamiTF315551.

Miscellaneous databases

PROiQ9Z144.

Gene expression databases

BgeeiENSRNOG00000008539.
GenevisibleiQ9Z144. RN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG2_RAT
AccessioniPrimary (citable) accession number: Q9Z144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.